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GF and UB have received support from Oncoscience GmbH for meeting travel to present study results. NEIE is an employee of the Center of Molecular Immunology, the research institution that patented and manufactures nimotuzumab. DR is an employee of Oncoscience GmbH. FB was an employee and has had stock options of Oncoscience GmbH that funded this study and has provided the investigational drug.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and national committees. The trial was conducted in accordance with 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The institutional review boards or ethics committees of all participating centers reviewed and approved the protocol. 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