{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T19:55:50Z","timestamp":1788033350785,"version":"build-2784847793"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2016,6,15]],"date-time":"2016-06-15T00:00:00Z","timestamp":1465948800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurooncol"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1007\/s11060-016-2179-9","type":"journal-article","created":{"date-parts":[[2016,6,15]],"date-time":"2016-06-15T13:19:49Z","timestamp":1465996789000},"page":"329-335","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Whole brain radiotherapy in management of non-small-cell lung carcinoma associated leptomeningeal carcinomatosis: evaluation of prognostic factors"],"prefix":"10.1007","volume":"129","author":[{"given":"Yurday","family":"Ozdemir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berna Akkus","family":"Yildirim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erkan","family":"Topkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,6,15]]},"reference":[{"issue":"9","key":"2179_CR1","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1200\/JCO.1988.6.9.1474","volume":"6","author":"JB Sorensen","year":"1988","unstructured":"Sorensen JB, Hansen HH, Hansen M, Dombernowsky P (1988) Brain metastases in adenocarcinoma of the lung: frequency, risk groups, and prognosis. J Clin Oncol 6(9):1474\u20131480","journal-title":"J Clin Oncol"},{"issue":"6","key":"2179_CR2","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00066-014-0648-7","volume":"190","author":"M Kocher","year":"2014","unstructured":"Kocher M, Wittig A, Piroth MD, Treuer H, Seegenschmiedt H, Ruge M et al (2014) Stereotactic radiosurgery for treatment of brain metastases. a report of the DEGRO working group on stereotactic radiotherapy. Strahlenther Onkol 190(6):521\u2013532","journal-title":"Strahlenther Onkol"},{"issue":"3","key":"2179_CR3","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.lungcan.2011.11.022","volume":"76","author":"JH Park","year":"2012","unstructured":"Park JH, Kim YJ, Lee JO, Lee KW, Kim JH, Bang SM et al (2012) Clinical outcomes of leptomeningeal metastasis in patients with non-small cell lung cancer in the modern chemotherapy era. Lung Cancer 76(3):387\u2013392","journal-title":"Lung Cancer"},{"issue":"5","key":"2179_CR4","doi-asserted-by":"crossref","first-page":"693","DOI":"10.6004\/jnccn.2005.0039","volume":"3","author":"S Chowdhary","year":"2005","unstructured":"Chowdhary S, Chamberlain M (2005) Leptomeningeal metastases: current concepts and management guidelines. J Natl Compr Canc Netw 3(5):693\u2013703","journal-title":"J Natl Compr Canc Netw"},{"issue":"4","key":"2179_CR5","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1001\/archneur.55.4.506","volume":"55","author":"MC Chamberlain","year":"1998","unstructured":"Chamberlain MC, Kormanik P (1998) Carcinoma meningitis secondary to non-small cell lung cancer: combined modality therapy. Arch Neurol 55(4):506\u2013512","journal-title":"Arch Neurol"},{"issue":"2","key":"2179_CR6","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1097\/JTO.0b013e3182398e4f","volume":"7","author":"PG Morris","year":"2012","unstructured":"Morris PG, Reiner AS, Szenberg OR, Clarke JL, Panageas KS, Perez HR et al (2012) Leptomeningeal metastasis from non-small cell lung cancer: survival and the impact of whole brain radiotherapy. J Thorac Oncol 7(2):382\u2013385","journal-title":"J Thorac Oncol"},{"issue":"6","key":"2179_CR7","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1097\/CCO.0b013e32833de986","volume":"22","author":"MC Chamberlain","year":"2010","unstructured":"Chamberlain MC (2010) Leptomeningeal metastasis. Curr Opin Oncol 22(6):627\u2013635","journal-title":"Curr Opin Oncol"},{"issue":"4","key":"2179_CR8","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/1097-0142(19820215)49:4<759::AID-CNCR2820490427>3.0.CO;2-7","volume":"49","author":"WR Wasserstrom","year":"1982","unstructured":"Wasserstrom WR, Glass JP, Posner JB (1982) Diagnosis and treatment of leptomeningeal metastases from solid tumors: experience with 90 patients. Cancer 49(4):759\u2013772","journal-title":"Cancer"},{"issue":"3","key":"2179_CR9","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1001\/archneurol.2010.18","volume":"67","author":"MD Groves","year":"2010","unstructured":"Groves MD (2010) New strategies in the management of leptomeningeal metastases. Arch Neurol 67(3):305\u2013312","journal-title":"Arch Neurol"},{"issue":"10","key":"2179_CR10","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1200\/JCO.1987.5.10.1655","volume":"5","author":"RN Hitchins","year":"1987","unstructured":"Hitchins RN, Bell DR, Woods RL, Levi JA (1987) A prospective randomized trial of single-agent versus combination chemotherapy in meningeal carcinomatosis. J Clin Oncol 5(10):1655\u20131662","journal-title":"J Clin Oncol"},{"issue":"3","key":"2179_CR11","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1200\/JCO.1993.11.3.561","volume":"11","author":"SA Grossman","year":"1993","unstructured":"Grossman SA, Finkelstein DM, Ruckdeschel JC, Trump DL, Moynihan T, Ettinger DS (1993) Randomized prospective comparison of intraventricular methotrexate and thiotepa in patients with previously untreated neoplastic meningitis. Eastern Cooperative Oncology Group. J Clin Oncol 11(3):561\u2013569","journal-title":"J Clin Oncol"},{"issue":"10","key":"2179_CR12","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1136\/jnnp.51.10.1277","volume":"51","author":"W Boogerd","year":"1988","unstructured":"Boogerd W, vd Sande JJ, Moffie D (1988) Acute fever and delayed leukoencephalopathy following low dose intraventricular methotrexate. J Neurol Neurosurg Psychiatry 51(10):1277\u20131283","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2179_CR13","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/1756-9966-27-80","volume":"27","author":"AA Yavuz","year":"2008","unstructured":"Yavuz AA, Topkan E, Onal C, Yavuz MN (2008) Prophylactic cranial irradiation in locally advanced non-small cell lung cancer: outcome of recursive partitioning analysis group 1 patients. J Exp Clin Cancer Res 27:80","journal-title":"J Exp Clin Cancer Res"},{"issue":"4","key":"2179_CR14","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/PL00002398","volume":"177","author":"B Hermann","year":"2001","unstructured":"Hermann B, Hultenschmidt B, Sautter-Bihl ML (2001) Radiotherapy of the neuroaxis for palliative treatment of leptomeningeal carcinomatosis. Strahlenther Onkol 177(4):195\u2013199","journal-title":"Strahlenther Onkol"},{"key":"2179_CR15","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.6004\/jnccn.2014.0151","volume":"12","author":"LB Nabors","year":"2014","unstructured":"Nabors LB, Portnow J, Ammirati M, Brem H, Brown P, Butowski N et al (2014) Central nervous system cancers, version 2.2014. Featured updates to the NCCN guidelines. J Natl Compr Canc Netw 12:1517\u20131523","journal-title":"J Natl Compr Canc Netw"},{"issue":"5","key":"2179_CR16","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1097\/JTO.0b013e318287c943","volume":"8","author":"HS Gwak","year":"2013","unstructured":"Gwak HS, Joo J, Kim S, Yoo H, Shin SH, Han JY et al (2013) Analysis of treatment outcomes of intraventricular chemotherapy in 105 patients for leptomeningeal carcinomatosis from non-small-cell lung cancer. J Thorac Oncol 8(5):599\u2013605","journal-title":"J Thorac Oncol"},{"issue":"2","key":"2179_CR17","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/JTO.0b013e3182773f21","volume":"8","author":"SJ Lee","year":"2013","unstructured":"Lee SJ, Lee JI, Nam DH, Ahn YC, Han JH, Sun JM et al (2013) Leptomeningeal carcinomatosis in non-small-cell lung cancer patients: impact on survival and correlated prognostic factors. J Thorac Oncol 8(2):185\u2013191","journal-title":"J Thorac Oncol"},{"issue":"7","key":"2179_CR18","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1200\/JCO.2011.40.1174","volume":"31","author":"JW Welsh","year":"2013","unstructured":"Welsh JW, Komaki R, Amini A, Munsell MF, Unger W, Allen PK et al (2013) Phase II trial of erlotinib plus concurrent whole-brain radiation therapy for patients with brain metastases from non-small-cell lung cancer. J Clin Oncol 31(7):895\u2013902","journal-title":"J Clin Oncol"},{"issue":"2","key":"2179_CR19","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1053\/ctrv.1999.0119","volume":"25","author":"SA Grossman","year":"1999","unstructured":"Grossman SA, Krabak MJ (1999) Leptomeningeal carcinomatosis. Cancer Treat Rev 25(2):103\u2013119","journal-title":"Cancer Treat Rev"},{"issue":"11","key":"2179_CR20","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1001\/archneur.1997.00550230037013","volume":"54","author":"MC Chamberlain","year":"1997","unstructured":"Chamberlain MC, Kormanik PA (1997) Prognostic significance of coexistent bulky metastatic central nervous system disease in patients with leptomeningeal metastases. Arch Neurol 54(11):1364\u20131368","journal-title":"Arch Neurol"},{"issue":"1","key":"2179_CR21","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.clineuro.2012.03.048","volume":"115","author":"JA Palma","year":"2013","unstructured":"Palma JA, Fernandez-Torron R, Esteve-Belloch P, Fontes-Villalba A, Hernandez A, Fernandez-Hidalgo O et al (2013) Leptomeningeal carcinomatosis: prognostic value of clinical, cerebrospinal fluid, and neuroimaging features. Clin Neurol Neurosurg 115(1):19\u201325","journal-title":"Clin Neurol Neurosurg"},{"issue":"2","key":"2179_CR22","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/cncr.24041","volume":"115","author":"J Bruna","year":"2009","unstructured":"Bruna J, Gonzalez L, Miro J, Velasco R, Gil M, Tortosa A et al (2009) Leptomeningeal carcinomatosis: prognostic implications of clinical and cerebrospinal fluid features. Cancer 115(2):381\u2013389","journal-title":"Cancer"},{"issue":"2","key":"2179_CR23","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s00066-011-0025-8","volume":"188","author":"C Gani","year":"2012","unstructured":"Gani C, Muller AC, Eckert F, Schroeder C, Bender B, Pantazis G et al (2012) Outcome after whole brain radiotherapy alone in intracranial leptomeningeal carcinomatosis from solid tumors. Strahlenther Onkol 188(2):148\u2013153","journal-title":"Strahlenther Onkol"},{"issue":"2","key":"2179_CR24","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s11060-008-9758-3","volume":"93","author":"F Waki","year":"2009","unstructured":"Waki F, Ando M, Takashima A, Yonemori K, Nokihara H, Miyake M et al (2009) Prognostic factors and clinical outcomes in patients with leptomeningeal metastasis from solid tumors. J Neurooncol 93(2):205\u2013212","journal-title":"J Neurooncol"},{"issue":"3","key":"2179_CR25","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.lungcan.2015.06.001","volume":"89","author":"L Gong","year":"2015","unstructured":"Gong L, Xiong M, Huang Z, Miao L, Fan Y (2015) Icotinib might be effective for the treatment of leptomeningeal carcinomatosis in non-small cell lung cancer with sensitive EGFR mutations. Lung Cancer 89(3):268\u2013273","journal-title":"Lung Cancer"},{"issue":"3","key":"2179_CR26","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.lungcan.2015.05.023","volume":"89","author":"E Thunnissen","year":"2015","unstructured":"Thunnissen E et al (2015) Treatment and survival of patients with EGFR-mutated non-small cell lung cancer and leptomeningeal metastasis: a retrospective cohort analysis. Lung Cancer 89(3):255\u2013261","journal-title":"Lung Cancer"},{"issue":"5","key":"2179_CR27","doi-asserted-by":"crossref","first-page":"984","DOI":"10.3171\/2012.1.JNS111560","volume":"116","author":"JH Ahn","year":"2012","unstructured":"Ahn JH, Lee SH, Kim S, Joo J, Yoo H, Lee SH et al (2012) Risk for leptomeningeal seeding after resection for brain metastases: implication of tumor location with mode of resection. J Neurosurg 116(5):984\u2013993","journal-title":"J Neurosurg"},{"issue":"1","key":"2179_CR28","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s11060-014-1539-6","volume":"120","author":"AJ Huang","year":"2014","unstructured":"Huang AJ, Huang KE, Page BR, Ayala-Peacock DN, Lucas JT Jr, Lesser GJ et al (2014) Risk factors for leptomeningeal carcinomatosis in patients with brain metastases who have previously undergone stereotactic radiosurgery. J Neurooncol 120(1):163\u2013169","journal-title":"J Neurooncol"}],"container-title":["Journal of Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-016-2179-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11060-016-2179-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-016-2179-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T12:25:05Z","timestamp":1498307105000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11060-016-2179-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,15]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["2179"],"URL":"https:\/\/doi.org\/10.1007\/s11060-016-2179-9","relation":{},"ISSN":["0167-594X","1573-7373"],"issn-type":[{"value":"0167-594X","type":"print"},{"value":"1573-7373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,15]]}}}