{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:44:06Z","timestamp":1786981446893,"version":"build-2736575974"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T00:00:00Z","timestamp":1631750400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T00:00:00Z","timestamp":1631750400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurooncol"],"published-print":{"date-parts":[[2021,10,30]]},"DOI":"10.1007\/s11060-021-03843-2","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T07:15:48Z","timestamp":1631776548000},"page":"63-70","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Paediatric atypical choroid plexus papilloma: is adjuvant therapy necessary?"],"prefix":"10.1007","volume":"155","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8220-5784","authenticated-orcid":false,"given":"Chantelle","family":"Browne-Farmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili-Naz","family":"Hazrati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasin","family":"Mamatjan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gelareh","family":"Zadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Dirks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Rutka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Malkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Bouffet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uri","family":"Tabori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay","family":"Ramaswamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ute","family":"Bartels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,16]]},"reference":[{"key":"3843_CR1","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1097\/00006123-199803000-00006","volume":"42","author":"C Berger","year":"1998","unstructured":"Berger C, Thiesse P, Lellouch-Tubiana A et al (1998) Choroid plexus carcinomas in childhood: clinical features and prognostic factors. Neurosurgery 42:470\u2013475","journal-title":"Neurosurgery"},{"key":"3843_CR2","unstructured":"WHO classification of tumors of the Central Nervous System (2016) WHO\/IARC Classification of Tumors, Revised 4th Edition, 1; 124\u2013129"},{"issue":"11","key":"3843_CR3","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1097\/01.jnen.0000240464.26005.90","volume":"65","author":"A Jeibmann","year":"2006","unstructured":"Jeibmann A, Hasselbatt M, Gerss J et al (2006) Prognostic implications of atypical histological features in choroid plexus papilloma. J Neuropathol Exp Neurol 65(11):1069\u20131073","journal-title":"J Neuropathol Exp Neurol"},{"issue":"3","key":"3843_CR4","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1007\/s11060-009-9936-y","volume":"95","author":"B Wrede","year":"2009","unstructured":"Wrede B, Hasselblatt M et al (2009) Atypical choroid plexus papilloma: clinical experience in the CPT-SIOP-2000 study. J Neurooncol 95(3):383\u2013392","journal-title":"J Neurooncol"},{"issue":"3","key":"3843_CR5","doi-asserted-by":"publisher","first-page":"284","DOI":"10.3171\/2017.2.PEDS16526","volume":"20","author":"M Scala","year":"2017","unstructured":"Scala M, Morana G et al (2017) Atypical choroid plexus papillomas: spontaneous resolution of diffuse leptomeningeal contrast enhancement after primary tumor removal in 2 pediatric cases. J Neurosurg Pediatr 20(3):284\u2013288","journal-title":"J Neurosurg Pediatr"},{"key":"3843_CR6","unstructured":"Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (2016) WHO classification of the central nervous system; Revised 4th Edition. IARC"},{"key":"3843_CR7","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s00401-020-02230-x","volume":"141","author":"S Mansouri","year":"2021","unstructured":"Mansouri S, Suppiah S, Mamatjan Y et al (2021) Epigenomic, genomic, and transcriptomic landscape of schwannomatosis. Acta Neuropathol 141:101\u2013116. https:\/\/doi.org\/10.1007\/s00401-020-02230-x","journal-title":"Acta Neuropathol"},{"key":"3843_CR8","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s00401-018-1888-x","volume":"136","author":"F Cavalli","year":"2018","unstructured":"Cavalli F, H\u00fcbner J, Sharma T et al (2018) Heterogeneity within the PF-EPN-B ependymoma subgroup. Acta Neuropathol 136:227\u2013237. https:\/\/doi.org\/10.1007\/s00401-018-1888-x","journal-title":"Acta Neuropathol"},{"key":"3843_CR9","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s11060-020-03694-3","volume":"52","author":"N Amer","year":"2021","unstructured":"Amer N, Taha H, Hesham D et al (2021) Aggresomes predict poor outcomes and implicate proteostasis in the pathogenesis of pediatric choroid plexus tumors. J Neurooncol 52:67\u201378","journal-title":"J Neurooncol"},{"key":"3843_CR10","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/nature26000","volume":"555","author":"D Capper","year":"2018","unstructured":"Capper D, Jones D, Sill M et al (2018) DNA methylation-based classification of central nervous system tumours. Nature 555:469\u2013474. https:\/\/doi.org\/10.1038\/nature26000 (Epub 2018 Mar 14)","journal-title":"Nature"},{"issue":"3","key":"3843_CR11","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s11060-017-2384-1","volume":"132","author":"M Bahar","year":"2017","unstructured":"Bahar M, Hashem H, Tekautz T et al (2017) Choroid plexus tumors in adult and pediatric populations: the Cleveland clinic and university hospitals experience. J Neurooncol 132(3):427\u2013432","journal-title":"J Neurooncol"},{"key":"3843_CR12","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/s00381-010-1269-9","volume":"27","author":"L Lafay-Cousin","year":"2011","unstructured":"Lafay-Cousin L, Keene D, Carret A et al (2011) Choroid plexus tumours in children less than 36 months: the Canadian pediatric brain tumour consortium (CPBTC) experience. Childs Nerv Syst 27:259\u2013264","journal-title":"Childs Nerv Syst"},{"issue":"10","key":"3843_CR13","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1038\/sj.bjc.6600609","volume":"87","author":"J Wolff","year":"2002","unstructured":"Wolff J, Sajedi M, Brandt R et al (2002) Choroid plexus tumours. Br J Cancer 87(10):1086\u20131091","journal-title":"Br J Cancer"},{"issue":"6","key":"3843_CR14","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1007\/s00401-015-1434-z","volume":"129","author":"C Thomas","year":"2015","unstructured":"Thomas C, Ruland V, Kordes U et al (2015) Pediatric atypical choroid plexus papilloma reconsidered: increased mitotic activity is prognostic in only older children. Acta Neuropathol 129(6):925\u2013927","journal-title":"Acta Neuropathol"},{"issue":"6","key":"3843_CR15","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1093\/neuonc\/nov322","volume":"18","author":"C Thomas","year":"2016","unstructured":"Thomas C, Sill M, Ruland V et al (2016) Methylation profiling of choroid plexus tumors reveals 3 clinically distinct subgroups. Neuro Oncol 18(6):790\u2013796","journal-title":"Neuro Oncol"},{"issue":"1","key":"3843_CR16","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1158\/1078-0432.CCR-14-1324","volume":"21","author":"D Merino","year":"2015","unstructured":"Merino D, Shlien A, Vilani A et al (2015) Molecular characterization of choroid plexus tumors reveals novel clinically relevant subgroups. Clin Cancer Res 21(1):184\u2013192","journal-title":"Clin Cancer Res"},{"issue":"2","key":"3843_CR17","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1097\/NEN.0000000000000154","volume":"74","author":"A Japp","year":"2015","unstructured":"Japp A, Gessi M, Messing-Junger M et al (2015) High-resolution genomic analysis does not qualify atypical plexus papilloma as a separate entity among choroid plexus tumors. J Neuropathol Exp Neurol 74(2):110\u2013120","journal-title":"J Neuropathol Exp Neurol"},{"issue":"1","key":"3843_CR18","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/s13148-019-0708-z","volume":"11","author":"M Pienkowska","year":"2019","unstructured":"Pienkowska M, Choufani S, Turinsky A et al (2019) DNA methylation signature is prognostic of choroid plexus tumour aggressiveness. Clin Epigenetics 11(1):117. https:\/\/doi.org\/10.1186\/s13148-019-0708-z","journal-title":"Clin Epigenetics"},{"issue":"12","key":"3843_CR19","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1200\/JCO.2009.26.8169","volume":"28","author":"U Tabori","year":"2010","unstructured":"Tabori U, Shlien A, Baskin B et al (2010) TP53 Alterations determine clinical subgroups and survival of patients with choroid plexus tumours. J Clin Oncol 28(12):1995\u20132001","journal-title":"J Clin Oncol"},{"key":"3843_CR20","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s11060-017-2561-2","volume":"135","author":"A Siegfried","year":"2017","unstructured":"Siegfried A, Munzer MS et al (2017) A French retrospective study on clinical outcome in 102 choroid plexus tumors in children. J Neurooncol 135:151\u2013160","journal-title":"J Neurooncol"},{"issue":"4","key":"3843_CR21","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1007\/s00701-019-03832-5","volume":"161","author":"A Hosmann","year":"2019","unstructured":"Hosmann A, Hinker F, Dorfer C et al (2019) Management of choroid plexus tumors-an institutional experience. Acta Neurochir (Wien) 161(4):745\u2013754. https:\/\/doi.org\/10.1007\/s00701-019-03832-5","journal-title":"Acta Neurochir (Wien)"},{"issue":"24","key":"3843_CR22","doi-asserted-by":"publisher","first-page":"2938","DOI":"10.4103\/0366-6999.247195","volume":"131","author":"WJ Zhou","year":"2018","unstructured":"Zhou WJ, Wang X, Peng JY et al (2018) Clinical features and prognostic risk factors of choroid plexus tumors in children. Chin Med J (Engl) 131(24):2938\u20132946. https:\/\/doi.org\/10.4103\/0366-6999.247195","journal-title":"Chin Med J (Engl)"},{"key":"3843_CR23","doi-asserted-by":"publisher","first-page":"e237","DOI":"10.1016\/j.wneu.2018.09.089","volume":"121","author":"C Dash","year":"2019","unstructured":"Dash C, Moorthy S, Garg K et al (2019) Management of choroid plexus tumors in infants and young children up to 4 years of age: an institutional experience. World Neurosurg 121:e237\u2013e245. https:\/\/doi.org\/10.1016\/j.wneu.2018.09.089","journal-title":"World Neurosurg"}],"container-title":["Journal of Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-021-03843-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11060-021-03843-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-021-03843-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T05:12:17Z","timestamp":1635138737000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11060-021-03843-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,16]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,10,30]]}},"alternative-id":["3843"],"URL":"https:\/\/doi.org\/10.1007\/s11060-021-03843-2","relation":{},"ISSN":["0167-594X","1573-7373"],"issn-type":[{"value":"0167-594X","type":"print"},{"value":"1573-7373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,16]]},"assertion":[{"value":"21 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflicts of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}