{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T17:00:07Z","timestamp":1792947607243,"version":"4.5.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100011019","name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal","doi-asserted-by":"publisher","award":["Starting 150834"],"award-info":[{"award-number":["Starting 150834"]}],"id":[{"id":"10.13039\/501100011019","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011019","name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal","doi-asserted-by":"publisher","award":["FK 138910"],"award-info":[{"award-number":["FK 138910"]}],"id":[{"id":"10.13039\/501100011019","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund","award":["EK\u00d6P-25-4-II-DE-59"],"award-info":[{"award-number":["EK\u00d6P-25-4-II-DE-59"]}]},{"DOI":"10.13039\/501100003825","name":"Hungarian Academy of Sciences","doi-asserted-by":"crossref","award":["Janos Bolyai Research Scholarship"],"award-info":[{"award-number":["Janos Bolyai Research Scholarship"]}],"id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009232","name":"University of Debrecen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009232","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mycopathologia"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Saccharomyces cerevisiae<\/jats:italic>\n                    has increasingly been recognized as an opportunistic pathogen. Sterile-site infections remain rare but are associated with substantial morbidity and mortality, especially in critically ill patients. This study aimed to characterize the epidemiological, clinical, and microbiological characteristics of sterile-site\n                    <jats:italic>S. cerevisiae<\/jats:italic>\n                    infections. We performed a retrospective analysis of all patients with\n                    <jats:italic>S. cerevisiae<\/jats:italic>\n                    isolated from sterile body sites between January 2019 and December 2025. Demographic data, underlying conditions, probiotic exposure, antifungal therapy, and outcomes were collected, and antifungal susceptibility testing was performed. Among 196 patients with\n                    <jats:italic>S. cerevisiae<\/jats:italic>\n                    isolates, 30 (15%) had sterile-site infections. The mean age was 47.2\u00a0years, and 23% were paediatric cases. Bloodstream infections were the most common source (n\u2009=\u20097, 23%), followed by intra-abdominal abscess aspirates and drained intra-abdominal wounds (each n\u2009=\u20095, 17%). Intensive care unit (ICU) admission occurred in 33%, prior gastrointestinal surgery in 63%, central venous catheter usage in all fatal cases, and prior probiotic exposure in 30%. Overall, 30-day mortality was 27%. In multivariable analysis, increasing age (adjusted OR 1.11 per year, 95% CI 1.02\u20131.37;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.008) and ICU admission (adjusted OR 10.09, 95% CI 1.23\u2013259.6;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03) were independent predictors of mortality. Fluconazole showed variable activity, whereas amphotericin B and echinocandins demonstrated low minimal inhibitory concentrations. Rare sterile-site\n                    <jats:italic>S. cerevisiae<\/jats:italic>\n                    infections are associated with high mortality related to host factors such as age and critical illness, supporting cautious probiotic use and first-line amphotericin B or echinocandins.\n                  <\/jats:p>","DOI":"10.1007\/s11046-026-01080-7","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T01:45:36Z","timestamp":1778723136000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical and Microbiological Characteristics of Sterile-Site Saccharomyces cerevisiae Infections in a Tertiary-Care Centre"],"prefix":"10.1007","volume":"191","author":[{"given":"Andrea","family":"Harmath","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilla T\u00fcnde","family":"Vass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1gnes","family":"Jakab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"T\u00f3th","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliz","family":"Boz\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Majoros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter P.","family":"Pfliegler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3946-2424","authenticated-orcid":false,"given":"Ren\u00e1t\u00f3","family":"Kov\u00e1cs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"1080_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/jof8050444","volume":"8","author":"R Abid","year":"2022","unstructured":"Abid R, Waseem H, Ali J, Ghazanfar S, Muhammad Ali G, Elasbali AM, et al. Probiotic yeast Saccharomyces: back to nature to improve human health. J Fungi. 2022;8:444. https:\/\/doi.org\/10.3390\/jof8050444.","journal-title":"J Fungi"},{"key":"1080_CR2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-33958-7","volume":"13","author":"BJ Kil","year":"2023","unstructured":"Kil BJ, Pyung YJ, Park H, Kang JW, Yun CH, Huh CS. Probiotic potential of Saccharomyces cerevisiae GILA with alleviating intestinal inflammation in a dextran sulfate sodium induced colitis mouse model. Sci Rep. 2023;13:6687. https:\/\/doi.org\/10.1038\/s41598-023-33958-7.","journal-title":"Sci Rep"},{"key":"1080_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/jof8101046","volume":"8","author":"P Belvoncikova","year":"2022","unstructured":"Belvoncikova P, Splichalova P, Videnska P, Gardlik R. The human mycobiome: colonization, composition and the role in health and disease. J Fungi (Basel). 2022;8:1046. https:\/\/doi.org\/10.3390\/jof8101046.","journal-title":"J Fungi (Basel)"},{"key":"1080_CR4","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/j.cmi.2025.02.009","volume":"31","author":"LX Li","year":"2025","unstructured":"Li LX, Gupta A, Hamill MM, Zhang SX, Manabe YC. Disseminated Saccharomyces cerevisiae infection in advanced HIV: a literature review. Clin Microbiol Infect. 2025;31:773\u20137. https:\/\/doi.org\/10.1016\/j.cmi.2025.02.009.","journal-title":"Clin Microbiol Infect"},{"key":"1080_CR5","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1086\/497832","volume":"41","author":"A Enache-Angoulvant","year":"2005","unstructured":"Enache-Angoulvant A, Hennequin C. Invasive Saccharomyces infection: a comprehensive review. Clin Infect Dis. 2005;41:1559\u201368. https:\/\/doi.org\/10.1086\/497832.","journal-title":"Clin Infect Dis"},{"key":"1080_CR6","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/978-3-319-72799-8_10","volume-title":"Adv Exp Med Biol","author":"L Vald\u00e9s-Varela","year":"2018","unstructured":"Vald\u00e9s-Varela L, Gueimonde M, Ruas-Madiedo P. Probiotics for prevention and treatment of Clostridium difficile infection. In: Adv Exp Med Biol, vol. 1050. 2018. p. 161\u201376. https:\/\/doi.org\/10.1007\/978-3-319-72799-8_10."},{"key":"1080_CR7","doi-asserted-by":"publisher","first-page":"e375","DOI":"10.1016\/S1473-3099(21)00203-6","volume":"21","author":"SC Chen","year":"2021","unstructured":"Chen SC, Perfect J, Colombo AL, et al. Global guideline for the diagnosis and management of rare yeast infections: an initiative of the ECMM in cooperation with ISHAM and ASM. Lancet Infect Dis. 2021;21:e375\u201386. https:\/\/doi.org\/10.1016\/S1473-3099(21)00203-6. 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Ethical approval was obtained from the institutional ethics committee of the University of Debrecen, Regional and Institutional Research Ethics Committee (DE RKEB\/IKEB) (approval number: 5775\u20132021).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"55"}}