{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T21:49:36Z","timestamp":1774388976592,"version":"3.50.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T00:00:00Z","timestamp":1639008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T00:00:00Z","timestamp":1639008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Bonn"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurooncol"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Recent investigations showed emerging evidence of the role of inflammation in the growth of sporadic vestibular schwannoma (VS). The present retrospective study investigated the impact of systemic inflammation on tumor progression using serum C-reactive protein (CRP) levels in a series of 87 surgically treated sporadic VS patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The optimal cut-off value for CRP was defined as 3.14\u00a0mg\/dl according to the receiver operating characteristic curve (AUC: 0.70, 95% CI 0.47\u20130.92). Patient cohort was dichotomized into normal (n\u2009=\u200966;\u2009&lt;\u20093.14\u00a0mg\/dl) and high baseline (n\u2009=\u200921;\u2009\u2265\u20093.14\u00a0mg\/dl) CRP groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>No significant differences in age, sex, comorbidities influencing the systemic inflammatory state, Karnofsky performance status (KPS), tumor size, extent of resection, or MIB-1 index were identified between the two groups defined by the baseline CRP levels. Univariable analysis demonstrated that a high CRP level (\u2265\u20093.14\u00a0mg\/dl) is significantly associated with a shortened progression-free survival (PFS) (hazard ratio (HR): 6.05, 95% CI 1.15\u201331.95, <jats:italic>p<\/jats:italic>\u2009=\u20090.03). Multivariable Cox regression analysis considering age, extent of resection, KPS, tumor size, and baseline CRP confirmed that an elevated CRP level (\u2265\u20093.14\u00a0mg\/dl) is an independent predictor of shortened PFS (HR: 7.20, 95% CI 1.08\u201348.14, <jats:italic>p<\/jats:italic>\u2009=\u20090.04).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The baseline CRP level thus serves as an independent predictor of PFS. Further investigations of the role of inflammation and tumor inflammatory microenvironment in the prediction of prognosis in sporadic VS are needed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1007\/s11060-021-03918-0","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T07:02:47Z","timestamp":1639033367000},"page":"365-375","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Elevated baseline C-reactive protein levels predict poor progression-free survival in sporadic vestibular schwannoma"],"prefix":"10.1007","volume":"156","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4680-0412","authenticated-orcid":false,"given":"Johannes","family":"Wach","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1gi","family":"G\u00fcresir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeri","family":"Borger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Schuss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Becker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Coch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Therese","family":"Schmitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"H\u00f6lzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marieta","family":"Toma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Herrlinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hartmut","family":"Vatter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erdem","family":"G\u00fcresir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,12,9]]},"reference":[{"key":"3918_CR1","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1227\/NEU.0b013e31824c010f","volume":"70","author":"MB Ammar","year":"2012","unstructured":"Ammar MB, Piccirillo E, Topsakal V, Taibah A, Sanna M (2012) Surgical results and technical refinements in translabyrinthine excision of vestibular schwannomas: the Gruppo Otologico experience. Neurosurgery 70:1481\u20131491. https:\/\/doi.org\/10.1227\/NEU.0b013e31824c010f","journal-title":"Neurosurgery"},{"key":"3918_CR2","doi-asserted-by":"publisher","first-page":"860","DOI":"10.3171\/2009.7.JNS0989","volume":"112","author":"M Samii","year":"2010","unstructured":"Samii M, Gerganov VM, Samii A (2010) Functional outcome after complete surgical removal of giant vestibular schwannomas. J Neurosurg 112:860\u2013867. https:\/\/doi.org\/10.3171\/2009.7.JNS0989","journal-title":"J Neurosurg"},{"key":"3918_CR3","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.wneu.2015.03.012","volume":"84","author":"Y Iwai","year":"2015","unstructured":"Iwai Y, Ishibashi K, Watanabe Y, Uemura G, Yamanaka K (2015) Functional preservation after planned partial resection followed by gamma knife radiosurgery for large vestibular schwannomas. World Neurosurg 84:292\u2013300. https:\/\/doi.org\/10.1016\/j.wneu.2015.03.012","journal-title":"World Neurosurg"},{"key":"3918_CR4","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.3171\/2010.11.JNS10257","volume":"114","author":"ME Sughrue","year":"2011","unstructured":"Sughrue ME, Kaur R, Rutkowski MJ et al (2011) Extent of resection and the long-term durability of vestibular schwannoma surgery. J Neurosurg 114:1218\u20131223. https:\/\/doi.org\/10.3171\/2010.11.JNS10257","journal-title":"J Neurosurg"},{"issue":"3","key":"3918_CR5","doi-asserted-by":"publisher","first-page":"E8","DOI":"10.3171\/2012.6.FOCUS12192","volume":"33","author":"D Kondziolka","year":"2012","unstructured":"Kondziolka D, Mousavi SH, Kano H, Flickinger JC, Lunsford LD (2012) The newly diagnosed verstibular schwannoma: radiosurgery, resection, or observation? Neurosurg Focus 33(3):E8. https:\/\/doi.org\/10.3171\/2012.6.FOCUS12192","journal-title":"Neurosurg Focus"},{"key":"3918_CR6","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.3171\/2014.2.JNS131497","volume":"120","author":"Z Chen","year":"2014","unstructured":"Chen Z, Prasad SC, Di Lella F et al (2014) The behavior of residual tumors and facial nerve outcomes after incomplete excision of vestibular schwannomas. J Neurosurg 120:1278\u20131287. https:\/\/doi.org\/10.3171\/2014.2.JNS131497","journal-title":"J Neurosurg"},{"key":"3918_CR7","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/nature01322","volume":"420","author":"LM Coussens","year":"2002","unstructured":"Coussens LM, Werb Z (2002) Inflammation and cancer. Nature 420:860\u2013867. https:\/\/doi.org\/10.1038\/nature01322","journal-title":"Nature"},{"key":"3918_CR8","doi-asserted-by":"publisher","first-page":"149","DOI":"10.2217\/fon.09.136","volume":"6","author":"CS Roxburgh","year":"2010","unstructured":"Roxburgh CS, McMillan DC (2010) Role of systemic inflammatory response in predicting survival in patients with primary operable cancer. Future Oncol 6:149\u2013163. https:\/\/doi.org\/10.2217\/fon.09.136","journal-title":"Future Oncol"},{"key":"3918_CR9","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1093\/neuonc\/noy177","volume":"21","author":"D Lewis","year":"2019","unstructured":"Lewis D, Roncaroli F, Agushi E et al (2019) Inflammation and vascular permeability correlate with growth in sporadic vestibular schwannoma. Neuro Oncol 21:314\u2013325. https:\/\/doi.org\/10.1093\/neuonc\/noy177","journal-title":"Neuro Oncol"},{"issue":"1","key":"3918_CR10","doi-asserted-by":"publisher","first-page":"vdaa23","DOI":"10.1093\/noajnI\/vdaa023","volume":"2","author":"CJ Hannan","year":"2020","unstructured":"Hannan CJ, Lewis D, O\u00b4Leary C, et al (2020) The inflammatory microenvironment in vestibular schwannoma. Neurooncol Adv 2(1):vdaa23. https:\/\/doi.org\/10.1093\/noajnI\/vdaa023","journal-title":"Neurooncol Adv"},{"issue":"5","key":"3918_CR11","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1007\/s00701-020-04283-z","volume":"162","author":"J Wach","year":"2020","unstructured":"Wach J, Brandecker S, G\u00fcresir \u00c1, Schuss P, Vatter H, G\u00fcresir E (2020) The impact of the MIB-1 index on facial nerve outcomes in vestibular schwannoma surgery. Acta Neurochir 162(5):1205\u20131213. https:\/\/doi.org\/10.1007\/s00701-020-04283-z","journal-title":"Acta Neurochir"},{"key":"3918_CR12","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/s40478-019-0760-0","volume":"7","author":"F Behling","year":"2019","unstructured":"Behling F, Ries V, Skardelly M et al (2019) COX2 expression is associated with proliferation and tumor extension in vestibular schwannoma but is not influenced by acetylsalicylic acid intake. Acta Neuropathol Commun 7:105. https:\/\/doi.org\/10.1186\/s40478-019-0760-0","journal-title":"Acta Neuropathol Commun"},{"issue":"1","key":"3918_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.trsl.2014.12.007","volume":"166","author":"S Dilwali","year":"2015","unstructured":"Dilwali S, Kao SY, Fujita T, Landegger LD, Stankovic KM (2015) Nonsteroidal anti-inflammatory medications are cytostatic against human vestibular schwannomas. Transl Res 166(1):1\u201311. https:\/\/doi.org\/10.1016\/j.trsl.2014.12.007","journal-title":"Transl Res"},{"key":"3918_CR14","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3171\/jns.2005.103.1.0059","volume":"103","author":"Y Yoshimoto","year":"2005","unstructured":"Yoshimoto Y (2005) Systematic review of the natural history of vestibular schwannoma. J Neurosurg 103:59\u201363. https:\/\/doi.org\/10.3171\/jns.2005.103.1.0059","journal-title":"J Neurosurg"},{"key":"3918_CR15","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1097\/MAO.0b013e3181de46ae","volume":"31","author":"Y Agrawal","year":"2010","unstructured":"Agrawal Y, Clark JH, Limb CJ, Niparko JK, Francis HW (2010) Predictors of vestibular schwannoma growth and clinical implications. Otol Neurotol 31:807\u2013812. https:\/\/doi.org\/10.1097\/MAO.0b013e3181de46ae","journal-title":"Otol Neurotol"},{"issue":"12","key":"3918_CR16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143080","volume":"10","author":"S Shrotriya","year":"2015","unstructured":"Shrotriya S, Walsh D, Bennani-Baiti N, Thomas S, Lorton C (2015) C-reactive protein is an important biomarker for prognosis tumor recurrence and treatment response in adult solid tumors: a systematic review. PLoS ONE 10(12):e0143080. https:\/\/doi.org\/10.1371\/journal.pone.0143080","journal-title":"PLoS ONE"},{"issue":"2","key":"3918_CR17","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1055\/s-0029-1242728","volume":"71","author":"S Kliesch","year":"2010","unstructured":"Kliesch S, Vogelgesang S, Benecke R, Horstmann GA, Schroeder HWS (2010) Malignant brain oedema after radiosurgery of a medium-sized vestibular schwannoma. Cent Eur Neurosurg 71(2):88\u201391. https:\/\/doi.org\/10.1055\/s-0029-1242728","journal-title":"Cent Eur Neurosurg"},{"key":"3918_CR18","doi-asserted-by":"publisher","first-page":"Doc03","DOI":"10.3205\/cto000142","volume":"16","author":"S Rosahl","year":"2017","unstructured":"Rosahl S, Bohr C, Lell M, Hamm K, Iro H (2017) Diagnostics and therapy of vestibular schwannomas\u2014an interdisciplinary challenge. GMS Curr Top Otorhinolaryngol Head Neck Surg 16:Doc03. https:\/\/doi.org\/10.3205\/cto000142","journal-title":"GMS Curr Top Otorhinolaryngol Head Neck Surg"},{"key":"3918_CR19","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1097\/00006123-199707000-00012","volume":"41","author":"WB Gormley","year":"1997","unstructured":"Gormley WB, Sekhar LN, Wright DC, Kamerer D, Schessel D (1997) Acoustic neuromas: results of current surgical management. Neurosurgery 41:50\u201358. https:\/\/doi.org\/10.1097\/00006123-199707000-00012","journal-title":"Neurosurgery"},{"key":"3918_CR20","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.3171\/2020.11.JNS101041","volume":"114","author":"M Fukuda","year":"2011","unstructured":"Fukuda M, Oishi M, Hiraishi T, Natsumeda M, Fujii Y (2011) Clinicopathological factors related to regrowth of vestibular schwannoma after incomplete resection. J Neurosurg 114:1224\u20131231. https:\/\/doi.org\/10.3171\/2020.11.JNS101041","journal-title":"J Neurosurg"},{"issue":"3","key":"3918_CR21","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1177\/0194599818770413","volume":"159","author":"KA Lees","year":"2018","unstructured":"Lees KA, Tombers NM, Link MJ et al (2018) Natural history of sporadic vestibular schwannoma: a volumetric study of tumor growth. Otolaryngol Head Neck Surg 159(3):535\u2013542. https:\/\/doi.org\/10.1177\/0194599818770413","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"8","key":"3918_CR22","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1007\/s00234-009-0529-4","volume":"51","author":"R van de Langenberg","year":"2009","unstructured":"van de Langenberg R, de Bondt BJ, Nelemans PJ, Baumert BG, Stokroos RJ (2009) Follow-up assessment of vestibular schwannomas: volume quantification versus two-dimensional measurements. Neuroradiology 51(8):517\u2013524. https:\/\/doi.org\/10.1007\/s00234-009-0529-4","journal-title":"Neuroradiology"},{"issue":"1","key":"3918_CR23","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1002\/(SICI)1097-0258(20000115)19:1<113::AID-SIM245>3.0.CO;2-O","volume":"19","author":"M Mazumdar","year":"2000","unstructured":"Mazumdar M, Glassman JR (2000) Categorizing a prognostic variable: review of methods, code for easy implementation and applications to decision-making about cancer treatments. Stat Med 19(1):113\u2013132","journal-title":"Stat Med"},{"issue":"2","key":"3918_CR24","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1111\/j.0006-341x.2000.00337.x","volume":"56","author":"PJ Heagerty","year":"2000","unstructured":"Heagerty PJ, Lumley T, Pepe MS (2000) Time-dependent ROC curves for censored survival data and a diagnostic marker. Biometrics 56(2):337\u2013344. https:\/\/doi.org\/10.1111\/j.0006-341x.2000.00337.x","journal-title":"Biometrics"},{"key":"3918_CR25","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1111\/coa.12670","volume":"42","author":"MI Syed","year":"2017","unstructured":"Syed MI, Wolf A, Ilan O et al (2017) The behaviour of residual tumour after the intentional incomplete excision of a vestibular schwannoma: is it such a bad thing to leave some behind? Clin Otolaryngol 42:92\u201397. https:\/\/doi.org\/10.1111\/coa.12670","journal-title":"Clin Otolaryngol"},{"issue":"1","key":"3918_CR26","doi-asserted-by":"publisher","first-page":"737","DOI":"10.3892\/mmr.2015.3415","volume":"12","author":"S Taurone","year":"2015","unstructured":"Taurone S, Bianchi E, Attanasio G et al (2015) Immunohistochemical profile of cytokines and growth factors expressed in vestibular schwannoma and in normal vestibular nerve tissue. Mol Med Rep 12(1):737\u2013745. https:\/\/doi.org\/10.3892\/mmr.2015.3415","journal-title":"Mol Med Rep"},{"issue":"10","key":"3918_CR27","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1097\/00004872-200310000-00002","volume":"21","author":"M Rattazzi","year":"2003","unstructured":"Rattazzi M, Puato M, Faggin E et al (2003) C-reactive protein and interleukin-6 in vascular disease: culpritis or passive bystanders? J Hypertens 21(10):1787\u20131803. https:\/\/doi.org\/10.1097\/00004872-200310000-00002","journal-title":"J Hypertens"},{"issue":"6","key":"3918_CR28","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1161\/ATVBAHA.111.225508","volume":"31","author":"S Devaraj","year":"2011","unstructured":"Devaraj S, Jialal I (2011) C-reactive protein polarizes human macrophages to an M1 phenotype and inhibits transformation to the M2 phenotype. Arterioscler Thromb Vasc Biol 31(6):1397\u20131402. https:\/\/doi.org\/10.1161\/ATVBAHA.111.225508","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"3918_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3171\/2019.7.JNS19879","volume":"4","author":"A Perry","year":"2019","unstructured":"Perry A, Graffeo CS, Carlstrom LP et al (2019) Predominance of M1 subtype among tumor-associated macrophages in phenotypically aggressive sporadic vestibular schwannoma. J Neurosurg 4:1\u20139. https:\/\/doi.org\/10.3171\/2019.7.JNS19879","journal-title":"J Neurosurg"},{"key":"3918_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3171\/2020.3.JNS193230","volume":"29","author":"D Lewis","year":"2020","unstructured":"Lewis D, Donofrio CA, O\u2019Leary C et al (2020) The microenvironment in sporadic and neurofibromatosis type II-related vestibular schwannoma: the same tumor or different? A comparative imaging and neuropathology study. J Neurosurg 29:1\u201311. https:\/\/doi.org\/10.3171\/2020.3.JNS193230","journal-title":"J Neurosurg"},{"issue":"1","key":"3918_CR31","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1097\/00129492-200501000-00017","volume":"26","author":"P Cay\u00e9-Thomasen","year":"2005","unstructured":"Cay\u00e9-Thomasen P, Werther K, Nalla A et al (2005) VEGF and VEGF receptor-1 concentration in vestibular schwannoma homogenates correlates to tumor growth rate. Otol Neurotol 26(1):98\u2013101. https:\/\/doi.org\/10.1097\/00129492-200501000-00017","journal-title":"Otol Neurotol"},{"issue":"6","key":"3918_CR32","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1038\/nm0603-669","volume":"9","author":"N Ferrara","year":"2003","unstructured":"Ferrara N, Gerber HP, LeCouter J (2003) The biology of VEGF and its receptors. Nat Med 9(6):669\u2013676. https:\/\/doi.org\/10.1038\/nm0603-669","journal-title":"Nat Med"},{"issue":"1","key":"3918_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41540-017-0037-9","volume":"4","author":"JC Weddell","year":"2017","unstructured":"Weddell JC, Chen S, Imoukhuede PI (2017) VEGFR1 promotes cell migration and proliferation through PLC\u03b3 and PI3K pathways. NPJ Syst Biol 4(1):1. https:\/\/doi.org\/10.1038\/s41540-017-0037-9","journal-title":"NPJ Syst Biol"},{"issue":"18","key":"3918_CR34","doi-asserted-by":"publisher","first-page":"5674","DOI":"10.1158\/1078-0432.CCR-18-2123","volume":"25","author":"A Freire Valls","year":"2019","unstructured":"Freire Valls A, Knipper K, Giannakouri E et al (2019) VEGFR1+ metastasis-associated macrophages contribute to metastatic angiogenesis and influence colorectal cancer patient outcome. Clin Cancer Res 25(18):5674\u20135685. https:\/\/doi.org\/10.1158\/1078-0432.CCR-18-2123","journal-title":"Clin Cancer Res"},{"issue":"18","key":"3918_CR35","doi-asserted-by":"publisher","first-page":"7342","DOI":"10.1158\/0008-5472.CAN-07-6241","volume":"68","author":"M Kerber","year":"2008","unstructured":"Kerber M, Reiss Y, Wickersheim A et al (2008) Flt-1 signaling in macrophages promotes glioma growth in vivo. Cancer Res 68(18):7342\u20137351. https:\/\/doi.org\/10.1158\/0008-5472.CAN-07-6241","journal-title":"Cancer Res"},{"issue":"6","key":"3918_CR36","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1097\/MAO.0b013e31825e73f5","volume":"33","author":"SR Plotkin","year":"2012","unstructured":"Plotkin SR, Merker VL, Halpin C et al (2012) Bevacizumab for progressive vestibular schwannoma in neurofibromatosis type 2: a retrospective review of 31 patients. Otol Neurotol 33(6):1046\u20131052. https:\/\/doi.org\/10.1097\/MAO.0b013e31825e73f5","journal-title":"Otol Neurotol"},{"issue":"4","key":"3918_CR37","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1056\/NEJMoa0902579","volume":"361","author":"SR Plotkin","year":"2009","unstructured":"Plotkin SR, Stemmer-Rachamimov AO, Barker FG 2nd et al (2009) Hearing improvement after bevacizumab in patients with neurofibromatosis type 2. N Engl J Med 361(4):358\u2013367. https:\/\/doi.org\/10.1056\/NEJMoa0902579","journal-title":"N Engl J Med"},{"issue":"1","key":"3918_CR38","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1002\/ajmg.a.34359","volume":"158A","author":"JO Blakeley","year":"2012","unstructured":"Blakeley JO, Evans DG, Adler J et al (2012) Consensus recommendations for current treatments and accelerating clinical trials for patients with neurofibromatosis type 2. Am J Med Genet A 158A(1):24\u201341. https:\/\/doi.org\/10.1002\/ajmg.a.34359","journal-title":"Am J Med Genet A"},{"issue":"11","key":"3918_CR39","doi-asserted-by":"publisher","first-page":"2294","DOI":"10.1093\/annonc\/mdq566","volume":"21","author":"VF Mautner","year":"2010","unstructured":"Mautner VF, Nguyen R, Knecht R, Bokemeyer C (2010) Radiographic regression of vestibular schwannomas induced by bevacizumab treatment: sustain under continuous drug application and rebound after drug discontinuation. Ann Oncol 21(11):2294\u20132295. https:\/\/doi.org\/10.1093\/annonc\/mdq566","journal-title":"Ann Oncol"},{"issue":"1","key":"3918_CR40","doi-asserted-by":"publisher","first-page":"15712","DOI":"10.1038\/s41598-021-95022-6","volume":"11","author":"D Lewis","year":"2021","unstructured":"Lewis D, McHugh DJ, Li KL, Zhu X, Mcbain C, Lloyd SK, Jackson A, Pathmanaban ON, King AT, Coope DJ (2021) Detection of early changes in the post-radiosurgery vestibular schwannoma microenvironment using multinuclear MRI. Sci Rep 11(1):15712","journal-title":"Sci Rep"},{"issue":"5\u20136","key":"3918_CR41","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/s0049-3848(03)00412-2","volume":"110","author":"KK Wu","year":"2003","unstructured":"Wu KK (2003) Control of COX-2 and iNOS gene expression by aspirin and salicylate. Thromb Res 110(5\u20136):273\u2013276. https:\/\/doi.org\/10.1016\/s0049-3848(03)00412-2","journal-title":"Thromb Res"},{"issue":"9","key":"3918_CR42","doi-asserted-by":"publisher","first-page":"5292","DOI":"10.1073\/pnas.96.9.5292","volume":"96","author":"XM Xu","year":"1999","unstructured":"Xu XM, Sansores-Garcia L, Chen XM, Matjevic-Aleksic N, Du M, Wu KK (1999) Suppression of inducible cyclooxygenase 2 gene transcription by aspirin and sodium salicylate. Proc Natl Acad Sci USA 96(9):5292\u20135297. https:\/\/doi.org\/10.1073\/pnas.96.9.5292","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Journal of Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-021-03918-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11060-021-03918-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-021-03918-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T13:15:10Z","timestamp":1643980510000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11060-021-03918-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,9]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["3918"],"URL":"https:\/\/doi.org\/10.1007\/s11060-021-03918-0","relation":{},"ISSN":["0167-594X","1573-7373"],"issn-type":[{"value":"0167-594X","type":"print"},{"value":"1573-7373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,9]]},"assertion":[{"value":"5 November 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 December 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 December 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of the University of Bonn (228\/2021).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}