{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T13:13:14Z","timestamp":1788095594053,"version":"build-2803163510"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,4,28]],"date-time":"2017-04-28T00:00:00Z","timestamp":1493337600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"None","award":["Not applicable"],"award-info":[{"award-number":["Not applicable"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurooncol"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1007\/s11060-017-2452-6","type":"journal-article","created":{"date-parts":[[2017,4,28]],"date-time":"2017-04-28T08:43:16Z","timestamp":1493368996000},"page":"419-427","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Diagnosis and treatment patterns for patients with leptomeningeal metastasis from solid tumors across Europe"],"prefix":"10.1007","volume":"133","author":[{"given":"Emilie","family":"Le Rhun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Rud\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Devos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kh\u00ea","family":"Hoang-Xuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieta","family":"Brandsma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"P\u00e9rez Segura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Soffietti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Weller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,4,28]]},"reference":[{"key":"2452_CR1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/now183","author":"M Chamberlain","year":"2016","unstructured":"Chamberlain M, Junck L, Brandsma et al (2016) Leptomeningeal metastases: a RANO proposal for response criteria. Neuro Oncol. doi:\n10.1093\/neuonc\/now183","journal-title":"Neuro Oncol"},{"key":"2452_CR2","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1097\/WCO.0000000000000393","volume":"29","author":"E Le Rhun","year":"2016","unstructured":"Le Rhun E, Galanis E (2016) Leptomeningeal metastases of solid cancer. Curr Opin Neurol 29:797\u2013805. doi:\n10.1097\/WCO.0000000000000393","journal-title":"Curr Opin Neurol"},{"key":"2452_CR3","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1159\/000121688","volume":"3","author":"AC Regierer","year":"2008","unstructured":"Regierer AC, Stroux A, K\u00fchnhardt D et al (2008) Contrast-enhancing meningeal lesions are associated with longer survival in breast cancer-related leptomeningeal metastasis. Breast Care Basel Switz 3:118\u2013123. doi:\n10.1159\/000121688","journal-title":"Breast Care Basel Switz"},{"key":"2452_CR4","doi-asserted-by":"publisher","first-page":"2183","DOI":"10.1093\/annonc\/mdq232","volume":"21","author":"H Gauthier","year":"2010","unstructured":"Gauthier H, Guilhaume MN, Bidard FC et al (2010) Survival of breast cancer patients with meningeal carcinomatosis. Ann Oncol 21:2183\u20132187. doi:\n10.1093\/annonc\/mdq232","journal-title":"Ann Oncol"},{"key":"2452_CR5","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1007\/s10549-011-1682-0","volume":"129","author":"S Lee","year":"2011","unstructured":"Lee S, Ahn HK, Park YH et al (2011) Leptomeningeal metastases from breast cancer: intrinsic subtypes may affect unique clinical manifestations. Breast Cancer Res Treat 129:809\u2013817. doi:\n10.1007\/s10549-011-1682-0","journal-title":"Breast Cancer Res Treat"},{"key":"2452_CR6","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1007\/s11060-010-0524-y","volume":"104","author":"CRAS Azevedo de","year":"2011","unstructured":"de Azevedo CRAS, Cruz MRS, Chinen LTD et al (2011) Meningeal carcinomatosis in breast cancer: prognostic factors and outcome. J Neurooncol 104:565\u2013572. doi:\n10.1007\/s11060-010-0524-y","journal-title":"J Neurooncol"},{"key":"2452_CR7","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s11060-013-1175-6","volume":"114","author":"S Yust-Katz","year":"2013","unstructured":"Yust-Katz S, Garciarena P, Liu D et al (2013) Breast cancer and leptomeningeal disease (LMD): hormone receptor status influences time to development of LMD and survival from LMD diagnosis. J Neurooncol 114:229\u2013235. doi:\n10.1007\/s11060-013-1175-6","journal-title":"J Neurooncol"},{"key":"2452_CR8","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s11060-013-1092-8","volume":"113","author":"E Le Rhun","year":"2013","unstructured":"Le Rhun E, Taillibert S, Zairi F et al (2013) A retrospective case series of 103 consecutive patients with leptomeningeal metastasis and breast cancer. J Neurooncol 113:83\u201392. doi:\n10.1007\/s11060-013-1092-8","journal-title":"J Neurooncol"},{"key":"2452_CR9","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1007\/s10549-014-3054-z","volume":"146","author":"S Abouharb","year":"2014","unstructured":"Abouharb S, Ensor J, Loghin ME et al (2014) Leptomeningeal disease and breast cancer: the importance of tumor subtype. Breast Cancer Res Treat 146:477\u2013486. doi:\n10.1007\/s10549-014-3054-z","journal-title":"Breast Cancer Res Treat"},{"key":"2452_CR10","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1097\/JTO.0b013e3182398e4f","volume":"7","author":"PG Morris","year":"2012","unstructured":"Morris PG, Reiner AS, Szenberg OR et al (2012) Leptomeningeal metastasis from non-small cell lung cancer: survival and the impact of whole brain radiotherapy. J Thorac Oncol 7:382\u2013385. doi:\n10.1097\/JTO.0b013e3182398e4f","journal-title":"J Thorac Oncol"},{"key":"2452_CR11","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.lungcan.2012.03.002","volume":"77","author":"S Umemura","year":"2012","unstructured":"Umemura S, Tsubouchi K, Yoshioka H et al (2012) Clinical outcome in patients with leptomeningeal metastasis from non-small cell lung cancer: Okayama Lung Cancer Study Group. Lung Cancer 77:134\u2013139. doi:\n10.1016\/j.lungcan.2012.03.002","journal-title":"Lung Cancer"},{"key":"2452_CR12","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1097\/JTO.0b013e318287c943","volume":"8","author":"H-S Gwak","year":"2013","unstructured":"Gwak H-S, Joo J, Kim S et al (2013) Analysis of treatment outcomes of intraventricular chemotherapy in 105 patients for leptomeningeal carcinomatosis from non-small-cell lung cancer. J Thorac Oncol 8:599\u2013605. doi:\n10.1097\/JTO.0b013e318287c943","journal-title":"J Thorac Oncol"},{"key":"2452_CR13","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.cllc.2013.12.009","volume":"15","author":"JW Riess","year":"2014","unstructured":"Riess JW, Nagpal S, Iv M et al (2014) Prolonged survival of patients with non-small-cell lung cancer with leptomeningeal carcinomatosis in the modern treatment era. Clin Lung Cancer 15:202\u2013206. doi:\n10.1016\/j.cllc.2013.12.009","journal-title":"Clin Lung Cancer"},{"key":"2452_CR14","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.lungcan.2015.05.023","volume":"89","author":"JL Kuiper","year":"2015","unstructured":"Kuiper JL, Hendriks LE, van der Wekken AJ et al (2015) Treatment and survival of patients with EGFR-mutated non-small cell lung cancer and leptomeningeal metastasis: a retrospective cohort analysis. Lung Cancer 89:255\u2013261. doi:\n10.1016\/j.lungcan.2015.05.023","journal-title":"Lung Cancer"},{"key":"2452_CR15","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1215\/15228517-2008-062","volume":"10","author":"L Harstad","year":"2008","unstructured":"Harstad L, Hess KR, Groves MD (2008) Prognostic factors and outcomes in patients with leptomeningeal melanomatosis. Neuro-Oncology 10:1010\u20131018. doi:\n10.1215\/15228517-2008-062","journal-title":"Neuro-Oncology"},{"key":"2452_CR16","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1093\/annonc\/mdw134","volume":"27","author":"MH Geukes Foppen","year":"2016","unstructured":"Geukes Foppen MH, Brandsma D, Blank CU et al (2016) Targeted treatment and immunotherapy in leptomeningeal metastases from melanoma. Ann Oncol 27:1138\u20131142. doi:\n10.1093\/annonc\/mdw134","journal-title":"Ann Oncol"},{"key":"2452_CR17","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s11060-007-9340-4","volume":"84","author":"H Rudnicka","year":"2007","unstructured":"Rudnicka H, Niwi\u0144ska A, Murawska M (2007) Breast cancer leptomeningeal metastasis\u2014the role of multimodality treatment. J Neurooncol 84:57\u201362. doi:\n10.1007\/s11060-007-9340-4","journal-title":"J Neurooncol"},{"key":"2452_CR18","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1007\/s12032-012-0408-4","volume":"30","author":"A Niwi\u0144ska","year":"2013","unstructured":"Niwi\u0144ska A, Rudnicka H, Murawska M (2013) Breast cancer leptomeningeal metastasis: propensity of breast cancer subtypes for leptomeninges and the analysis of factors influencing survival. Med Oncol 30:408. doi:\n10.1007\/s12032-012-0408-4","journal-title":"Med Oncol"},{"key":"2452_CR19","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1179\/1973947812Y.0000000034","volume":"24","author":"I Meattini","year":"2012","unstructured":"Meattini I, Livi L, Saieva C et al (2012) Prognostic factors and clinical features in patients with leptominengeal metastases from breast cancer: a single center experience. J Chemother 24:279\u2013284. doi:\n10.1179\/1973947812Y.0000000034","journal-title":"J Chemother"},{"key":"2452_CR20","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1111\/j.1524-4741.2012.01228.x","volume":"18","author":"F Lara-Medina","year":"2012","unstructured":"Lara-Medina F, Crismatt A, Villarreal-Garza C et al (2012) Clinical features and prognostic factors in patients with carcinomatous meningitis secondary to breast cancer. Breast J 18:233\u2013241. doi:\n10.1111\/j.1524-4741.2012.01228.x","journal-title":"Breast J"},{"key":"2452_CR21","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.lungcan.2011.11.022","volume":"76","author":"JH Park","year":"2012","unstructured":"Park JH, Kim YJ, Lee J-O et al (2012) Clinical outcomes of leptomeningeal metastasis in patients with non-small cell lung cancer in the modern chemotherapy era. Lung Cancer 76:387\u2013392. doi:\n10.1016\/j.lungcan.2011.11.022","journal-title":"Lung Cancer"},{"key":"2452_CR22","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.3346\/jkms.2014.29.8.1094","volume":"29","author":"J Kwon","year":"2014","unstructured":"Kwon J, Chie EK, Kim K et al (2014) Impact of multimodality approach for patients with leptomeningeal metastases from solid tumors. J Korean Med Sci 29:1094\u20131101. doi:\n10.3346\/jkms.2014.29.8.1094","journal-title":"J Korean Med Sci"},{"key":"2452_CR23","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1002\/(SICI)1097-0142(19980215)82:4<733::AID-CNCR17>3.0.CO;2-Z","volume":"82","author":"MJ Glantz","year":"1998","unstructured":"Glantz MJ, Cole BF, Glantz LK et al (1998) Cerebrospinal fluid cytology in patients with cancer: minimizing false-negative results. Cancer 82:733\u2013739","journal-title":"Cancer"},{"key":"2452_CR24","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1212\/WNL.42.6.1239","volume":"42","author":"LR Rogers","year":"1992","unstructured":"Rogers LR, Duchesneau PM, Nunez C et al (1992) Comparison of cisternal and lumbar CSF examination in leptomeningeal metastasis. Neurology 42:1239\u20131241","journal-title":"Neurology"},{"key":"2452_CR25","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/0022-510X(94)90159-7","volume":"121","author":"R Dux","year":"1994","unstructured":"Dux R, Kindler-R\u00f6hrborn A, Annas M et al (1994) A standardized protocol for flow cytometric analysis of cells isolated from cerebrospinal fluid. J Neurol Sci 121:74\u201378","journal-title":"J Neurol Sci"},{"key":"2452_CR26","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-015-1842-x","author":"F Zairi","year":"2015","unstructured":"Zairi F, Le Rhun E, Bertrand N et al (2015) Complications related to the use of an intraventricular access device for the treatment of leptomeningeal metastases from solid tumor: a single centre experience in 112 patients. J Neurooncol. doi:\n10.1007\/s11060-015-1842-x","journal-title":"J Neurooncol"},{"key":"2452_CR27","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.jocn.2015.11.005","volume":"27","author":"BC Kennedy","year":"2016","unstructured":"Kennedy BC, Brown LT, Komotar RJ, McKhann GM (2016) Stereotactic catheter placement for Ommaya reservoirs. J Clin Neurosci 27:44\u201347. doi:\n10.1016\/j.jocn.2015.11.005","journal-title":"J Clin Neurosci"},{"key":"2452_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2016.04.090","author":"PF Morgenstern","year":"2016","unstructured":"Morgenstern PF, Connors S, Reiner AS, Greenfield JP (2016) Image guidance for the placement of Ommaya reservoirs: a comparison of fluoroscopy and frameless stereotactic navigation in 145 patients. World Neurosurg. doi:\n10.1016\/j.wneu.2016.04.090","journal-title":"World Neurosurg"},{"key":"2452_CR29","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1200\/JCO.1987.5.10.1655","volume":"5","author":"RN Hitchins","year":"1987","unstructured":"Hitchins RN, Bell DR, Woods RL, Levi JA (1987) A prospective randomized trial of single-agent versus combination chemotherapy in meningeal carcinomatosis. J Clin Oncol 5:1655\u20131662","journal-title":"J Clin Oncol"},{"key":"2452_CR30","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1200\/JCO.1993.11.3.561","volume":"11","author":"SA Grossman","year":"1993","unstructured":"Grossman SA, Finkelstein DM, Ruckdeschel JC et al (1993) Randomized prospective comparison of intraventricular methotrexate and thiotepa in patients with previously untreated neoplastic meningitis. Eastern Cooperative Oncology Group. J Clin Oncol 11:561\u2013569","journal-title":"J Clin Oncol"},{"key":"2452_CR31","first-page":"3394","volume":"5","author":"MJ Glantz","year":"1999","unstructured":"Glantz MJ, Jaeckle KA, Chamberlain MC et al (1999) A randomized controlled trial comparing intrathecal sustained-release cytarabine (DepoCyt) to intrathecal methotrexate in patients with neoplastic meningitis from solid tumors. Clin Cancer Res 5:3394\u20133402","journal-title":"Clin Cancer Res"},{"key":"2452_CR32","doi-asserted-by":"publisher","first-page":"2726","DOI":"10.1016\/j.ejca.2004.08.012","volume":"40","author":"W Boogerd","year":"2004","unstructured":"Boogerd W, van den Bent MJ, Koehler PJ et al (2004) The relevance of intraventricular chemotherapy for leptomeningeal metastasis in breast cancer: a randomised study. Eur J Cancer 40:2726\u20132733. doi:\n10.1016\/j.ejca.2004.08.012","journal-title":"Eur J Cancer"},{"key":"2452_CR33","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1200\/JCO.2005.03.7689","volume":"24","author":"WR Shapiro","year":"2006","unstructured":"Shapiro WR, Schmid M, Glantz M, Miller JJ (2006) A randomized phase III\/IV study to determine benefit and safety of cytarabine liposome injection for treatment of neoplastic meningitis. J Clin Oncol 24:1528","journal-title":"J Clin Oncol"},{"key":"2452_CR34","doi-asserted-by":"publisher","first-page":"3110","DOI":"10.1200\/jco.1999.17.10.3110","volume":"17","author":"MJ Glantz","year":"1999","unstructured":"Glantz MJ, LaFollette S, Jaeckle KA et al (1999) Randomized trial of a slow-release versus a standard formulation of cytarabine for the intrathecal treatment of lymphomatous meningitis. J Clin Oncol 17:3110\u20133116. doi:\n10.1200\/jco.1999.17.10.3110","journal-title":"J Clin Oncol"},{"key":"2452_CR35","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1093\/neuonc\/nou089","volume":"16","author":"M Chamberlain","year":"2014","unstructured":"Chamberlain M, Soffietti R, Raizer J et al (2014) Leptomeningeal metastasis: a response assessment in neuro-oncology critical review of endpoints and response criteria of published randomized clinical trials. Neuro-Oncology 16:1176\u20131185. doi:\n10.1093\/neuonc\/nou089","journal-title":"Neuro-Oncology"},{"issue":"3","key":"2452_CR36","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1215\/15228517-2007-002","volume":"9","author":"LE Abrey","year":"2007","unstructured":"Abrey LE, Louis DN, Paleologos N, Lassman AB, Raizer JJ, Mason W, Finlay J, Mac Donald DR, De Angelis LM, Cairncross JG, Oligodendroglioma Study Group (2007) Survey of treatment recommendations for anaplastic oligodendroglioma. Neuro-Oncology 9(3):314\u2013318","journal-title":"Neuro-Oncology"}],"container-title":["Journal of Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11060-017-2452-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-017-2452-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-017-2452-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T09:54:32Z","timestamp":1501062872000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11060-017-2452-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,28]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["2452"],"URL":"https:\/\/doi.org\/10.1007\/s11060-017-2452-6","relation":{},"ISSN":["0167-594X","1573-7373"],"issn-type":[{"value":"0167-594X","type":"print"},{"value":"1573-7373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,28]]}}}