{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:40:51Z","timestamp":1792597251069,"version":"4.5.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2010,9,24]],"date-time":"2010-09-24T00:00:00Z","timestamp":1285286400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurooncol"],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1007\/s11060-010-0411-6","type":"journal-article","created":{"date-parts":[[2010,9,23]],"date-time":"2010-09-23T00:22:07Z","timestamp":1285201327000},"page":"533-539","source":"Crossref","is-referenced-by-count":23,"title":["uPA\/PAI-1 expression and uPA promoter methylation in meningiomas"],"prefix":"10.1007","volume":"103","author":[{"given":"Julia Annabel","family":"Kandenwein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tjoung-Won","family":"Park-Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Schramm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,9,24]]},"reference":[{"key":"411_CR1","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/1097-0142(19930801)72:3<639::AID-CNCR2820720304>3.0.CO;2-P","volume":"72","author":"WT Longstreth","year":"1993","unstructured":"Longstreth WT, Dennis LK, McGuire VM (1993) Epidemiology of intracranial meningiomas. Cancer 72:639\u2013648","journal-title":"Cancer"},{"key":"411_CR2","first-page":"176","volume-title":"Pathology and genetics of tumours of the nervous system: World Health Organisation classification of tumours","author":"DN Louis","year":"2000","unstructured":"Louis DN, Scheithauer BW, Budka B, von Deimling A, Kepes JJ (2000) Meningiomas. In: Kleihues P, Cavenee WK (eds) Pathology and genetics of tumours of the nervous system: World Health Organisation classification of tumours. IARC Press, Lyon, pp 176\u2013184"},{"issue":"3","key":"411_CR3","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s11060-009-9934-0","volume":"95","author":"A Durand","year":"2009","unstructured":"Durand A, Labrousse F, Jouvet A, Bauchet L, Kalamarid\u00e8s M, Menei P, Deruty R, Moreau JJ, F\u00e8vre-Montange M, Guyotat J (2009) WHO grade II and III meningiomas: a study of prognostic factors. J Neurooncol 95(3):367\u2013375","journal-title":"J Neurooncol"},{"issue":"2","key":"411_CR4","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1023\/A:1006434124794","volume":"48","author":"EB Hug","year":"2000","unstructured":"Hug EB, Devries A, Thornton AF et al (2000) Management of atypical and malignant meningiomas: role of high-dose, 3D-conformal radiation therapy. J Neurooncol 48(2):151\u2013160","journal-title":"J Neurooncol"},{"issue":"3","key":"411_CR5","doi-asserted-by":"crossref","first-page":"388","DOI":"10.3171\/jns.1994.81.3.0388","volume":"81","author":"PM Black","year":"1994","unstructured":"Black PM, Carroll R, Glowacka D, Riley K, Dashner K (1994) Platelet-derived growth factor expression and stimulation in human meningiomas. J Neurosurg 81(3):388\u2013393","journal-title":"J Neurosurg"},{"issue":"4","key":"411_CR6","first-page":"938","volume":"46","author":"K Lamszus","year":"2000","unstructured":"Lamszus K, Lengler U, Schmidt NO, Stavrou D, Erg\u00fcn S, Westphal M (2000) Vascular endothelial growth factor, hepatocyte growth factor\/scatter factor, basic fibroblast growth factor, and placenta growth factor in human meningiomas and their relation to angiogenesis and malignancy. Neurosurgery 46(4):938\u2013947","journal-title":"Neurosurgery"},{"issue":"5","key":"411_CR7","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1002\/cncr.10351","volume":"94","author":"DM Ho","year":"2002","unstructured":"Ho DM, Hsu CY, Ting LT, Chiang H (2002) Histopathology and MIB-1 labeling index predicted recurrence of meningiomas: a proposal of diagnostic criteria for patients with atypical meningioma. Cancer 94(5):1538\u20131547","journal-title":"Cancer"},{"key":"411_CR8","first-page":"164","volume-title":"World Health Organization classification of tumours of the central nervous system","author":"A Perry","year":"2007","unstructured":"Perry A, Louis DN, Scheithauer BW, Budka H, von Diemling A (2007) Meningiomas. In: Louis DN, Ohgaki H, Wiestler OD, Cavanee WK (eds) World Health Organization classification of tumours of the central nervous system, 4th edn. IARC, Lyon, pp 164\u2013172","edition":"4"},{"issue":"1","key":"411_CR9","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/jcp.1133","volume":"189","author":"G Deng","year":"2001","unstructured":"Deng G, Curriden SA, Hu G, Czekay RP, Loskutoff DJ (2001) Plasminogen activator inhibitor-1 regulates cell adhesion by binding to the somatomedin B domain of vitronectin. J Cell Physiol 189(1):23\u201333","journal-title":"J Cell Physiol"},{"issue":"5\u20136","key":"411_CR10","first-page":"313","volume":"157","author":"K Bajou","year":"2002","unstructured":"Bajou K (2002) Role of PAI-1 plasminogen activator inhibitor in tumor invasion and angiogenesis. Bull Mem Acad R Med Belg 157(5\u20136):313\u2013318","journal-title":"Bull Mem Acad R Med Belg"},{"issue":"2","key":"411_CR11","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/BF01052886","volume":"22","author":"AK Bindal","year":"1994","unstructured":"Bindal AK, Hammoud M, Shi WM, Wu SZ, Sawaya R, Rao JS (1994) Prognostic significance of proteolytic enzymes in human brain tumors. J Neurooncol 22(2):101\u2013110","journal-title":"J Neurooncol"},{"key":"411_CR12","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1227\/00006123-199502000-00018","volume":"36","author":"R Sawaya","year":"1995","unstructured":"Sawaya R, Yamamoto M, Ram\u00f6 OJ, Shi ML, Rayford A, Rao JS (1995) Plasminogen activator inhibitor-1 in brain tumors: relation to malignancy and necrosis. Neurosurgery 36:375\u2013380","journal-title":"Neurosurgery"},{"key":"411_CR13","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s007010050112","volume":"140","author":"Y Arai","year":"1998","unstructured":"Arai Y, Kubota T, Nakagawa T, Kabuto M, Sato K, Kobayashi H (1998) Production of urokinase-type plasminogen activator (u-PA) and plasminogen activator inhibitor-1 (PAI-1) in human brain tumours. Acta Neurochirurgica 140:377\u2013385","journal-title":"Acta Neurochirurgica"},{"issue":"6","key":"411_CR14","first-page":"1353","volume":"28","author":"S Kondraganti","year":"2006","unstructured":"Kondraganti S, Gondi CS, McCutcheon I et al (2006) RNAi-mediated downregulation of urokinase plasminogen activator and its receptor in human meningioma cells inhibits tumor invasion and growth. Int J Oncol 28(6):1353\u20131360","journal-title":"Int J Oncol"},{"key":"411_CR15","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1158\/1078-0432.CCR-03-0545","volume":"10","author":"P Pakneshan","year":"2004","unstructured":"Pakneshan P, Tetu B, Rabbani SA (2004) Demethylation of urokinase promoter as a prognostic marker in patients with breast carcinoma. Clinical Cancer Res 10:3035\u20133041","journal-title":"Clin Cancer Res"},{"issue":"9","key":"411_CR16","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1096\/fj.02-0973com","volume":"17","author":"P Pakneshan","year":"2003","unstructured":"Pakneshan P, Xing RH, Rabbani SA (2003) Methylation status of uPA promoter as a molecular mechanism regulating prostate cancer invasion and growth in vitro and in vivo. FASEB J 17(9):1081\u20131088","journal-title":"FASEB J"},{"key":"411_CR17","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/PL00000615","volume":"56","author":"JP Irigoyen","year":"1999","unstructured":"Irigoyen JP, Munoz-Canoves P, Montero L, Koziczak M, Nagamine Y (1999) The plasminogen activator system: biology and regulation. Cell Mol Life Sci 56:104\u2013132","journal-title":"Cell Mol Life Sci"},{"key":"411_CR18","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1242\/jcs.113.1.123","volume":"113","author":"DJ Webb","year":"2000","unstructured":"Webb DJ, Nguyen DH, Gonias SL (2000) Extracellular signal-regulated kinase functions in the urokinase receptor-dependent pathway by which neutralization of low density lipoprotein receptor-related protein promotes fibrosarcoma cell migration and matrigel invasion. J Cell Sci 113:123\u2013134","journal-title":"J Cell Sci"},{"issue":"14","key":"411_CR19","doi-asserted-by":"crossref","first-page":"12479","DOI":"10.1074\/jbc.M111147200","volume":"277","author":"M Jo","year":"2002","unstructured":"Jo M, Thomas KS, Somlyo AV, Somlyo AP, Gonias SL (2002) Cooperativity between the Ras-ERK and Rho-Rhi kinase pathways in urokinase-type plaminogen activator-stimulated cell migration. J Biol Chem 277(14):12479\u201312485","journal-title":"J Biol Chem"},{"key":"411_CR20","first-page":"59","volume":"31","author":"F Blasi","year":"2001","unstructured":"Blasi F (2001) u-PA and cell migration: urokinase receptor as a ligand for a chemotactic G-protein-coupled receptor. Haemostasis 31:59","journal-title":"Haemostasis"},{"key":"411_CR21","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1038\/sj.onc.1204261","volume":"20","author":"B Degryse","year":"2001","unstructured":"Degryse B, Orlando S, Resnati M, Rabbani SA, Blasi F (2001) Urokinase\/urokinase receptor and vitronectin\/alpha (v) beta (3) integrin induce chemotaxis and cytoskeleton reorganization through different signaling pathways. Oncogene 20:2032\u20132043","journal-title":"Oncogene"},{"key":"411_CR22","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s000180050497","volume":"57","author":"PA Andeasen","year":"2000","unstructured":"Andeasen PA, Egelund R, Petersen HH (2000) The plasminogen activation system in tumor growth, invasion and metastasis. Cell Mol Life Sci 57:25\u201340","journal-title":"Cell Mol Life Sci"},{"key":"411_CR23","first-page":"289","volume":"22","author":"K Siddique","year":"2003","unstructured":"Siddique K, Yanamandra N, Gujrati M, Dinh D, Rao JS, Olivero W (2003) Expression of matrix metalloproteinases, their inhibitors and urokinase plasminogen activator in human meningiomas. Int J Oncol 22:289\u2013294","journal-title":"Int J Oncol"},{"issue":"1","key":"411_CR24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s10014-006-0193-x","volume":"23","author":"G Nagashima","year":"2006","unstructured":"Nagashima G, Fujimoto T, Suzuki R, Asai J, Itokawa H, Noda M (2006) Dural invasion of meningioma: a histological and immunohistochemical study. Brain Tumor Pathol 23(1):13\u201317","journal-title":"Brain Tumor Pathol"},{"issue":"2","key":"411_CR25","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1080\/10408360601040970","volume":"44","author":"N Harbeck","year":"2007","unstructured":"Harbeck N, Schmitt M, Paepke S, Allgayer H, Kates RE (2007) Tumor-associated proteolytic factors uPA and PAI-1: critical appraisal of their clinical relevance in breast cancer and their integration into decision-support algorithms. Crit Rev Clin Lab Sci 44(2):179\u2013201","journal-title":"Crit Rev Clin Lab Sci"},{"issue":"2","key":"411_CR26","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.lungcan.2005.10.002","volume":"51","author":"H Pappot","year":"2006","unstructured":"Pappot H, Pedersen AN, Br\u00fcnner N, Christensen IJ (2006) The complex between urokinase (uPA) and its type-1 inhibitor (PAI-1) in pulmonary adenocarcinoma: relation to prognosis. Lung Cancer 51(2):193\u2013200","journal-title":"Lung Cancer"},{"issue":"17","key":"411_CR27","first-page":"4671","volume":"154","author":"H Pedersen","year":"1994","unstructured":"Pedersen H, Br\u00fcnner N, Francis D et al (1994) Prognostic impact of urokinase, urokinase receptor, and type 1 plasminogen activator inhibitor in squamous and large cell lung cancer tissue. Cancer Res 154(17):4671\u20134675","journal-title":"Cancer Res"},{"issue":"6","key":"411_CR28","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nrg816","volume":"3","author":"PA Jones","year":"2002","unstructured":"Jones PA, Baylin SB (2002) The fundamental role of epigenetic events in cancer. Nat Rev Genet 3(6):415\u2013428","journal-title":"Nat Rev Genet"},{"key":"411_CR29","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0065-230X(08)60702-2","volume":"72","author":"SB Baylin","year":"1998","unstructured":"Baylin SB, Herman JG, Graff JR, Vertino PM, Issa JP (1998) Alterations in DNA methylation: a fundamental aspect of neoplasia. Adv Cancer Res 72:141\u2013196","journal-title":"Adv Cancer Res"},{"issue":"5","key":"411_CR30","doi-asserted-by":"crossref","first-page":"999","DOI":"10.3171\/JNS\/2008\/108\/5\/0999","volume":"108","author":"A Semmler","year":"2008","unstructured":"Semmler A, Simon M, Moskau S, Linnebank M (2008) Polymorphisms of methionine metabolism and susceptibility to meningioma formation: laboratory investigation. J Neurosurg 108(5):999\u20131004","journal-title":"J Neurosurg"},{"issue":"5","key":"411_CR31","first-page":"937","volume":"33","author":"O Kargiotis","year":"2008","unstructured":"Kargiotis O, Chetty C, Gogineni V et al (2008) uPA\/uPAR down regulation inhibits radiation-induced migration, invasion and angiogenesis in IOMM-Lee meningioma cells and decreases tumor growth in vivo. Int J Oncol 33(5):937\u2013947","journal-title":"Int J Oncol"}],"container-title":["Journal of Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-010-0411-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11060-010-0411-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-010-0411-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T13:01:05Z","timestamp":1636549265000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11060-010-0411-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9,24]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["411"],"URL":"https:\/\/doi.org\/10.1007\/s11060-010-0411-6","relation":{},"ISSN":["0167-594X","1573-7373"],"issn-type":[{"value":"0167-594X","type":"print"},{"value":"1573-7373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,9,24]]}}}