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We performed a nation-wide randomized controlled trial to evaluate the effects of an online guided self-help intervention for depressive symptoms in adult glioma patients. Glioma patients with depressive symptoms were randomized to a 5-week online course based on problem-solving therapy, or a waiting list control group. After having received the intervention, the glioma patient groups combined were compared with patients with cancer outside the central nervous system (non-CNS cancer controls), who also received the intervention. Sample size calculations yielded 63 participants to be recruited per arm. The primary outcome [depressive symptoms (CES-D)] and secondary outcomes [fatigue (Checklist Individual Strength (CIS)) and HRQOL (Short Form-36)], were assessed online at baseline, post-intervention, and 3 and 12\u00a0months follow-up. In total, 89 glioma patients (intervention\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200945; waiting list\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200944) and 26 non-CNS cancer controls were included, of whom 35 and 54% completed the intervention, respectively. Recruitment could not be extended beyond 3.5\u00a0years due to funding. On depression, no statistically significant differences between the groups were found. Fatigue decreased post-treatment in the glioma intervention group compared with the waiting list group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.054,\n                    <jats:italic>d<\/jats:italic>\n                    \u2009=\u20090.306). At 12 months, the physical component summary (HRQOL) remained stable in glioma patients, while scores improved in non-CNS cancer controls (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.035,\n                    <jats:italic>d<\/jats:italic>\n                    \u2009=\u20090.883). In this underpowered study, no evidence for the effectiveness of online guided self-help for depression or HRQOL in glioma patients was found, but it may improve fatigue.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial registration<\/jats:bold>\n                    Netherlands Trial Register NTR3223.\n                  <\/jats:p>","DOI":"10.1007\/s11060-017-2712-5","type":"journal-article","created":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T08:30:46Z","timestamp":1513153846000},"page":"191-203","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Internet-based guided self-help for glioma patients with depressive symptoms: a randomized controlled trial"],"prefix":"10.1007","volume":"137","clinical-trial-number":[{"clinical-trial-number":"ntr3223","registry":"10.18810\/dutch-trial-register"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0409-7949","authenticated-orcid":false,"given":"Florien W.","family":"Boele","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irma M.","family":"Verdonck-de Leeuw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pim","family":"Cuijpers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan J.","family":"Heimans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom J.","family":"Snijders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maaike","family":"Vos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingeborg","family":"Bosma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cees C.","family":"Tijssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaap C.","family":"Reijneveld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"On behalf of the Dutch Society for Neuro-Oncology (LWNO)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,12,13]]},"reference":[{"key":"2712_CR1","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1093\/jnci\/djq458","volume":"103","author":"AG Rooney","year":"2011","unstructured":"Rooney AG, Carson A, Grant R (2011) Depression in cerebral glioma patients: a systematic review of observational studies. 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