{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:34:56Z","timestamp":1787697296835,"version":"build-2784847793"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T00:00:00Z","timestamp":1565740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T00:00:00Z","timestamp":1565740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100012524","name":"American Lebanese Syrian Associated Charities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012524","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurooncol"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1007\/s11060-019-03264-2","type":"journal-article","created":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T15:03:34Z","timestamp":1565795014000},"page":"603-610","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Long-term visual acuity outcomes after radiation therapy for sporadic optic pathway glioma"],"prefix":"10.1007","volume":"144","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5963-9181","authenticated-orcid":false,"given":"Sahaja","family":"Acharya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Quesada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Coca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cody","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Hoehn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Qaddoumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick A.","family":"Boop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amar","family":"Gajjar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Merchant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,8,14]]},"reference":[{"issue":"5","key":"3264_CR1","doi-asserted-by":"publisher","first-page":"E2","DOI":"10.3171\/FOC-07\/11\/E2","volume":"23","author":"MJ Binning","year":"2007","unstructured":"Binning MJ, Liu JK, Kestle JRW, Brockmeyer DL, Walker ML (2007) Optic pathway gliomas: a review. Neurosurg Focus 23(5):E2. \n                    https:\/\/doi.org\/10.3171\/FOC-07\/11\/E2","journal-title":"Neurosurg Focus"},{"key":"3264_CR2","volume-title":"Principles and practice of pediatric oncology","year":"2016","unstructured":"Pizzo PA, Poplack DG (eds) (2016) Principles and practice of pediatric oncology, 7th edn. Wolters Kluwer, Philadelphia","edition":"7"},{"issue":"2","key":"3264_CR3","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s11060-017-2517-6","volume":"134","author":"E Trevisson","year":"2017","unstructured":"Trevisson E, Cassina M, Opocher E et al (2017) Natural history of optic pathway gliomas in a cohort of unselected patients affected by neurofibromatosis 1. J Neurooncol 134(2):279\u2013287. \n                    https:\/\/doi.org\/10.1007\/s11060-017-2517-6","journal-title":"J Neurooncol"},{"issue":"1","key":"3264_CR4","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1177\/0883073817739509","volume":"33","author":"CJ Campen","year":"2018","unstructured":"Campen CJ, Gutmann DH (2018) Optic pathway gliomas in neurofibromatosis type 1. J Child Neurol 33(1):73\u201381. \n                    https:\/\/doi.org\/10.1177\/0883073817739509","journal-title":"J Child Neurol"},{"issue":"3","key":"3264_CR5","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/j.ijrobp.2017.07.023","volume":"99","author":"DS Tsang","year":"2017","unstructured":"Tsang DS, Murphy ES, Merchant TE (2017) Radiation therapy for optic pathway and hypothalamic low-grade gliomas in children. Int J Radiat Oncol Biol Phys 99(3):642\u2013651. \n                    https:\/\/doi.org\/10.1016\/j.ijrobp.2017.07.023","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"10","key":"3264_CR6","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1136\/bjophthalmol-2017-311305","volume":"102","author":"K Falzon","year":"2018","unstructured":"Falzon K, Drimtzias E, Picton S, Simmons I (2018) Visual outcomes after chemotherapy for optic pathway glioma in children with and without neurofibromatosis type 1: results of the International Society of Paediatric Oncology (SIOP) Low-Grade Glioma 2004 trial UK cohort. Br J Ophthalmol 102(10):1367\u20131371. \n                    https:\/\/doi.org\/10.1136\/bjophthalmol-2017-311305","journal-title":"Br J Ophthalmol"},{"issue":"23","key":"3264_CR7","doi-asserted-by":"publisher","first-page":"4190","DOI":"10.1002\/cncr.29649","volume":"121","author":"AJ Dodgshun","year":"2015","unstructured":"Dodgshun AJ, Elder JE, Hansford JR, Sullivan MJ (2015) Long-term visual outcome after chemotherapy for optic pathway glioma in children: site and age are strongly predictive. Cancer 121(23):4190\u20134196. \n                    https:\/\/doi.org\/10.1002\/cncr.29649","journal-title":"Cancer"},{"issue":"1","key":"3264_CR8","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.ijrobp.2011.10.067","volume":"84","author":"RM Awdeh","year":"2012","unstructured":"Awdeh RM, Kiehna EN, Drewry RD et al (2012) Visual outcomes in pediatric optic pathway glioma after conformal radiation therapy. Int J Radiat Oncol Biol Phys 84(1):46\u201351. \n                    https:\/\/doi.org\/10.1016\/j.ijrobp.2011.10.067","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"3264_CR9","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s11060-016-2163-4","volume":"129","author":"MJ Wan","year":"2016","unstructured":"Wan MJ, Ullrich NJ, Manley PE, Kieran MW, Goumnerova LC, Hiedary G (2016) Long-term visual outcomes of optic pathway gliomas in pediatric patients without neurofibromatosis type 1. J Neurooncol 129(1):173\u2013178","journal-title":"J Neurooncol"},{"issue":"1","key":"3264_CR10","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1136\/adc.87.1.65","volume":"87","author":"S Singhal","year":"2002","unstructured":"Singhal S, Birch J, Kerr B, Lashford L, Evans D (2002) Neurofibromatosis type 1 and sporadic optic gliomas. Arch Dis Child 87(1):65\u201370. \n                    https:\/\/doi.org\/10.1136\/adc.87.1.65","journal-title":"Arch Dis Child"},{"issue":"7","key":"3264_CR11","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1177\/08830738030180070401","volume":"18","author":"E Czyzyk","year":"2003","unstructured":"Czyzyk E, J\u00f3\u017awiak S, Roszkowski M, Schwartz RA (2003) Optic pathway gliomas in children with and without neurofibromatosis 1. J Child Neurol 18(7):471\u2013478. \n                    https:\/\/doi.org\/10.1177\/08830738030180070401","journal-title":"J Child Neurol"},{"issue":"4","key":"3264_CR12","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1080\/02688690310001601216","volume":"17","author":"J Ashtrup","year":"2003","unstructured":"Ashtrup J (2003) Natural history and clinical management of optic pathway glioma. Br J Neurosurg 17(4):327\u2013335","journal-title":"Br J Neurosurg"},{"issue":"22","key":"3264_CR13","doi-asserted-by":"publisher","first-page":"3691","DOI":"10.1200\/JCO.2008.21.2738","volume":"27","author":"TE Merchant","year":"2009","unstructured":"Merchant TE, Conklin HM, Wu S, Lustig RH, Xiong X (2009) Late effects of conformal radiation therapy for pediatric patients with low-grade glioma: prospective evaluation of cognitive, endocrine, and hearing deficits. J Clin Oncol 27(22):3691\u20133697. \n                    https:\/\/doi.org\/10.1200\/JCO.2008.21.2738","journal-title":"J Clin Oncol"},{"issue":"1","key":"3264_CR14","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1002\/1097-0142(19900101)65:1<45::AID-CNCR2820650111>3.0.CO;2-Z","volume":"65","author":"SM Pierce","year":"1990","unstructured":"Pierce SM, Barnes PD, Loeffler JS, McGinn C, Tarbell NJ (1990) Definitive radiation therapy in the management of symptomatic patients with optic glioma. Survival and long-term effects. Cancer 65(1):45\u201352","journal-title":"Cancer"},{"issue":"3","key":"3264_CR15","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/S0167-8140(00)00149-3","volume":"54","author":"GG Grabenbauer","year":"2000","unstructured":"Grabenbauer GG, Schuchardt U, Buchfelder M et al (2000) Radiation therapy of optico-hypothalamic gliomas (OHG)\u2014radiographic response, vision and late toxicity. Radiother Oncol 54(3):239\u2013245","journal-title":"Radiother Oncol"},{"issue":"6","key":"3264_CR16","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1001\/archneurpsyc.1958.02340060003001","volume":"79","author":"HW Dodge","year":"1958","unstructured":"Dodge HW, Love JG, Craig WM et al (1958) Gliomas of the optic nerves. AMA Arch Neurol Psychiatry 79(6):607\u2013621. \n                    https:\/\/doi.org\/10.1001\/archneurpsyc.1958.02340060003001","journal-title":"AMA Arch Neurol Psychiatry"},{"key":"3264_CR17","volume-title":"Neuro-ophthalmology: diagnosis and management","year":"2010","unstructured":"Liu GT, Volpe NJ, Galetta SL (eds) (2010) Neuro-ophthalmology: diagnosis and management, 2nd edn. Saunders, Philadelphia","edition":"2"},{"issue":"3","key":"3264_CR18","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1001\/archopht.120.3.268","volume":"120","author":"The Pediatric Eye Disease Investigator Group","year":"2002","unstructured":"The Pediatric Eye Disease Investigator Group (2002) A randomized trial of atropine vs. patching for treatment of moderate amblyopia in children. Arch Ophthalmol 120(3):268\u2013278. \n                    https:\/\/doi.org\/10.1001\/archopht.120.3.268","journal-title":"Arch Ophthalmol"},{"issue":"2","key":"3264_CR19","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","volume":"45","author":"EA Eisenhauer","year":"2009","unstructured":"Eisenhauer EA, Therasse P, Bogaerts J et al (2009) New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer 45(2):228\u2013247. \n                    https:\/\/doi.org\/10.1016\/j.ejca.2008.10.026","journal-title":"Eur J Cancer"},{"issue":"1","key":"3264_CR20","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s00401-011-0841-z","volume":"122","author":"D Capper","year":"2011","unstructured":"Capper D, Preusser M, Habel A et al (2011) Assessment of BRAF V600E mutation status by immunohistochemistry with a mutation-specific monoclonal antibody. Acta Neuropathol 122(1):11\u201319. \n                    https:\/\/doi.org\/10.1007\/s00401-011-0841-z","journal-title":"Acta Neuropathol"},{"issue":"2","key":"3264_CR21","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s00401-011-0887-y","volume":"123","author":"D Capper","year":"2012","unstructured":"Capper D, Berghoff AS, Magerle M et al (2012) Immunohistochemical testing of BRAF V600E status in 1,120 tumor tissue samples of patients with brain metastases. Acta Neuropathol 123(2):223\u2013233. \n                    https:\/\/doi.org\/10.1007\/s00401-011-0887-y","journal-title":"Acta Neuropathol"},{"issue":"6","key":"3264_CR22","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1007\/s00401-016-1539-z","volume":"131","author":"I Qaddoumi","year":"2016","unstructured":"Qaddoumi I, Orisme W, Wen J et al (2016) Genetic alterations in uncommon low-grade neuroepithelial tumors: BRAF, FGFR1, and MYB mutations occur at high frequency and align with morphology. Acta Neuropathol 131(6):833\u2013845. \n                    https:\/\/doi.org\/10.1007\/s00401-016-1539-z","journal-title":"Acta Neuropathol"},{"issue":"446","key":"3264_CR23","doi-asserted-by":"publisher","first-page":"496","DOI":"10.2307\/2670170","volume":"94","author":"JP Fine","year":"1999","unstructured":"Fine JP, Gray RJ (1999) A proportional hazards model for the subdistribution of a competing risk. J Am Stat Assoc 94(446):496\u2013509. \n                    https:\/\/doi.org\/10.2307\/2670170","journal-title":"J Am Stat Assoc"},{"key":"3264_CR24","unstructured":"World Health Organization (2006) List of Official ICD-10 Updates Ratified, October 2006. Geneva. \n                    https:\/\/www.who.int\/classifications\/icd\/2006Updates.pdf\n                    \n                  . Accessed 17 May 2019"},{"issue":"11","key":"3264_CR25","doi-asserted-by":"publisher","first-page":"2041","DOI":"10.1007\/s00381-015-2855-7","volume":"31","author":"K Aquilina","year":"2015","unstructured":"Aquilina K, Daniels DJ, Spoudeas H, Phipps K, Gan H-W, Boop FA (2015) Optic pathway glioma in children: does visual deficit correlate with radiology in focal exophytic lesions? Childs Nerv Syst 31(11):2041\u20132049. \n                    https:\/\/doi.org\/10.1007\/s00381-015-2855-7","journal-title":"Child Nerv Syst"},{"key":"3264_CR26","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw435.09","author":"MW Kieran","year":"2016","unstructured":"Kieran MW, Bouffet E, Tabori U et al (2016) CNS tumours. The first study of dabrafenib in pediatric patients with BRAF V600-mutant relapsed or refractory low-grade gliomas. Ann Oncol. \n                    https:\/\/doi.org\/10.1093\/annonc\/mdw435.09","journal-title":"Ann Oncol"},{"key":"3264_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30277-3","author":"J Fangusaro","year":"2019","unstructured":"Fangusaro J, Onar-Thomas A, Poussaint TY et al (2019) Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre, phase 2 trial. Lancet Oncol. \n                    https:\/\/doi.org\/10.1016\/S1470-2045(19)30277-3","journal-title":"Lancet Oncol"},{"issue":"1","key":"3264_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11060-012-0944-y","volume":"110","author":"RA Avery","year":"2012","unstructured":"Avery RA, Ferner RE, Listernick R, Fisher MJ, Gutmann DH, Liu GT (2012) Visual acuity in children with low grade gliomas of the visual pathway: implications for patient care and clinical research. J Neurooncol 110(1):1\u20137. \n                    https:\/\/doi.org\/10.1007\/s11060-012-0944-y","journal-title":"J Neurooncol"},{"issue":"5","key":"3264_CR29","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1016\/j.ajo.2015.07.036","volume":"160","author":"RA Avery","year":"2015","unstructured":"Avery RA, Cnaan A, Schuman JS et al (2015) Longitudinal change of circumpapillary retinal nerve fiber layer thickness in children with optic pathway gliomas. Am J Ophthalmol 160(5):944\u2013952.e1. \n                    https:\/\/doi.org\/10.1016\/j.ajo.2015.07.036","journal-title":"Am J Ophthalmol"},{"issue":"21 Suppl 1","key":"3264_CR30","doi-asserted-by":"publisher","first-page":"S15","DOI":"10.1212\/01.wnl.0000435745.95155.b8","volume":"81","author":"MJ Fisher","year":"2013","unstructured":"Fisher MJ, Avery RA, Allen JC et al (2013) Functional outcome measures for NF1-associated optic pathway glioma clinical trials. Neurology 81(21 Suppl 1):S15\u2013S24. \n                    https:\/\/doi.org\/10.1212\/01.wnl.0000435745.95155.b8","journal-title":"Neurology"}],"container-title":["Journal of Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-019-03264-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11060-019-03264-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-019-03264-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T23:31:54Z","timestamp":1597275114000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11060-019-03264-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,14]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["3264"],"URL":"https:\/\/doi.org\/10.1007\/s11060-019-03264-2","relation":{},"ISSN":["0167-594X","1573-7373"],"issn-type":[{"value":"0167-594X","type":"print"},{"value":"1573-7373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,14]]},"assertion":[{"value":"11 June 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"No conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}