{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:43:53Z","timestamp":1786981433211,"version":"build-2736575974"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:00:00Z","timestamp":1171929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:00:00Z","timestamp":1171929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurooncol"],"published-print":{"date-parts":[[2007,8]]},"DOI":"10.1007\/s11060-007-9340-4","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T03:32:26Z","timestamp":1171855946000},"page":"57-62","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":122,"title":["Breast cancer leptomeningeal metastasis\u2014the role of multimodality treatment"],"prefix":"10.1007","volume":"84","author":[{"given":"Halina","family":"Rudnicka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Niwi\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Murawska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,2,20]]},"reference":[{"key":"9340_CR1","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1093\/oxfordjournals.annonc.a010755","volume":"7","author":"GC Jayson","year":"1996","unstructured":"Jayson GC, Howell A (1996) Carcinomatous meningitis in solid tumours. Ann Oncol 7:773\u2013786","journal-title":"Ann Oncol"},{"key":"9340_CR2","unstructured":"Steinfeld AD (1999) Radiation therapy. In: Roses DF (ed) Breast cancer, 2nd edn. Churchill Livingstone, Philadelphia"},{"key":"9340_CR3","volume-title":"The breast. Comprehensive management of benign and malignant diseases","author":"KA Johnson","year":"1998","unstructured":"Johnson KA, Kramer BS, Crane JM (1998) Management of central nervous system metastases in breast cancer. In: Bland KI, Copeland EM (eds) The breast. Comprehensive management of benign and malignant diseases, 2nd edn. WB Saunders Company, Philadelphia"},{"key":"9340_CR4","volume-title":"Diseases of the breast","author":"LM De Angelis","year":"2000","unstructured":"De Angelis LM, Rogers LR, Foley KM (2000) Leptomeningeal metastasis. In: Harris JR, Lippman ME, Morrow M, Osborne CK (eds) Diseases of the breast, 2nd edn. Lippincott Wiliams &Wilkins, Philadelphia"},{"key":"9340_CR5","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1053\/ctrv.1999.0119","volume":"25","author":"SA Grossman","year":"1999","unstructured":"Grossman SA, Krabak MJ (1999) Leptomeningeal carcinomatosis. Cancer Treat Rev 25:103\u2013119","journal-title":"Cancer Treat Rev"},{"key":"9340_CR6","doi-asserted-by":"publisher","first-page":"3605","DOI":"10.1200\/JCO.2005.01.131","volume":"23","author":"MC Chamberlain","year":"2005","unstructured":"Chamberlain MC (2005) Neoplastic meningitis. J Clin Oncol 23:3605\u20133613","journal-title":"J Clin Oncol"},{"key":"9340_CR7","volume-title":"Diseases of the breast","author":"L De Angelis","year":"2004","unstructured":"De Angelis L (2004) Leptomeningeal metastasis. In: Harris JR, Lippman ME, Morrow M, Osborne CK (eds) Diseases of the breast, 3rd edn. Lippincott Williams&Wilkins, Philadelphia"},{"key":"9340_CR8","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1002\/1097-0142(19820215)49:4<759::AID-CNCR2820490427>3.0.CO;2-7","volume":"49","author":"WR Wasserstrom","year":"1982","unstructured":"Wasserstrom WR, Glass JP, Posner JB (1982) Diagnosis and treatment of leptomeningeal metastasis from solid tumours: experience with 90 patients. Cancer 49:759\u2013772","journal-title":"Cancer"},{"key":"9340_CR9","doi-asserted-by":"publisher","first-page":"3135","DOI":"10.1002\/1097-0142(19941215)74:12<3135::AID-CNCR2820741212>3.0.CO;2-8","volume":"74","author":"GC Jayson","year":"1994","unstructured":"Jayson GC, Howell A, Harris M et al (1994) Carcinomatous meningitis in breast cancer: an agressive disease variant. Cancer 74:3135\u20133141","journal-title":"Cancer"},{"key":"9340_CR10","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1002\/(SICI)1097-0142(19960401)77:7<1315::AID-CNCR14>3.0.CO;2-4","volume":"77","author":"K Fisazi","year":"1996","unstructured":"Fisazi K, Asselain B, Vincent- Salomon A et al (1996) Meningeal carcinomatosis in patients with breast carcinoma. Cancer 77:1315\u20131323","journal-title":"Cancer"},{"key":"9340_CR11","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1200\/JCO.1986.4.1.68","volume":"4","author":"L Giannone","year":"1986","unstructured":"Giannone L, Greco FA, Hainsworth JD (1986) Combination intraventricular chemotherapy for meningeal neoplasia. J Clin Oncol 4:68\u201373","journal-title":"J Clin Oncol"},{"key":"9340_CR12","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1002\/1097-0142(19820715)50:2<219::AID-CNCR2820500209>3.0.CO;2-7","volume":"49","author":"H Yap","year":"1982","unstructured":"Yap H, Yap B, Rasmussen S et al (1982) Treatment for meningeal carcinomatosis on breast cancer. Cancer 49:219\u2013222","journal-title":"Cancer"},{"key":"9340_CR13","doi-asserted-by":"publisher","first-page":"2726","DOI":"10.1016\/j.ejca.2004.08.012","volume":"40","author":"W Boogerd","year":"2004","unstructured":"Boogerd W, Bent MJ, Koehler PJ et al (2004) The relevance of intraventricular chemotherapy for leptomeningeal metastasis in breast cancer: a randomized study. Eur J Cancer 40:2726\u20132733","journal-title":"Eur J Cancer"},{"key":"9340_CR14","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1023\/A:1005976003347","volume":"38","author":"J Hildebrand","year":"1998","unstructured":"Hildebrand J (1998) Prophylaxis and treatment of leptomeningeal carcinomatosis in solid tumors of adulthood. J Neurooncol 38:193\u2013198","journal-title":"J Neurooncol"},{"key":"9340_CR15","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1002\/1097-0142(19910315)67:6<1685::AID-CNCR2820670635>3.0.CO;2-M","volume":"67","author":"W Boogerd","year":"1991","unstructured":"Boogerd W, Hart AAM, van der Sande JJ et al (1991) Meningeal carcinomatosis in breast cancer. Prognostic factors and influence of treatment. Cancer 67:1685\u20131695","journal-title":"Cancer"},{"key":"9340_CR16","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1200\/JCO.1993.11.3.561","volume":"11","author":"SA Grossman","year":"1993","unstructured":"Grossman SA, Finkelstein DM, Ruckdeschel DL et al (1993) Randomised prospective comparison of intraventricular methotrexate and thiotepa in patients with previously untreated neoplastic meningitis. J Clin Oncol 11:561\u2013569","journal-title":"J Clin Oncol"},{"key":"9340_CR17","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1212\/WNL.33.12.1565","volume":"33","author":"BW de Ongerboer Visser","year":"1983","unstructured":"Ongerboer de Visser BW, Somers R, Nooyen WH et al (1983) Intraventricular methotrexate therapy of leptomeningeal metastasis from breast cancer. Neurology 33:1565\u20131572","journal-title":"Neurology"},{"key":"9340_CR18","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1200\/JCO.1987.5.10.1655","volume":"5","author":"RN Hitchins","year":"1987","unstructured":"Hitchins RN, Bell DR, Woods RL et al (1987) A prospective randomized trial of single agent versus combination chemotherapy in meningeal carcinomatosis. J Clin Oncol 5:1655\u20131662","journal-title":"J Clin Oncol"},{"key":"9340_CR19","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1212\/WNL.44.8.1463","volume":"4","author":"T Siegal","year":"1994","unstructured":"Siegal T, Lossos A, Pfeffer MR (1994) Leptomeningeal metastases: analysis of 31 patients with sustained off-therapy response following combined-modality therapy. Neurology 4:1463\u20131469","journal-title":"Neurology"},{"key":"9340_CR20","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1002\/(SICI)1097-0142(19980501)82:9<1764::AID-CNCR24>3.0.CO;2-1","volume":"82","author":"F Bokstein","year":"1998","unstructured":"Bokstein F, Lossos A, Siegal T (1998) Leptomeningeal metastases from solid tumors: a comparison of two prospective series treated with and without intra-cerebrospinal fluid chemotherapy. Cancer 82:1756\u20131763","journal-title":"Cancer"},{"key":"9340_CR21","first-page":"2502","volume":"49","author":"MR Gilbert","year":"1989","unstructured":"Gilbert MR, Harding BL, Grossman SA (1989) Methotrexate neurotoxicity: in vitro studies using cerebellar explants from rats. Cancer Res 49:2502\u20132505","journal-title":"Cancer Res"},{"key":"9340_CR22","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1136\/jnnp.51.10.1277","volume":"51","author":"Boogerd","year":"1988","unstructured":"Boogerd , van der Sande JJ, Moffie D (1988) Acute fever and delayed leucoencephalophathy following low dose intraventricular methotrexate. J Neurol Neurosurg Psych 51:1277\u20131283","journal-title":"J Neurol Neurosurg Psych"},{"key":"9340_CR23","doi-asserted-by":"publisher","first-page":"1724","DOI":"10.1002\/1097-0142(19811015)48:8<1724::AID-CNCR2820480807>3.0.CO;2-U","volume":"48","author":"H Mena","year":"1981","unstructured":"Mena H, Garcia JH, Velandia F (1981) Central and peripheral myelopathy associated with systemic neoplastic and chemotherapy. Cancer 48:1724\u20131737","journal-title":"Cancer"},{"key":"9340_CR24","first-page":"107","volume":"5","author":"SM Blaney","year":"1991","unstructured":"Blaney SM, Balis FM, Poplack DG (1991) Pharmacologic approaches to the treatment of meningeal malignancy. Oncology 5:107\u2013116","journal-title":"Oncology"},{"key":"9340_CR25","first-page":"1232","volume":"37","author":"Y Ushio","year":"1977","unstructured":"Ushio Y, Posner JB, Shapiro WR et al (1977) Chemotherapy of experimental meningeal carcinomathosis. Cancer Res 37:1232\u20131237","journal-title":"Cancer Res"},{"key":"9340_CR26","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1001\/archneur.1994.00540170033013","volume":"51","author":"R Grant","year":"1994","unstructured":"Grant R, Naylor B, Greenberg HS et al (1994) Clinical outcome in aggresively treated meningeal carcinomathosis. Arch Neurol 51:457\u2013461","journal-title":"Arch Neurol"},{"key":"9340_CR27","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1200\/JCO.1998.16.4.1561","volume":"16","author":"MJ Glantz","year":"1998","unstructured":"Glantz MJ, Cole BF, Recht L et al (1998) High-dose intravenous methotrexate for patients with nonleukemic leptomeningeal cancer: is intrathecal chemotherapy necessary? J Clin Oncol 16:1561\u20131567","journal-title":"J Clin Oncol"},{"key":"9340_CR28","doi-asserted-by":"publisher","first-page":"1892","DOI":"10.1002\/1097-0142(19940401)73:7<1892::AID-CNCR2820730720>3.0.CO;2-C","volume":"73","author":"PJ Mencel","year":"1994","unstructured":"Mencel PJ, DeAngelis LM, Motzer RJ (1994) Hormonal ablation is effective therapy for carcinomatous meningitis from prostatic carcinoma. Cancer 73:1892\u20131894","journal-title":"Cancer"},{"key":"9340_CR29","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/0169-5002(93)90185-Z","volume":"3","author":"WT Van der Graaf","year":"1993","unstructured":"Van der Graaf WT, Haaxma-Reiche H, Burghouts JT et al (1993) Teniposide for meningeal carcinomatosis of small-cell lung cancer. Lung Cancer 3:247\u2013249","journal-title":"Lung Cancer"}],"container-title":["Journal of Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-007-9340-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11060-007-9340-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-007-9340-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-007-9340-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,15]],"date-time":"2022-05-15T02:32:51Z","timestamp":1652581971000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11060-007-9340-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2,20]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["9340"],"URL":"https:\/\/doi.org\/10.1007\/s11060-007-9340-4","relation":{},"ISSN":["0167-594X","1573-7373"],"issn-type":[{"value":"0167-594X","type":"print"},{"value":"1573-7373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,2,20]]},"assertion":[{"value":"8 January 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2007","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 February 2007","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}