{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T03:37:06Z","timestamp":1792899426624,"version":"4.5.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,1,19]],"date-time":"2014-01-19T00:00:00Z","timestamp":1390089600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurooncol"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1007\/s11060-014-1362-0","type":"journal-article","created":{"date-parts":[[2014,1,18]],"date-time":"2014-01-18T02:59:57Z","timestamp":1390013997000},"page":"125-131","source":"Crossref","is-referenced-by-count":194,"title":["Targeting metabolism with a ketogenic diet during the treatment of glioblastoma multiforme"],"prefix":"10.1007","volume":"117","author":[{"given":"Colin E.","family":"Champ","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D.","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff S.","family":"Volek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Werner-Wasik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Andrews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James J.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Glass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyndon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,1,19]]},"reference":[{"key":"1362_CR1","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa043330","volume":"352","author":"R Stupp","year":"2005","unstructured":"Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJB, Belanger K, Brandes AA, Marosi C, Bogdahn U, Curschmann J, Janzer RC, Ludwin SK, Gorlia T, Allgeier A, Lacombe D, Cairncross JG, Eisenhauer E, Mirimanoff RO (2005) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352:987\u2013996. doi: 10.1056\/NEJMoa043330","journal-title":"N Engl J Med"},{"key":"1362_CR2","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1126\/science.123.3191.309","volume":"123","author":"O Warburg","year":"1956","unstructured":"Warburg O (1956) On the origin of cancer cells. Science 123:309\u2013314","journal-title":"Science"},{"key":"1362_CR3","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0006-291X(90)91263-R","volume":"170","author":"T Yamamoto","year":"1990","unstructured":"Yamamoto T, Seino Y, Fukumoto H, Koh G, Yano H, Inagaki N, Yamada Y, Inoue K, Manabe T, Imura H (1990) Over-expression of facilitative glucose transporter genes in human cancer. Biochem Biophys Res Commun 170:223\u2013230","journal-title":"Biochem Biophys Res Commun"},{"key":"1362_CR4","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.semcancer.2008.11.006","volume":"19","author":"SP Mathupala","year":"2009","unstructured":"Mathupala SP, Ko YH, Pedersen PL (2009) Hexokinase-2 bound to mitochondria: cancer\u2019s stygian link to the \u201cWarburg Effect\u201d and a pivotal target for effective therapy. Semin Cancer Biol 19:17\u201324. doi: 10.1016\/j.semcancer.2008.11.006","journal-title":"Semin Cancer Biol"},{"key":"1362_CR5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1758-3284-2-19","volume":"2","author":"GJ Kubicek","year":"2010","unstructured":"Kubicek GJ, Champ C, Fogh S, Wang F, Reddy E, Intenzo C, Dusing RW, Machtay M (2010) FDG-PET staging and importance of lymph node SUV in head and neck cancer. Head Neck Oncol 2:19. doi: 10.1186\/1758-3284-2-19","journal-title":"Head Neck Oncol"},{"key":"1362_CR6","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1186\/1471-2407-11-315","volume":"11","author":"GD Maurer","year":"2011","unstructured":"Maurer GD, Brucker DP, Bahr O, Harter PN, Hattingen E, Walenta S, Mueller-Klieser W, Steinbach JP, Rieger J (2011) Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy. BMC Cancer 11:315. doi: 10.1186\/1471-2407-11-315","journal-title":"BMC Cancer"},{"key":"1362_CR7","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1528-1167.2008.01853.x","volume":"49","author":"TN Seyfried","year":"2008","unstructured":"Seyfried TN, Kiebish M, Mukherjee P, Marsh J (2008) Targeting energy metabolism in brain cancer with calorically restricted ketogenic diets. Epilepsia 49:114\u2013116. doi: 10.1111\/j.1528-1167.2008.01853.x","journal-title":"Epilepsia"},{"key":"1362_CR8","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1200\/JCO.2008.19.1098","volume":"27","author":"RL Derr","year":"2009","unstructured":"Derr RL, Ye X, Islas MU, Desideri S, Saudek CD, Grossman SA (2009) Association between hyperglycemia and survival in patients with newly diagnosed glioblastoma. J Clin Oncol 27:1082\u20131086. doi: 10.1200\/JCO.2008.19.1098","journal-title":"J Clin Oncol"},{"key":"1362_CR9","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1227\/01.NEU.0000315282.61035.48","volume":"63","author":"MJ McGirt","year":"2008","unstructured":"McGirt MJ, Chaichana KL, Gathinji M, Attenello F, Than K, Ruiz AJ, Olivi A, Quinones-Hinojosa A (2008) Persistent outpatient hyperglycemia is independently associated with decreased survival after primary resection of malignant brain astrocytomas. Neurosurgery 63:286\u2013291. doi: 10.1227\/01.NEU.0000315282.61035.48","journal-title":"Neurosurgery"},{"key":"1362_CR10","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.nut.2012.05.001","volume":"28","author":"EJ Fine","year":"2012","unstructured":"Fine EJ, Segal-Isaacson CJ, Feinman RD, Herszkopf S, Romano MC, Tomuta N, Bontempo AF, Negassa A, Sparano JA (2012) Targeting insulin inhibition as a metabolic therapy in advanced cancer: a pilot safety and feasibility dietary trial in 10 patients. Nutrition 28:1028\u20131035. doi: 10.1016\/j.nut.2012.05.001","journal-title":"Nutrition"},{"key":"1362_CR11","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0197-0186(00)00102-9","volume":"38","author":"RL Leino","year":"2001","unstructured":"Leino RL, Gerhart DZ, Duelli R, Enerson BE, Drewes LR (2001) Diet-induced ketosis increases monocarboxylate transporter (MCT1) levels in rat brain. Neurochem Int 38:519\u2013527. doi: 10.1016\/s0197-0186(00)00102-9","journal-title":"Neurochem Int"},{"key":"1362_CR12","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.plefa.2003.07.006","volume":"70","author":"A Nehlig","year":"2004","unstructured":"Nehlig A (2004) Brain uptake and metabolism of ketone bodies in animal models. Prostaglandins Leukot Essent Fatty Acids 70:265\u2013275. doi: 10.1016\/j.plefa.2003.07.006","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"1362_CR13","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1215\/15228517-2006-035","volume":"9","author":"R Simanek","year":"2007","unstructured":"Simanek R, Vormittag R, Hassler M, Roessler K, Schwarz M, Zielinski C, Pabinger I, Marosi C (2007) Venous thromboembolism and survival in patients with high-grade glioma. Neuro-oncology 9:89\u201395. doi: 10.1215\/15228517-2006-035","journal-title":"Neuro-oncology"},{"key":"1362_CR14","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1538-7836.2005.01141.x","volume":"3","author":"M Heijer Den","year":"2005","unstructured":"Den Heijer M, Lewington S, Clarke R (2005) Homocysteine, MTHFR and risk of venous thrombosis: a meta-analysis of published epidemiological studies. J Thromb Haemost 3:292\u2013299. doi: 10.1111\/j.1538-7836.2005.01141.x","journal-title":"J Thromb Haemost"},{"key":"1362_CR15","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1042\/cs0810189","volume":"81","author":"SA Amiel","year":"1991","unstructured":"Amiel SA, Archibald HR, Chusney G, Williams AJ, Gale EA (1991) Ketone infusion lowers hormonal responses to hypoglycaemia: evidence for acute cerebral utilization of a non-glucose fuel. Clin Sci (Lond) 81:189\u2013194","journal-title":"Clin Sci (Lond)"},{"key":"1362_CR16","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s11745-008-3274-2","volume":"44","author":"J Volek","year":"2009","unstructured":"Volek J, Phinney S, Forsythe C, Quann E, Wood R, Puglisi M, Kraemer W, Bibus D, Fernandez M, Feinman R (2009) Carbohydrate restriction has a more favorable impact on the metabolic syndrome than a low fat diet. Lipids 44:297\u2013309. doi: 10.1007\/s11745-008-3274-2","journal-title":"Lipids"},{"issue":"10","key":"1362_CR17","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.nut.2012.05.001","volume":"28","author":"EJ Fine","year":"2012","unstructured":"Fine EJ, Segal-Isaacson CJ, Feinman RD, Herszkopf S, Romano MC, Tomuta N, Bontempo AF, Negassa A, Sparano JA (2012) Targeting insulin inhibition as a metabolic therapy in advanced cancer: a pilot safety and feasibility dietary trial in 10 patients. Nutrition 28(10):1028\u20131035. doi: 10.1016\/j.nut.2012.05.001","journal-title":"Nutrition"},{"key":"1362_CR18","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1634\/theoncologist.2012-0164","volume":"18","author":"CE Champ","year":"2013","unstructured":"Champ CE, Baserga R, Mishra MV, Jin L, Sotgia F, Lisanti MP, Pestell RG, Dicker AP, Simone NL (2013) Nutrient restriction and radiation therapy for cancer treatment: when less is more. Oncologist 18:97\u2013103. doi: 10.1634\/theoncologist.2012-0164","journal-title":"Oncologist"},{"key":"1362_CR19","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1743-7075-7-74","volume":"7","author":"P Stafford","year":"2010","unstructured":"Stafford P, Abdelwahab M, Kim D, Preul M, Rho J, Scheck A (2010) The ketogenic diet reverses gene expression patterns and reduces reactive oxygen species levels when used as an adjuvant therapy for glioma. Nutr Metab 7:74","journal-title":"Nutr Metab"},{"key":"1362_CR20","doi-asserted-by":"crossref","first-page":"e36197","DOI":"10.1371\/journal.pone.0036197","volume":"7","author":"MG Abdelwahab","year":"2012","unstructured":"Abdelwahab MG, Fenton KE, Preul MC, Rho JM, Lynch A, Stafford P, Scheck AC (2012) The ketogenic diet is an effective adjuvant to radiation therapy for the treatment of malignant glioma. PLoS ONE 7:e36197. doi: 10.1371\/journal.pone.0036197","journal-title":"PLoS ONE"},{"key":"1362_CR21","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1743-7075-7-33","volume":"7","author":"G Zuccoli","year":"2010","unstructured":"Zuccoli G, Marcello N, Pisanello A, Servadei F, Vaccaro S, Mukherjee P, Seyfried T (2010) Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: case report. Nutr Metab 7:33","journal-title":"Nutr Metab"},{"key":"1362_CR22","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0002-8223(95)00189-1","volume":"95","author":"LC Nebeling","year":"1995","unstructured":"Nebeling LC, Lerner E (1995) Implementing a ketogenic diet based on medium-chain triglyceride oil in pediatric patients with cancer. J Am Diet Assoc 95:693\u2013697","journal-title":"J Am Diet Assoc"},{"key":"1362_CR23","doi-asserted-by":"crossref","first-page":"5574","DOI":"10.1038\/sj.onc.1203854","volume":"19","author":"R Baserga","year":"2000","unstructured":"Baserga R (2000) The contradictions of the insulin-like growth factor 1 receptor. Oncogene 19:5574\u20135581. doi: 10.1038\/sj.onc.1203854","journal-title":"Oncogene"},{"key":"1362_CR24","first-page":"4848","volume":"54","author":"M Resnicoff","year":"1994","unstructured":"Resnicoff M, Coppola D, Sell C, Rubin R, Ferrone S, Baserga R (1994) Growth inhibition of human melanoma cells in nude mice by antisense strategies to the type 1 insulin-like growth factor receptor. Cancer Res 54:4848\u20134850","journal-title":"Cancer Res"},{"key":"1362_CR25","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/bjc.1992.65","volume":"65","author":"VM Macaulay","year":"1992","unstructured":"Macaulay VM (1992) Insulin-like growth factors and cancer. Br J Cancer 65:311\u2013320","journal-title":"Br J Cancer"},{"key":"1362_CR26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/jsre.2000.5923","volume":"94","author":"ES Perer","year":"2000","unstructured":"Perer ES, Madan AK, Shurin A, Zakris E, Romeguera K, Pang Y, Beech DJ (2000) Insulin-like growth factor I receptor antagonism augments response to chemoradiation therapy in colon cancer cells. J Surg Res 94:1\u20135. doi: 10.1006\/jsre.2000.5923S0022-4804(00)95923-7","journal-title":"J Surg Res"},{"key":"1362_CR27","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1200\/JCO.2001.19.8.2189","volume":"19","author":"DW Andrews","year":"2001","unstructured":"Andrews DW, Resnicoff M, Flanders AE, Kenyon L, Curtis M, Merli G, Baserga R, Iliakis G, Aiken RD (2001) Results of a pilot study involving the use of an antisense oligodeoxynucleotide directed against the insulin-like growth factor type I receptor in malignant astrocytomas. J Clin Oncol 19:2189\u20132200","journal-title":"J Clin Oncol"},{"key":"1362_CR28","first-page":"3079","volume":"57","author":"BC Turner","year":"1997","unstructured":"Turner BC, Haffty BG, Narayanan L, Yuan J, Havre PA, Gumbs AA, Kaplan L, Burgaud JL, Carter D, Baserga R, Glazer PM (1997) Insulin-like growth factor-I receptor overexpression mediates cellular radioresistance and local breast cancer recurrence after lumpectomy and radiation. Cancer Res 57:3079\u20133083","journal-title":"Cancer Res"},{"key":"1362_CR29","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1155\/2012\/506868","volume":"2012","author":"CE Champ","year":"2012","unstructured":"Champ CE, Volek JS, Siglin J, Jin L, Simone NL (2012) Weight gain, metabolic syndrome, and breast cancer recurrence: are dietary recommendations supported by the data? Int J Breast Cancer 2012:9. doi: 10.1155\/2012\/506868","journal-title":"Int J Breast Cancer"},{"key":"1362_CR30","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/1743-7075-8-75","volume":"8","author":"RJ Klement","year":"2011","unstructured":"Klement RJ, Kammerer U (2011) Is there a role for carbohydrate restriction in the treatment and prevention of cancer? Nutr Metab (Lond) 8:75. doi: 10.1186\/1743-7075-8-75","journal-title":"Nutr Metab (Lond)"},{"key":"1362_CR31","doi-asserted-by":"crossref","first-page":"959","DOI":"10.2217\/fon.13.31","volume":"9","author":"BA Simone","year":"2013","unstructured":"Simone BA, Champ CE, Rosenberg AL, Berger AC, Monti DA, Dicker AP, Simone NL (2013) Selectively starving cancer cells through dietary manipulation: methods and clinical implications. Future Oncol 9:959\u2013976. doi: 10.2217\/fon.13.31","journal-title":"Future Oncol"}],"container-title":["Journal of Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-014-1362-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11060-014-1362-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-014-1362-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T16:01:58Z","timestamp":1565107318000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11060-014-1362-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,19]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["1362"],"URL":"https:\/\/doi.org\/10.1007\/s11060-014-1362-0","relation":{},"ISSN":["0167-594X","1573-7373"],"issn-type":[{"value":"0167-594X","type":"print"},{"value":"1573-7373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,19]]}}}