{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:28:23Z","timestamp":1792682903185,"version":"4.5.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2014,8,24]],"date-time":"2014-08-24T00:00:00Z","timestamp":1408838400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurooncol"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1007\/s11060-014-1591-2","type":"journal-article","created":{"date-parts":[[2014,8,23]],"date-time":"2014-08-23T04:55:23Z","timestamp":1408769723000},"page":"589-595","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Symptoms and medication management in the end of life phase of high-grade glioma patients"],"prefix":"10.1007","volume":"120","author":[{"given":"J. A. F.","family":"Koekkoek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Dirven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. M.","family":"Sizoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. R. W.","family":"Pasman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. J.","family":"Heimans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. J.","family":"Postma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Deliens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Grant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"McNamara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Stockhammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Medicus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J. B.","family":"Taphoorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. C.","family":"Reijneveld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,8,24]]},"reference":[{"issue":"10","key":"1591_CR1","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.ejca.2011.12.013","volume":"48","author":"E Crocetti","year":"2012","unstructured":"Crocetti E, Trama A, Stiller C, Caldarella A, Soffietti R, Jaal J et al (2012) Epidemiology of glial and non-glial brain tumours in Europe. Eur J Cancer 48(10):1532\u20131542","journal-title":"Eur J Cancer"},{"issue":"9830","key":"1591_CR2","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1016\/S0140-6736(11)61346-9","volume":"379","author":"D Ricard","year":"2012","unstructured":"Ricard D, Idbaih A, Ducray F, Lahutte M, Hoang-Xuan K, Delattre JY (2012) Primary brain tumours in adults. Lancet 379(9830):1984\u20131996","journal-title":"Lancet"},{"issue":"5","key":"1591_CR3","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1056\/NEJMra0708126","volume":"359","author":"PY Wen","year":"2008","unstructured":"Wen PY, Kesari S (2008) Malignant gliomas in adults. N Engl J Med 359(5):492\u2013507","journal-title":"N Engl J Med"},{"issue":"6","key":"1591_CR4","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1097\/CCO.0b013e32833e078c","volume":"22","author":"A Pace","year":"2010","unstructured":"Pace A, Metro G, Fabi A (2010) Supportive care in neurooncology. Curr Opin Oncol 22(6):621\u2013626","journal-title":"Curr Opin Oncol"},{"issue":"3","key":"1591_CR5","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s00520-013-2088-9","volume":"22","author":"EM Sizoo","year":"2014","unstructured":"Sizoo EM, Pasman HR, Dirven L, Marosi C, Grisold W, Stockhammer G et al (2014) The end-of-life phase of high-grade glioma patients: a systematic review. Support Care Cancer 22(3):847\u2013857","journal-title":"Support Care Cancer"},{"issue":"2","key":"1591_CR6","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s11060-014-1393-6","volume":"117","author":"T Walbert","year":"2014","unstructured":"Walbert T, Khan M (2014) End-of-life symptoms and care in patients with primary malignant brain tumors: a systematic literature review. J Neurooncol 117(2):217\u2013224","journal-title":"J Neurooncol"},{"issue":"8","key":"1591_CR7","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1007\/s00415-002-0839-5","volume":"249","author":"JJ Heimans","year":"2002","unstructured":"Heimans JJ, Taphoorn MJ (2002) Impact of brain tumour treatment on quality of life. J Neurol 249(8):955\u2013960","journal-title":"J Neurol"},{"issue":"6","key":"1591_CR8","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.jpsychores.2007.06.018","volume":"63","author":"M Janda","year":"2007","unstructured":"Janda M, Steginga S, Langbecker D, Dunn J, Walker D, Eakin E (2007) Quality of life among patients with a brain tumor and their carers. J Psychosom Res 63(6):617\u2013623","journal-title":"J Psychosom Res"},{"issue":"11","key":"1591_CR9","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1093\/neuonc\/nop045","volume":"12","author":"EM Sizoo","year":"2010","unstructured":"Sizoo EM, Braam L, Postma TJ, Pasman HR, Heimans JJ, Klein M et al (2010) Symptoms and problems in the end-of-life phase of high-grade glioma patients. Neuro Oncol 12(11):1162\u20131166","journal-title":"Neuro Oncol"},{"issue":"6","key":"1591_CR10","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1177\/026921630301700615","volume":"17","author":"C Bausewein","year":"2003","unstructured":"Bausewein C, Hau P, Borasio GD, Voltz R (2003) How do patients with primary brain tumours die? Palliat Med 17(6):558\u2013559","journal-title":"Palliat Med"},{"issue":"2","key":"1591_CR11","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1634\/theoncologist.2012-0247","volume":"18","author":"EM Sizoo","year":"2013","unstructured":"Sizoo EM, Taphoorn MJ, Uitdehaag B, Heimans JJ, Deliens L, Reijneveld JC et al (2013) The end-of-life phase of high-grade glioma patients: dying with dignity? Oncologist 18(2):198\u2013203","journal-title":"Oncologist"},{"issue":"1","key":"1591_CR12","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s11060-008-9670-x","volume":"91","author":"A Pace","year":"2009","unstructured":"Pace A, Di LC, Guariglia L, Jandolo B, Carapella CM, Pompili A (2009) End of life issues in brain tumor patients. J Neurooncol 91(1):39\u201343","journal-title":"J Neurooncol"},{"issue":"1","key":"1591_CR13","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1089\/jpm.2007.0137","volume":"11","author":"S Oberndorfer","year":"2008","unstructured":"Oberndorfer S, Lindeck-Pozza E, Lahrmann H, Struhal W, Hitzenberger P, Grisold W (2008) The end-of-life hospital setting in patients with glioblastoma. J Palliat Med 11(1):26\u201330","journal-title":"J Palliat Med"},{"issue":"9","key":"1591_CR14","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1007\/s00520-009-0735-y","volume":"18","author":"C Ostgathe","year":"2010","unstructured":"Ostgathe C, Gaertner J, Kotterba M, Klein S, Lindena G, Nauck F et al (2010) Differential palliative care issues in patients with primary and secondary brain tumours. Support Care Cancer 18(9):1157\u20131163","journal-title":"Support Care Cancer"},{"issue":"7","key":"1591_CR15","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1191\/0269216305pm1068oa","volume":"19","author":"S Faithfull","year":"2005","unstructured":"Faithfull S, Cook K, Lucas C (2005) Palliative care of patients with a primary malignant brain tumour: case review of service use and support provided. Palliat Med 19(7):545\u2013550","journal-title":"Palliat Med"},{"key":"1591_CR16","doi-asserted-by":"crossref","unstructured":"Koekkoek JA, Dirven L, Reijneveld JC, Sizoo EM, Pasman HR, Postma TJ, et al. (2014) End of life care in high-grade glioma patients in three European countries: a comparative study. J Neurooncol","DOI":"10.1007\/s11060-014-1548-5"},{"issue":"2","key":"1591_CR17","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ejca.2011.11.010","volume":"48","author":"EM Sizoo","year":"2012","unstructured":"Sizoo EM, Pasman HR, Buttolo J, Heimans JJ, Klein M, Deliens L et al (2012) Decision-making in the end-of-life phase of high-grade glioma patients. Eur J Cancer 48(2):226\u2013232","journal-title":"Eur J Cancer"},{"issue":"2","key":"1591_CR18","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s11060-013-1289-x","volume":"116","author":"EM Sizoo","year":"2014","unstructured":"Sizoo EM, Dirven L, Reijneveld JC, Postma TJ, Heimans JJ, Deliens L et al (2014) Measuring health-related quality of life in high-grade glioma patients at the end of life using a proxy-reported retrospective questionnaire. J Neurooncol 116(2):283\u2013290","journal-title":"J Neurooncol"},{"issue":"7","key":"1591_CR19","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1089\/jpm.2013.0028","volume":"16","author":"Y Liu","year":"2013","unstructured":"Liu Y, Zhang PY, Na J, Ma C, Huo WL, Han L et al (2013) Prevalence, intensity, and prognostic significance of common symptoms in terminally ill cancer patients. J Palliat Med 16(7):752\u2013757","journal-title":"J Palliat Med"},{"key":"1591_CR20","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/1471-2296-14-201","volume":"14","author":"CD Ruijs","year":"2013","unstructured":"Ruijs CD, Kerkhof AJ, van der Wal G, Onwuteaka-Philipsen BD (2013) Symptoms, unbearability and the nature of suffering in terminal cancer patients dying at home: a prospective primary care study. BMC Fam Pract 14:201","journal-title":"BMC Fam Pract"},{"issue":"4","key":"1591_CR21","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1093\/annonc\/mdn700","volume":"20","author":"M Costantini","year":"2009","unstructured":"Costantini M, Ripamonti C, Beccaro M, Montella M, Borgia P, Casella C et al (2009) Prevalence, distress, management, and relief of pain during the last 3\u00a0months of cancer patients\u2019 life. Results of an Italian mortality follow-back survey. Ann Oncol 20(4):729\u2013735","journal-title":"Ann Oncol"},{"issue":"4","key":"1591_CR22","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1191\/0269216303pm760oa","volume":"17","author":"J Potter","year":"2003","unstructured":"Potter J, Hami F, Bryan T, Quigley C (2003) Symptoms in 400 patients referred to palliative care services: prevalence and patterns. Palliat Med 17(4):310\u2013314","journal-title":"Palliat Med"},{"issue":"9354","key":"1591_CR23","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0140-6736(03)12328-8","volume":"361","author":"A Behin","year":"2003","unstructured":"Behin A, Hoang-Xuan K, Carpentier AF, Delattre JY (2003) Primary brain tumours in adults. Lancet 361(9354):323\u2013331","journal-title":"Lancet"},{"issue":"4","key":"1591_CR24","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/SPC.0b013e32836575f9","volume":"7","author":"T Steigleder","year":"2013","unstructured":"Steigleder T, Stiel S, Ostgathe C (2013) Dying of brain tumours: specific aspects of care. Curr Opin Support Palliat Care 7(4):417\u2013423","journal-title":"Curr Opin Support Palliat Care"},{"issue":"18","key":"1591_CR25","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1200\/JCO.2009.26.9712","volume":"28","author":"C Lo","year":"2010","unstructured":"Lo C, Zimmermann C, Rydall A, Walsh A, Jones JM, Moore MJ et al (2010) Longitudinal study of depressive symptoms in patients with metastatic gastrointestinal and lung cancer. J Clin Oncol 28(18):3084\u20133089","journal-title":"J Clin Oncol"},{"issue":"4","key":"1591_CR26","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1093\/fampra\/cmr006","volume":"28","author":"CD Ruijs","year":"2011","unstructured":"Ruijs CD, Kerkhof AJ, van der Wal G, Onwuteaka-Philipsen BD (2011) Depression and explicit requests for euthanasia in end-of-life cancer patients in primary care in the Netherlands: a longitudinal, prospective study. Fam Pract 28(4):393\u2013399","journal-title":"Fam Pract"},{"issue":"3","key":"1591_CR27","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s00520-013-2019-9","volume":"22","author":"MC Korte-Verhoef De","year":"2014","unstructured":"De Korte-Verhoef MC, Pasman HR, Schweitzer BP, Francke AL, Onwuteaka-Philipsen BD, Deliens L (2014) Reasons for hospitalisation at the end of life: differences between cancer and non-cancer patients. Support Care Cancer 22(3):645\u2013652","journal-title":"Support Care Cancer"},{"issue":"3","key":"1591_CR28","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1046\/j.1532-5415.2002.50117.x","volume":"50","author":"P Hall","year":"2002","unstructured":"Hall P, Schroder C, Weaver L (2002) The last 48 hours of life in long-term care: a focused chart audit. J Am Geriatr Soc 50(3):501\u2013506","journal-title":"J Am Geriatr Soc"},{"issue":"7","key":"1591_CR29","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1089\/jpm.2013.0028","volume":"16","author":"Y Liu","year":"2013","unstructured":"Liu Y, Zhang PY, Na J, Ma C, Huo WL, Han L et al (2013) Prevalence, intensity, and prognostic significance of common symptoms in terminally ill cancer patients. J Palliat Med 16(7):752\u2013757","journal-title":"J Palliat Med"},{"issue":"2","key":"1591_CR30","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/pon.1881","volume":"21","author":"P Gagnon","year":"2012","unstructured":"Gagnon P, Allard P, Gagnon B, Merette C, Tardif F (2012) Delirium prevention in terminal cancer: assessment of a multicomponent intervention. Psychooncology 21(2):187\u2013194","journal-title":"Psychooncology"},{"issue":"1","key":"1591_CR31","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s11060-012-0993-2","volume":"111","author":"A Pace","year":"2013","unstructured":"Pace A, Villani V, Di LC, Guariglia L, Maschio M, Pompili A et al (2013) Epilepsy in the end-of-life phase in patients with high-grade gliomas. J Neurooncol 111(1):83\u201386","journal-title":"J Neurooncol"},{"issue":"1","key":"1591_CR32","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1136\/bmjspcare-2013-000456","volume":"4","author":"EM Sizoo","year":"2014","unstructured":"Sizoo EM, Koekkoek JA, Postma TJ, Heimans JJ, Pasman HR, Deliens L et al (2014) Seizures in patients with high-grade glioma: a serious challenge in the end-of-life phase. BMJ Support Palliat Care 4(1):77\u201380","journal-title":"BMJ Support Palliat Care"},{"issue":"4","key":"1591_CR33","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1089\/jpm.2000.3.4.465","volume":"3","author":"HG Krouwer","year":"2000","unstructured":"Krouwer HG, Pallagi JL, Graves NM (2000) Management of seizures in brain tumor patients at the end of life. J Palliat Med 3(4):465\u2013475","journal-title":"J Palliat Med"},{"issue":"4","key":"1591_CR34","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/s00520-012-1619-0","volume":"21","author":"NJ Raijmakers","year":"2013","unstructured":"Raijmakers NJ, van Zuylen L, Furst CJ, Beccaro M, Maiorana L, Pilastri P et al (2013) Variation in medication use in cancer patients at the end of life: a cross-sectional analysis. Support Care Cancer 21(4):1003\u20131011","journal-title":"Support Care Cancer"},{"issue":"1","key":"1591_CR35","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1089\/jpm.2012.0205","volume":"16","author":"O Lindqvist","year":"2013","unstructured":"Lindqvist O, Lundquist G, Dickman A, Bukki J, Lunder U, Hagelin CL et al (2013) Four essential drugs needed for quality care of the dying: a Delphi-study based international expert consensus opinion. J Palliat Med 16(1):38\u201343","journal-title":"J Palliat Med"},{"issue":"2","key":"1591_CR36","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2165\/00002018-200225020-00004","volume":"25","author":"F Pisani","year":"2002","unstructured":"Pisani F, Oteri G, Costa C, Di RG, Di PR (2002) Effects of psychotropic drugs on seizure threshold. Drug Saf 25(2):91\u2013110","journal-title":"Drug Saf"},{"issue":"2","key":"1591_CR37","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1177\/082585979401000207","volume":"10","author":"NI Cherny","year":"1994","unstructured":"Cherny NI, Portenoy RK (1994) Sedation in the management of refractory symptoms: guidelines for evaluation and treatment. J Palliat Care 10(2):31\u201338","journal-title":"J Palliat Care"},{"issue":"4","key":"1591_CR38","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1097\/CCO.0b013e3283622c47","volume":"25","author":"M Maltoni","year":"2013","unstructured":"Maltoni M, Scarpi E, Nanni O (2013) Palliative sedation in end-of-life care. Curr Opin Oncol 25(4):360\u2013367","journal-title":"Curr Opin Oncol"},{"issue":"6","key":"1591_CR39","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1007\/s00520-013-1721-y","volume":"21","author":"J Bukki","year":"2013","unstructured":"Bukki J, Scherbel J, Stiel S, Klein C, Meidenbauer N, Ostgathe C (2013) Palliative care needs, symptoms, and treatment intensity along the disease trajectory in medical oncology outpatients: a retrospective chart review. Support Care Cancer 21(6):1743\u20131750","journal-title":"Support Care Cancer"},{"issue":"8","key":"1591_CR40","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1056\/NEJMoa1000678","volume":"363","author":"JS Temel","year":"2010","unstructured":"Temel JS, Greer JA, Muzikansky A, Gallagher ER, Admane S, Jackson VA et al (2010) Early palliative care for patients with metastatic non-small-cell lung cancer. N Engl J Med 363(8):733\u2013742","journal-title":"N Engl J Med"}],"container-title":["Journal of Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-014-1591-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11060-014-1591-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-014-1591-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T06:52:04Z","timestamp":1565765524000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11060-014-1591-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,24]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["1591"],"URL":"https:\/\/doi.org\/10.1007\/s11060-014-1591-2","relation":{},"ISSN":["0167-594X","1573-7373"],"issn-type":[{"value":"0167-594X","type":"print"},{"value":"1573-7373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,24]]}}}