{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T06:58:41Z","timestamp":1784617121647,"version":"3.55.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurooncol"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Surgical series of pineal region gliomas are rarely available. Whereas it is a general assumption that the extent of surgical resection correlates with survival outcomes of intracranial gliomas; the impact of the microsurgical resection on the long-term outcomes of pineal gliomas has been questioned. We present a surgical series of pineal region gliomas with focus on the survival outcome analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>17 histologically confirmed pineal region glioma patients classified as diffuse and non-diffuse gliomas were retrospectively analyzed. A detailed description of the series was followed by regression models to identify predictors of clinical outcomes. Uni- a multivariate survival analysis was performed to determine independent predictors of mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although the number of treated patients was small, only WHO grade histopathology remained significant (p\u2009=\u20090.02) after multivariate survival analysis with extent of resection, age, tumor volume, and preoperative functional status. The extent of the surgical resection did not correlate with the disease survival rates of non-diffuse (p\u2009=\u20091), diffuse (p\u2009=\u20090.2), nor all gliomas (p\u2009=\u20090.6). 15 of 17 patients underwent gross total (nine patients) or subtotal resection. The preoperative functional status of the patients showed overall improvement on the immediate (p\u2009&lt;\u20090.001) and long-term (p\u2009=\u20090.03) follow-up after 106 (3 \u2013 324) months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The extent of the surgical resection does not seem to significantly impact on the survival outcomes of pineal region gliomas. Thus, genotype and molecular features may essentially affect the outcome. Further research on the field is required.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s11060-020-03571-z","type":"journal-article","created":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T18:54:27Z","timestamp":1593629667000},"page":"651-658","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Long-term survival outcomes of pineal region gliomas"],"prefix":"10.1007","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5220-1216","authenticated-orcid":false,"given":"Joham","family":"Choque-Velasquez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Resendiz-Nieves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behnam Rezai","family":"Jahromi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szymon","family":"Baluszek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajjad","family":"Muhammad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Colasanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha","family":"Hernesniemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,1]]},"reference":[{"issue":"19","key":"3571_CR1","first-page":"1878","volume":"32085","author":"J Choque-Velasquez","year":"2019","unstructured":"Choque-Velasquez J, Resendiz-Nieves J, Jahromi BR et al (2019) Extent of resection and long-term survival of pineal region tumors in Helsinki Neurosurgery. World Neurosurgery. 32085(19):1878\u20138750","journal-title":"World Neurosurgery."},{"key":"3571_CR2","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.surneu.2008.07.019","volume":"70","author":"J Hernesniemi","year":"2008","unstructured":"Hernesniemi J, Romani R, Albayrak BS et al (2008) Microsurgical management of pineal region lesions: personal experience with 119 patients. Surg Neurol 70:576\u2013583. https:\/\/doi.org\/10.1016\/j.surneu.2008.07.019","journal-title":"Surg Neurol"},{"key":"3571_CR3","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/s0090-3019(03)00080-6","volume":"59","author":"AN Konovalov","year":"2003","unstructured":"Konovalov AN, Pitskhelauri DI (2003) Principles of treatment of the pineal region tumors. Surg Neurol 59:250\u2013268. https:\/\/doi.org\/10.1016\/s0090-3019(03)00080-6","journal-title":"Surg Neurol"},{"key":"3571_CR4","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1007\/BF01417679","volume":"134","author":"JN Bruce","year":"1995","unstructured":"Bruce JN, Stein BM (1995) Surgical management of pineal region tumors. Acta Neurochir 134:130\u2013135","journal-title":"Acta Neurochir"},{"key":"3571_CR5","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/BF01540866","volume":"116","author":"HD Herrmann","year":"1992","unstructured":"Herrmann HD, Winkler D, Westphal M (1992) Treatment of tumours of the pineal region and posterior part of the third ventricle. Acta Neurochir 116:137\u2013146","journal-title":"Acta Neurochir"},{"key":"3571_CR6","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/BF01541249","volume":"116","author":"J Vaquero","year":"1992","unstructured":"Vaquero J, Ramiro J, Martinez R, Bravo G (1992) Neurosurgical experience with tumours of the pineal region at Clinica Puerta de Hierro. Acta Neurochir 116:23\u201332","journal-title":"Acta Neurochir"},{"key":"3571_CR7","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s11060-013-1200-9","volume":"115","author":"S Magrini","year":"2013","unstructured":"Magrini S, Feletti A, Marton E, Longatti P (2013) Gliomas of the pineal region. J Neurooncol 115:103\u2013111. https:\/\/doi.org\/10.1007\/s11060-013-1200-9","journal-title":"J Neurooncol"},{"key":"3571_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2019.06.189","author":"D Li","year":"2019","unstructured":"Li D, Wen R, Gao Y et al (2019) Pineal region gliomas : a single center experience with 25 cases. World Neurosurg. https:\/\/doi.org\/10.1016\/j.wneu.2019.06.189","journal-title":"World Neurosurg"},{"key":"3571_CR9","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/nan.12432","volume":"44","author":"P Wesseling","year":"2018","unstructured":"Wesseling P, Capper D (2018) WHO 2016 Classification of gliomas. Neuropathol Appl Neurobiol 44:139\u2013150. https:\/\/doi.org\/10.1111\/nan.12432","journal-title":"Neuropathol Appl Neurobiol"},{"key":"3571_CR10","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","volume":"131","author":"DN Louis","year":"2016","unstructured":"Louis DN, Perry A, Reifenberger G et al (2016) The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol 131:803\u2013820. https:\/\/doi.org\/10.1007\/s00401-016-1545-1","journal-title":"Acta Neuropathol"},{"key":"3571_CR11","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017-2151","author":"AP Hardin","year":"2017","unstructured":"Hardin AP, Hackell JM (2017) Age Limit of Pediatrics. Pediatrics. https:\/\/doi.org\/10.1542\/peds.2017-2151","journal-title":"Pediatrics"},{"key":"3571_CR12","doi-asserted-by":"crossref","unstructured":"(1988) American Academy of Pediatrics Council on Child and Adolescent Health: Age limits of pediatrics. Pediatrics 81:736","DOI":"10.1542\/peds.81.5.736"},{"key":"3571_CR13","doi-asserted-by":"publisher","first-page":"e604","DOI":"10.1016\/j.wneu.2018.02.107","volume":"113","author":"J Choque-Velasquez","year":"2018","unstructured":"Choque-Velasquez J, Colasanti R, Resendiz-Nieves JC et al (2018) Praying Sitting Position for Pineal Region Surgery: An Efficient Variant of a Classic Position in Neurosurgery. World neurosurgery 113:e604\u2013e611. https:\/\/doi.org\/10.1016\/j.wneu.2018.02.107","journal-title":"World neurosurgery"},{"key":"3571_CR14","doi-asserted-by":"publisher","first-page":"160","DOI":"10.4103\/sni.sni_128_18","volume":"9","author":"J Choque-Velasquez","year":"2018","unstructured":"Choque-Velasquez J, Colasanti R, Resendiz-Nieves JC et al (2018) Venous air embolisms and sitting position in Helsinki pineal region surgery. Surgical neurology international 9:160. https:\/\/doi.org\/10.4103\/sni.sni_128_18","journal-title":"Surgical neurology international"},{"key":"3571_CR15","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1007\/s11060-009-9881-9","volume":"94","author":"M Al-Hussaini","year":"2009","unstructured":"Al-Hussaini M, Sultan I, Abuirmileh N et al (2009) Pineal gland tumors: experience from the SEER database. J Neurooncol 94:351\u2013358. https:\/\/doi.org\/10.1007\/s11060-009-9881-9","journal-title":"J Neurooncol"},{"key":"3571_CR16","doi-asserted-by":"publisher","first-page":"v1","DOI":"10.1093\/neuonc\/now207","volume":"18","author":"QT Ostrom","year":"2016","unstructured":"Ostrom QT, Gittleman H, Xu J et al (2016) CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2009\u20132013. Neuro-oncology 18:v1\u2013v75. https:\/\/doi.org\/10.1093\/neuonc\/now207","journal-title":"Neuro-oncology"},{"key":"3571_CR17","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.neuchi.2014.02.006","volume":"61","author":"C Mottolese","year":"2015","unstructured":"Mottolese C, Beuriat PA, Szathmari A (2015) Pineal tumours: Experience of the French National Register and the Lyon School, results and considerations. Neurochirurgie 61:223\u2013235. https:\/\/doi.org\/10.1016\/j.neuchi.2014.02.006","journal-title":"Neurochirurgie"},{"key":"3571_CR18","doi-asserted-by":"publisher","first-page":"491","DOI":"10.4103\/0028-3886.258045","volume":"67","author":"A Verma","year":"2019","unstructured":"Verma A, Epari S, Bakiratharajan D et al (2019) Primary pineal tumors\u2014Unraveling histological challenges and certain clinical myths. Neurol India 67:491\u2013502. https:\/\/doi.org\/10.4103\/0028-3886.258045","journal-title":"Neurol India"},{"key":"3571_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000210049","volume":"23","author":"S Shibui","year":"2009","unstructured":"Shibui S, Nomura K (2009) Statistical analysis of pineal tumors based on the data of Brain Tumor Registry of Japan. Progress in neurological surgery 23:1\u201311. https:\/\/doi.org\/10.1159\/000210049","journal-title":"Progress in neurological surgery"},{"key":"3571_CR20","doi-asserted-by":"publisher","first-page":"16","DOI":"10.14791\/btrt.2017.5.1.16","volume":"5","author":"YS Dho","year":"2017","unstructured":"Dho YS, Jung KW, Ha J et al (2017) An Updated Nationwide Epidemiology of Primary Brain Tumors in Republic of Korea, 2013. Brain tumor research and treatment 5:16\u201323. https:\/\/doi.org\/10.14791\/btrt.2017.5.1.16","journal-title":"Brain tumor research and treatment"},{"key":"3571_CR21","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1111\/bpa.12336","volume":"26","author":"DA Solomon","year":"2016","unstructured":"Solomon DA, Wood MD, Tihan T et al (2016) Diffuse Midline Gliomas with Histone H3\u2013K27M Mutation: A Series of 47 Cases Assessing the Spectrum of Morphologic Variation and Associated Genetic Alterations. Brain Pathol 26:569\u2013580. https:\/\/doi.org\/10.1111\/bpa.12336","journal-title":"Brain Pathol"},{"key":"3571_CR22","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1159\/000481513","volume":"53","author":"AR Gilbert","year":"2018","unstructured":"Gilbert AR, Zaky W, Gokden M et al (2018) Extending the Neuroanatomic Territory of Diffuse Midline Glioma, K27M Mutant: Pineal Region Origin. Pediatr Neurosurg 53:59\u201363. https:\/\/doi.org\/10.1159\/000481513","journal-title":"Pediatr Neurosurg"},{"key":"3571_CR23","doi-asserted-by":"publisher","first-page":"123","DOI":"10.3389\/fonc.2017.00123","volume":"7","author":"HB Stowe","year":"2017","unstructured":"Stowe HB, Miller CR, Wu J et al (2017) Pineal Region Glioblastoma, a Case Report and Literature Review. Frontiers in oncology 7:123. https:\/\/doi.org\/10.3389\/fonc.2017.00123","journal-title":"Frontiers in oncology"},{"key":"3571_CR24","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s11060-018-2931-4","volume":"140","author":"RS D\u2019Amico","year":"2018","unstructured":"D\u2019Amico RS, Zanazzi G, Wu P et al (2018) Pineal region glioblastomas display features of diffuse midline and non-midline gliomas. J Neurooncol 140:63\u201373. https:\/\/doi.org\/10.1007\/s11060-018-2931-4","journal-title":"J Neurooncol"},{"key":"3571_CR25","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1564-x","author":"V Venkataramani","year":"2019","unstructured":"Venkataramani V, Tanev DI, Strahle C et al (2019) Glutamatergic synaptic input to glioma cells drives brain tumour progression. Nature. https:\/\/doi.org\/10.1038\/s41586-019-1564-x","journal-title":"Nature"}],"container-title":["Journal of Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-020-03571-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11060-020-03571-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-020-03571-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T16:58:03Z","timestamp":1667235483000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11060-020-03571-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["3571"],"URL":"https:\/\/doi.org\/10.1007\/s11060-020-03571-z","relation":{},"ISSN":["0167-594X","1573-7373"],"issn-type":[{"value":"0167-594X","type":"print"},{"value":"1573-7373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"5 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 June 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Prof. Juha Hernesniemi is an Aesculap counselor. The authors have no personal financial or institutional interest in any of the drugs, materials, and devices described in this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"This project has been approved by the Ethics Committee of HUH.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}