{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:58:22Z","timestamp":1788436702253,"version":"build-2803163510"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2010,11,11]],"date-time":"2010-11-11T00:00:00Z","timestamp":1289433600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurooncol"],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1007\/s11060-010-0451-y","type":"journal-article","created":{"date-parts":[[2010,11,10]],"date-time":"2010-11-10T18:26:10Z","timestamp":1289413570000},"page":"699-704","source":"Crossref","is-referenced-by-count":13,"title":["Prognostic significance of cyclin\u00a0A and B1 in pediatric embryonal tumors"],"prefix":"10.1007","volume":"103","author":[{"given":"Maria","family":"Moschovi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George A.","family":"Alexiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalia","family":"Patereli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalliopi","family":"Stefanaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ipatia","family":"Doussis-Anagnostopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasios","family":"Stofas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Sfakianos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neofytos","family":"Prodromou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,11,11]]},"reference":[{"key":"451_CR1","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1177\/0883073808321765","volume":"23","author":"NG Gottardo","year":"2008","unstructured":"Gottardo NG, Gajjar A (2008) Chemotherapy for malignant brain tumors of childhood. J Child Neurol 23:1149\u20135119","journal-title":"J Child Neurol"},{"key":"451_CR2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00401-007-0243-4","volume":"114","author":"DN Louis","year":"2007","unstructured":"Louis DN, Ohgaki H, Wiestler OD et al (2007) The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 114:97\u2013109","journal-title":"Acta Neuropathol"},{"key":"451_CR3","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S1470-2045(06)70867-1","volume":"7","author":"A Gajjar","year":"2006","unstructured":"Gajjar A, Chintagumpala M, Ashley D et al (2006) Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial. Lancet Oncol 7:813\u2013820","journal-title":"Lancet Oncol"},{"key":"451_CR4","doi-asserted-by":"crossref","first-page":"4202","DOI":"10.1200\/JCO.2006.06.4980","volume":"24","author":"RJ Packer","year":"2006","unstructured":"Packer RJ, Gajjar A, Vezina G et al (2006) Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma. J Clin Oncol 24:4202\u20134208","journal-title":"J Clin Oncol"},{"key":"451_CR5","doi-asserted-by":"crossref","first-page":"5208","DOI":"10.1038\/sj.onc.1206558","volume":"22","author":"U Galderisi","year":"2003","unstructured":"Galderisi U, Jori FP, Giordano A (2003) Cell cycle regulation and neural differentiation. Oncogene 22:5208\u20135219","journal-title":"Oncogene"},{"key":"451_CR6","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.semcdb.2005.02.014","volume":"16","author":"TK Fung","year":"2005","unstructured":"Fung TK, Poon RY (2005) A roller coaster ride with the mitotic cyclins. Semin Cell Dev Biol 16:335\u2013342","journal-title":"Semin Cell Dev Biol"},{"key":"451_CR7","doi-asserted-by":"crossref","first-page":"3900","DOI":"10.4161\/cc.8.23.10071","volume":"8","author":"S Tane","year":"2009","unstructured":"Tane S, Chibazakura T (2009) Cyclin\u00a0A overexpression induces chromosomal double-strand breaks in mammalian cells. Cell Cycle 8:3900\u20133903","journal-title":"Cell Cycle"},{"key":"451_CR8","doi-asserted-by":"crossref","first-page":"216","DOI":"10.5858\/2000-124-0216-OOCAAC","volume":"124","author":"K Allan","year":"2000","unstructured":"Allan K, Jordan RC, Ang LC et al (2000) Overexpression of cyclin\u00a0A and cyclin\u00a0B1 proteins in astrocytomas. Arch Pathol Lab Med 124:216\u2013220","journal-title":"Arch Pathol Lab Med"},{"key":"451_CR9","doi-asserted-by":"crossref","first-page":"3772","DOI":"10.1002\/j.1460-2075.1994.tb06688.x","volume":"13","author":"J Pines","year":"1994","unstructured":"Pines J, Hunter T (1994) The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin\u00a0B. EMBO J 13:3772\u20133781","journal-title":"EMBO J"},{"key":"451_CR10","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/0092-8674(93)90364-V","volume":"73","author":"SL Holloway","year":"1993","unstructured":"Holloway SL, Glotzer M, King RW et al (1993) Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor. Cell 73:1393\u20131402","journal-title":"Cell"},{"key":"451_CR11","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/(SICI)1097-0320(19960501)24:1<49::AID-CYTO6>3.0.CO;2-D","volume":"24","author":"S Kakino","year":"1996","unstructured":"Kakino S, Sasaki K, Kurose A, Ito H (1996) Intracellular localization of cyclin\u00a0B1 during the cell cycle in glioma cells. Cytometry 24:49\u201354","journal-title":"Cytometry"},{"key":"451_CR12","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1750-3639.2007.00058.x","volume":"17","author":"CS McManamy","year":"2007","unstructured":"McManamy CS, Pears J, Weston CL et al (2007) Nodule formation and desmoplasia in medulloblastomas-defining the nodular\/desmoplastic variant and its biological behavior. Brain Pathol 17:151\u2013164","journal-title":"Brain Pathol"},{"key":"451_CR13","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/cncr.10189","volume":"94","author":"CG Eberhart","year":"2002","unstructured":"Eberhart CG, Kepner JL, Goldthwaite PT et al (2002) Histopathologic grading of medulloblastomas: a Pediatric Oncology Group study. Cancer 94:552\u2013560","journal-title":"Cancer"},{"key":"451_CR14","doi-asserted-by":"crossref","first-page":"971","DOI":"10.3171\/jns.1999.91.6.0971","volume":"91","author":"F Giangaspero","year":"1999","unstructured":"Giangaspero F, Perilongo G, Fondelli MP et al (1999) Medulloblastoma with extensive nodularity: a variant with favorable prognosis. J Neurosurg 91:971\u2013977","journal-title":"J Neurosurg"},{"key":"451_CR15","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00401-006-0064-x","volume":"112","author":"F Giangaspero","year":"2006","unstructured":"Giangaspero F, Wellek S, Masuoka J et al (2006) Stratification of medulloblastoma on the basis of histopathological grading. Acta Neuropathol 112:5\u201312","journal-title":"Acta Neuropathol"},{"key":"451_CR16","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/415436a","volume":"415","author":"SL Pomeroy","year":"2002","unstructured":"Pomeroy SL, Tamayo P, Gaasenbeek M et al (2002) Prediction of central nervous system embryonal tumour outcome based on gene expression. Nature 415:436\u2013442","journal-title":"Nature"},{"key":"451_CR17","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1093\/jnen\/63.5.441","volume":"63","author":"CG Eberhart","year":"2004","unstructured":"Eberhart CG, Kratz J, Wang Y et al (2004) Histopathological and molecular prognostic markers in medulloblastoma: c-myc, N-myc, TrkC, and anaplasia. J Neuropathol Exp Neurol 63:441\u2013449","journal-title":"J Neuropathol Exp Neurol"},{"key":"451_CR18","doi-asserted-by":"crossref","first-page":"12867","DOI":"10.1073\/pnas.91.26.12867","volume":"91","author":"RA Segal","year":"1994","unstructured":"Segal RA, Goumnerova LC, Kwon YK et al (1994) Expression of the neurotrophin receptor TrkC is linked to a favourable outcome in medulloblastoma. Proc Natl Acad Sci USA 91:12867\u201312871","journal-title":"Proc Natl Acad Sci USA"},{"key":"451_CR19","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1200\/JCO.2004.06.032","volume":"22","author":"A Gajjar","year":"2004","unstructured":"Gajjar A, Hernan R, Kocak M et al (2004) Clinical, histopathologic, and molecular markers of prognosis: toward a new disease risk stratification system for medulloblastoma. J Clin Oncol 22:984\u2013993","journal-title":"J Clin Oncol"},{"key":"451_CR20","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/1097-0215(20000920)89:5<395::AID-IJC1>3.0.CO;2-V","volume":"89","author":"J Herms","year":"2000","unstructured":"Herms J, Neidt I, Luscher B et al (2000) C-MYC expression in medulloblastoma and its prognostic value. Int J Cancer 89:395\u2013402","journal-title":"Int J Cancer"},{"key":"451_CR21","doi-asserted-by":"crossref","unstructured":"Northcott PA, Korshunov A, Witt H et al (2010) Medulloblastoma comprises four distinct molecular variants. J Clin Oncol. Oct 4 [Epub ahead of print]","DOI":"10.1158\/1538-7445.AM10-4347"},{"key":"451_CR22","doi-asserted-by":"crossref","first-page":"e3088","DOI":"10.1371\/journal.pone.0003088","volume":"28","author":"M Kool","year":"2008","unstructured":"Kool M, Koster J, Bunt J et al (2008) Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features. PLoS One 28:e3088","journal-title":"PLoS One"},{"key":"451_CR23","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1002\/1097-0142(19941001)74:7<1921::AID-CNCR2820740716>3.0.CO;2-9","volume":"74","author":"K Onda","year":"1994","unstructured":"Onda K, Davis RL, Shibuya M et al (1994) Correlation between the bromodeoxyuridine labeling index and the MIB-1 and Ki-67 proliferating cell indices in cerebral gliomas. Cancer 74:1921\u20131926","journal-title":"Cancer"},{"key":"451_CR24","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/bjc.1992.273","volume":"66","author":"E Jaros","year":"1992","unstructured":"Jaros E, Perry RH, Adam L et al (1992) Prognostic implications of p53 protein, epidermal growth factor receptor and Ki-67 labelling in brain tumours. Br J Cancer 66:373\u2013385","journal-title":"Br J Cancer"},{"key":"451_CR25","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s00381-008-0784-4","volume":"25","author":"Y Ertan","year":"2009","unstructured":"Ertan Y, Sezak M, Demira\u011f B et al (2009) Medulloblastoma: clinicopathologic evaluation of 42 pediatric cases. Childs Nerv Syst 25:353\u2013356","journal-title":"Childs Nerv Syst"},{"key":"451_CR26","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1023\/A:1006330324991","volume":"45","author":"R Miralbell","year":"1999","unstructured":"Miralbell R, Tolnay M, Bieri S et al (1999) Pediatric medulloblastoma: prognostic value of p53, bcl-2, Mib-1, and microvessel density. J Neurooncol 45:103\u2013110","journal-title":"J Neurooncol"},{"key":"451_CR27","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1590\/S0004-282X2008000300020","volume":"66","author":"RT Meurer","year":"2008","unstructured":"Meurer RT, Martins DT, Hilbig A et al (2008) Immunohistochemical expression of markers Ki-67, neun, synaptophysin, p53 and HER2 in medulloblastoma and its correlation with clinicopathological parameters. Arq Neuropsiquiatr 66:385\u2013390","journal-title":"Arq Neuropsiquiatr"},{"key":"451_CR28","doi-asserted-by":"crossref","unstructured":"Patereli A, Alexiou GA, Stefanaki K et al (2010) Expression of EGFR and HER-2 in pediatric embryonal brain tumors. Pediatr Neurosurg. doi: 10.1159\/000316640","DOI":"10.1159\/000316640"},{"key":"451_CR29","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1126\/science.274.5293.1672","volume":"6","author":"CJ Sherr","year":"1996","unstructured":"Sherr CJ (1996) Cancer cell cycles. Science 6:1672\u20131677","journal-title":"Science"},{"key":"451_CR30","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/0006-291X(92)91851-G","volume":"182","author":"F Zindy","year":"1992","unstructured":"Zindy F, Lamas E, Chenivesse X et al (1992) Cyclin\u00a0A is required in S phase in normal epithelial cells. Biochem Biophys Res Commun 182:1144\u20131154","journal-title":"Biochem Biophys Res Commun"},{"key":"451_CR31","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1158\/1055-9965.EPI-09-0169","volume":"18","author":"C Ahlin","year":"2009","unstructured":"Ahlin C, Zhou W, Holmqvist M et al (2009) Cyclin\u00a0A is a proliferative marker with good prognostic value in node-negative breast cancer. Cancer Epidemiol Biomarkers Prev 18:2501\u20132506","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"451_CR32","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/MPA.0b013e3181bb9204","volume":"39","author":"Y Kamio","year":"2010","unstructured":"Kamio Y, Maeda K, Moriya T et al (2010) Clinicopathological significance of cell cycle regulatory factors and differentiation-related factors in pancreatic neoplasms. Pancreas 39:345\u2013352","journal-title":"Pancreas"},{"key":"451_CR33","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ejogrb.2006.10.008","volume":"136","author":"BS Yoon","year":"2008","unstructured":"Yoon BS, Kim YT, Kim S et al (2008) Prognostic value of nuclear DNA quantification and cyclin\u00a0A expression in epithelial ovarian carcinoma. Eur J Obstet Gynecol Reprod Biol 136:110\u2013115","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"451_CR34","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1002\/(SICI)1097-0142(19990401)85:7<1569::AID-CNCR19>3.0.CO;2-M","volume":"85","author":"BV Kallakury","year":"1999","unstructured":"Kallakury BV, Sheehan CE, Rhee SJ et al (1999) The prognostic significance of proliferation-associated nucleolar protein p120 expression in prostate adenocarcinoma: a comparison with cyclins A and B1, Ki-67, proliferating cell nuclear antigen, and p34cdc2. Cancer 85:1569\u20131576","journal-title":"Cancer"},{"key":"451_CR35","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/j.1349-7006.2007.00444.x","volume":"98","author":"T Suzuki","year":"2007","unstructured":"Suzuki T, Urano T, Miki Y et al (2007) Nuclear cyclin\u00a0B1 in human breast carcinoma as a potent prognostic factor. Cancer Sci 98:644\u2013651","journal-title":"Cancer Sci"},{"key":"451_CR36","doi-asserted-by":"crossref","first-page":"4154","DOI":"10.1158\/1078-0432.CCR-07-4159","volume":"14","author":"T Haas de","year":"2008","unstructured":"de Haas T, Hasselt N, Troost D et al (2008) Molecular risk stratification of medulloblastoma patients based on immunohistochemical analysis of MYC, LDHB, and CCNB1 expression. Clin Cancer Res 14:4154\u20134160","journal-title":"Clin Cancer Res"}],"container-title":["Journal of Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-010-0451-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11060-010-0451-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-010-0451-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T10:08:24Z","timestamp":1636798104000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11060-010-0451-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,11]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["451"],"URL":"https:\/\/doi.org\/10.1007\/s11060-010-0451-y","relation":{},"ISSN":["0167-594X","1573-7373"],"issn-type":[{"value":"0167-594X","type":"print"},{"value":"1573-7373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,11]]}}}