{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:19:10Z","timestamp":1790151550919,"version":"4.0.1"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T00:00:00Z","timestamp":1616112000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T00:00:00Z","timestamp":1616112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurooncol"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1007\/s11060-021-03704-y","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T10:43:23Z","timestamp":1616150603000},"page":"467-482","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Adjuvant therapeutic potential of moderate hypothermia for glioblastoma"],"prefix":"10.1007","volume":"152","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8520-1677","authenticated-orcid":false,"given":"Cl\u00e9mentine","family":"Fulbert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7930-1476","authenticated-orcid":false,"given":"St\u00e9phan","family":"Chabard\u00e8s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5976-4713","authenticated-orcid":false,"given":"David","family":"Ratel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,19]]},"reference":[{"key":"3704_CR1","doi-asserted-by":"publisher","unstructured":"Louis DN et al (2016) The 201e6 World Health Organization classification of tumors of the central nervous system: a summary. Acta Neuropathol (Berl) 131(6):803\u2013820. https:\/\/doi.org\/10.1007\/s00401-016-1545-1","DOI":"10.1007\/s00401-016-1545-1"},{"key":"3704_CR2","doi-asserted-by":"publisher","unstructured":"Ostrom QT et al (2019) CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2012-2016. Neuro-Oncol 21(Suppl 5):v1\u2013v100. https:\/\/doi.org\/10.1093\/neuonc\/noz150","DOI":"10.1093\/neuonc\/noz150"},{"key":"3704_CR3","doi-asserted-by":"publisher","unstructured":"Stupp R et al (2005) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352(10):987\u2013996. https:\/\/doi.org\/10.1056\/NEJMoa043330","DOI":"10.1056\/NEJMoa043330"},{"key":"3704_CR4","doi-asserted-by":"publisher","unstructured":"Stupp R et al (2009) Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol 10(5):459\u2013466. https:\/\/doi.org\/10.1016\/S1470-2045(09)70025-7","DOI":"10.1016\/S1470-2045(09)70025-7"},{"issue":"Suppl 3","key":"3704_CR5","doi-asserted-by":"publisher","first-page":"iii93","DOI":"10.1093\/annonc\/mdu050","volume":"25","author":"R Stupp","year":"2014","unstructured":"Stupp R, Brada M, van den Bent MJ, Tonn J-C, Pentheroudakis G, ESMO Guidelines Working Group (2014) High-grade glioma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol Off J Eur Soc Med Oncol 25(Suppl 3):iii93\u2013ii101. https:\/\/doi.org\/10.1093\/annonc\/mdu050","journal-title":"Ann Oncol Off J Eur Soc Med Oncol"},{"key":"3704_CR6","doi-asserted-by":"publisher","unstructured":"Lee SY (2016) Temozolomide resistance in glioblastoma multiforme. Genes Dis 3(3):198\u2013210. https:\/\/doi.org\/10.1016\/j.gendis.2016.04.007","DOI":"10.1016\/j.gendis.2016.04.007"},{"key":"3704_CR7","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.biopha.2018.10.063.","volume":"109","author":"X Zhang","year":"2019","unstructured":"Zhang X, Ding K, Wang J, Li X, Zhao P (2019) Chemoresistance caused by the microenvironment of glioblastoma and the corresponding solutions. Biomed Pharmacother 109:39\u201346. https:\/\/doi.org\/10.1016\/j.biopha.2018.10.063.","journal-title":"Biomed Pharmacother"},{"key":"3704_CR8","doi-asserted-by":"publisher","unstructured":"L. Hamard, D. Ratel, L. Selek, F. Berger, B. van der Sanden, et D. Wion, The brain tissue response to surgical injury and its possible contribution to glioma recurrence, J Neuro-Oncol, vol. 128, no 1, p. 1\u20138, mai 2016, doi: https:\/\/doi.org\/10.1007\/s11060-016-2096-y.","DOI":"10.1007\/s11060-016-2096-y"},{"key":"3704_CR9","doi-asserted-by":"publisher","unstructured":"O. Okolie et al., Reactive astrocytes potentiate tumor aggressiveness in a murine glioma resection and recurrence model, Neuro-Oncol, vol. 18, no 12, p. 1622\u20131633, d\u00e9c. 2016, doi: https:\/\/doi.org\/10.1093\/neuonc\/now117.","DOI":"10.1093\/neuonc\/now117"},{"key":"3704_CR10","doi-asserted-by":"publisher","unstructured":"Lem\u00e9e J-M, Clavreul A, Menei P (2015) Intratumoral heterogeneity in glioblastoma: don\u2019t forget the peritumoral brain zone. Neuro-Oncol 17(10):1322\u20131332. https:\/\/doi.org\/10.1093\/neuonc\/nov119.","DOI":"10.1093\/neuonc\/nov119."},{"key":"3704_CR11","doi-asserted-by":"publisher","unstructured":"Stupp R et al (2017) Effect of tumor-treating fields plus maintenance Temozolomide vs maintenance Temozolomide alone on survival in patients with glioblastoma: a randomized clinical trial. JAMA 318(23):2306\u20132316. https:\/\/doi.org\/10.1001\/jama.2017.18718","DOI":"10.1001\/jama.2017.18718"},{"key":"3704_CR12","doi-asserted-by":"publisher","unstructured":"Saigal S, Sharma JP, Dhurwe R, Kumar S, Gurjar M (2015) Targeted temperature management: current evidence and practices in critical care. Indian J Crit Care Med Peer-Rev Off Publ Indian Soc Crit Care Med 19(9):537\u2013546. https:\/\/doi.org\/10.4103\/0972-5229.164806.","DOI":"10.4103\/0972-5229.164806."},{"key":"3704_CR13","doi-asserted-by":"publisher","unstructured":"Dietrich WD, Bramlett HM (2016) Therapeutic hypothermia and targeted temperature management in traumatic brain injury: clinical challenges for successful translation. Brain Res 1640(Part A):94\u2013103. https:\/\/doi.org\/10.1016\/j.brainres.2015.12.034","DOI":"10.1016\/j.brainres.2015.12.034"},{"key":"3704_CR14","doi-asserted-by":"publisher","unstructured":"Gunn AJ et al (2017) Therapeutic hypothermia translates from ancient history in to practice. Pediatr Res 81(1\u20132):202\u2013209. https:\/\/doi.org\/10.1038\/pr.2016.198","DOI":"10.1038\/pr.2016.198"},{"key":"3704_CR15","doi-asserted-by":"publisher","unstructured":"Nolan JP et al (2003) Therapeutic hypothermia after cardiac arrest: an advisory statement by the advanced life support task force of the international liaison committee on resuscitation. Circulation 108(1):118\u2013121. https:\/\/doi.org\/10.1161\/01.CIR.0000079019.02601.90","DOI":"10.1161\/01.CIR.0000079019.02601.90"},{"key":"3704_CR16","doi-asserted-by":"publisher","unstructured":"Richmond S, Wyllie J (2010) European resuscitation council guidelines for resuscitation 2010: Section 7. Resuscitation of babies at birth. Resuscitation 81(10):1389\u20131399. https:\/\/doi.org\/10.1016\/j.resuscitation.2010.08.018","DOI":"10.1016\/j.resuscitation.2010.08.018"},{"key":"3704_CR17","doi-asserted-by":"publisher","unstructured":"Neutelings T, Lambert CA, Nusgens BV, Colige e AC (2013) Effects of mild cold shock (25\u00b0C) followed by warming up at 37\u00b0C on the cellular stress response. PLoS One 8(7):e69687. https:\/\/doi.org\/10.1371\/journal.pone.0069687","DOI":"10.1371\/journal.pone.0069687"},{"key":"3704_CR18","unstructured":"Matijasevic Z (2002) Selective protection of non-cancer cells by hypothermia. Anticancer Res 22(6A):3267\u20133272"},{"key":"3704_CR19","doi-asserted-by":"publisher","unstructured":"Zhang X et al (2012) Effect of mild hypothermia on breast cancer cells adhesion and migration. Biosci Trends. https:\/\/doi.org\/10.5582\/bst.2012.v6.6.313","DOI":"10.5582\/bst.2012.v6.6.313"},{"key":"3704_CR20","doi-asserted-by":"publisher","unstructured":"Kalamida D, Karagounis IV, Mitrakas A, Kalamida S, Giatromanolaki A, Koukourakis MI (2015) Fever-range hyperthermia vs. hypothermia effect on Cancer cell viability, proliferation and HSP90 expression. PLoS One 10(1):e0116021. https:\/\/doi.org\/10.1371\/journal.pone.0116021","DOI":"10.1371\/journal.pone.0116021"},{"key":"3704_CR21","doi-asserted-by":"publisher","unstructured":"Fulbert C, Gaude C, Sulpice E, Chabard\u00e8s S, Ratel D (2019) Moderate hypothermia inhibits both proliferation and migration of human glioblastoma cells. J Neuro-Oncol. https:\/\/doi.org\/10.1007\/s11060-019-03263-3","DOI":"10.1007\/s11060-019-03263-3"},{"key":"3704_CR22","doi-asserted-by":"publisher","unstructured":"Jackson TC, Kochanek PM (2019) A new vision for therapeutic hypothermia in the era of targeted temperature management: a speculative synthesis. Ther Hypothermia Temp Manag 9(1):13\u201347. https:\/\/doi.org\/10.1089\/ther.2019.0001","DOI":"10.1089\/ther.2019.0001"},{"key":"3704_CR23","doi-asserted-by":"publisher","unstructured":"Karnatovskaia LV, Wartenberg KE, Freeman WD (2014) Therapeutic hypothermia for neuroprotection: history, mechanisms, risks, and clinical applications. The Neurohospitalist 4(3):153\u2013163. https:\/\/doi.org\/10.1177\/1941874413519802","DOI":"10.1177\/1941874413519802"},{"key":"3704_CR24","doi-asserted-by":"publisher","unstructured":"Lee JH et al (2016) Improved therapeutic benefits by combining physical cooling with pharmacological hypothermia after severe stroke in rats. Stroke 47(7):1907\u20131913. https:\/\/doi.org\/10.1161\/STROKEAHA.116.013061","DOI":"10.1161\/STROKEAHA.116.013061"},{"key":"3704_CR25","doi-asserted-by":"publisher","first-page":"e181","DOI":"10.1016\/j.wneu.2018.09.073","volume":"121","author":"J Park","year":"2019","unstructured":"Park J, Kim J-H, Suk K, Han HS, Ohk B, Kim DG (2019) Selective brain hypothermia augmenting neuroprotective effects of decompressive Craniectomy for permanent middle cerebral artery infarction in a rat model. World Neurosurg 121:e181\u2013e190. https:\/\/doi.org\/10.1016\/j.wneu.2018.09.073","journal-title":"World Neurosurg"},{"key":"3704_CR26","doi-asserted-by":"publisher","unstructured":"W. Jiang, P. Desjardins, et R. F. Butterworth, Direct evidence for central Proinflammatory mechanisms in rats with experimental acute liver failure: protective effect of hypothermia, J Cereb Blood Flow Metab, vol. 29, no 5, p. 944\u2013952, mai 2009, doi: https:\/\/doi.org\/10.1038\/jcbfm.2009.18.","DOI":"10.1038\/jcbfm.2009.18"},{"key":"3704_CR27","doi-asserted-by":"publisher","unstructured":"Mandrik \u00c9V (1959) The effect of hypothermia on metastasis of Brown-Pearce tumors. Bull Exp Biol Med 47(1):66\u201370. https:\/\/doi.org\/10.1007\/BF00781021","DOI":"10.1007\/BF00781021"},{"key":"3704_CR28","unstructured":"Popovic VP, Masironi R (1966) Disappearance of normothermic tumors in shallow (30\u00b0 C) hypothermia. Cancer Res 26(5):863\u2013864"},{"key":"3704_CR29","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/0024-3205(65)90262-6","volume":"4","author":"VP Popovic","year":"1965","unstructured":"Popovic VP, Masironi R (1965) Disappearance of euthermic tumors after 10-hour generalized hypothermia. Life Sci 1962 4:533\u2013543. https:\/\/doi.org\/10.1016\/0024-3205(65)90262-6","journal-title":"Life Sci 1962"},{"key":"3704_CR30","doi-asserted-by":"publisher","unstructured":"Kelleher DK, Nauth C, Thews O, Krueger W, Vaupel P (1998) Localized hypothermia: impact on oxygenation, microregional perfusion, metabolic and bioenergetic status of subcutaneous rat tumours. Br J Cancer 78(1):56\u201361. https:\/\/doi.org\/10.1038\/bjc.1998.442","DOI":"10.1038\/bjc.1998.442"},{"key":"3704_CR31","doi-asserted-by":"publisher","unstructured":"Neveu M-A, Joudiou N, Preter GD, Dehoux J-P, Jordan BF, Gallez e B (2017) 17O MRS assesses the effect of mild hypothermia on oxygen consumption rate in tumors. NMR Biomed 30(8):e3726. https:\/\/doi.org\/10.1002\/nbm.3726","DOI":"10.1002\/nbm.3726"},{"key":"3704_CR32","doi-asserted-by":"crossref","unstructured":"Nias AH, Perry PM, Photiou AR (1988) Modulating the oxygen tension in tumours by hypothermia and hyperbaric oxygen. J R Soc Med 81(11):633\u2013636","DOI":"10.1177\/014107688808101106"},{"key":"3704_CR33","doi-asserted-by":"publisher","unstructured":"Fisher CJ et al (2017) ALA-PpIX mediated photodynamic therapy of malignant gliomas augmented by hypothermia. PLoS One 12(7). https:\/\/doi.org\/10.1371\/journal.pone.0181654","DOI":"10.1371\/journal.pone.0181654"},{"key":"3704_CR34","unstructured":"Matijasevic Z, Snyder JE, Ludlum DB (1998) Hypothermia causes a reversible, p53-mediated cell cycle arrest in cultured fibroblasts. Oncol Res 10(11\u201312):605\u2013610"},{"key":"3704_CR35","doi-asserted-by":"publisher","unstructured":"Plesnila N, M\u00fcller E, Guretzki S, Ringel F, Staub F, Baethmann e A (2000) Effect of hypothermia on the volume of rat glial cells. J Physiol 523(1):155\u2013162. https:\/\/doi.org\/10.1111\/j.1469-7793.2000.00155.x","DOI":"10.1111\/j.1469-7793.2000.00155.x"},{"key":"3704_CR36","doi-asserted-by":"publisher","unstructured":"J. Zhang, M. F. G. Stevens, et T. D. Bradshaw, Temozolomide: mechanisms of action, repair and resistance, Curr Mol Pharmacol, vol. 5, no 1, p. 102\u2013114, 2012, doi: https:\/\/doi.org\/10.2174\/1874467211205010102.","DOI":"10.2174\/1874467211205010102"},{"key":"3704_CR37","doi-asserted-by":"publisher","unstructured":"Perazzoli G et al (2015) Temozolomide resistance in glioblastoma cell lines: implication of MGMT, MMR, P-glycoprotein and CD133 expression. PLoS One 10(10):e0140131. https:\/\/doi.org\/10.1371\/journal.pone.0140131","DOI":"10.1371\/journal.pone.0140131"},{"key":"3704_CR38","doi-asserted-by":"publisher","unstructured":"Hientz K, Mohr A, Bhakta-Guha D, Efferth T (2017) The role of p53 in cancer drug resistance and targeted chemotherapy. Oncotarget 8(5):8921\u20138946. https:\/\/doi.org\/10.18632\/oncotarget.13475","DOI":"10.18632\/oncotarget.13475"},{"key":"3704_CR39","doi-asserted-by":"publisher","unstructured":"Wang X, Chen J, Liu Y, You C, Mao Q (2013) Mutant TP53 enhances the resistance of glioblastoma cells to temozolomide by up-regulating O(6)-methylguanine DNA-methyltransferase. Neurol Sci 34(8):1421\u20131428. https:\/\/doi.org\/10.1007\/s10072-012-1257-9","DOI":"10.1007\/s10072-012-1257-9"},{"key":"3704_CR40","doi-asserted-by":"publisher","unstructured":"Austin JP, Glaser EM (1969) Enhancement of anti-tumour effect by cooling. Int J Biometeorol 13(2):183\u2013187. https:\/\/doi.org\/10.1007\/bf01552739","DOI":"10.1007\/bf01552739"},{"key":"3704_CR41","doi-asserted-by":"publisher","unstructured":"Hultborn R, Lundgren-Eriksson L, Ottosson-L\u00f6nn S, Ryd W, Weiss e L (1990) Chlorpromazine-induced hypothermia in tumour-bearing mice, acute cytotoxic drug lethality and long-term survival. Acta Oncol Stockh Swed 29(7):941\u2013944. https:\/\/doi.org\/10.3109\/02841869009096394","DOI":"10.3109\/02841869009096394"}],"container-title":["Journal of Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-021-03704-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11060-021-03704-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-021-03704-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T17:18:33Z","timestamp":1619716713000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11060-021-03704-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,19]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["3704"],"URL":"https:\/\/doi.org\/10.1007\/s11060-021-03704-y","relation":{},"ISSN":["0167-594X","1573-7373"],"issn-type":[{"value":"0167-594X","type":"print"},{"value":"1573-7373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,19]]},"assertion":[{"value":"25 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}