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However, indications have continued to expand and now include gliomas of different grades, brain metastasis (BM), radiation necrosis (RN), other types of brain tumors as well as spine metastasis. LITT is emerging as a safe, reliable, minimally invasive clinical approach, particularly for deep seated, focal malignant brain tumors and radiation necrosis. The role of LITT for treatment of other types of tumors of the brain and for spine tumors appears to be evolving at a small number of centers. While the technology appears to be safe and increasingly utilized, there have been few prospective clinical trials and most published studies combine different pathologies in the same report.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Well-designed prospective trials will be required to firmly establish the role of LITT in the treatment of lesions of the brain and spine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11060-020-03652-z","type":"journal-article","created":{"date-parts":[[2021,2,21]],"date-time":"2021-02-21T04:03:16Z","timestamp":1613880196000},"page":"429-442","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["Laser interstitial thermotherapy (LITT) for the treatment of tumors of the brain and spine: a brief review"],"prefix":"10.1007","volume":"151","author":[{"given":"Clark","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Tatsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Elder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9607-5063","authenticated-orcid":false,"given":"Andrew E.","family":"Sloan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,21]]},"reference":[{"key":"3652_CR1","doi-asserted-by":"publisher","first-page":"E14","DOI":"10.3171\/2016.8.FOCUS16233","volume":"41","author":"J Wright","year":"2016","unstructured":"Wright J, Chugh J, Wright CH, Alonso F, Hdeib A, Gittleman H, Barnholtz-Sloan J, Sloan AE (2016) Laser interstitial thermal therapy followed by minimal-access transsulcal resection for the treatment of large and difficult to access brain tumors. 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