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The human patients infected with\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>brasiliensis<\/jats:italic>\n                    usually respond favorably to antifungal therapy. However, therapeutic failure may occur, and management may be particularly challenging in cases of severe disease. We recently reported that at least seven\n                    <jats:italic>S. brasiliensis<\/jats:italic>\n                    genotypes circulate across South America. However, their biological and clinical relevance of this genetic diversity remains poorly understood. In this study, we investigated whether distinct\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>brasiliensis<\/jats:italic>\n                    genotypes are associated with reduced susceptibility to the main antifungal agents used in the treatment of human and animal sporotrichosis. A total of 92 clinical, veterinary, and environmental\n                    <jats:italic>S. brasiliensis<\/jats:italic>\n                    strains from Brazil, Paraguay and Argentina, genotyping them using a four-gene MLST scheme. Mating type was assessed as well as antifungal susceptibility according to the M38-A2 CLSI guidelines. Results were interpreted according to the established epidemiological cutoff values for\n                    <jats:italic>S. brasiliensis<\/jats:italic>\n                    . The isolates are clustered into six distinct genotypes, with mating type showing a strong association with phylogenetic clades. Non-wild type strains were identified across four haplotypes (H1, H2, H3 and H4) for all antifungal drugs tested. These non-wild type strains were isolated from six distinct Brazilian states and were not associated to a specific genetic background. Nevertheless, non-wild-type strains were predominantly detected among feline isolates, most of which originated from Minas Gerais and belonged to haplotype H2. However, because only a limited number of H2 isolates were included in this study, additional isolates from this haplotype are need to confirm this association. Together, these findings suggest that decreased antifungal susceptibility in\n                    <jats:italic>S. brasiliensis<\/jats:italic>\n                    is not genotype-restricted but may be influenced by host-related or epidemiological factors, particularly in the context of feline sporotrichosis.\n                  <\/jats:p>","DOI":"10.1007\/s11046-026-01113-1","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:02:56Z","timestamp":1792087376000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Susceptibility Profiles Among Sporothrix brasiliensis Genotypes in the Ongoing Zoonotic Sporotrichosis Epidemic in Brazil, Argentina and Paraguay"],"prefix":"10.1007","volume":"191","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9318-6240","authenticated-orcid":false,"given":"Vanessa Brito","family":"de Souza Rabello","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3330-3847","authenticated-orcid":false,"given":"Marcus","family":"de Melo Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7378-1990","authenticated-orcid":false,"given":"Fernando","family":"Almeida-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2448-3198","authenticated-orcid":false,"given":"Thiago Brasil","family":"de Moura Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4997-8734","authenticated-orcid":false,"given":"Andrea Reis","family":"Bernardes-Engemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3883-0080","authenticated-orcid":false,"given":"Melissa Orzechowski","family":"Xavier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6639-6058","authenticated-orcid":false,"given":"Rodrigo","family":"Almeida-Paes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1479-0615","authenticated-orcid":false,"given":"Mar\u00eda Cecilia","family":"L\u00f3pez-Joffre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0955-9340","authenticated-orcid":false,"given":"Cristina Elena","family":"Canteros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1425-5912","authenticated-orcid":false,"given":"Lisandra Serra","family":"Damasceno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8428-7616","authenticated-orcid":false,"given":"Isabella Dib Ferreira","family":"Gremi\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9660-4156","authenticated-orcid":false,"given":"Jos\u00e9 Guillermo Pereira","family":"Brunelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9933-8340","authenticated-orcid":false,"given":"Wieland","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7619-1921","authenticated-orcid":false,"given":"Rosely Maria","family":"Zancop\u00e9-Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"key":"1113_CR1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1093\/mmy\/myu062","volume":"53","author":"A Chakrabarti","year":"2015","unstructured":"Chakrabarti A, Bonifaz A, Gutierrez-Galhardo MC, Mochizuki T, Li S. 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