{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:57:58Z","timestamp":1791151078816,"version":"4.1.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2013,11,17]],"date-time":"2013-11-17T00:00:00Z","timestamp":1384646400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurooncol"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1007\/s11060-013-1308-y","type":"journal-article","created":{"date-parts":[[2013,11,16]],"date-time":"2013-11-16T02:22:22Z","timestamp":1384568542000},"page":"207-212","source":"Crossref","is-referenced-by-count":16,"title":["Glioblastoma treatment using perphenazine to block the subventricular zone\u2019s tumor trophic functions"],"prefix":"10.1007","volume":"116","author":[{"given":"R. E.","family":"Kast","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. M.","family":"Ellingson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Marosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.-E.","family":"Halatsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,11,17]]},"reference":[{"issue":"9","key":"1308_CR1","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1016\/j.bcp.2003.12.035","volume":"67","author":"T Efferth","year":"2004","unstructured":"Efferth T, Ramirez T, Gebhart E, Halatsch ME (2004) Combination treatment of glioblastoma multiforme cell lines with the anti-malarial artesunate and the epidermal growth factor receptor tyrosine kinase inhibitor OSI-774. Biochem Pharmacol 67(9):1689\u20131700","journal-title":"Biochem Pharmacol"},{"issue":"4","key":"1308_CR2","doi-asserted-by":"crossref","first-page":"502","DOI":"10.18632\/oncotarget.969","volume":"4","author":"RE Kast","year":"2013","unstructured":"Kast RE, Boockvar JA, Br\u00fcning A et al (2013) A conceptually new treatment approach for relapsed glioblastoma: coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma Care. Oncotarget 4(4):502\u2013530","journal-title":"Oncotarget"},{"issue":"4","key":"1308_CR3","first-page":"425","volume":"20","author":"RE Kast","year":"2010","unstructured":"Kast RE (2010) Profound blockage of CXCR4 signaling at multiple points using the synergy between plerixafor, mirtazapine, and clotrimazole as a new glioblastoma treatment adjunct. Turk Neurosurg 20(4):425\u2013429","journal-title":"Turk Neurosurg"},{"issue":"11","key":"1308_CR4","doi-asserted-by":"crossref","first-page":"e49087","DOI":"10.1371\/journal.pone.0049087","volume":"7","author":"K Azim","year":"2012","unstructured":"Azim K, Fiorelli R, Zweifel S, Hurtado-Chong A, Yoshikawa K, Slomianka L, Raineteau O (2012) 3-Dimensional examination of the adult mouse subventricular zone reveals lineage-specific microdomains. PLoS One 7(11):e49087","journal-title":"PLoS One"},{"issue":"6","key":"1308_CR5","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1111\/j.1460-9568.2011.07611.x","volume":"33","author":"SZ Young","year":"2011","unstructured":"Young SZ, Taylor MM, Bordey A (2011) Neurotransmitters couple brain activity to subventricular zone neurogenesis. Eur J Neurosci 33(6):1123\u20131132","journal-title":"Eur J Neurosci"},{"key":"1308_CR6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0079-6123(00)27002-7","volume":"127","author":"A Alvarez-Buylla","year":"2000","unstructured":"Alvarez-Buylla A, Herrera DG, Wichterle H (2000) The subventricular zone: source of neuronal precursors for brain repair. Prog Brain Res 127:1\u201311","journal-title":"Prog Brain Res"},{"issue":"1","key":"1308_CR7","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s11060-010-0477-1","volume":"104","author":"GS Young","year":"2011","unstructured":"Young GS, Macklin EA, Setayesh K et al (2011) Longitudinal MRI evidence for decreased survival among periventricular glioblastoma. J Neurooncol 104(1):261\u2013269","journal-title":"J Neurooncol"},{"key":"1308_CR8","doi-asserted-by":"crossref","unstructured":"Sadahiro H, Yoshikawa K, Ideguchi M et al (2013) Pathological features of highly invasive glioma stem cells in a mouse xenograft model. Brain Tumor Pathol. doi: 10.1007\/s10014-013-0149-x","DOI":"10.1007\/s10014-013-0149-x"},{"issue":"4 Suppl 2","key":"1308_CR9","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1053\/j.seminoncol.2009.05.003","volume":"36","author":"M Glantz","year":"2009","unstructured":"Glantz M, Kesari S, Recht L, Fleischhack G, Van Horn A (2009) Understanding the origins of gliomas and developing novel therapies: cerebrospinal fluid and subventricular zone interplay. Semin Oncol 36(4 Suppl 2):S17\u2013S24","journal-title":"Semin Oncol"},{"issue":"1","key":"1308_CR10","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.neuroscience.2008.06.065","volume":"156","author":"D Gleason","year":"2008","unstructured":"Gleason D, Fallon JH, Guerra M, Liu JC, Bryant PJ (2008) Ependymal stem cells divide asymmetrically and transfer progeny into the subventricular zone when activated by injury. Neuroscience 156(1):81\u201388","journal-title":"Neuroscience"},{"issue":"9","key":"1308_CR11","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1523\/JNEUROSCI.3574-07.2008","volume":"28","author":"P Yang","year":"2008","unstructured":"Yang P, Arnold SA, Habas A, Hetman M, Hagg T (2008) Ciliary neurotrophic factor mediates dopamine D2 receptor-induced CNS neurogenesis in adult mice. J Neurosci 28(9):2231\u20132241","journal-title":"J Neurosci"},{"issue":"8","key":"1308_CR12","doi-asserted-by":"crossref","first-page":"590","DOI":"10.18632\/oncotarget.319","volume":"2","author":"DM Mu\u00f1oz","year":"2011","unstructured":"Mu\u00f1oz DM, Guha A (2011) Mouse models to interrogate the implications of the differentiation status in the ontogeny of gliomas. Oncotarget 2(8):590\u2013598","journal-title":"Oncotarget"},{"issue":"4","key":"1308_CR13","doi-asserted-by":"crossref","first-page":"e35150","DOI":"10.1371\/journal.pone.0035150","volume":"7","author":"J Najbauer","year":"2012","unstructured":"Najbauer J, Huszthy PC, Barish ME et al (2012) Cellular host responses to gliomas. PLoS One 7(4):e35150. doi: 10.1371\/journal.pone.0035150","journal-title":"PLoS One"},{"issue":"Suppl3","key":"1308_CR14","doi-asserted-by":"crossref","first-page":"S608","DOI":"10.1245\/s10434-011-2093-5","volume":"19","author":"A Tchoghandjian","year":"2012","unstructured":"Tchoghandjian A, Baeza-Kallee N, Beclin C et al (2012) Cortical and subventricular zone glioblastoma-derived stem-like cells display different molecular profiles and differential in vitro and in vivo properties. Ann Surg Oncol 19(Suppl3):S608\u2013S619. doi: 10.1245\/s10434-011-2093-5","journal-title":"Ann Surg Oncol"},{"issue":"3","key":"1308_CR15","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/ijc.25709","volume":"129","author":"J Kroonen","year":"2011","unstructured":"Kroonen J, Nassen J, Boulanger YG et al (2011) Human glioblastoma-initiating cells invade specifically the subventricular zones and olfactory bulbs of mice after striatal injection. Int J Cancer 129(3):574\u2013585","journal-title":"Int J Cancer"},{"issue":"2","key":"1308_CR16","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.expneurol.2009.07.013","volume":"219","author":"B Winner","year":"2009","unstructured":"Winner B, Desplats P, Hagl C et al (2009) Dopamine receptor activation promotes adult neurogenesis in an acute Parkinson model. Exp Neurol 219(2):543\u2013552","journal-title":"Exp Neurol"},{"issue":"3","key":"1308_CR17","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1111\/j.1471-4159.2010.06799.x","volume":"114","author":"Y Kim","year":"2010","unstructured":"Kim Y, Wang WZ, Comte I et al (2010) Dopamine stimulation of postnatal murine subventricular zone neurogenesis via the D3 receptor. J Neurochem 114(3):750\u2013760","journal-title":"J Neurochem"},{"issue":"4","key":"1308_CR18","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.ijrobp.2013.02.014","volume":"86","author":"L Chen","year":"2013","unstructured":"Chen L, Guerrero-Cazares H, Ye X et al (2013) Increased subventricular zone radiation dose correlates with survival in glioblastoma patients after gross total resection. Int J Radiat Oncol Biol Phys 86(4):616\u2013622","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"1308_CR19","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s11060-012-0887-3","volume":"109","author":"T Gupta","year":"2012","unstructured":"Gupta T, Nair V, Paul SN et al (2012) Can irradiation of potential cancer stem-cell niche in the subventricular zone influence survival in patients with newly diagnosed glioblastoma? J Neurooncol 109(1):195\u2013203","journal-title":"J Neurooncol"},{"key":"1308_CR20","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1186\/1471-2407-10-384","volume":"10","author":"P Evers","year":"2010","unstructured":"Evers P, Lee PP, DeMarco J et al (2010) Irradiation of the potential cancer stem cell niches in the adult brain improves progression-free survival of patients with malignant glioma. BMC Cancer 10:384","journal-title":"BMC Cancer"},{"issue":"4","key":"1308_CR21","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.ijrobp.2013.01.009","volume":"86","author":"P Lee","year":"2013","unstructured":"Lee P, Eppinga W, Lagerwaard F et al (2013) Evaluation of high ipsilateral subventricular zone radiation therapy dose in glioblastoma: a pooled analysis. Int J Radiat Oncol Biol Phys 86(4):609\u2013615","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"1308_CR22","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3174\/ajnr.A3253","volume":"34","author":"BM Ellingson","year":"2013","unstructured":"Ellingson BM, Lai A, Harris RJ et al (2013) Probabilistic radiographic atlas of glioblastoma phenotypes. AJNR Am J Neuroradiol 34(3):533\u2013540","journal-title":"AJNR Am J Neuroradiol"},{"issue":"2","key":"1308_CR23","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.neuroimage.2011.09.076","volume":"59","author":"BM Ellingson","year":"2012","unstructured":"Ellingson BM, Cloughesy TF, Pope WB et al (2012) Anatomic localization of O6-methylguanine DNA methyltransferase (MGMT) promoter methylated and unmethylated tumors: a radiographic study in 358 de novo human glioblastomas. Neuroimage 59(2):908\u2013916","journal-title":"Neuroimage"},{"issue":"3","key":"1308_CR24","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s11060-009-9983-4","volume":"96","author":"M Kappadakunnel","year":"2010","unstructured":"Kappadakunnel M, Eskin A, Dong J et al (2010) Stem cell associated gene expression in glioblastoma multiforme: relationship to survival and the subventricular zone. J Neurooncol 96(3):359\u2013367","journal-title":"J Neurooncol"},{"issue":"4","key":"1308_CR25","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1215\/15228517-2007-023","volume":"9","author":"DA Lim","year":"2007","unstructured":"Lim DA, Cha S, Mayo MC et al (2007) Relationship of glioblastoma multiforme to neural stem cell regions predicts invasive and multifocal tumor phenotype. Neuro Oncol 9(4):424\u2013429","journal-title":"Neuro Oncol"},{"issue":"4","key":"1308_CR26","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/glia.22449","volume":"61","author":"CL Lao","year":"2013","unstructured":"Lao CL, Lu CS, Chen JC (2013) Dopamine D(3) receptor activation promotes neural stem\/progenitor cell proliferation through AKT and ERK1\/2 pathways and expands type-B and -C cells in adult subventricular zone. Glia 61(4):475\u2013489","journal-title":"Glia"},{"issue":"3","key":"1308_CR27","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.nbd.2005.01.004","volume":"18","author":"SA Baker","year":"2005","unstructured":"Baker SA, Baker KA, Hagg T (2005) D3 dopamine receptors do not regulate neurogenesis in the subventricular zone of adult mice. Neurobiol Dis 18(3):523\u2013527","journal-title":"Neurobiol Dis"},{"issue":"6","key":"1308_CR28","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.neuropharm.2011.01.026","volume":"60","author":"S Merlo","year":"2011","unstructured":"Merlo S, Canonico PL, Sortino MA (2011) Distinct effects of pramipexole on the proliferation of adult mouse sub-ventricular zone-derived cells and the appearance of a neuronal phenotype. Neuropharmacology 60(6):892\u2013900","journal-title":"Neuropharmacology"},{"issue":"6","key":"1308_CR29","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1111\/j.1471-4159.2004.02823.x","volume":"91","author":"V Coronas","year":"2004","unstructured":"Coronas V, Bantubungi K, Fombonne J, Krantic S, Schiffmann SN, Roger M (2004) Dopamine D3 receptor stimulation promotes the proliferation of cells derived from the post-natal subventricular zone. J Neurochem 91(6):1292\u20131301","journal-title":"J Neurochem"},{"issue":"21","key":"1308_CR30","doi-asserted-by":"crossref","first-page":"8754","DOI":"10.1073\/pnas.0803955106","volume":"106","author":"GC O\u2019Keeffe","year":"2009","unstructured":"O\u2019Keeffe GC, Tyers P, Aarsland D, Dalley JW, Barker RA, Caldwell MA (2009) Dopamine-induced proliferation of adult neural precursor cells in the mammalian subventricular zone is mediated through EGF. Proc Natl Acad Sci USA 106(21):8754\u20138759","journal-title":"Proc Natl Acad Sci USA"},{"issue":"18","key":"1308_CR31","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1097\/WNR.0b013e32834d2f65","volume":"22","author":"GC O\u2019Keeffe","year":"2011","unstructured":"O\u2019Keeffe GC, Barker RA (2011) Dopamine stimulates epidermal growth factor release from adult neural precursor cells derived from the subventricular zone by a disintegrin and metalloprotease. Neuroreport 22(18):956\u2013958","journal-title":"Neuroreport"},{"issue":"1","key":"1308_CR32","first-page":"CD003443","volume":"25","author":"B Hartung","year":"2005","unstructured":"Hartung B, Wada M, Laux G, Leucht S (2005) Perphenazine for schizophrenia. Cochrane Database Syst Rev 25(1):CD003443","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"1308_CR33","doi-asserted-by":"crossref","first-page":"75","DOI":"10.4088\/JCP.09m05258gre","volume":"72","author":"DE Addington","year":"2011","unstructured":"Addington DE, Mohamed S, Rosenheck RA et al (2011) Impact of second-generation antipsychotics and perphenazine on depressive symptoms in a randomized trial of treatment for chronic schizophrenia. J Clin Psychiatry 72(1):75\u201380. doi: 10.4088\/JCP.09m05258gre","journal-title":"J Clin Psychiatry"},{"issue":"12","key":"1308_CR34","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1097\/EJA.0b013e32833b7969","volume":"27","author":"A Schnabel","year":"2010","unstructured":"Schnabel A, Eberhart LH, Muellenbach R, Morin AM, Roewer N, Kranke P (2010) Efficacy of perphenazine to prevent postoperative nausea and vomiting: a quantitative systematic review. Eur J Anaesthesiol 27(12):1044\u20131051","journal-title":"Eur J Anaesthesiol"},{"issue":"2","key":"1308_CR35","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0165-0327(93)90041-H","volume":"28","author":"RF Anton Jr","year":"1993","unstructured":"Anton RF Jr, Burch EA Jr (1993) Response of psychotic depression subtypes to pharmacotherapy. J Affect Disord 28(2):125\u2013131","journal-title":"J Affect Disord"},{"issue":"1\u20133","key":"1308_CR36","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ejphar.2011.05.050","volume":"666","author":"Y Tadori","year":"2011","unstructured":"Tadori Y, Forbes RA, McQuade RD, Kikuchi T (2011) Functional potencies of dopamine agonists and antagonists at human dopamine D2 and D3 receptors. Eur J Pharmacol 666(1\u20133):43\u201352","journal-title":"Eur J Pharmacol"},{"issue":"10","key":"1308_CR37","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1523\/JNEUROSCI.5118-04.2005","volume":"25","author":"R Glass","year":"2005","unstructured":"Glass R, Synowitz M, Kronenberg G et al (2005) Glioblastoma-induced attraction of endogenous neural precursor cells is associated with improved survival. J Neurosci 25(10):2637\u20132646","journal-title":"J Neurosci"},{"issue":"11","key":"1308_CR38","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1634\/stemcells.2008-0307","volume":"26","author":"JH Walzlein","year":"2008","unstructured":"Walzlein JH, Synowitz M, Engels B et al (2008) The antitumorigenic response of neural precursors depends on subventricular proliferation and age. Stem Cells 26(11):2945\u20132954","journal-title":"Stem Cells"},{"issue":"1","key":"1308_CR39","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.coph.2009.10.001","volume":"10","author":"R Maggio","year":"2010","unstructured":"Maggio R, Millan MJ (2010) Dopamine D2\u2013D3 receptor heteromers: pharmacological properties and therapeutic significance. Curr Opin Pharmacol 10(1):100\u2013107","journal-title":"Curr Opin Pharmacol"},{"issue":"12","key":"1308_CR40","doi-asserted-by":"crossref","first-page":"8864","DOI":"10.1074\/jbc.M111.326678","volume":"287","author":"C Pou","year":"2012","unstructured":"Pou C, Mannoury la Cour C, Stoddart LA, Millan MJ, Milligan G (2012) Functional homomers and heteromers of dopamine D2L and D3 receptors co-exist at the cell surface. J Biol Chem 287(12):8864\u20138878","journal-title":"J Biol Chem"},{"issue":"2","key":"1308_CR41","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0922-4106(93)90029-9","volume":"244","author":"BJ Vilner","year":"1993","unstructured":"Vilner BJ, Bowen WD (1993) Sigma receptor-active neuroleptics are cytotoxic to C6 glioma cells in culture. Eur J Pharmacol 244(2):199\u2013201","journal-title":"Eur J Pharmacol"},{"issue":"8","key":"1308_CR42","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1593\/neo.07451","volume":"9","author":"RE Kast","year":"2007","unstructured":"Kast RE (2007) Glioblastoma: looking at the currently marketed sigma-1 agonists and antagonists. Neoplasia 9(8):689","journal-title":"Neoplasia"},{"issue":"16","key":"1308_CR43","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1016\/j.ejca.2009.07.011","volume":"45","author":"V M\u00e9galizzi","year":"2009","unstructured":"M\u00e9galizzi V, Decaestecker C, Debeir O et al (2009) Screening of anti-glioma effects induced by sigma-1 receptor ligands: potential new use for old anti-psychiatric medicines. Eur J Cancer 45(16):2893\u20132905","journal-title":"Eur J Cancer"},{"issue":"2","key":"1308_CR44","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.neuron.2013.09.032","volume":"80","author":"M Betizeau","year":"2013","unstructured":"Betizeau M, Cortay V, Patti D et al (2013) Precursor diversity and complexity of lineage relationships in the outer subventricular zone of the primate. Neuron 80(2):442\u2013457. doi: 10.1016\/j.neuron.2013.09.032","journal-title":"Neuron"},{"key":"1308_CR45","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3389\/fgene.2013.00194","volume":"4","author":"G Gonzales-Roybal","year":"2013","unstructured":"Gonzales-Roybal G, Lim DA (2013) Chromatin-based epigenetics of adult subventricular zone neural stem cells. Front Genet 4:194","journal-title":"Front Genet"}],"container-title":["Journal of Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-013-1308-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11060-013-1308-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-013-1308-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:17:46Z","timestamp":1559348266000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11060-013-1308-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,17]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["1308"],"URL":"https:\/\/doi.org\/10.1007\/s11060-013-1308-y","relation":{},"ISSN":["0167-594X","1573-7373"],"issn-type":[{"value":"0167-594X","type":"print"},{"value":"1573-7373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,17]]}}}