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Molecular events driving the majority of choroid plexus tumors remain poorly\nunderstood. Recently, DNA methylation profiling has revealed different epigenetic\nsubgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Comprehensive review of epigenetic profiles of choroid plexus tumors in the\ncontext of histopathological, genetic, and clinical features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>DNA methylation profiling segregates choroid plexus tumors into three distinct\nepigenetic subgroups: supratentorial pediatric low-risk choroid plexus tumors (CPP and aCPP),\ninfratentorial adult low-risk choroid plexus tumors (CPP and aCPP), and supratentorial\npediatric high-risk choroid plexus tumors (CPP and aCPP and CPC). Epigenetic subgrouping\nprovides additional prognostic information in comparison to histopathological grading.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Epigenetic profiling of choroid plexus tumors can be used for the\nidentification of patients at risk of recurrence and is expected to play a role for treatment\nstratification and patient management in the context of future clinical trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11060-020-03509-5","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T22:02:44Z","timestamp":1588024964000},"page":"39-45","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Epigenetics impacts upon prognosis and clinical management of choroid\nplexus tumors"],"prefix":"10.1007","volume":"148","author":[{"given":"Christian","family":"Thomas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Metrock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Kordes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hasselblatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girish","family":"Dhall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,4,28]]},"reference":[{"key":"3509_CR1","volume-title":"World health organization histological classification of tumours of the central nervous system","author":"DN Louis","year":"2016","unstructured":"Louis DN, Ohgaki H, Wiestler ODCW (2016) World health organization histological\nclassification of tumours of the central nervous system. 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