{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:06:52Z","timestamp":1790251612631,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2008,10,11]],"date-time":"2008-10-11T00:00:00Z","timestamp":1223683200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurooncol"],"published-print":{"date-parts":[[2009,1]]},"DOI":"10.1007\/s11060-008-9705-3","type":"journal-article","created":{"date-parts":[[2008,10,10]],"date-time":"2008-10-10T17:27:19Z","timestamp":1223659639000},"page":"183-189","source":"Crossref","is-referenced-by-count":68,"title":["A North American brain tumor consortium phase II study of poly-ICLC for adult patients with recurrent anaplastic gliomas"],"prefix":"10.1007","volume":"91","author":[{"given":"Nicholas","family":"Butowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen R.","family":"Lamborn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bee L.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Prados","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Cloughesy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"DeAngelis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Abrey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Fink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Lieberman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minesh","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Ian Robins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry","family":"Junck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres M.","family":"Salazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,10,11]]},"reference":[{"issue":"10","key":"9705_CR1","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa043330","volume":"352","author":"R Stupp","year":"2005","unstructured":"Stupp R et al (2005) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352(10):987\u2013996. doi: 10.1056\/NEJMoa043330","journal-title":"N Engl J Med"},{"issue":"1","key":"9705_CR2","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.critrevonc.2007.03.003","volume":"63","author":"R Stupp","year":"2007","unstructured":"Stupp R et al (2007) Anaplastic astrocytoma in adults. Crit Rev Oncol Hematol 63(1):72\u201380. doi: 10.1016\/j.critrevonc.2007.03.003","journal-title":"Crit Rev Oncol Hematol"},{"issue":"23","key":"9705_CR3","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1056\/NEJM198012043032303","volume":"303","author":"MD Walker","year":"1980","unstructured":"Walker MD et al (1980) Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery. N Engl J Med 303(23):1323\u20131329","journal-title":"N Engl J Med"},{"issue":"3","key":"9705_CR4","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3171\/jns.1978.49.3.0333","volume":"49","author":"MD Walker","year":"1978","unstructured":"Walker MD et al (1978) Evaluation of BCNU and\/or radiotherapy in the treatment of anaplastic gliomas. A cooperative clinical trial. J Neurosurg 49(3):333\u2013343","journal-title":"J Neurosurg"},{"issue":"9311","key":"9705_CR5","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/S0140-6736(02)08091-1","volume":"359","author":"LA Stewart","year":"2002","unstructured":"Stewart LA (2002) Chemotherapy in adult high-grade glioma: a systematic review and meta-analysis of individual patient data from 12 randomised trials. Lancet 359(9311):1011\u20131018. doi: 10.1016\/S0140-6736(02)08091-1","journal-title":"Lancet"},{"issue":"11","key":"9705_CR6","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1200\/JCO.1999.17.11.3389","volume":"17","author":"MD Prados","year":"1999","unstructured":"Prados MD et al (1999) Procarbazine, lomustine, and vincristine (PCV) chemotherapy for anaplastic astrocytoma: a retrospective review of radiation therapy oncology group protocols comparing survival with carmustine or PCV adjuvant chemotherapy. J Clin Oncol 17(11):3389\u20133395","journal-title":"J Clin Oncol"},{"issue":"2","key":"9705_CR7","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0360-3016(90)90096-3","volume":"18","author":"VA Levin","year":"1990","unstructured":"Levin VA et al (1990) Superiority of post-radiotherapy adjuvant chemotherapy with CCNU, procarbazine, and vincristine (PCV) over BCNU for anaplastic gliomas: NCOG 6G61 final report. Int J Radiat Oncol Biol Phys 18(2):321\u2013324","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"9","key":"9705_CR8","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1200\/JCO.1999.17.9.2762","volume":"17","author":"WK Yung","year":"1999","unstructured":"Yung WK et al (1999) Multicenter phase II trial of temozolomide in patients with anaplastic astrocytoma or anaplastic oligoastrocytoma at first relapse. Temodal Brain Tumor Group. J Clin Oncol 17(9):2762\u20132771","journal-title":"J Clin Oncol"},{"issue":"2","key":"9705_CR9","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/S0022-5347(17)43953-X","volume":"137","author":"MJ Droller","year":"1987","unstructured":"Droller MJ (1987) Immunotherapy of metastatic renal cell carcinoma with polyinosinic-polycytidylic acid. J Urol 137(2):202\u2013206","journal-title":"J Urol"},{"issue":"6","key":"9705_CR10","first-page":"664","volume":"4","author":"MJ Hawkins","year":"1985","unstructured":"Hawkins MJ, Levin M, Borden EC (1985) An Eastern Cooperative Oncology Group phase I-II pilot study of polyriboinosinic-polyribocytidylic acid poly-L-lysine complex in patients with metastatic malignant melanoma. J Biol Response Mod 4(6):664\u2013668","journal-title":"J Biol Response Mod"},{"issue":"6","key":"9705_CR11","first-page":"640","volume":"4","author":"SE Krown","year":"1985","unstructured":"Krown SE et al (1985) Phase I trials of poly(I,C) complexes in advanced cancer. J Biol Response Mod 4(6):640\u2013649","journal-title":"J Biol Response Mod"},{"issue":"1","key":"9705_CR12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/jir.1982.2.1","volume":"2","author":"O Nakamura","year":"1982","unstructured":"Nakamura O et al (1982) Phase I-II trials of poly(ICLC) in malignant brain tumor patients. J Interferon Res 2(1):1\u20134","journal-title":"J Interferon Res"},{"issue":"3","key":"9705_CR13","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0090-8258(86)90313-6","volume":"24","author":"MA Rettenmaier","year":"1986","unstructured":"Rettenmaier MA, Berman ML, DiSaia PJ (1986) Treatment of advanced ovarian cancer with polyinosinic-polycytidylic lysine carboxymethylcellulose [poly(ICLC)]. Gynecol Oncol 24(3):359\u2013361. doi: 10.1016\/0090-8258(86)90313-6","journal-title":"Gynecol Oncol"},{"issue":"11","key":"9705_CR14","first-page":"1341","volume":"70","author":"RL Theriault","year":"1986","unstructured":"Theriault RL et al (1986) Evaluation of polyinosinic-polycytidylic and poly-L-lysine in metastatic breast cancer. Cancer Treat Rep 70(11):1341\u20131342","journal-title":"Cancer Treat Rep"},{"issue":"4","key":"9705_CR15","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.4049\/jimmunol.135.4.2483","volume":"135","author":"JE Talmadge","year":"1985","unstructured":"Talmadge JE et al (1985) Hyporesponsiveness to augmentation of murine natural killer cell activity in different anatomical compartments by multiple injections of various immunomodulators including recombinant interferons and interleukin 2. J Immunol 135(4):2483\u20132491","journal-title":"J Immunol"},{"issue":"11","key":"9705_CR16","first-page":"3005","volume":"52","author":"CH Ewel","year":"1992","unstructured":"Ewel CH et al (1992) Polyinosinic-polycytidylic acid complexed with poly-L-lysine and carboxymethylcellulose in combination with interleukin 2 in patients with cancer: clinical and immunological effects. Cancer Res 52(11):3005\u20133010","journal-title":"Cancer Res"},{"issue":"1","key":"9705_CR17","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3171\/jns.1992.77.1.0120","volume":"77","author":"KL Black","year":"1992","unstructured":"Black KL et al (1992) Inflammatory leukocytes associated with increased immunosuppression by glioblastoma. J Neurosurg 77(1):120\u2013126","journal-title":"J Neurosurg"},{"issue":"3","key":"9705_CR18","first-page":"1058","volume":"45","author":"JE Talmadge","year":"1985","unstructured":"Talmadge JE et al (1985) Immunomodulatory effects in mice of polyinosinic-polycytidylic acid complexed with poly-L-lysine and carboxymethylcellulose. Cancer Res 45(3):1058\u20131065","journal-title":"Cancer Res"},{"issue":"5","key":"9705_CR19","first-page":"475","volume":"4","author":"HB Levy","year":"1985","unstructured":"Levy HB (1985) Historical overview of the use of polynucleotides in cancer. J Biol Response Mod 4(5):475\u2013480","journal-title":"J Biol Response Mod"},{"key":"9705_CR20","first-page":"653","volume":"41","author":"HB Levy","year":"1981","unstructured":"Levy HB, Levine AS (1981) Antitumor effects of interferon and poly ICLC, and their possible utility as anti-neoplastic agents in man. Tex Rep Biol Med 41:653\u2013662","journal-title":"Tex Rep Biol Med"},{"key":"9705_CR21","doi-asserted-by":"crossref","unstructured":"Matsumoto M, Seya T (2008) TLR3: interferon induction by double-stranded RNA including poly(I:C). Adv Drug Deliv Rev 60(7):805\u2013812","DOI":"10.1016\/j.addr.2007.11.005"},{"key":"9705_CR22","doi-asserted-by":"crossref","unstructured":"Kim H et\u00a0al (2008) Double-stranded RNA mediates interferon regulatory factor 3 activation and interleukin-6 production by engaging Toll-like receptor 3 in human brain astrocytes. Immunology 124(4):480\u2013488","DOI":"10.1111\/j.1365-2567.2007.02799.x"},{"key":"9705_CR23","first-page":"277","volume":"383","author":"S Balachandran","year":"2007","unstructured":"Balachandran S, Barber GN (2007) PKR in innate immunity, cancer, and viral oncolysis. Methods Mol Biol 383:277\u2013301. doi: 10.1007\/978-1-59745-335-6_18","journal-title":"Methods Mol Biol"},{"issue":"6","key":"9705_CR24","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1227\/00006123-199606000-00006","volume":"38","author":"AM Salazar","year":"1996","unstructured":"Salazar AM et al (1996) Long-term treatment of malignant gliomas with intramuscularly administered polyinosinic-polycytidylic acid stabilized with polylysine and carboxymethylcellulose: an open pilot study. Neurosurgery 38(6):1096\u20131103. doi: 10.1097\/00006123-199606000-00006 (discussion 1103\u20131104)","journal-title":"Neurosurgery"},{"key":"9705_CR25","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1479-5876-5-10","volume":"5","author":"X Zhu","year":"2007","unstructured":"Zhu X et al (2007) Toll like receptor-3 ligand poly-ICLC promotes the efficacy of peripheral vaccinations with tumor antigen-derived peptide epitopes in murine CNS tumor models. J Transl Med 5:10. doi: 10.1186\/1479-5876-5-10","journal-title":"J Transl Med"},{"issue":"1","key":"9705_CR26","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0360-3016(94)00488-7","volume":"32","author":"VA Levin","year":"1995","unstructured":"Levin VA et al (1995) Radiation therapy and bromodeoxyuridine chemotherapy followed by procarbazine, lomustine, and vincristine for the treatment of anaplastic gliomas. Int J Radiat Oncol Biol Phys 32(1):75\u201383. doi: 10.1016\/0360-3016(94)00488-7","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"7","key":"9705_CR27","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1200\/JCO.1990.8.7.1277","volume":"8","author":"DR Macdonald","year":"1990","unstructured":"Macdonald DR et al (1990) Response criteria for phase II studies of supratentorial malignant glioma. J Clin Oncol 8(7):1277\u20131280","journal-title":"J Clin Oncol"},{"issue":"8","key":"9705_CR28","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1200\/JCO.1999.17.8.2572","volume":"17","author":"ET Wong","year":"1999","unstructured":"Wong ET et al (1999) Outcomes and prognostic factors in recurrent glioma patients enrolled onto phase II clinical trials. J Clin Oncol 17(8):2572\u20132578","journal-title":"J Clin Oncol"},{"key":"9705_CR29","doi-asserted-by":"crossref","unstructured":"Butowski N et\u00a0al (2008) A phase II clinical trial of poly-ICLC with radiation for adult patients with newly diagnosed supratentorial glioblastoma: a North American Brain Tumor Consortium (NABTC01-05). doi: 10.1007\/s11060-008-9693-3","DOI":"10.1007\/s11060-008-9693-3"},{"issue":"2","key":"9705_CR30","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1215\/15228517-2007-062","volume":"10","author":"KR Lamborn","year":"2008","unstructured":"Lamborn KR et al (2008) Progression-free survival: an important end point in evaluating therapy for recurrent high-grade gliomas. Neuro Oncol 10(2):162\u2013170. doi: 10.1215\/15228517-2007-062","journal-title":"Neuro Oncol"}],"container-title":["Journal of Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-008-9705-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11060-008-9705-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-008-9705-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T10:59:50Z","timestamp":1684580390000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11060-008-9705-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,11]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["9705"],"URL":"https:\/\/doi.org\/10.1007\/s11060-008-9705-3","relation":{},"ISSN":["0167-594X","1573-7373"],"issn-type":[{"value":"0167-594X","type":"print"},{"value":"1573-7373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,11]]}}}