{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:49:05Z","timestamp":1761896945441,"version":"3.37.3"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T00:00:00Z","timestamp":1545264000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"crossref","award":["2010\/07020-9"],"award-info":[{"award-number":["2010\/07020-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","award":["471885\/2013-4"],"award-info":[{"award-number":["471885\/2013-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurooncol"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1007\/s11060-018-03042-6","type":"journal-article","created":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T05:12:52Z","timestamp":1545282772000},"page":"373-382","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["MicroRNA profile of pediatric pilocytic astrocytomas identifies two tumor-specific signatures when compared to non-neoplastic white matter"],"prefix":"10.1007","volume":"141","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6007-8908","authenticated-orcid":false,"given":"Luiz Guilherme","family":"Darrigo J\u00fanior","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1217-3852","authenticated-orcid":false,"given":"Regia Caroline Peixoto","family":"Lira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola Fernanda","family":"Fedatto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4856-9426","authenticated-orcid":false,"given":"David Santos","family":"Marco Antonio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4434-429X","authenticated-orcid":false,"given":"Elvis Terci","family":"Valera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Aguiar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1316-3525","authenticated-orcid":false,"given":"Jos\u00e9 Andres","family":"Yunes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia Regina","family":"Brandalise","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3790-3476","authenticated-orcid":false,"given":"Luciano","family":"Neder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3879-7142","authenticated-orcid":false,"given":"Fabiano Pinto","family":"Saggioro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8695-810X","authenticated-orcid":false,"given":"Aline Paix\u00e3o","family":"Becker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Santos","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9lio Rubens","family":"Machado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo Alexandre","family":"Panepucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8821-4211","authenticated-orcid":false,"given":"Luiz Gonzaga","family":"Tone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6618-789X","authenticated-orcid":false,"given":"Carlos Alberto","family":"Scrideli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,12,20]]},"reference":[{"key":"3042_CR1","first-page":"2085","volume":"62","author":"DH Gutmann","year":"2002","unstructured":"Gutmann DH, Hedrick NM, Li J et al (2002) Comparative gene expression profile analysis of neurofibromatosis 1-associated and sporadic pilocytic astrocytomas. Cancer Res 62:2085\u20132091","journal-title":"Cancer Res"},{"key":"3042_CR2","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1227\/01.NEU.0000079330.01541.6E","volume":"53","author":"C Fernandez","year":"2003","unstructured":"Fernandez C, Figarella-Branger D, Girard N et al (2003) Pilocytic astrocytomas in children: prognostic factors\u2014a retrospective study of 80 cases. Neurosurgery 53:544\u2013555. \n                    https:\/\/doi.org\/10.1227\/01.NEU.0000079330.01541.6E","journal-title":"Neurosurgery"},{"issue":"2","key":"3042_CR3","doi-asserted-by":"publisher","first-page":"97109","DOI":"10.1007\/s00401-007-0243-4","volume":"114","author":"D Louis","year":"2007","unstructured":"Louis D, Carvenee W (2007) WHO classification of tumours of the central nervous system. Acta Neuropathol 114(2):97\u2013109","journal-title":"Acta Neuropathol"},{"key":"3042_CR4","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.3171\/jns.2003.98.6.1170","volume":"98","author":"C Burkhard","year":"2003","unstructured":"Burkhard C, Di Patre P-L, Sch\u00fcler D et al (2003) A population-based study of the incidence and survival rates in patients with pilocytic astrocytoma. J Neurosurg 98:1170\u20131174. \n                    https:\/\/doi.org\/10.3171\/jns.2003.98.6.1170","journal-title":"J Neurosurg"},{"key":"3042_CR5","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1002\/pbc.22557","volume":"55","author":"M Ronghe","year":"2010","unstructured":"Ronghe M, Hargrave D, Bartels U et al (2010) Vincristine and carboplatin chemotherapy for unresectable and\/or recurrent low-grade astrocytoma of the brainstem. Pediatr Blood Cancer 55:471\u2013477. \n                    https:\/\/doi.org\/10.1002\/pbc.22557","journal-title":"Pediatr Blood Cancer"},{"key":"3042_CR6","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1093\/jjco\/hyp012","volume":"39","author":"Y Sawamura","year":"2009","unstructured":"Sawamura Y, Kamoshima Y, Kato T et al (2009) Chemotherapy with cisplatin and vincristine for optic pathway\/hypothalamic astrocytoma in young children. Jpn J Clin Oncol 39:277\u2013283. \n                    https:\/\/doi.org\/10.1093\/jjco\/hyp012","journal-title":"Jpn J Clin Oncol"},{"key":"3042_CR7","first-page":"329","volume-title":"Handbook of clinical neurology","author":"M Bornhorst","year":"2016","unstructured":"Bornhorst M, Frappaz D, Packer RJ (2016) Pilocytic astrocytomas. In: Handbook of clinical neurology. Elsevier, Amsterdam, pp\u00a0329\u2013344"},{"key":"3042_CR8","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.bbcan.2014.02.004","volume":"1845","author":"G Bergthold","year":"2014","unstructured":"Bergthold G, Bandopadhayay P, Bi WL et al (2014) Pediatric low-grade gliomas: how modern biology reshapes the clinical field. Biochim Biophys Acta 1845:294\u2013307. \n                    https:\/\/doi.org\/10.1016\/j.bbcan.2014.02.004","journal-title":"Biochim Biophys Acta"},{"key":"3042_CR9","doi-asserted-by":"publisher","first-page":"1799","DOI":"10.1007\/s00018-011-0898-9","volume":"69","author":"DTW Jones","year":"2012","unstructured":"Jones DTW, Gronych J, Lichter P et al (2012) MAPK pathway activation in pilocytic astrocytoma. Cell Mol Life Sci 69:1799\u20131811. \n                    https:\/\/doi.org\/10.1007\/s00018-011-0898-9","journal-title":"Cell Mol Life Sci"},{"key":"3042_CR10","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1093\/neuonc\/nos269","volume":"15","author":"C Ho","year":"2013","unstructured":"Ho C, Bar E, Giannini C et al (2013) MicroRNA profiling in pediatric pilocytic astrocytoma reveals biologically relevant targets, including PBX3, NFIB, and METAP2. Neuro Oncol 15:69\u201382","journal-title":"Neuro Oncol"},{"key":"3042_CR11","doi-asserted-by":"publisher","first-page":"418672","DOI":"10.1155\/2012\/418672","volume":"2012","author":"S Dahiya","year":"2012","unstructured":"Dahiya S, Yu J, Kaul A et al (2012) Novel BRAF alteration in a sporadic pilocytic astrocytoma. Case Rep Med 2012:418672. \n                    https:\/\/doi.org\/10.1155\/2012\/418672","journal-title":"Case Rep Med"},{"key":"3042_CR12","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1093\/jnen\/60.9.917","volume":"60","author":"L Kluwe","year":"2001","unstructured":"Kluwe L, Hagel C, Tatagiba M et al (2001) Loss of NF1 alleles distinguish sporadic from NF1-associated pilocytic astrocytomas. J Neuropathol Exp Neurol 60:917\u2013920","journal-title":"J Neuropathol Exp Neurol"},{"key":"3042_CR13","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1177\/0883073809339213","volume":"24","author":"S Pfister","year":"2009","unstructured":"Pfister S, Hartmann C, Korshunov A (2009) Histology and molecular pathology of pediatric brain tumors. J Child Neurol 24:1375\u20131386. \n                    https:\/\/doi.org\/10.1177\/0883073809339213","journal-title":"J Child Neurol"},{"key":"3042_CR14","doi-asserted-by":"publisher","first-page":"605","DOI":"10.3892\/ijo.2011.1305","volume":"40","author":"A Catania","year":"2012","unstructured":"Catania A, Maira F, Skarmoutsou E et al (2012) Insight into the role of microRNAs in brain tumors (review). Int J Oncol 40:605\u2013624. \n                    https:\/\/doi.org\/10.3892\/ijo.2011.1305","journal-title":"Int J Oncol"},{"key":"3042_CR15","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s12035-011-8197-x","volume":"44","author":"R Hummel","year":"2011","unstructured":"Hummel R, Maurer J, Haier J (2011) MicroRNAs in brain tumors: a new diagnostic and therapeutic perspective? Mol Neurobiol 44:223\u2013234. \n                    https:\/\/doi.org\/10.1007\/s12035-011-8197-x","journal-title":"Mol Neurobiol"},{"key":"3042_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ydbio.2006.08.028","volume":"302","author":"B Zhang","year":"2007","unstructured":"Zhang B, Pan X, Cobb GP, Anderson T (2007) microRNAs as oncogenes and tumor suppressors. Dev Biol 302:1\u201312. \n                    https:\/\/doi.org\/10.1016\/j.ydbio.2006.08.028","journal-title":"Dev Biol"},{"key":"3042_CR17","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","volume":"131","author":"DN Louis","year":"2016","unstructured":"Louis DN, Perry A, Reifenberger G et al (2016) The 2016 world health organization classification of tumors of the central nervous system: a summary. Acta Neuropathol 131:803\u2013820","journal-title":"Acta Neuropathol"},{"key":"3042_CR18","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1097\/NEN.0000000000000213","volume":"74","author":"AP Becker","year":"2015","unstructured":"Becker AP, Scapulatempo-Neto C, Carloni AC et al (2015) KIAA1549: BRAF gene fusion and FGFR1 hotspot mutations are prognostic factors in pilocytic astrocytomas. J Neuropathol Exp Neurol 74:743\u2013754. \n                    https:\/\/doi.org\/10.1097\/NEN.0000000000000213","journal-title":"J Neuropathol Exp Neurol"},{"key":"3042_CR19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038946","author":"SU Meyer","year":"2012","unstructured":"Meyer SU, Kaiser S, Wagner C et al (2012) Profound effect of profiling platform and normalization strategy on detection of differentially expressed microRNAs\u2014a comparative study. PLoS ONE. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0038946","journal-title":"PLoS ONE"},{"key":"3042_CR20","doi-asserted-by":"publisher","first-page":"W460","DOI":"10.1093\/nar\/gkv403","volume":"43","author":"IS Vlachos","year":"2015","unstructured":"Vlachos IS, Zagganas K, Paraskevopoulou MD et al (2015) DIANA-miRPath v3.0: deciphering microRNA function with experimental support. Nucleic Acids Res 43:W460\u2013W466. \n                    https:\/\/doi.org\/10.1093\/nar\/gkv403","journal-title":"Nucleic Acids Res"},{"key":"3042_CR21","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25:402\u2013408. \n                    https:\/\/doi.org\/10.1006\/meth.2001.1262","journal-title":"Methods"},{"key":"3042_CR22","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1111\/j.1365-2796.2008.01926.x","volume":"263","author":"JB Cowland","year":"2008","unstructured":"Cowland JB, Hother C, Gronbaek K (2008) MicroRNAs and cancer. J Intern Med 263:366\u2013375. \n                    https:\/\/doi.org\/10.1111\/j.1365-2796.2008.01926.x","journal-title":"J Intern Med"},{"key":"3042_CR23","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/S0092-8674(03)00428-8","volume":"113","author":"V Ambros","year":"2003","unstructured":"Ambros V (2003) MicroRNA pathways in flies and worms: growth, death, fat, stress, and timing. Cell 113:673\u2013676","journal-title":"Cell"},{"key":"3042_CR24","doi-asserted-by":"publisher","first-page":"99","DOI":"10.2147\/AHMT.S53391","volume":"8","author":"TP Diwanji","year":"2017","unstructured":"Diwanji TP, Engelman A, Snider JW, Mohindra P (2017) Epidemiology, diagnosis, and optimal management of glioma in adolescents and young adults. Adolesc Health Med Ther 8:99\u2013113. \n                    https:\/\/doi.org\/10.2147\/AHMT.S53391","journal-title":"Adolesc Health Med Ther"},{"key":"3042_CR25","doi-asserted-by":"publisher","DOI":"10.1002\/pbc","author":"DK Birks","year":"2011","unstructured":"Birks DK, Barton VN, Donson AM et al (2011) Survey of MicroRNA expression in pediatric brain tumors. Pediatr Blood Cancer. \n                    https:\/\/doi.org\/10.1002\/pbc","journal-title":"Pediatr Blood Cancer"},{"key":"3042_CR26","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s40478-016-0323-6","volume":"4","author":"JN Jeyapalan","year":"2016","unstructured":"Jeyapalan JN, Doctor GT, Jones TA et al (2016) DNA methylation analysis of paediatric low-grade astrocytomas identifies a tumour-specific hypomethylation signature in pilocytic astrocytomas. Acta Neuropathol Commun 4:54. \n                    https:\/\/doi.org\/10.1186\/s40478-016-0323-6","journal-title":"Acta Neuropathol Commun"},{"key":"3042_CR27","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s40478-015-0266-3","volume":"3","author":"TA Jones","year":"2015","unstructured":"Jones TA, Jeyapalan JN, Forshew T et al (2015) Molecular analysis of pediatric brain tumors identifies microRNAs in pilocytic astrocytomas that target the MAPK and NF-\u03baB pathways. Acta Neuropathol Commun 3:86. \n                    https:\/\/doi.org\/10.1186\/s40478-015-0266-3","journal-title":"Acta Neuropathol Commun"},{"key":"3042_CR28","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/cdd.2009.56","volume":"17","author":"H Hermeking","year":"2010","unstructured":"Hermeking H (2010) The miR-34 family in cancer and apoptosis. Cell Death Differ 17:193\u2013199. \n                    https:\/\/doi.org\/10.1038\/cdd.2009.56","journal-title":"Cell Death Differ"},{"key":"3042_CR29","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/35042675","volume":"408","author":"B Vogelstein","year":"2000","unstructured":"Vogelstein B, Lane D, Levine AJ (2000) Surfing the p53 network. Nature 408:307","journal-title":"Nature"},{"key":"3042_CR30","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1002\/(SICI)1097-0215(19980610)76:6<797::AID-IJC5>3.0.CO;2-T","volume":"800","author":"N Ishii","year":"1998","unstructured":"Ishii N, Sawamura Y, Tada M et al (1998) Absence of p53 gene mutations in a tumor panel representative of pilocytic astrocytoma diversity using a p53 functional assay. Int J Cancer 800:797\u2013800","journal-title":"Int J Cancer"},{"key":"3042_CR31","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s11060-013-1119-1","volume":"113","author":"H Gao","year":"2013","unstructured":"Gao H, Zhao H, Xiang W (2013) Expression level of human miR-34a correlates with glioma grade and prognosis. J Neurooncol 113:221\u2013228. \n                    https:\/\/doi.org\/10.1007\/s11060-013-1119-1","journal-title":"J Neurooncol"},{"key":"3042_CR32","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1177\/0883073813476141","volume":"28","author":"Z Sadighi","year":"2013","unstructured":"Sadighi Z, Slopis J (2013) Pilocytic astrocytoma: a disease with evolving molecular heterogeneity. J Child Neurol 28:625\u2013632. \n                    https:\/\/doi.org\/10.1177\/0883073813476141","journal-title":"J Child Neurol"},{"key":"3042_CR33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074175","author":"W Zha","year":"2013","unstructured":"Zha W, Cao L, Shen Y, Huang M (2013) Roles of Mir-144-ZFX pathway in growth regulation of non-small-cell lung cancer. PLoS ONE. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0074175","journal-title":"PLoS ONE"},{"key":"3042_CR34","doi-asserted-by":"publisher","first-page":"817","DOI":"10.3892\/ol.2012.810","volume":"4","author":"Y Katayama","year":"2012","unstructured":"Katayama Y, Maeda M, Miyaguchi K et al (2012) Identification of pathogenesis-related microRNAs in hepatocellular carcinoma by expression profiling. Oncol Lett 4:817\u2013823. \n                    https:\/\/doi.org\/10.3892\/ol.2012.810","journal-title":"Oncol Lett"},{"key":"3042_CR35","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/j.humpath.2015.01.023","volume":"46","author":"L Lin","year":"2015","unstructured":"Lin L, Zheng Y, Tu Y et al (2015) MicroRNA-144 suppresses tumorigenesis and tumor progression of astrocytoma by targeting EZH2. Hum Pathol 46:971\u2013980. \n                    https:\/\/doi.org\/10.1016\/j.humpath.2015.01.023","journal-title":"Hum Pathol"},{"key":"3042_CR36","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1136\/jcp.2010.085621","volume":"64","author":"KJ Schmitz","year":"2011","unstructured":"Schmitz KJ, Helwig J, Bertram S et al (2011) Differential expression of microRNA-675, microRNA-139-3p and microRNA-335 in benign and malignant adrenocortical tumours. J Clin Pathol 64:529\u2013535. \n                    https:\/\/doi.org\/10.1136\/jcp.2010.085621","journal-title":"J Clin Pathol"},{"key":"3042_CR37","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1111\/cns.12089","volume":"19","author":"R-Y Li","year":"2013","unstructured":"Li R-Y, Chen L-C, Zhang H-Y et al (2013) MiR-139 inhibits Mcl-1 expression and potentiates TMZ-induced apoptosis in glioma. CNS Neurosci Ther 19:477\u2013483. \n                    https:\/\/doi.org\/10.1111\/cns.12089","journal-title":"CNS Neurosci Ther"}],"container-title":["Journal of Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11060-018-03042-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-018-03042-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-018-03042-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T16:18:16Z","timestamp":1589991496000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11060-018-03042-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,20]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["3042"],"URL":"https:\/\/doi.org\/10.1007\/s11060-018-03042-6","relation":{},"ISSN":["0167-594X","1573-7373"],"issn-type":[{"type":"print","value":"0167-594X"},{"type":"electronic","value":"1573-7373"}],"subject":[],"published":{"date-parts":[[2018,12,20]]},"assertion":[{"value":"25 July 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 November 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors declare that they had no conflict of interest that could be perceived to impair the impartiality of the research reported.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}