{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T08:31:16Z","timestamp":1768465876031,"version":"3.49.0"},"reference-count":96,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100000024","name":"CIHR","doi-asserted-by":"crossref","award":["137011"],"award-info":[{"award-number":["137011"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurooncol"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1007\/s11060-020-03633-2","type":"journal-article","created":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T14:02:51Z","timestamp":1603375371000},"page":"63-73","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Embryonal tumors with multi-layered rosettes: a disease of dysregulated miRNAs"],"prefix":"10.1007","volume":"150","author":[{"given":"Nikhil","family":"Raghuram","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iqra","family":"Mumal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Bouffet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1987-6980","authenticated-orcid":false,"given":"Annie","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,10,22]]},"reference":[{"issue":"4","key":"3633_CR1","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1007\/s100249910049","volume":"3","author":"CG Eberhart","year":"2000","unstructured":"Eberhart CG, Brat DJ, Cohen KJ, Burger PC (2000) Pediatric neuroblastic brain tumors containing abundant neuropil and true rosettes. Pediatr Dev Pathol 3(4):346\u2013352. https:\/\/doi.org\/10.1007\/s100249910049","journal-title":"Pediatr Dev Pathol"},{"issue":"6","key":"3633_CR2","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.ccr.2009.10.025","volume":"16","author":"M Li","year":"2009","unstructured":"Li M, Lee KF, Lu Y, Clarke I, Shih D, Eberhart C, Collins VP, Van Meter T, Picard D, Zhou L, Boutros PC, Modena P, Liang ML, Scherer SW, Bouffet E, Rutka JT, Pomeroy SL, Lau CC, Taylor MD, Gajjar A, Dirks PB, Hawkins CE, Huang A (2009) Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors. Cancer Cell 16(6):533\u2013546. https:\/\/doi.org\/10.1016\/j.ccr.2009.10.025","journal-title":"Cancer Cell"},{"issue":"4","key":"3633_CR3","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1007\/s00401-008-0467-y","volume":"117","author":"S Pfister","year":"2009","unstructured":"Pfister S, Remke M, Castoldi M, Bai AH, Muckenthaler MU, Kulozik A, von Deimling A, Pscherer A, Lichter P, Korshunov A (2009) Novel genomic amplification targeting the microRNA cluster at 19q13.42 in a pediatric embryonal tumor with abundant neuropil and true rosettes. Acta Neuropathol 117(4):457\u2013464. https:\/\/doi.org\/10.1007\/s00401-008-0467-y","journal-title":"Acta Neuropathol"},{"issue":"1","key":"3633_CR4","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1093\/neuonc\/not162","volume":"16","author":"T Spence","year":"2014","unstructured":"Spence T, Perotti C, Sin-Chan P, Picard D, Wu W, Singh A, Anderson C, Blough MD, Cairncross JG, Lafay-Cousin L, Strother D, Hawkins C, Narendran A, Huang A, Chan JA (2014) A novel C19MC amplified cell line links Lin28\/let-7 to mTOR signaling in embryonal tumor with multilayered rosettes. Neuro Oncol 16(1):62\u201371. https:\/\/doi.org\/10.1093\/neuonc\/not162","journal-title":"Neuro Oncol"},{"issue":"2","key":"3633_CR5","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s00401-013-1228-0","volume":"128","author":"A Korshunov","year":"2014","unstructured":"Korshunov A, Sturm D, Ryzhova M, Hovestadt V, Gessi M, Jones DT, Remke M, Northcott P, Perry A, Picard D, Rosenblum M, Antonelli M, Aronica E, Schuller U, Hasselblatt M, Woehrer A, Zheludkova O, Kumirova E, Puget S, Taylor MD, Giangaspero F, Peter Collins V, von Deimling A, Lichter P, Huang A, Pietsch T, Pfister SM, Kool M (2014) Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity. Acta Neuropathol 128(2):279\u2013289. https:\/\/doi.org\/10.1007\/s00401-013-1228-0","journal-title":"Acta Neuropathol"},{"issue":"2","key":"3633_CR6","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/s00401-010-0710-1","volume":"120","author":"W Paulus","year":"2010","unstructured":"Paulus W, Kleihues P (2010) Genetic profiling of CNS tumors extends histological classification. Acta Neuropathol 120(2):269\u2013270. https:\/\/doi.org\/10.1007\/s00401-010-0710-1","journal-title":"Acta Neuropathol"},{"issue":"2","key":"3633_CR7","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/s00401-014-1291-1","volume":"128","author":"T Spence","year":"2014","unstructured":"Spence T, Sin-Chan P, Picard D, Barszczyk M, Hoss K, Lu M, Kim SK, Ra YS, Nakamura H, Fangusaro J, Hwang E, Kiehna E, Toledano H, Wang Y, Shi Q, Johnston D, Michaud J, La Spina M, Buccoliero AM, Adamek D, Camelo-Piragua S, Peter Collins V, Jones C, Kabbara N, Jurdi N, Varlet P, Perry A, Scharnhorst D, Fan X, Muraszko KM, Eberhart CG, Ng HK, Gururangan S, Van Meter T, Remke M, Lafay-Cousin L, Chan JA, Sirachainan N, Pomeroy SL, Clifford SC, Gajjar A, Shago M, Halliday W, Taylor MD, Grundy R, Lau CC, Phillips J, Bouffet E, Dirks PB, Hawkins CE, Huang A (2014) CNS-PNETs with C19MC amplification and\/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity. Acta Neuropathol 128(2):291\u2013303. https:\/\/doi.org\/10.1007\/s00401-014-1291-1","journal-title":"Acta Neuropathol"},{"issue":"7786","key":"3633_CR8","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1038\/s41586-019-1815-x","volume":"576","author":"S Lambo","year":"2019","unstructured":"Lambo S, Grobner SN, Rausch T, Waszak SM, Schmidt C, Gorthi A, Romero JC, Mauermann M, Brabetz S, Krausert S, Buchhalter I, Koster J, Zwijnenburg DA, Sill M, Hubner JM, Mack N, Schwalm B, Ryzhova M, Hovestadt V, Papillon-Cavanagh S, Chan JA, Landgraf P, Ho B, Milde T, Witt O, Ecker J, Sahm F, Sumerauer D, Ellison DW, Orr BA, Darabi A, Haberler C, Figarella-Branger D, Wesseling P, Schittenhelm J, Remke M, Taylor MD, Gil-da-Costa MJ, Lastowska M, Grajkowska W, Hasselblatt M, Hauser P, Pietsch T, Uro-Coste E, Bourdeaut F, Masliah-Planchon J, Rigau V, Alexandrescu S, Wolf S, Li XN, Schuller U, Snuderl M, Karajannis MA, Giangaspero F, Jabado N, von Deimling A, Jones DTW, Korbel JO, von Hoff K, Lichter P, Huang A, Bishop AJR, Pfister SM, Korshunov A, Kool M (2019) The molecular landscape of ETMR at diagnosis and relapse. Nature 576(7786):274\u2013280. https:\/\/doi.org\/10.1038\/s41586-019-1815-x","journal-title":"Nature"},{"issue":"8","key":"3633_CR9","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1016\/S1470-2045(12)70257-7","volume":"13","author":"D Picard","year":"2012","unstructured":"Picard D, Miller S, Hawkins CE, Bouffet E, Rogers HA, Chan TS, Kim SK, Ra YS, Fangusaro J, Korshunov A, Toledano H, Nakamura H, Hayden JT, Chan J, Lafay-Cousin L, Hu P, Fan X, Muraszko KM, Pomeroy SL, Lau CC, Ng HK, Jones C, Van Meter T, Clifford SC, Eberhart C, Gajjar A, Pfister SM, Grundy RG, Huang A (2012) Markers of survival and metastatic potential in childhood CNS primitive neuro-ectodermal brain tumours: an integrative genomic analysis. Lancet Oncol 13(8):838\u2013848. https:\/\/doi.org\/10.1016\/S1470-2045(12)70257-7","journal-title":"Lancet Oncol"},{"issue":"6","key":"3633_CR10","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","volume":"131","author":"DN Louis","year":"2016","unstructured":"Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P, Ellison DW (2016) The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol 131(6):803\u2013820. https:\/\/doi.org\/10.1007\/s00401-016-1545-1","journal-title":"Acta Neuropathol"},{"issue":"5","key":"3633_CR11","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1007\/s00381-013-2037-4","volume":"29","author":"D Adamek","year":"2013","unstructured":"Adamek D, Sofowora KD, Cwiklinska M, Herman-Sucharska I, Kwiatkowski S (2013) Embryonal tumor with abundant neuropil and true rosettes: an autopsy case-based update and review of the literature. Childs Nerv Syst 29(5):849\u2013854. https:\/\/doi.org\/10.1007\/s00381-013-2037-4","journal-title":"Childs Nerv Syst"},{"issue":"2","key":"3633_CR12","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s00381-015-2920-2","volume":"32","author":"M Horwitz","year":"2016","unstructured":"Horwitz M, Dufour C, Leblond P, Bourdeaut F, Faure-Conter C, Bertozzi AI, Delisle MB, Palenzuela G, Jouvet A, Scavarda D, Vinchon M, Padovani L, Gaudart J, Branger DF, Andre N (2016) Embryonal tumors with multilayered rosettes in children: the SFCE experience. Childs Nerv Syst 32(2):299\u2013305. https:\/\/doi.org\/10.1007\/s00381-015-2920-2","journal-title":"Childs Nerv Syst"},{"issue":"4","key":"3633_CR13","first-page":"169","volume":"6","author":"MN Murphy","year":"1987","unstructured":"Murphy MN, Dhalla SS, Diocee M, Halliday W, Wiseman NE, deSa DJ (1987) Congenital ependymoblastoma presenting as a sacrococcygeal mass in a newborn: an immunohistochemical, light and electron microscopic study. Clin Neuropathol 6(4):169\u2013173","journal-title":"Clin Neuropathol"},{"issue":"1","key":"3633_CR14","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/BF00692223","volume":"49","author":"M Lorentzen","year":"1980","unstructured":"Lorentzen M, Hagerstrand I (1980) Congenital ependymoblastoma. Acta Neuropathol 49(1):71\u201374. https:\/\/doi.org\/10.1007\/BF00692223","journal-title":"Acta Neuropathol"},{"issue":"1","key":"3633_CR15","doi-asserted-by":"publisher","first-page":"e34","DOI":"10.1097\/MPH.0000000000001117","volume":"41","author":"CD Grassham","year":"2019","unstructured":"Grassham CD, Rady S, Foster K, SantaCruz KS, Kuttesch JF, Maxwell JR (2019) A Congenital Case of Ependymoblastoma: A Rare and Aggressive Brain Tumor. J Pediatr Hematol Oncol 41(1):e34\u2013e37. https:\/\/doi.org\/10.1097\/MPH.0000000000001117","journal-title":"J Pediatr Hematol Oncol"},{"issue":"4","key":"3633_CR16","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.jmu.2017.09.004","volume":"25","author":"SH Chen","year":"2017","unstructured":"Chen SH, Ho CS, Chiu NC, Chen HJ, Lin YJ (2017) Rare Brain Tumor in a Neonate. J Med Ultrasound 25(4):240\u2013243. https:\/\/doi.org\/10.1016\/j.jmu.2017.09.004","journal-title":"J Med Ultrasound"},{"issue":"2","key":"3633_CR17","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1097\/PAS.0b013e318186235b","volume":"33","author":"M Gessi","year":"2009","unstructured":"Gessi M, Giangaspero F, Lauriola L, Gardiman M, Scheithauer BW, Halliday W, Hawkins C, Rosenblum MK, Burger PC, Eberhart CG (2009) Embryonal tumors with abundant neuropil and true rosettes: a distinctive CNS primitive neuroectodermal tumor. Am J Surg Pathol 33(2):211\u2013217. https:\/\/doi.org\/10.1097\/PAS.0b013e318186235b","journal-title":"Am J Surg Pathol"},{"issue":"3","key":"3633_CR18","doi-asserted-by":"publisher","first-page":"291","DOI":"10.3171\/2015.3.PEDS14727","volume":"16","author":"H Sato","year":"2015","unstructured":"Sato H, Terakawa Y, Tsuyuguchi N, Kuwae Y, Ohsawa M, Ohata K (2015) Embryonal tumor with abundant neuropil and true rosettes in the brainstem: case report. J Neurosurg Pediatr 16(3):291\u2013295. https:\/\/doi.org\/10.3171\/2015.3.PEDS14727","journal-title":"J Neurosurg Pediatr"},{"issue":"3","key":"3633_CR19","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1097\/MPH.0000000000001460","volume":"42","author":"M Honnorat","year":"2020","unstructured":"Honnorat M, Al-Karmi S, Hawkins C, Johnston D, Gerstle T, Schechter T, Huang A, Bouffet E (2020) Presacral medulloepithelioma: case report and literature review. J Pediatr Hematol Oncol 42(3):244\u2013247. https:\/\/doi.org\/10.1097\/MPH.0000000000001460","journal-title":"J Pediatr Hematol Oncol"},{"issue":"5","key":"3633_CR20","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1111\/jon.12524","volume":"28","author":"B Wang","year":"2018","unstructured":"Wang B, Gogia B, Fuller GN, Ketonen LM (2018) Embryonal tumor with multilayered rosettes, C19MC-altered: clinical, pathological, and neuroimaging findings. J Neuroimaging 28(5):483\u2013489. https:\/\/doi.org\/10.1111\/jon.12524","journal-title":"J Neuroimaging"},{"issue":"4","key":"3633_CR21","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1007\/s00381-017-3657-x","volume":"34","author":"AH Shah","year":"2018","unstructured":"Shah AH, Khatib Z, Niazi T (2018) Extracranial extra-CNS spread of embryonal tumor with multilayered rosettes (ETMR): case series and systematic review. Childs Nerv Syst 34(4):649\u2013654. https:\/\/doi.org\/10.1007\/s00381-017-3657-x","journal-title":"Childs Nerv Syst"},{"key":"3633_CR22","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.jocn.2017.01.029","volume":"40","author":"M Abedalthagafi","year":"2017","unstructured":"Abedalthagafi M, Aldandan SW, Alrayis M, Ahmed AA (2017) Lymph node metastasis of presacral ependymoblastoma in a young child. J Clin Neurosci 40:64\u201366. https:\/\/doi.org\/10.1016\/j.jocn.2017.01.029","journal-title":"J Clin Neurosci"},{"issue":"2","key":"3633_CR23","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1002\/pbc.22995","volume":"57","author":"J Rubens","year":"2011","unstructured":"Rubens J, Gosiengfiao Y, Tomita T, Jacobsohn DA, Fangusaro J (2011) Long-term survival in a pediatric patient with supratentorial primitive neuro-ectodermal tumor and extraneural metastasis at diagnosis. Pediatr Blood Cancer 57(2):341\u2013344. https:\/\/doi.org\/10.1002\/pbc.22995","journal-title":"Pediatr Blood Cancer"},{"issue":"1","key":"3633_CR24","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1111\/j.1750-3639.2008.00253.x","volume":"20","author":"AR Judkins","year":"2010","unstructured":"Judkins AR, Ellison DW (2010) Ependymoblastoma: dear, damned, distracting diagnosis, farewell!*. Brain Pathol 20(1):133\u2013139. https:\/\/doi.org\/10.1111\/j.1750-3639.2008.00253.x","journal-title":"Brain Pathol"},{"issue":"6","key":"3633_CR25","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1016\/j.ajo.2015.03.002","volume":"159","author":"FA Jakobiec","year":"2015","unstructured":"Jakobiec FA, Kool M, Stagner AM, Pfister SM, Eagle RC, Proia AD, Korshunov A (2015) Intraocular Medulloepitheliomas and Embryonal Tumors With Multilayered Rosettes of the Brain: Comparative Roles of LIN28A and C19MC. Am J Ophthalmol 159(6):1065\u20131074 e1061. https:\/\/doi.org\/10.1016\/j.ajo.2015.03.002","journal-title":"Am J Ophthalmol"},{"issue":"1","key":"3633_CR26","doi-asserted-by":"publisher","first-page":"15","DOI":"10.5414\/NP300636","volume":"33","author":"J Ceccom","year":"2014","unstructured":"Ceccom J, Bourdeaut F, Loukh N, Rigau V, Milin S, Takin R, Richer W, Uro-Coste E, Couturier J, Bertozzi AI, Delattre O, Delisle MB (2014) Embryonal tumor with multilayered rosettes: diagnostic tools update and review of the literature. Clin Neuropathol 33(1):15\u201322. https:\/\/doi.org\/10.5414\/NP300636","journal-title":"Clin Neuropathol"},{"issue":"2","key":"3633_CR27","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/s00401-010-0688-8","volume":"120","author":"A Korshunov","year":"2010","unstructured":"Korshunov A, Remke M, Gessi M, Ryzhova M, Hielscher T, Witt H, Tobias V, Buccoliero AM, Sardi I, Gardiman MP, Bonnin J, Scheithauer B, Kulozik AE, Witt O, Mork S, von Deimling A, Wiestler OD, Giangaspero F, Rosenblum M, Pietsch T, Lichter P, Pfister SM (2010) Focal genomic amplification at 19q13.42 comprises a powerful diagnostic marker for embryonal tumors with ependymoblastic rosettes. Acta Neuropathol 120(2):253\u2013260. https:\/\/doi.org\/10.1007\/s00401-010-0688-8","journal-title":"Acta Neuropathol"},{"issue":"5","key":"3633_CR28","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1111\/j.1750-3639.2012.00574.x","volume":"22","author":"S Nobusawa","year":"2012","unstructured":"Nobusawa S, Yokoo H, Hirato J, Kakita A, Takahashi H, Sugino T, Tasaki K, Itoh H, Hatori T, Shimoyama Y, Nakazawa A, Nishizawa S, Kishimoto H, Matsuoka K, Nakayama M, Okura N, Nakazato Y (2012) Analysis of chromosome 19q13.42 amplification in embryonal brain tumors with ependymoblastic multilayered rosettes. Brain Pathol 22(5):689\u2013697. https:\/\/doi.org\/10.1111\/j.1750-3639.2012.00574.x","journal-title":"Brain Pathol"},{"issue":"11","key":"3633_CR29","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.1007\/s00381-017-3551-6","volume":"33","author":"S Rao","year":"2017","unstructured":"Rao S, Rajeswarie RT, Chickabasaviah Yasha T, Nandeesh BN, Arivazhagan A, Santosh V (2017) LIN28A, a sensitive immunohistochemical marker for Embryonal Tumor with Multilayered Rosettes (ETMR), is also positive in a subset of Atypical Teratoid\/Rhabdoid Tumor (AT\/RT). Childs Nerv Syst 33(11):1953\u20131959. https:\/\/doi.org\/10.1007\/s00381-017-3551-6","journal-title":"Childs Nerv Syst"},{"issue":"1","key":"3633_CR30","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.ccell.2019.06.002","volume":"36","author":"P Sin-Chan","year":"2019","unstructured":"Sin-Chan P, Mumal I, Suwal T, Ho B, Fan X, Singh I, Du Y, Lu M, Patel N, Torchia J, Popovski D, Fouladi M, Guilhamon P, Hansford JR, Leary S, Hoffman LM, Mulcahy Levy JM, Lassaletta A, Solano-Paez P, Rivas E, Reddy A, Gillespie GY, Gupta N, Van Meter TE, Nakamura H, Wong TT, Ra YS, Kim SK, Massimi L, Grundy RG, Fangusaro J, Johnston D, Chan J, Lafay-Cousin L, Hwang EI, Wang Y, Catchpoole D, Michaud J, Ellezam B, Ramanujachar R, Lindsay H, Taylor MD, Hawkins CE, Bouffet E, Jabado N, Singh SK, Kleinman CL, Barsyte-Lovejoy D, Li XN, Dirks PB, Lin CY, Mack SC, Rich JN, Huang A (2019) A C19MC-LIN28A-MYCN oncogenic circuit driven by hijacked super-enhancers is a distinct therapeutic vulnerability in ETMRs: a lethal brain tumor. Cancer Cell 36(1):51-67 e57. https:\/\/doi.org\/10.1016\/j.ccell.2019.06.002","journal-title":"Cancer Cell"},{"issue":"44","key":"3633_CR31","doi-asserted-by":"publisher","first-page":"16970","DOI":"10.1073\/pnas.0808616105","volume":"105","author":"MY Kalani","year":"2008","unstructured":"Kalani MY, Cheshier SH, Cord BJ, Bababeygy SR, Vogel H, Weissman IL, Palmer TD, Nusse R (2008) Wnt-mediated self-renewal of neural stem\/progenitor cells. Proc Natl Acad Sci U S A 105(44):16970\u201316975. https:\/\/doi.org\/10.1073\/pnas.0808616105","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"3633_CR32","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1002\/stem.36","volume":"27","author":"EM Wexler","year":"2009","unstructured":"Wexler EM, Paucer A, Kornblum HI, Palmer TD, Geschwind DH (2009) Endogenous Wnt signaling maintains neural progenitor cell potency. Stem Cells 27(5):1130\u20131141. https:\/\/doi.org\/10.1002\/stem.36","journal-title":"Stem Cells"},{"issue":"6","key":"3633_CR33","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1242\/dev.126.6.1211","volume":"126","author":"TP Yamaguchi","year":"1999","unstructured":"Yamaguchi TP, Bradley A, McMahon AP, Jones S (1999) A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo. Development 126(6):1211\u20131223","journal-title":"Development"},{"issue":"4","key":"3633_CR34","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1016\/j.cell.2014.10.032","volume":"159","author":"TS Gujral","year":"2014","unstructured":"Gujral TS, Chan M, Peshkin L, Sorger PK, Kirschner MW, MacBeath G (2014) A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis. Cell 159(4):844\u2013856. https:\/\/doi.org\/10.1016\/j.cell.2014.10.032","journal-title":"Cell"},{"issue":"15","key":"3633_CR35","doi-asserted-by":"publisher","first-page":"2489","DOI":"10.1242\/dev.009324","volume":"135","author":"E Dessaud","year":"2008","unstructured":"Dessaud E, McMahon AP, Briscoe J (2008) Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network. Development 135(15):2489\u20132503. https:\/\/doi.org\/10.1242\/dev.009324","journal-title":"Development"},{"issue":"3","key":"3633_CR36","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1006\/scdb.1999.0295","volume":"10","author":"J Briscoe","year":"1999","unstructured":"Briscoe J, Ericson J (1999) The specification of neuronal identity by graded Sonic Hedgehog signalling. Semin Cell Dev Biol 10(3):353\u2013362. https:\/\/doi.org\/10.1006\/scdb.1999.0295","journal-title":"Semin Cell Dev Biol"},{"issue":"4","key":"3633_CR37","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1111\/joa.12361","volume":"227","author":"C Tickle","year":"2015","unstructured":"Tickle C (2015) How the embryo makes a limb: determination, polarity and identity. J Anat 227(4):418\u2013430. https:\/\/doi.org\/10.1111\/joa.12361","journal-title":"J Anat"},{"issue":"2","key":"3633_CR38","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1023\/a:1006369223282","volume":"18","author":"MJ Smalley","year":"1999","unstructured":"Smalley MJ, Dale TC (1999) Wnt signalling in mammalian development and cancer. Cancer Metastasis Rev 18(2):215\u2013230. https:\/\/doi.org\/10.1023\/a:1006369223282","journal-title":"Cancer Metastasis Rev"},{"issue":"1","key":"3633_CR39","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s12964-018-0220-7","volume":"16","author":"GB Carballo","year":"2018","unstructured":"Carballo GB, Honorato JR, de Lopes GPF, Spohr T (2018) A highlight on Sonic hedgehog pathway. Cell Commun Signal 16(1):11. https:\/\/doi.org\/10.1186\/s12964-018-0220-7","journal-title":"Cell Commun Signal"},{"issue":"1","key":"3633_CR40","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.ydbio.2012.06.020","volume":"369","author":"R van Amerongen","year":"2012","unstructured":"van Amerongen R, Fuerer C, Mizutani M, Nusse R (2012) Wnt5a can both activate and repress Wnt\/beta-catenin signaling during mouse embryonic development. Dev Biol 369(1):101\u2013114. https:\/\/doi.org\/10.1016\/j.ydbio.2012.06.020","journal-title":"Dev Biol"},{"key":"3633_CR41","doi-asserted-by":"publisher","DOI":"10.3390\/cancers8090079","author":"MS Asem","year":"2016","unstructured":"Asem MS, Buechler S, Wates RB, Miller DL, Stack MS (2016) Wnt5a signaling in cancer. Cancers (Basel). https:\/\/doi.org\/10.3390\/cancers8090079","journal-title":"Cancers (Basel)"},{"issue":"7035","key":"3633_CR42","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1038\/nature03319","volume":"434","author":"T Reya","year":"2005","unstructured":"Reya T, Clevers H (2005) Wnt signalling in stem cells and cancer. Nature 434(7035):843\u2013850. https:\/\/doi.org\/10.1038\/nature03319","journal-title":"Nature"},{"issue":"34","key":"3633_CR43","doi-asserted-by":"publisher","first-page":"4741","DOI":"10.1038\/onc.2010.215","volume":"29","author":"A Singh","year":"2010","unstructured":"Singh A, Settleman J (2010) EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene 29(34):4741\u20134751. https:\/\/doi.org\/10.1038\/onc.2010.215","journal-title":"Oncogene"},{"issue":"12","key":"3633_CR44","doi-asserted-by":"publisher","first-page":"3261","DOI":"10.1002\/jcp.25797","volume":"232","author":"T Chen","year":"2017","unstructured":"Chen T, You Y, Jiang H, Wang ZZ (2017) Epithelial-mesenchymal transition (EMT): A biological process in the development, stem cell differentiation, and tumorigenesis. J Cell Physiol 232(12):3261\u20133272. https:\/\/doi.org\/10.1002\/jcp.25797","journal-title":"J Cell Physiol"},{"issue":"4","key":"3633_CR45","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1158\/0008-5472.CAN-16-1693","volume":"77","author":"E Binda","year":"2017","unstructured":"Binda E, Visioli A, Giani F, Trivieri N, Palumbo O, Restelli S, Dezi F, Mazza T, Fusilli C, Legnani F, Carella M, Di Meco F, Duggal R, Vescovi AL (2017) Wnt5a Drives an Invasive Phenotype in Human Glioblastoma Stem-like Cells. Cancer Res 77(4):996\u20131007. https:\/\/doi.org\/10.1158\/0008-5472.CAN-16-1693","journal-title":"Cancer Res"},{"issue":"10","key":"3633_CR46","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1038\/nm.4402","volume":"23","author":"JE Neumann","year":"2017","unstructured":"Neumann JE, Wefers AK, Lambo S, Bianchi E, Bockstaller M, Dorostkar MM, Meister V, Schindler P, Korshunov A, von Hoff K, Nowak J, Warmuth-Metz M, Schneider MR, Renner-Muller I, Merk DJ, Shakarami M, Sharma T, Chavez L, Glass R, Chan JA, Taketo MM, Neumann P, Kool M, Schuller U (2017) A mouse model for embryonal tumors with multilayered rosettes uncovers the therapeutic potential of Sonic-hedgehog inhibitors. Nat Med 23(10):1191\u20131202. https:\/\/doi.org\/10.1038\/nm.4402","journal-title":"Nat Med"},{"issue":"5","key":"3633_CR47","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2016.01.015","volume":"164","author":"D Sturm","year":"2016","unstructured":"Sturm D, Orr BA, Toprak UH, Hovestadt V, Jones DTW, Capper D, Sill M, Buchhalter I, Northcott PA, Leis I, Ryzhova M, Koelsche C, Pfaff E, Allen SJ, Balasubramanian G, Worst BC, Pajtler KW, Brabetz S, Johann PD, Sahm F, Reimand J, Mackay A, Carvalho DM, Remke M, Phillips JJ, Perry A, Cowdrey C, Drissi R, Fouladi M,\nGiangaspero F, Lastowska M, Grajkowska W, Scheurlen W, Pietsch T, Hagel C, Gojo J, Lotsch D, Berger W, Slavc I, Haberler C, Jouvet A, Holm S, Hofer S, Prinz M, Keohane C, Fried I, Mawrin C, Scheie D, Mobley BC, Schniederjan MJ, Santi M, Buccoliero AM, Dahiya S, Kramm CM, von Bueren AO, von Hoff K, Rutkowski S, Herold-Mende C, Fruhwald MC, Milde T, Hasselblatt M, Wesseling P, Rossler J, Schuller U, Ebinger M, Schittenhelm J, Frank S, Grobholz R, Vajtai I, Hans V, Schneppenheim R, Zitterbart K, Collins VP, Aronica E, Varlet P, Puget S, Dufour C, Grill J, Figarella-Branger D, Wolter M, Schuhmann MU, Shalaby T, Grotzer M, van Meter T, Monoranu CM, Felsberg J, Reifenberger G, Snuderl M, Forrester LA, Koster J, Versteeg R, Volckmann R, van Sluis P, Wolf S, Mikkelsen T, Gajjar A, Aldape K, Moore AS, Taylor MD, Jones C, Jabado N, Karajannis MA, Eils R, Schlesner M, Lichter P, von Deimling A, Pfister SM, Ellison DW, Korshunov A, Kool M (2016) New brain tumor entities emerge from molecular classification of CNS-PNETs. Cell 164(5):1060\u20131072. https:\/\/doi.org\/10.1016\/j.cell.2016.01.015","journal-title":"Cell"},{"issue":"7697","key":"3633_CR48","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/nature26000","volume":"555","author":"D Capper","year":"2018","unstructured":"Capper D, Jones DTW, Sill M, Hovestadt V, Schrimpf D, Sturm D, Koelsche C, Sahm F, Chavez L, Reuss DE, Kratz A, Wefers AK, Huang K, Pajtler KW, Schweizer L, Stichel D, Olar A, Engel NW, Lindenberg K, Harter PN, Braczynski AK, Plate KH, Dohmen H, Garvalov BK, Coras R, Holsken A, Hewer E, Bewerunge-Hudler M, Schick M, Fischer R, Beschorner R, Schittenhelm J, Staszewski O, Wani K, Varlet P, Pages M, Temming P, Lohmann D, Selt F, Witt H, Milde T, Witt O, Aronica E, Giangaspero F, Rushing E, Scheurlen W, Geisenberger C, Rodriguez FJ, Becker A, Preusser M, Haberler C, Bjerkvig R, Cryan J, Farrell M, Deckert M, Hench J, Frank S, Serrano J, Kannan K, Tsirigos A, Bruck W, Hofer S, Brehmer S, Seiz-Rosenhagen M, Hanggi D, Hans V, Rozsnoki S, Hansford JR, Kohlhof P, Kristensen BW, Lechner M, Lopes B, Mawrin C, Ketter R, Kulozik A, Khatib Z, Heppner F, Koch A, Jouvet A, Keohane C, Muhleisen H, Mueller W, Pohl U, Prinz M, Benner A, Zapatka M, Gottardo NG, Driever PH, Kramm CM, Muller HL, Rutkowski S, von Hoff K, Fruhwald MC, Gnekow A, Fleischhack G, Tippelt S, Calaminus G, Monoranu CM, Perry A, Jones C, Jacques TS, Radlwimmer B, Gessi M, Pietsch T, Schramm J, Schackert G, Westphal M, Reifenberger G, Wesseling P, Weller M, Collins VP, Blumcke I, Bendszus M, Debus J, Huang A, Jabado N, Northcott PA, Paulus W, Gajjar A, Robinson GW, Taylor MD, Jaunmuktane Z, Ryzhova M, Platten M, Unterberg A, Wick W, Karajannis MA, Mittelbronn M, Acker T, Hartmann C, Aldape K, Schuller U, Buslei R, Lichter P, Kool M, Herold-Mende C, Ellison DW, Hasselblatt M, Snuderl M, Brandner S, Korshunov A, von Deimling A, Pfister SM (2018) DNA methylation-based classification of central nervous system tumours. Nature 555(7697):469\u2013474. https:\/\/doi.org\/10.1038\/nature26000","journal-title":"Nature"},{"issue":"6453","key":"3633_CR49","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1038\/366362a0","volume":"366","author":"E Li","year":"1993","unstructured":"Li E, Beard C, Jaenisch R (1993) Role for DNA methylation in genomic imprinting. Nature 366(6453):362\u2013365. https:\/\/doi.org\/10.1038\/366362a0","journal-title":"Nature"},{"key":"3633_CR50","doi-asserted-by":"publisher","first-page":"76","DOI":"10.3389\/fgene.2017.00076","volume":"8","author":"BP Madakashira","year":"2017","unstructured":"Madakashira BP, Sadler KC (2017) DNA methylation, nuclear organization, and cancer. Front Genet 8:76. https:\/\/doi.org\/10.3389\/fgene.2017.00076","journal-title":"Front Genet"},{"issue":"1","key":"3633_CR51","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/ng.2849","volume":"46","author":"CL Kleinman","year":"2014","unstructured":"Kleinman CL, Gerges N, Papillon-Cavanagh S, Sin-Chan P, Pramatarova A, Quang DA, Adoue V, Busche S, Caron M, Djambazian H, Bemmo A, Fontebasso AM, Spence T, Schwartzentruber J, Albrecht S, Hauser P, Garami M, Klekner A, Bognar L, Montes JL, Staffa A, Montpetit A, Berube P, Zakrzewska M, Zakrzewski K, Liberski PP, Dong Z, Siegel PM, Duchaine T, Perotti C, Fleming A, Faury D, Remke M, Gallo M, Dirks P, Taylor MD, Sladek R, Pastinen T, Chan JA, Huang A, Majewski J, Jabado N (2014) Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumor ETMR. Nat Genet 46(1):39\u201344. https:\/\/doi.org\/10.1038\/ng.2849","journal-title":"Nat Genet"},{"issue":"5","key":"3633_CR52","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1093\/hmg\/ddm341","volume":"17","author":"B Jin","year":"2008","unstructured":"Jin B, Tao Q, Peng J, Soo HM, Wu W, Ying J, Fields CR, Delmas AL, Liu X, Qiu J, Robertson KD (2008) DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune function. Hum Mol Genet 17(5):690\u2013709. https:\/\/doi.org\/10.1093\/hmg\/ddm341","journal-title":"Hum Mol Genet"},{"issue":"3","key":"3633_CR53","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.neuroscience.2006.07.053","volume":"142","author":"D Watanabe","year":"2006","unstructured":"Watanabe D, Uchiyama K, Hanaoka K (2006) Transition of mouse de novo methyltransferases expression from Dnmt3b to Dnmt3a during neural progenitor cell development. Neuroscience 142(3):727\u2013737. https:\/\/doi.org\/10.1016\/j.neuroscience.2006.07.053","journal-title":"Neuroscience"},{"issue":"3","key":"3633_CR54","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/s0092-8674(00)81656-6","volume":"99","author":"M Okano","year":"1999","unstructured":"Okano M, Bell DW, Haber DA, Li E (1999) DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99(3):247\u2013257. https:\/\/doi.org\/10.1016\/s0092-8674(00)81656-6","journal-title":"Cell"},{"key":"3633_CR55","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/B978-0-12-387685-0.00007-X","volume":"101","author":"F Chedin","year":"2011","unstructured":"Chedin F (2011) The DNMT3 family of mammalian de novo DNA methyltransferases. Prog Mol Biol Transl Sci 101:255\u2013285. https:\/\/doi.org\/10.1016\/B978-0-12-387685-0.00007-X","journal-title":"Prog Mol Biol Transl Sci"},{"key":"3633_CR56","doi-asserted-by":"publisher","first-page":"117727191984645","DOI":"10.1177\/1177271919846454","volume":"14","author":"KK Wong","year":"2019","unstructured":"Wong KK, Lawrie CH, Green TM (2019) Oncogenic roles and inhibitors of DNMT1, DNMT3A, and DNMT3B in acute myeloid leukaemia. Biomark Insights 14:1177271919846454. https:\/\/doi.org\/10.1177\/1177271919846454","journal-title":"Biomark Insights"},{"issue":"25","key":"3633_CR57","doi-asserted-by":"publisher","first-page":"2424","DOI":"10.1056\/NEJMoa1005143","volume":"363","author":"TJ Ley","year":"2010","unstructured":"Ley TJ, Ding L, Walter MJ, McLellan MD, Lamprecht T, Larson DE, Kandoth C, Payton JE, Baty J, Welch J, Harris CC, Lichti CF, Townsend RR, Fulton RS, Dooling DJ, Koboldt DC, Schmidt H, Zhang Q, Osborne JR, Lin L, O\u2019Laughlin M, McMichael JF, Delehaunty KD, McGrath SD, Fulton LA, Magrini VJ, Vickery TL, Hundal J, Cook LL, Conyers JJ, Swift GW, Reed JP, Alldredge PA, Wylie T, Walker J, Kalicki J, Watson MA, Heath S, Shannon WD, Varghese N, Nagarajan R, Westervelt P, Tomasson MH, Link DC, Graubert TA, DiPersio JF, Mardis ER, Wilson RK (2010) DNMT3A mutations in acute myeloid leukemia. N Engl J Med 363(25):2424\u20132433. https:\/\/doi.org\/10.1056\/NEJMoa1005143","journal-title":"N Engl J Med"},{"issue":"7","key":"3633_CR58","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1038\/ng1590","volume":"37","author":"I Bentwich","year":"2005","unstructured":"Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z (2005) Identification of hundreds of conserved and nonconserved human microRNAs. Nat Genet 37(7):766\u2013770. https:\/\/doi.org\/10.1038\/ng1590","journal-title":"Nat Genet"},{"issue":"10","key":"3633_CR59","doi-asserted-by":"publisher","first-page":"3464","DOI":"10.1093\/nar\/gkp205","volume":"37","author":"ML Bortolin-Cavaille","year":"2009","unstructured":"Bortolin-Cavaille ML, Dance M, Weber M, Cavaille J (2009) C19MC microRNAs are processed from introns of large Pol-II, non-protein-coding transcripts. Nucleic Acids Res 37(10):3464\u20133473. https:\/\/doi.org\/10.1093\/nar\/gkp205","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"3633_CR60","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","volume":"136","author":"DP Bartel","year":"2009","unstructured":"Bartel DP (2009) MicroRNAs: target recognition and regulatory functions. Cell 136(2):215\u2013233. https:\/\/doi.org\/10.1016\/j.cell.2009.01.002","journal-title":"Cell"},{"key":"3633_CR61","doi-asserted-by":"publisher","first-page":"31","DOI":"10.3389\/fgene.2017.00031","volume":"8","author":"J Balzeau","year":"2017","unstructured":"Balzeau J, Menezes MR, Cao S, Hagan JP (2017) The LIN28\/let-7 pathway in cancer. Front Genet 8:31. https:\/\/doi.org\/10.3389\/fgene.2017.00031","journal-title":"Front Genet"},{"issue":"10","key":"3633_CR62","doi-asserted-by":"publisher","first-page":"2496","DOI":"10.1634\/stemcells.2008-0356","volume":"26","author":"M Bar","year":"2008","unstructured":"Bar M, Wyman SK, Fritz BR, Qi J, Garg KS, Parkin RK, Kroh EM, Bendoraite A, Mitchell PS, Nelson AM, Ruzzo WL, Ware C, Radich JP, Gentleman R, Ruohola-Baker H, Tewari M (2008) MicroRNA discovery and profiling in human embryonic stem cells by deep sequencing of small RNA libraries. Stem Cells 26(10):2496\u20132505. https:\/\/doi.org\/10.1634\/stemcells.2008-0356","journal-title":"Stem Cells"},{"issue":"18","key":"3633_CR63","doi-asserted-by":"publisher","first-page":"3566","DOI":"10.1093\/hmg\/ddq272","volume":"19","author":"M Noguer-Dance","year":"2010","unstructured":"Noguer-Dance M, Abu-Amero S, Al-Khtib M, Lefevre A, Coullin P, Moore GE, Cavaille J (2010) The primate-specific microRNA gene cluster (C19MC) is imprinted in the placenta. Hum Mol Genet 19(18):3566\u20133582. https:\/\/doi.org\/10.1093\/hmg\/ddq272","journal-title":"Hum Mol Genet"},{"issue":"2\u20133","key":"3633_CR64","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.diff.2009.06.003","volume":"78","author":"A Zovoilis","year":"2009","unstructured":"Zovoilis A, Smorag L, Pantazi A, Engel W (2009) Members of the miR-290 cluster modulate in vitro differentiation of mouse embryonic stem cells. Differentiation 78(2\u20133):69\u201378. https:\/\/doi.org\/10.1016\/j.diff.2009.06.003","journal-title":"Differentiation"},{"issue":"1","key":"3633_CR65","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.diff.2010.08.002","volume":"81","author":"Z Lichner","year":"2011","unstructured":"Lichner Z, Pall E, Kerekes A, Pallinger E, Maraghechi P, Bosze Z, Gocza E (2011) The miR-290-295 cluster promotes pluripotency maintenance by regulating cell cycle phase distribution in mouse embryonic stem cells. Differentiation 81(1):11\u201324. https:\/\/doi.org\/10.1016\/j.diff.2010.08.002","journal-title":"Differentiation"},{"key":"3633_CR66","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.placenta.2016.10.004","volume":"48","author":"L Xie","year":"2016","unstructured":"Xie L, Sadovsky Y (2016) The function of miR-519d in cell migration, invasion, and proliferation suggests a role in early placentation. Placenta 48:34\u201337. https:\/\/doi.org\/10.1016\/j.placenta.2016.10.004","journal-title":"Placenta"},{"issue":"1","key":"3633_CR67","doi-asserted-by":"publisher","first-page":"3029","DOI":"10.1038\/s41598-020-59812-8","volume":"10","author":"EF Mong","year":"2020","unstructured":"Mong EF, Yang Y, Akat KM, Canfield J, VanWye J, Lockhart J, Tsibris JCM, Schatz F, Lockwood CJ, Tuschl T, Kayisli UA, Totary-Jain H (2020) Chromosome 19 microRNA cluster enhances cell reprogramming by inhibiting epithelial-to-mesenchymal transition. Sci Rep 10(1):3029. https:\/\/doi.org\/10.1038\/s41598-020-59812-8","journal-title":"Sci Rep"},{"issue":"4","key":"3633_CR68","doi-asserted-by":"publisher","first-page":"e1008642","DOI":"10.1371\/journal.pgen.1008642","volume":"16","author":"BA Setty","year":"2020","unstructured":"Setty BA, Jinesh GG, Arnold M, Pettersson F, Cheng CH, Cen L, Yoder SJ, Teer JK, Flores ER, Reed DR, Brohl AS (2020) The genomic landscape of undifferentiated embryonal sarcoma of the liver is typified by C19MC structural rearrangement and overexpression combined with TP53 mutation or loss. PLoS Genet 16(4):e1008642. https:\/\/doi.org\/10.1371\/journal.pgen.1008642","journal-title":"PLoS Genet"},{"issue":"4","key":"3633_CR69","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1002\/path.4363","volume":"233","author":"A Ward","year":"2014","unstructured":"Ward A, Shukla K, Balwierz A, Soons Z, Konig R, Sahin O, Wiemann S (2014) MicroRNA-519a is a novel oncomir conferring tamoxifen resistance by targeting a network of tumour-suppressor genes in ER + breast cancer. J Pathol 233(4):368\u2013379. https:\/\/doi.org\/10.1002\/path.4363","journal-title":"J Pathol"},{"issue":"3","key":"3633_CR70","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1002\/path.3995","volume":"227","author":"F Fornari","year":"2012","unstructured":"Fornari F, Milazzo M, Chieco P, Negrini M, Marasco E, Capranico G, Mantovani V, Marinello J, Sabbioni S, Callegari E, Cescon M, Ravaioli M, Croce CM, Bolondi L, Gramantieri L (2012) In hepatocellular carcinoma miR-519d is up-regulated by p53 and DNA hypomethylation and targets CDKN1A\/p21, PTEN, AKT3 and TIMP2. J Pathol 227(3):275\u2013285. https:\/\/doi.org\/10.1002\/path.3995","journal-title":"J Pathol"},{"issue":"21","key":"3633_CR71","doi-asserted-by":"publisher","first-page":"22461","DOI":"10.1074\/jbc.M313813200","volume":"279","author":"M Suzuki","year":"2004","unstructured":"Suzuki M, Mizuno A (2004) A novel human Cl(-) channel family related to Drosophila flightless locus. J Biol Chem 279(21):22461\u201322468. https:\/\/doi.org\/10.1074\/jbc.M313813200","journal-title":"J Biol Chem"},{"issue":"12","key":"3633_CR72","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1007\/s12032-017-1055-6","volume":"34","author":"J Guo","year":"2017","unstructured":"Guo J, Qu H, Chen Y, Xia J (2017) The role of RNA-binding protein tristetraprolin in cancer and immunity. Med Oncol 34(12):196. https:\/\/doi.org\/10.1007\/s12032-017-1055-6","journal-title":"Med Oncol"},{"issue":"3","key":"3633_CR73","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/ng1253","volume":"35","author":"E Bernstein","year":"2003","unstructured":"Bernstein E, Kim SY, Carmell MA, Murchison EP, Alcorn H, Li MZ, Mills AA, Elledge SJ, Anderson KV, Hannon GJ (2003) Dicer is essential for mouse development. Nat Genet 35(3):215\u2013217. https:\/\/doi.org\/10.1038\/ng1253","journal-title":"Nat Genet"},{"issue":"8","key":"3633_CR74","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/nrm3838","volume":"15","author":"M Ha","year":"2014","unstructured":"Ha M, Kim VN (2014) Regulation of microRNA biogenesis. Nat Rev Mol Cell Biol 15(8):509\u2013524. https:\/\/doi.org\/10.1038\/nrm3838","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"10","key":"3633_CR75","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1038\/nrc3802","volume":"14","author":"WD Foulkes","year":"2014","unstructured":"Foulkes WD, Priest JR, Duchaine TF (2014) DICER1: mutations, microRNAs and mechanisms. Nat Rev Cancer 14(10):662\u2013672. https:\/\/doi.org\/10.1038\/nrc3802","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"3633_CR76","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s00401-018-1935-7","volume":"137","author":"E Uro-Coste","year":"2019","unstructured":"Uro-Coste E, Masliah-Planchon J, Siegfried A, Blanluet M, Lambo S, Kool M, Roujeau T, Boetto S, Palenzuela G, Bertozzi AI, Gambart M, Coupier I, Oliver-Petit I, Golmard L, Julia S, Savagner F, Mohand-Oumoussa B, Tauziede-Espariat A, Delisle MB, Figarella-Branger D, Bourdeaut F, Rigau V (2019) ETMR-like infantile cerebellar embryonal tumors in the extended morphologic spectrum of DICER1-related tumors. Acta Neuropathol 137(1):175\u2013177. https:\/\/doi.org\/10.1007\/s00401-018-1935-7","journal-title":"Acta Neuropathol"},{"issue":"4","key":"3633_CR77","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1007\/s00401-019-01997-y","volume":"139","author":"L de Kock","year":"2020","unstructured":"de Kock L, Priest JR, Foulkes WD, Alexandrescu S (2020) An update on the central nervous system manifestations of DICER1 syndrome. Acta Neuropathol 139(4):689\u2013701. https:\/\/doi.org\/10.1007\/s00401-019-01997-y","journal-title":"Acta Neuropathol"},{"key":"3633_CR78","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-020-02182-2","author":"S Lambo","year":"2020","unstructured":"Lambo S, von Hoff K, Korshunov A, Pfister SM, Kool M (2020) ETMR: a tumor entity in its infancy. Acta Neuropathol. https:\/\/doi.org\/10.1007\/s00401-020-02182-2","journal-title":"Acta Neuropathol"},{"issue":"7","key":"3633_CR79","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1038\/ng.392","volume":"41","author":"SR Viswanathan","year":"2009","unstructured":"Viswanathan SR, Powers JT, Einhorn W, Hoshida Y, Ng TL, Toffanin S, O\u2019Sullivan M, Lu J, Phillips LA, Lockhart VL, Shah SP, Tanwar PS, Mermel CH, Beroukhim R, Azam M, Teixeira J, Meyerson M, Hughes TP, Llovet JM, Radich J, Mullighan CG, Golub TR, Sorensen PH, Daley GQ (2009) Lin28 promotes transformation and is associated with advanced human malignancies. Nat Genet 41(7):843\u2013848. https:\/\/doi.org\/10.1038\/ng.392","journal-title":"Nat Genet"},{"issue":"5872","key":"3633_CR80","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1126\/science.1154040","volume":"320","author":"SR Viswanathan","year":"2008","unstructured":"Viswanathan SR, Daley GQ, Gregory RI (2008) Selective blockade of microRNA processing by Lin28. Science 320(5872):97\u2013100. https:\/\/doi.org\/10.1126\/science.1154040","journal-title":"Science"},{"issue":"1","key":"3633_CR81","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1634\/stemcells.22-1-51","volume":"22","author":"M Richards","year":"2004","unstructured":"Richards M, Tan SP, Tan JH, Chan WK, Bongso A (2004) The transcriptome profile of human embryonic stem cells as defined by SAGE. Stem Cells 22(1):51\u201364. https:\/\/doi.org\/10.1634\/stemcells.22-1-51","journal-title":"Stem Cells"},{"issue":"4","key":"3633_CR82","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.cell.2010.02.007","volume":"140","author":"SR Viswanathan","year":"2010","unstructured":"Viswanathan SR, Daley GQ (2010) Lin28: A microRNA regulator with a macro role. Cell 140(4):445\u2013449. https:\/\/doi.org\/10.1016\/j.cell.2010.02.007","journal-title":"Cell"},{"issue":"5858","key":"3633_CR83","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1126\/science.1151526","volume":"318","author":"J Yu","year":"2007","unstructured":"Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S, Nie J, Jonsdottir GA, Ruotti V, Stewart R, Slukvin II, Thomson JA (2007) Induced pluripotent stem cell lines derived from human somatic cells. Science 318(5858):1917\u20131920. https:\/\/doi.org\/10.1126\/science.1151526","journal-title":"Science"},{"issue":"9","key":"3633_CR84","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1242\/dev.120543","volume":"142","author":"M Yang","year":"2015","unstructured":"Yang M, Yang SL, Herrlinger S, Liang C, Dzieciatkowska M, Hansen KC, Desai R, Nagy A, Niswander L, Moss EG, Chen JF (2015) Lin28 promotes the proliferative capacity of neural progenitor cells in brain development. Development 142(9):1616\u20131627. https:\/\/doi.org\/10.1242\/dev.120543","journal-title":"Development"},{"key":"3633_CR85","doi-asserted-by":"publisher","DOI":"10.1242\/dev.173765","author":"S Herrlinger","year":"2019","unstructured":"Herrlinger S, Shao Q, Yang M, Chang Q, Liu Y, Pan X, Yin H, Xie LW, Chen JF (2019) Lin28-mediated temporal promotion of protein synthesis is crucial for neural progenitor cell maintenance and brain development in mice. Development. https:\/\/doi.org\/10.1242\/dev.173765","journal-title":"Development"},{"issue":"5","key":"3633_CR86","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.gde.2005.08.007","volume":"15","author":"ME Bianchi","year":"2005","unstructured":"Bianchi ME, Agresti A (2005) HMG proteins: dynamic players in gene regulation and differentiation. Curr Opin Genet Dev 15(5):496\u2013506. https:\/\/doi.org\/10.1016\/j.gde.2005.08.007","journal-title":"Curr Opin Genet Dev"},{"issue":"5","key":"3633_CR87","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1139\/O09-057","volume":"87","author":"RS Gieni","year":"2009","unstructured":"Gieni RS, Hendzel MJ (2009) Polycomb group protein gene silencing, non-coding RNA, stem cells, and cancer. Biochem Cell Biol 87(5):711\u2013746. https:\/\/doi.org\/10.1139\/O09-057","journal-title":"Biochem Cell Biol"},{"issue":"6","key":"3633_CR88","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1007\/s00401-012-1068-3","volume":"124","author":"A Korshunov","year":"2012","unstructured":"Korshunov A, Ryzhova M, Jones DT, Northcott PA, van Sluis P, Volckmann R, Koster J, Versteeg R, Cowdrey C, Perry A, Picard D, Rosenblum M, Giangaspero F, Aronica E, Schuller U, Hasselblatt M, Collins VP, von Deimling A, Lichter P, Huang A, Pfister SM, Kool M (2012) LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR). Acta Neuropathol 124(6):875\u2013881. https:\/\/doi.org\/10.1007\/s00401-012-1068-3","journal-title":"Acta Neuropathol"},{"issue":"10","key":"3633_CR89","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1038\/nrneurol.2012.182","volume":"8","author":"L Padovani","year":"2012","unstructured":"Padovani L, Andre N, Constine LS, Muracciole X (2012) Neurocognitive function after radiotherapy for paediatric brain tumours. Nat Rev Neurol 8(10):578\u2013588. https:\/\/doi.org\/10.1038\/nrneurol.2012.182","journal-title":"Nat Rev Neurol"},{"key":"3633_CR90","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.ctro.2018.11.002","volume":"15","author":"S Jaramillo","year":"2019","unstructured":"Jaramillo S, Grosshans DR, Philip N, Varan A, Akyuz C, McAleer MF, Mahajan A, McGovern SL (2019) Radiation for ETMR: Literature review and case series of patients treated with proton therapy. Clin Transl Radiat Oncol 15:31\u201337. https:\/\/doi.org\/10.1016\/j.ctro.2018.11.002","journal-title":"Clin Transl Radiat Oncol"},{"issue":"12","key":"3633_CR91","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1177\/0883073812471434","volume":"28","author":"GA Alexiou","year":"2013","unstructured":"Alexiou GA, Stefanaki K, Vartholomatos G, Sfakianos G, Prodromou N, Moschovi M (2013) Embryonal tumor with abundant neuropil and true rosettes: a systematic literature review and report of 2 new cases. J Child Neurol 28(12):1709\u20131715. https:\/\/doi.org\/10.1177\/0883073812471434","journal-title":"J Child Neurol"},{"issue":"11","key":"3633_CR92","doi-asserted-by":"publisher","first-page":"2080","DOI":"10.18632\/oncotarget.1534","volume":"4","author":"A Henssen","year":"2013","unstructured":"Henssen A, Thor T, Odersky A, Heukamp L, El-Hindy N, Beckers A, Speleman F, Althoff K, Schafers S, Schramm A, Sure U, Fleischhack G, Eggert A, Schulte JH (2013) BET bromodomain protein inhibition is a therapeutic option for medulloblastoma. Oncotarget 4(11):2080\u20132095. https:\/\/doi.org\/10.18632\/oncotarget.1534","journal-title":"Oncotarget"},{"issue":"6","key":"3633_CR93","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1016\/j.cell.2011.08.017","volume":"146","author":"JE Delmore","year":"2011","unstructured":"Delmore JE, Issa GC, Lemieux ME, Rahl PB, Shi J, Jacobs HM, Kastritis E, Gilpatrick T, Paranal RM, Qi J, Chesi M, Schinzel AC, McKeown MR, Heffernan TP, Vakoc CR, Bergsagel PL, Ghobrial IM, Richardson PG, Young RA, Hahn WC, Anderson KC, Kung AL, Bradner JE, Mitsiades CS (2011) BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell 146(6):904\u2013917. https:\/\/doi.org\/10.1016\/j.cell.2011.08.017","journal-title":"Cell"},{"key":"3633_CR94","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.ddtec.2016.06.004","volume":"19","author":"G Andrieu","year":"2016","unstructured":"Andrieu G, Belkina AC, Denis GV (2016) Clinical trials for BET inhibitors run ahead of the science. Drug Discov Today Technol 19:45\u201350. https:\/\/doi.org\/10.1016\/j.ddtec.2016.06.004","journal-title":"Drug Discov Today Technol"},{"issue":"12","key":"3633_CR95","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1093\/neuonc\/nox093","volume":"19","author":"C Schmidt","year":"2017","unstructured":"Schmidt C, Schubert NA, Brabetz S, Mack N, Schwalm B, Chan JA, Selt F, Herold-Mende C, Witt O, Milde T, Pfister SM, Korshunov A, Kool M (2017) Preclinical drug screen reveals topotecan, actinomycin D, and volasertib as potential new therapeutic candidates for ETMR brain tumor patients. Neuro Oncol 19(12):1607\u20131617. https:\/\/doi.org\/10.1093\/neuonc\/nox093","journal-title":"Neuro Oncol"},{"issue":"10","key":"3633_CR96","doi-asserted-by":"publisher","first-page":"3091","DOI":"10.1016\/j.celrep.2018.04.116","volume":"23","author":"L Wang","year":"2018","unstructured":"Wang L, Rowe RG, Jaimes A, Yu C, Nam Y, Pearson DS, Zhang J, Xie X, Marion W, Heffron GJ, Daley GQ, Sliz P (2018) Small-molecule inhibitors disrupt let-7 oligouridylation and release the selective blockade of let-7 processing by LIN28. Cell Rep 23(10):3091\u20133101. https:\/\/doi.org\/10.1016\/j.celrep.2018.04.116","journal-title":"Cell Rep"}],"container-title":["Journal of Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-020-03633-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11060-020-03633-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-020-03633-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T23:19:32Z","timestamp":1634858372000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11060-020-03633-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":96,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["3633"],"URL":"https:\/\/doi.org\/10.1007\/s11060-020-03633-2","relation":{},"ISSN":["0167-594X","1573-7373"],"issn-type":[{"value":"0167-594X","type":"print"},{"value":"1573-7373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"3 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}