{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:00:46Z","timestamp":1784296846683,"version":"3.55.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,1,3]],"date-time":"2021-01-03T00:00:00Z","timestamp":1609632000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,3]],"date-time":"2021-01-03T00:00:00Z","timestamp":1609632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurooncol"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1007\/s11060-020-03683-6","type":"journal-article","created":{"date-parts":[[2021,1,3]],"date-time":"2021-01-03T22:03:09Z","timestamp":1609711389000},"page":"115-123","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Meningiomas and cyproterone acetate: a retrospective, monocentric cohort of 388 patients treated by surgery or radiotherapy for intracranial meningioma"],"prefix":"10.1007","volume":"152","author":[{"given":"Edouard","family":"Samarut","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2278-0488","authenticated-orcid":false,"given":"Alexandre","family":"Lugat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aymeric","family":"Amelot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emeric","family":"Scharbarg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samy","family":"Hadjadj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Primot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Loussouarn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Thillays","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Buffenoir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Cariou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Drui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Roualdes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,3]]},"reference":[{"key":"3683_CR1","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.critrevonc.2008.01.010","volume":"67","author":"C Marosi","year":"2008","unstructured":"Marosi C, Hassler M, Roessler K, Reni M, Sant M, Mazza E et al (2008) Meningioma. Crit Rev Oncol Hematol 67:153\u2013171. https:\/\/doi.org\/10.1016\/j.critrevonc.2008.01.010","journal-title":"Crit Rev Oncol Hematol"},{"key":"3683_CR2","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s11060-010-0386-3","volume":"99","author":"J Wiemels","year":"2010","unstructured":"Wiemels J, Wrensch M, Claus EB (2010) Epidemiology and etiology of meningioma. J Neurooncol 99:307\u2013314. https:\/\/doi.org\/10.1007\/s11060-010-0386-3","journal-title":"J Neurooncol"},{"issue":"Suppl 4","key":"3683_CR3","doi-asserted-by":"publisher","first-page":"iv1","DOI":"10.1093\/neuonc\/nov189","volume":"17","author":"QT Ostrom","year":"2015","unstructured":"Ostrom QT, Gittleman H, Fulop J, Liu M, Blanda R, Kromer C et al (2015) CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2008\u20132012. Neuro-Oncol 17(Suppl 4):iv1-i62. https:\/\/doi.org\/10.1093\/neuonc\/nov189","journal-title":"Neuro-Oncol"},{"key":"3683_CR4","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1159\/000338081","volume":"39","author":"L Cea-Soriano","year":"2012","unstructured":"Cea-Soriano L, Wallander M-A, Garc\u00eda Rodr\u00edguez LA (2012) Epidemiology of meningioma in the United Kingdom. Neuroepidemiology 39:27\u201334. https:\/\/doi.org\/10.1159\/000338081","journal-title":"Neuroepidemiology"},{"key":"3683_CR5","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.neuchi.2014.11.013","volume":"64","author":"S Zouaoui","year":"2018","unstructured":"Zouaoui S, Darlix A, Rigau V, Mathieu-Daud\u00e9 H, Bauchet F, Bessaoud F et al (2018) Descriptive epidemiology of 13,038 newly diagnosed and histologically confirmed meningiomas in France: 2006\u20132010. Neurochirurgie 64:15\u201321. https:\/\/doi.org\/10.1016\/j.neuchi.2014.11.013","journal-title":"Neurochirurgie"},{"key":"3683_CR6","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.wneu.2016.09.094","volume":"97","author":"R Yamanaka","year":"2017","unstructured":"Yamanaka R, Hayano A, Kanayama T (2017) Radiation-induced meningiomas: an exhaustive review of the literature. World Neurosurg 97:635\u2013644","journal-title":"World Neurosurg"},{"key":"3683_CR7","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1002\/cncr.20543","volume":"101","author":"S Yonehara","year":"2004","unstructured":"Yonehara S, Brenner AV, Kishikawa M, Inskip PD, Preston DL, Ron E et al (2004) Clinical and epidemiologic characteristics of first primary tumors of the central nervous system and related organs among atomic bomb survivors in Hiroshima and Nagasaki, 1958\u20131995. Cancer 101:1644\u20131654. https:\/\/doi.org\/10.1002\/cncr.20543","journal-title":"Cancer"},{"key":"3683_CR8","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1016\/S1470-2045(11)70275-3","volume":"12","author":"RS Kotecha","year":"2011","unstructured":"Kotecha RS, Pascoe EM, Rushing EJ, Rorke-Adams LB, Zwerdling T, Gao X et al (2011) Meningiomas in children and adolescents: a meta-analysis of individual patient data. Lancet Oncol 12:1229\u20131239. https:\/\/doi.org\/10.1016\/S1470-2045(11)70275-3","journal-title":"Lancet Oncol"},{"key":"3683_CR9","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.neuchi.2014.05.006","volume":"64","author":"I Baldi","year":"2018","unstructured":"Baldi I, Engelhardt J, Bonnet C, Bauchet L, Berteaud E, Gr\u00fcber A et al (2018) Epidemiology of meningiomas. Neurochirurgie 64:5\u201314. https:\/\/doi.org\/10.1016\/j.neuchi.2014.05.006","journal-title":"Neurochirurgie"},{"key":"3683_CR10","first-page":"1312","volume":"53","author":"RS Carroll","year":"1993","unstructured":"Carroll RS, Glowacka D, Dashner K, Black PM (1993) Progesterone receptor expression in meningiomas. Cancer Res 53:1312\u20131316","journal-title":"Cancer Res"},{"key":"3683_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1055\/s-0029-1211261","volume":"102","author":"F Neumann","year":"2009","unstructured":"Neumann F (2009) The antiandrogen cyproterone acetate: discovery, chemistry, basic pharmacology, clinical use and tool in basic research. Exp Clin Endocrinol Diabetes 102:1\u201332. https:\/\/doi.org\/10.1055\/s-0029-1211261","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"3683_CR12","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1186\/1471-2407-6-152","volume":"6","author":"B Custer","year":"2006","unstructured":"Custer B, Longstreth W, Phillips LE, Koepsell TD, Van Belle G (2006) Hormonal exposures and the risk of intracranial meningioma in women: a population-based case-control study. BMC Cancer 6:152. https:\/\/doi.org\/10.1186\/1471-2407-6-152","journal-title":"BMC Cancer"},{"key":"3683_CR13","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1002\/ijc.21950","volume":"119","author":"E Lee","year":"2006","unstructured":"Lee E, Grutsch J, Persky V, Glick R, Mendes J, Davis F (2006) Association of meningioma with reproductive factors. Int J Cancer 119:1152\u20131157. https:\/\/doi.org\/10.1002\/ijc.21950","journal-title":"Int J Cancer"},{"key":"3683_CR14","doi-asserted-by":"publisher","first-page":"649","DOI":"10.3171\/2012.9.JNS12811","volume":"118","author":"EB Claus","year":"2013","unstructured":"Claus EB, Calvocoressi L, Bondy ML, Wrensch M, Wiemels JL, Schildkraut JM (2013) Exogenous hormone use, reproductive factors, and risk of intracranial meningioma in females: Clinical article. J Neurosurg 118:649\u2013656. https:\/\/doi.org\/10.3171\/2012.9.JNS12811","journal-title":"J Neurosurg"},{"key":"3683_CR15","doi-asserted-by":"publisher","first-page":"2411","DOI":"10.1056\/NEJMc071938","volume":"357","author":"R Gazzeri","year":"2007","unstructured":"Gazzeri R, Galarza M, Gazzeri G (2007) Growth of a meningioma in a transsexual patient after estrogen\u2013progestin therapy. N Engl J Med 357:2411\u20132412. https:\/\/doi.org\/10.1056\/NEJMc071938","journal-title":"N Engl J Med"},{"key":"3683_CR16","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1007\/s00701-015-2532-3","volume":"157","author":"AL Bernat","year":"2015","unstructured":"Bernat AL, Oyama K, Hamdi S, Mandonnet E, Vexiau D, Pocard M et al (2015) Growth stabilization and regression of meningiomas after discontinuation of cyproterone acetate: a case series of 12 patients. Acta Neurochir (Wien) 157:1741\u20131746. https:\/\/doi.org\/10.1007\/s00701-015-2532-3","journal-title":"Acta Neurochir (Wien)"},{"key":"3683_CR17","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1111\/j.1365-2125.2011.04031.x","volume":"72","author":"M Gil","year":"2011","unstructured":"Gil M, Oliva B, Timoner J, Maci\u00e1 MA, Bryant V, de Abajo FJ (2011) Risk of meningioma among users of high doses of cyproterone acetate as compared with the general population: evidence from a population-based cohort study. Br J Clin Pharmacol 72:965\u2013968. https:\/\/doi.org\/10.1111\/j.1365-2125.2011.04031.x","journal-title":"Br J Clin Pharmacol"},{"key":"3683_CR18","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1136\/jnnp.20.1.22","volume":"20","author":"D SIMPSON","year":"1957","unstructured":"SIMPSON D (1957) The recurrence of intracranial meningiomas after surgical treatment. J Neurol Neurosurg Psychiatry 20:22\u201339. https:\/\/doi.org\/10.1136\/jnnp.20.1.22","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"3683_CR19","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1007\/s00701-010-0787-2","volume":"152","author":"H Cebula","year":"2010","unstructured":"Cebula H, Pham TQ, Boyer P, Froelich S (2010) Regression of meningiomas after discontinuation of cyproterone acetate in a transsexual patient. Acta Neurochir (Wien) 152:1955\u20131956. https:\/\/doi.org\/10.1007\/s00701-010-0787-2","journal-title":"Acta Neurochir (Wien)"},{"issue":"10","key":"3683_CR20","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1111\/and.12550","volume":"48","author":"PV ter Wengel","year":"2016","unstructured":"ter Wengel PV, Martin E, Gooren L, Den Heijer M, Peerdeman SM (2016) Meningiomas in three male-to-female transgender subjects using oestrogens\/progestogens and review of the literature. Andrologia 48(10):1130\u20131137. https:\/\/doi.org\/10.1111\/and.12550","journal-title":"Andrologia"},{"key":"3683_CR21","doi-asserted-by":"publisher","first-page":"456","DOI":"10.4103\/sni.sni_22_18","volume":"34","author":"I Mancini","year":"2018","unstructured":"Mancini I, Rotilio A, Coati I, Seracchioli R, Martelli V, Meriggiola MC (2018) Presentation of a meningioma in a transwoman after nine years of cyproterone acetate and estradiol intake: case report and literature review. Gynecol Endocrinol Off J Int Soc Gynecol Endocrinol 34:456\u2013459. https:\/\/doi.org\/10.4103\/sni.sni_22_18","journal-title":"Gynecol Endocrinol Off J Int Soc Gynecol Endocrinol"},{"key":"3683_CR22","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.endonu.2012.07.004","volume":"60","author":"MT Bergoglio","year":"2013","unstructured":"Bergoglio MT, G\u00f3mez-Balaguer M, Almonacid Folch E, Hurtado Murillo F, Hern\u00e1ndez-Mijares A (2013) Symptomatic meningioma induced by cross-sex hormone treatment in a male-to-female transsexual. Endocrinol Nutr 60:264\u2013267. https:\/\/doi.org\/10.1016\/j.endonu.2012.07.004","journal-title":"Endocrinol Nutr"},{"key":"3683_CR23","doi-asserted-by":"publisher","first-page":"327","DOI":"10.2176\/nmc.cr2012-0417","volume":"54","author":"T Anda","year":"2014","unstructured":"Anda T, Honda M, Ishihara T, Kamei T (2014) Progression of intracranial meningioma during luteinizing hormone-releasing hormone agonist treatment for prostate cancer: case report. Neurol Med Chir (Tokyo) 54:327\u2013330. https:\/\/doi.org\/10.2176\/nmc.cr2012-0417","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"3683_CR24","doi-asserted-by":"publisher","first-page":"4955","DOI":"10.1038\/s41388-018-0328-7","volume":"37","author":"J Boetto","year":"2018","unstructured":"Boetto J, Apra C, Bielle F, Peyre M, Kalamarides M (2018) Selective vulnerability of the primitive meningeal layer to prenatal Smo activation for skull base meningothelial meningioma formation. Oncogene 37:4955\u20134963. https:\/\/doi.org\/10.1038\/s41388-018-0328-7","journal-title":"Oncogene"},{"key":"3683_CR25","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1007\/s00701-019-03848-x","volume":"61","author":"T Passeri","year":"2019","unstructured":"Passeri T, Champagne P-O, Bernat A-L, Hanakita S, Salle H, Mandonnet E et al (2019) Spontaneous regression of meningiomas after interruption of nomegestrol acetate: a series of three patients. Acta Neurochir (Wien) 61:761\u2013765. https:\/\/doi.org\/10.1007\/s00701-019-03848-x","journal-title":"Acta Neurochir (Wien)"},{"key":"3683_CR26","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1093\/annonc\/mdx763","volume":"29","author":"M Peyre","year":"2018","unstructured":"Peyre M, Gaillard S, de Marcellus C, Giry M, Bielle F, Villa C et al (2018) Progestin-associated shift of meningioma mutational landscape. Ann Oncol 29:681\u2013686. https:\/\/doi.org\/10.1093\/annonc\/mdx763","journal-title":"Ann Oncol"},{"key":"3683_CR27","doi-asserted-by":"publisher","first-page":"32713","DOI":"10.18632\/oncotarget.5296","volume":"6","author":"M Peyre","year":"2015","unstructured":"Peyre M, Salaud C, Clermont-Taranchon E, Niwa-Kawakita M, Goutagny S, Mawrin C et al (2015) PDGF activation in PGDS-positive arachnoid cells induces meningioma formation in mice promoting tumor progression in combination with Nf2 and Cdkn2ab loss. Oncotarget 6:32713\u201332722. https:\/\/doi.org\/10.18632\/oncotarget.5296","journal-title":"Oncotarget"},{"key":"3683_CR28","doi-asserted-by":"publisher","first-page":"227","DOI":"10.2176\/nmc.48.227","volume":"48","author":"J Shimizu","year":"2008","unstructured":"Shimizu J, Matsumoto M, Yamazaki E, Yasue M (2008) Spontaneous regression of an asymptomatic meningioma associated with discontinuation of progesterone agonist administration. Neurol Med Chir (Tokyo) 48:227\u2013230. https:\/\/doi.org\/10.2176\/nmc.48.227","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"3683_CR29","doi-asserted-by":"publisher","first-page":"814.e7","DOI":"10.1016\/j.wneu.2017.03.013","volume":"101","author":"M Kalamarides","year":"2017","unstructured":"Kalamarides M, Peyre M (2017) Dramatic shrinkage with reduced vascularization of large meningiomas after cessation of progestin treatment. World Neurosurg 101:814.e7-814.e10. https:\/\/doi.org\/10.1016\/j.wneu.2017.03.013","journal-title":"World Neurosurg"},{"key":"3683_CR30","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s11060-019-03104-3","volume":"142","author":"AI Islim","year":"2019","unstructured":"Islim AI, Mohan M, Moon RDC, Srikandarajah N, Mills SJ, Brodbelt AR et al (2019) Incidental intracranial meningiomas: a systematic review and meta-analysis of prognostic factors and outcomes. J Neurooncol 142:211\u2013221. https:\/\/doi.org\/10.1007\/s11060-019-03104-3","journal-title":"J Neurooncol"},{"key":"3683_CR31","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1002\/ijc.20776","volume":"114","author":"EE Hatch","year":"2005","unstructured":"Hatch EE, Linet MS, Zhang J, Fine HA, Shapiro WR, Selker RG et al (2005) Reproductive and hormonal factors and risk of brain tumors in adult females. Int J Cancer 114:797\u2013805. https:\/\/doi.org\/10.1002\/ijc.20776","journal-title":"Int J Cancer"},{"key":"3683_CR32","doi-asserted-by":"publisher","first-page":"848","DOI":"10.3171\/jns.2003.99.5.0848","volume":"99","author":"BS Jhawar","year":"2003","unstructured":"Jhawar BS, Fuchs CS, Colditz GA, Stampfer MJ (2003) Sex steroid hormone exposures and risk for meningioma. J Neurosurg 99:848\u2013853. https:\/\/doi.org\/10.3171\/jns.2003.99.5.0848","journal-title":"J Neurosurg"},{"key":"3683_CR33","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1093\/aje\/kwj254","volume":"164","author":"A Wigertz","year":"2006","unstructured":"Wigertz A, L\u00f6nn S, Mathiesen T, Ahlbom A, Hall P, Feychting M et al (2006) Risk of brain tumors associated with exposure to exogenous female sex hormones. Am J Epidemiol 164:629\u2013636. https:\/\/doi.org\/10.1093\/aje\/kwj254","journal-title":"Am J Epidemiol"},{"key":"3683_CR34","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1200\/JCO.2007.14.2133","volume":"26","author":"S Blitshteyn","year":"2008","unstructured":"Blitshteyn S, Crook JE, Jaeckle KA (2008) Is there an association between meningioma and hormone replacement therapy? J Clin Oncol Off J Am Soc Clin Oncol 26:279\u2013282. https:\/\/doi.org\/10.1200\/JCO.2007.14.2133","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol"},{"key":"3683_CR35","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s11060-019-03147-6","volume":"143","author":"MN Shahin","year":"2019","unstructured":"Shahin MN, Magill ST, Dalle Ore CL, Viner JA, Peters PN, Solomon DA et al (2019) Fertility treatment is associated with multiple meningiomas and younger age at diagnosis. J Neurooncol 143:137\u2013144. https:\/\/doi.org\/10.1007\/s11060-019-03147-6","journal-title":"J Neurooncol"},{"key":"3683_CR36","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.neuchi.2019.12.013","volume":"66","author":"A Roux","year":"2020","unstructured":"Roux A, Tauziede-Espariat A, Zanello M, Gareton A, Malaize H, Benzakoun J, Zah-Bi G, Oppenheim C, Plu-Bureau G, Chretien F, Pallud J (2020) Symptomatic progestin-associated atypical grade II meningioma. A first case report. Neurochirurgie 66:174\u2013178. https:\/\/doi.org\/10.1016\/j.neuchi.2019.12.013","journal-title":"Neurochirurgie"},{"key":"3683_CR37","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s11060-020-03576-8","volume":"149","author":"C Apra","year":"2020","unstructured":"Apra C, Roblot P, Alkhayri A, Le Gu\u00e9rinel C, Polivka M, Chauvet D (2020) Female gender and exogenous progesterone exposition as risk factors for spheno-orbital meningiomas. J Neurooncol 149:95\u2013101. https:\/\/doi.org\/10.1007\/s11060-020-03576-8","journal-title":"J Neurooncol"},{"key":"3683_CR38","unstructured":"Weill A, Cadier B, Nguyen P, Coste J (2019) Exposition \u00e0 de fortes doses d\u2019ac\u00e9tate de cyprot\u00e9rone. Am\u00e9lie Sant\u00e9. https:\/\/www.ameli.fr\/l-assurance-maladie\/statistiques-et-publications\/etudes-en-sante-publique\/etudes-pharmaco-epidemiologiques\/acetate-de-cyproterone-et-risque-de-meningiome.php"}],"container-title":["Journal of Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-020-03683-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11060-020-03683-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-020-03683-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T08:26:12Z","timestamp":1614327972000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11060-020-03683-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,3]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["3683"],"URL":"https:\/\/doi.org\/10.1007\/s11060-020-03683-6","relation":{},"ISSN":["0167-594X","1573-7373"],"issn-type":[{"value":"0167-594X","type":"print"},{"value":"1573-7373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,3]]},"assertion":[{"value":"14 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 December 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The local ethics\ncommittee (GNEDS: <i>Groupe Nantais d\u2019Ethique dans le Domaine de la Sant\u00e9)\napproved the collection and use of this data<\/i> (approval on November 12,\n2018).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}