{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T07:52:16Z","timestamp":1791100336108,"version":"4.1.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2010,5,9]],"date-time":"2010-05-09T00:00:00Z","timestamp":1273363200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurooncol"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1007\/s11060-010-0195-8","type":"journal-article","created":{"date-parts":[[2010,5,8]],"date-time":"2010-05-08T09:22:52Z","timestamp":1273310572000},"page":"339-343","source":"Crossref","is-referenced-by-count":71,"title":["STAT3 tyrosine phosphorylation influences survival in glioblastoma"],"prefix":"10.1007","volume":"100","author":[{"given":"Peter","family":"Birner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalina","family":"Toumangelova-Uzeir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevdalin","family":"Natchev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marin","family":"Guentchev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,5,9]]},"reference":[{"key":"195_CR1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1101\/sqb.1999.64.425","volume":"64","author":"JF Bromberg","year":"1999","unstructured":"Bromberg JF, Darnell JE Jr (1999) Potential roles of Stat1 and Stat3 in cellular transformation. Cold Spring Harb Symp Quant Biol 64:425\u2013428","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"195_CR2","doi-asserted-by":"crossref","first-page":"5665","DOI":"10.1158\/1078-0432.CCR-06-2491","volume":"13","author":"D Germain","year":"2007","unstructured":"Germain D, Frank DA (2007) Targeting the cytoplasmic and nuclear functions of signal transducers and activators of transcription 3 for cancer therapy. Clin Cancer Res 13:5665\u20135669","journal-title":"Clin Cancer Res"},{"key":"195_CR3","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/ncb1138","volume":"6","author":"S Kamakura","year":"2004","unstructured":"Kamakura S, Oishi K, Yoshimatsu T, Nakafuku M, Masuyama N, Gotoh Y (2004) Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling. Nat Cell Biol 6:547\u2013554","journal-title":"Nat Cell Biol"},{"key":"195_CR4","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1172\/JCI0215650","volume":"109","author":"DE Levy","year":"2002","unstructured":"Levy DE, Lee CK (2002) What does Stat3 do? J Clin Invest 109:1143\u20131148","journal-title":"J Clin Invest"},{"key":"195_CR5","doi-asserted-by":"crossref","first-page":"5828","DOI":"10.1158\/0008-5472.CAN-05-0317","volume":"65","author":"K Schlessinger","year":"2005","unstructured":"Schlessinger K, Levy DE (2005) Malignant transformation but not normal cell growth depends on signal transducer and activator of transcription 3. Cancer Res 65:5828\u20135834","journal-title":"Cancer Res"},{"key":"195_CR6","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1158\/1541-7786.MCR-07-2180","volume":"6","author":"EC Brantley","year":"2008","unstructured":"Brantley EC, Benveniste EN (2008) Signal transducer and activator of transcription-3: a molecular hub for signaling pathways in gliomas. Mol Cancer Res 6:675\u2013684","journal-title":"Mol Cancer Res"},{"key":"195_CR7","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0898-6568(99)00077-7","volume":"12","author":"LK Schaefer","year":"2000","unstructured":"Schaefer LK, Menter DG, Schaefer TS (2000) Activation of stat3 and stat1 DNA binding and transcriptional activity in human brain tumour cell lines by gp130 cytokines. Cell Signal 12:143\u2013151","journal-title":"Cell Signal"},{"key":"195_CR8","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1038\/sj.onc.1205263","volume":"21","author":"LK Schaefer","year":"2002","unstructured":"Schaefer LK, Ren Z, Fuller GN, Schaefer TS (2002) Constitutive activation of Stat3alpha in brain tumors: localization to tumor endothelial cells and activation by the endothelial tyrosine kinase receptor (VEGFR-2). Oncogene 21:2058\u20132065","journal-title":"Oncogene"},{"key":"195_CR9","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/labinvest.3700123","volume":"84","author":"H Wang","year":"2004","unstructured":"Wang H, Wang H, Zhang W, Huang HJ, Liao WS, Fuller GN (2004) Analysis of the activation status of Akt, NFkappaB, and Stat3 in human diffuse gliomas. Lab Invest 84:941\u2013951","journal-title":"Lab Invest"},{"key":"195_CR10","doi-asserted-by":"crossref","first-page":"3308","DOI":"10.1038\/sj.onc.1207455","volume":"23","author":"J Weissenberger","year":"2004","unstructured":"Weissenberger J, Loeffler S, Kappeler A et al (2004) IL-6 is required for glioma development in a mouse model. Oncogene 23:3308\u20133316","journal-title":"Oncogene"},{"key":"195_CR11","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.ejca.2008.11.027","volume":"45","author":"A Dasgupta","year":"2009","unstructured":"Dasgupta A, Raychaudhuri B, Haqqi T et al (2009) Stat3 activation is required for the growth of U87 cell-derived tumours in mice. Eur J Cancer 45:677\u2013684","journal-title":"Eur J Cancer"},{"key":"195_CR12","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1002\/glia.20863","volume":"57","author":"L Zhang","year":"2009","unstructured":"Zhang L, Alizadeh D, Van Handel M, Kortylewski M, Yu H, Badie B (2009) Stat3 inhibition activates tumor macrophages and abrogates glioma growth in mice. Glia 57:1458\u20131467","journal-title":"Glia"},{"key":"195_CR13","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ccr.2009.02.011","volume":"15","author":"S Pe\u00f1uelas","year":"2009","unstructured":"Pe\u00f1uelas S, Anido J, Prieto-S\u00e1nchez R et al (2009) TGF-beta increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastoma. Cancer Cell 15:315\u2013327","journal-title":"Cancer Cell"},{"key":"195_CR14","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1002\/stem.185","volume":"27","author":"MM Sherry","year":"2009","unstructured":"Sherry MM, Reeves A, Wu JK, Cochran BH (2009) STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells. Stem Cells 27:2383\u20132392","journal-title":"Stem Cells"},{"key":"195_CR15","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1002\/jnr.10110","volume":"67","author":"E Paillaud","year":"2009","unstructured":"Paillaud E, Costa S, Fages C et al (2009) Retinoic acid increases proliferation rate of GL-15 glioma cells, involving activation of STAT-3 transcription factor. J Neurosci Res 67:670\u2013679","journal-title":"J Neurosci Res"},{"key":"195_CR16","first-page":"1270","volume":"63","author":"MA Blaskovich","year":"2003","unstructured":"Blaskovich MA, Sun J, Cantor A, Turkson J, Jove R, Sebti SM (2003) Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase\/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Res 63:1270\u20131279","journal-title":"Cancer Res"},{"key":"195_CR17","doi-asserted-by":"crossref","first-page":"2956","DOI":"10.1158\/0008-5472.CAN-04-3592","volume":"65","author":"SO Rahaman","year":"2005","unstructured":"Rahaman SO, Vogelbaum MA, Haque SJ (2005) Aberrant Stat3 signaling by interleukin-4 in malignant glioma cells: involvement of IL-13Ralpha2. Cancer Res 65:2956\u20132963","journal-title":"Cancer Res"},{"key":"195_CR18","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1471-2407-3-23","volume":"3","author":"L Konnikova","year":"2003","unstructured":"Konnikova L, Kotecki M, Kruger MM, Cochran BH (2003) Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells. BMC Cancer 3:23","journal-title":"BMC Cancer"},{"key":"195_CR19","doi-asserted-by":"crossref","first-page":"6042","DOI":"10.1158\/1078-0432.CCR-07-4923","volume":"14","author":"HW Lo","year":"2008","unstructured":"Lo HW, Cao X, Zhu H, Ali-Osman F (2008) Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators. Clin Cancer Res 14:6042\u20136054","journal-title":"Clin Cancer Res"},{"key":"195_CR20","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1038\/sj.onc.1210031","volume":"26","author":"A Iwamaru","year":"2007","unstructured":"Iwamaru A, Szymanski S, Iwado E et al (2007) A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in\u00a0vitro and in\u00a0vivo. Oncogene 26:2435\u20132444","journal-title":"Oncogene"},{"key":"195_CR21","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ccr.2007.12.005","volume":"13","author":"J Lee","year":"2008","unstructured":"Lee J, Son MJ, Woolard K et al (2008) Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells. Cancer Cell 13:69\u201380","journal-title":"Cancer Cell"},{"key":"195_CR22","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1006\/mcbr.1999.0117","volume":"1","author":"H Halfter","year":"1999","unstructured":"Halfter H, Friedrich M, Postert C, Ringelstein EB, St\u00f6gbauer F (1999) Activation of Jak-Stat and MAPK2 pathways by oncostatin M leads to growth inhibition of human glioma cells. Mol Cell Biol Res Commun 1:109\u2013116","journal-title":"Mol Cell Biol Res Commun"},{"key":"195_CR23","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1097\/01.jnen.0000248549.14962.b2","volume":"65","author":"M Mizoguchi","year":"2006","unstructured":"Mizoguchi M, Betensky RA, Batchelor TT, Bernay DC, Louis DN, Nutt CL (2006) Activation of STAT3, MAPK, and AKT in malignant astrocytic gliomas: correlation with EGFR status, tumor grade, and survival. J Neuropathol Exp Neurol 65:1181\u20131188","journal-title":"J Neuropathol Exp Neurol"},{"key":"195_CR24","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.4049\/jimmunol.180.4.2089","volume":"180","author":"M Fujita","year":"2008","unstructured":"Fujita M, Zhu X, Sasaki K et al (2008) Inhibition of STAT3 promotes the efficacy of adoptive transfer therapy using type-1 CTLs by modulation of the immunological microenvironment in a murine intracranial glioma. J Immunol 180:2089\u20132098","journal-title":"J Immunol"},{"key":"195_CR25","first-page":"2381","volume":"18","author":"E Cattaneo","year":"1998","unstructured":"Cattaneo E, Magrassi L, De-Fraja C et al (1998) Variations in the levels of the JAK\/STAT and ShcA proteins in human brain tumors. Anticancer Res 18:2381\u20132387","journal-title":"Anticancer Res"},{"key":"195_CR26","first-page":"482","volume":"55","author":"J Ehrmann","year":"2008","unstructured":"Ehrmann J, Strakova N, Vrzalikova K, Hezova R, Kolar Z (2008) Expression of STATs and their inhibitors SOCS and PIAS in brain tumors. In vitro and in\u00a0vivo study. Neoplasma 55:482\u2013487","journal-title":"Neoplasma"},{"key":"195_CR27","doi-asserted-by":"crossref","first-page":"7290","DOI":"10.1038\/sj.onc.1208894","volume":"24","author":"MK Ghosh","year":"2005","unstructured":"Ghosh MK, Sharma P, Harbor PC, Rahaman SO, Haque SJ (2005) PI3K-AKT pathway negatively controls EGFR-dependent DNA-binding activity of Stat3 in glioblastoma multiforme cells. Oncogene 24:7290\u20137300","journal-title":"Oncogene"},{"key":"195_CR28","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1101\/gad.1606508","volume":"22","author":"N Iglesia de la","year":"2008","unstructured":"de la Iglesia N, Konopka G, Puram SV et al (2008) Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway. Genes Dev 22:449\u2013462","journal-title":"Genes Dev"},{"key":"195_CR29","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1242\/dev.02419","volume":"133","author":"T Yoshimatsu","year":"2006","unstructured":"Yoshimatsu T, Kawaguchi D, Oishi K et al (2006) Non-cell-autonomous action of STAT3 in maintenance of neural precursor cells in the mouse neocortex. Development 133:2553\u20132563","journal-title":"Development"},{"key":"195_CR30","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/nature03128","volume":"432","author":"SK Singh","year":"2004","unstructured":"Singh SK, Hawkins C, Clarke ID et al (2004) Identification of human brain tumour initiating cells. Nature 432:396\u2013401","journal-title":"Nature"},{"key":"195_CR31","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nrc1275","volume":"4","author":"H Yu","year":"2004","unstructured":"Yu H, Jove R (2004) The STATs of cancer\u2014new molecular targets come of age. Nat Rev Cancer 4:97\u2013105","journal-title":"Nat Rev Cancer"}],"container-title":["Journal of Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-010-0195-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11060-010-0195-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-010-0195-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T04:19:40Z","timestamp":1559362780000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11060-010-0195-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,9]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["195"],"URL":"https:\/\/doi.org\/10.1007\/s11060-010-0195-8","relation":{},"ISSN":["0167-594X","1573-7373"],"issn-type":[{"value":"0167-594X","type":"print"},{"value":"1573-7373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,9]]}}}