{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:40:49Z","timestamp":1792597249205,"version":"4.5.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2007,12,8]],"date-time":"2007-12-08T00:00:00Z","timestamp":1197072000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurooncol"],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1007\/s11060-007-9500-6","type":"journal-article","created":{"date-parts":[[2007,12,7]],"date-time":"2007-12-07T09:12:23Z","timestamp":1197018743000},"page":"63-70","source":"Crossref","is-referenced-by-count":20,"title":["Meningiomas exhibit loss of heterozygosity of the APC gene"],"prefix":"10.1007","volume":"87","author":[{"given":"Nives","family":"Pe\u0107ina-\u0160laus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Niku\u0161eva Marti\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davor","family":"Tomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vili","family":"Bero\u0161","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Zeljko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hrvoje","family":"\u010cupi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,12,8]]},"reference":[{"key":"9500_CR1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/0092-8674(81)90021-0","volume":"66","author":"J Groden","year":"1991","unstructured":"Groden J, Thliveris A, Samowitz W, Carlson M, Gelbert L, Albertsen H, Joslyn G, Stevens J, Spirio L, Robertson M (1991) Identification and characterization of the familial adenomatous polyposis coli gene. Cell 66:589\u2013600","journal-title":"Cell"},{"key":"9500_CR2","doi-asserted-by":"crossref","first-page":"22429","DOI":"10.1074\/jbc.R600015200","volume":"281","author":"MD Gordon","year":"2006","unstructured":"Gordon MD, Nusse R (2006) Wnt signalling: multiple pathways, multiple receptors, and multiple transcription factors. J Biol Chem 281:22429\u201322433","journal-title":"J Biol Chem"},{"key":"9500_CR3","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1126\/science.287.5458.1606","volume":"287","author":"M Peifer","year":"2000","unstructured":"Peifer M, Polakis P (2000) Wnt signaling in oncogenesis and embriogenesis\u2014a look outside the nucleus. Science 287:1606\u20131609","journal-title":"Science"},{"key":"9500_CR4","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1080\/00313020410001671984","volume":"36","author":"N Pecina-Slaus","year":"2004","unstructured":"Pecina-Slaus N, Gall-Troselj K, Slaus M, Radic K, Nikuseva-Martic T, Pavelic K (2004) Genetic changes of the E-cadherin and APC tumour suppressor genes in clear cell renal cell carcinoma. Pathology 36:145\u2013151","journal-title":"Pathology"},{"key":"9500_CR5","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/ijc.1342","volume":"93","author":"A Koch","year":"2001","unstructured":"Koch A, Waha A, Tonn JC, Sorensen N, Berthold F, Wolter M, Reifenberger J, Hartmann W, Friedl W, Reifenberger G, Wiestler OD, Pietsch T (2001) Somatic mutations of WNT\/wingless signaling pathway components in primitive neuroectodermal tumors. Int J Cancer 93:445\u2013449","journal-title":"Int J Cancer"},{"key":"9500_CR6","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0304-3835(02)00085-X","volume":"183","author":"SL Howng","year":"2002","unstructured":"Howng SL, Wu CH, Cheng TS, Sy WD, Lin PC, Wang C, Hong YR (2002) Differential expression of Wnt genes, beta-catenin and E-cadherin in human brain tumors. Cancer Lett 183:95\u2013101","journal-title":"Cancer Lett"},{"key":"9500_CR7","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/neu.20166","volume":"64","author":"MP Fogarty","year":"2005","unstructured":"Fogarty MP, Kessler JD, Wechsler-Reya RJ (2005) Morphing into Cancer: the role of developmental signaling pathways in brain tumor formation. J Neurobiol 64:458\u2013475","journal-title":"J Neurobiol"},{"key":"9500_CR8","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1126\/science.281.5382.1509","volume":"281","author":"TC He","year":"1998","unstructured":"He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, Morin PJ, Vogelstein B, Kinzler KW (1998) Identification of c-MYC as a target of the APC pathway. Science 281:1509\u20131512","journal-title":"Science"},{"key":"9500_CR9","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/jnen\/61.3.215","volume":"61","author":"P Kleihues","year":"2002","unstructured":"Kleihues P, Louis DN, Scheithauer BW, Rorke LB, Reifenberger G, Burger PC, Cavenee WK (2002) The WHO classification of tumors of the nervous system. J Neuropathol Exp Neurol 61:215\u2013225","journal-title":"J Neuropathol Exp Neurol"},{"key":"9500_CR10","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S1474-4422(06)70625-1","volume":"5","author":"MJ Riemenschneider","year":"2006","unstructured":"Riemenschneider MJ, Perry A, Reifenberger G (2006) Histological classification and molecular genetics of meningiomas. Lancet Neurol 5:1045\u20131054","journal-title":"Lancet Neurol"},{"key":"9500_CR11","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1097\/01.pap.0000175117.47918.f7","volume":"12","author":"CE Fuller","year":"2005","unstructured":"Fuller CE, Perry A (2005) Molecular diagnostics in central nervous system tumors. Adv Anat Pathol 12:180\u2013194","journal-title":"Adv Anat Pathol"},{"key":"9500_CR12","doi-asserted-by":"crossref","first-page":"14719","DOI":"10.1073\/pnas.94.26.14719","volume":"94","author":"RG Weber","year":"1997","unstructured":"Weber RG, Bostrom J, Wolter M, Baudis M, Collins VP, Reifenberger G, Lichter P (1997) Analysis of genomic alterations in benign, atypical, and anaplastic meningiomas: toward a genetic model of meningioma progression. Proc Natl Acad Sci USA 94:14719\u201314724","journal-title":"Proc Natl Acad Sci USA"},{"key":"9500_CR13","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0092-8674(00)80689-3","volume":"100","author":"AC Hall","year":"2000","unstructured":"Hall AC, Lucas FR, Salinas PC (2000) Axonal remodeling and synaptic differentiation in the cerebellum is regulated by WNT-7a signaling. Cell 100:525\u2013535","journal-title":"Cell"},{"key":"9500_CR14","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S0959-4388(00)00100-8","volume":"10","author":"A Patapoutian","year":"2000","unstructured":"Patapoutian A, Reichardt LF (2000) Roles of wnt proteins in neural development maintenance. Curr Opin Neurobiol 10:392\u2013399","journal-title":"Curr Opin Neurobiol"},{"key":"9500_CR15","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1038\/nn1132","volume":"6","author":"X Yu","year":"2003","unstructured":"Yu X, Malenka RC (2003) Beta-catenin is critical for dendritic morphogenesis. Nature Neurosci 6:1169\u20131177","journal-title":"Nature Neurosci"},{"key":"9500_CR16","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1038\/nature04108","volume":"437","author":"DC Lie","year":"2005","unstructured":"Lie DC, Colamarino SA, Song HJ, Desire L, Mira H, Consiglio A, Lein ES, Jessberger S, Lansford H, Dearie AR, Gage FH (2005) Wnt signalling regulates adult hippocampal neurogenesis. Nature 437:1370\u20131375","journal-title":"Nature"},{"key":"9500_CR17","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0306-4522(98)00605-8","volume":"91","author":"JS Brakeman","year":"1999","unstructured":"Brakeman JS, Gu SH, Wang XB, Dolin G, Baraban JM (1999) Neuronal localization of the Adenomatous polyposis coli tumor suppressor protein. Neuroscience 91:661\u2013672","journal-title":"Neuroscience"},{"key":"9500_CR18","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/gcc.2870090304","volume":"9","author":"T Mori","year":"1994","unstructured":"Mori T, Nagase H, Horii A, Miyoshi Y, Shimano T, Nakatsuru S, Nakatsuru S, Aoki T, Arakawa H, Yanagisawa A, Ushio Y (1994) Germ-line and somatic mutations of the APC gene in patients with Turcot syndrome and analysis of APC mutations in brain tumors. Genes Chromosomes Cancer 9:168\u2013172","journal-title":"Genes Chromosomes Cancer"},{"key":"9500_CR19","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1056\/NEJM199503303321302","volume":"332","author":"SR Hamilton","year":"1995","unstructured":"Hamilton SR, Liu B, Parsons RE, Papadopoulos N, Jen J, Powell SM, Krush AJ, Berk T, Cohen Z, Tetu B (1995) The molecular basis of Turcot\u2019s syndrome. N Engl J Med 332:839\u2013840","journal-title":"N Engl J Med"},{"key":"9500_CR20","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s11060-004-2749-0","volume":"l70","author":"A Perry","year":"2004","unstructured":"Perry A, Gutmann DH, Reifenberger G (2004) Molecular pathogenesis of meningiomas. J Neuroonco l70:183\u2013202","journal-title":"J Neuroonco"},{"key":"9500_CR21","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/ijc.20733","volume":"114","author":"Wrobel G","year":"2005","unstructured":"Wrobel G, Roerig P, Kokocinski F, Neben K, Hahn M, Reifenberger G, Lichter P (2005) Microarray-based gene expression profiling of benign, atypical and anaplastic meningiomas identified novel genes associated with meningioma progression. Int J Cancer 114:249\u2013256","journal-title":"Int J Cancer"},{"key":"9500_CR22","unstructured":"Pecina-Slaus N (2003) Tumor suppresor gene E-cadherin and its role in normal and malignant cells. Cancer Cell Int E3:17. http:\/\/www.cancerci.com\/content\/3\/1\/17"},{"key":"9500_CR23","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s004280050151","volume":"432","author":"K Schwechheimer","year":"1998","unstructured":"Schwechheimer K, Zhou L, Birchmeier W (1998) E-Cadherin in human brain tumours: loss of immunoreactivity in malignant meningiomas. Virchows Arch 432:163\u2013167","journal-title":"Virchows Arch"},{"key":"9500_CR24","first-page":"8","volume":"24","author":"S Utsuki","year":"2005","unstructured":"Utsuki S, Oka H, Sato Y, Kawano N, Tsuchiya B, Kobayashi I, Fujii K (2005) Invasive meningioma is associated with a low expression of E-cadherin and beta-catenin. Clin Neuropathol 24:8\u201312","journal-title":"Clin Neuropathol"},{"key":"9500_CR25","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/j.1365-2559.2006.02440.x","volume":"49","author":"EC Brunner","year":"2006","unstructured":"Brunner EC, Romeike BF, Jung M, Comtesse N, Meese E (2006) Altered expression of beta-catenin\/E-cadherin in meningiomas. Histopathology 49:178\u2013187","journal-title":"Histopathology"},{"key":"9500_CR26","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1227\/01.NEU.0000141081.07086.A0","volume":"55","author":"JY Lee","year":"2004","unstructured":"Lee JY, Finkelstein S, Hamilton RL, Rekha R, King JT Jr, Omalu B (2004) Loss of heterozygosity analysis of benign, atypical, and anaplastic meningiomas. Neurosurgery 55:1163\u20131173","journal-title":"Neurosurgeryr"}],"container-title":["Journal of Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-007-9500-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11060-007-9500-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-007-9500-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:19:17Z","timestamp":1559348357000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11060-007-9500-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,8]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["9500"],"URL":"https:\/\/doi.org\/10.1007\/s11060-007-9500-6","relation":{},"ISSN":["0167-594X","1573-7373"],"issn-type":[{"value":"0167-594X","type":"print"},{"value":"1573-7373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12,8]]}}}