{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T22:16:41Z","timestamp":1778969801606,"version":"3.51.4"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T00:00:00Z","timestamp":1656547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T00:00:00Z","timestamp":1656547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003542","name":"Ministerium f\u00fcr Wissenschaft, Forschung und Kunst Baden-W\u00fcrttemberg","doi-asserted-by":"publisher","award":["31-7635.41\/215\/2"],"award-info":[{"award-number":["31-7635.41\/215\/2"]}],"id":[{"id":"10.13039\/501100003542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012940","name":"Universit\u00e4tsklinikum T\u00fcbingen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012940","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurooncol"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Introduction<\/jats:title>\n                <jats:p>Peripheral and intraspinal schwannomas are common and clinically complex pathologies in patients with Neurofibromatosis Type 2 (NF2) and Schwannomatosis (SWNT). Functional preservation and pain relief are the major goals in treating these tumors.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This retrospective observational study investigates the clinical and functional outcome of 205 operated peripheral (n\u2009=\u2009148, 72%) and intraspinal (n\u2009=\u200957, 28%) schwannomas in 85 patients (53 NF2, 32 SWNT) treated at our department between 2006 and 2017. Associated factors such as genetics, age, and location were evaluated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Persisting drug-resistant pain was the most common symptom (84%, n\u2009=\u2009173) and indication for surgery (54%, n\u2009=\u2009110). Improvement in pain intensity was postoperatively seen in 81%. Peripheral nerve schwannomas exhibited worse pain intensity preoperatively compared to intraspinal lesions (<jats:italic>p<\/jats:italic>\u2009=\u20090.017 NF2, <jats:italic>p<\/jats:italic>\u2009=\u20090.029 SWNT). More total resections could be achieved in 93% of SWNT vs. 82% of NF2-associated tumors, <jats:italic>p<\/jats:italic>\u2009=\u20090.030). NF2 patients with intraspinal lesions were more neurologically affected (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Perioperative comparison of both tumor syndromes showed more neurological deficits (<jats:italic>p<\/jats:italic>\u2009=\u20090.027), and less pain (<jats:italic>p<\/jats:italic>\u2009=\u20090.024) in NF2-associated tumors. Mosaic NF2 patients had worse pain levels before surgery, and SWNT patients had a worse neurological function and more pain compared to non-mosaic or non-mutated cases.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Resection of peripheral and intraspinal schwannomas is an effective and low-risk treatment in both NF2 and SWNT. Patients with severe pain have a particular benefit from surgical treatment. Intraspinal lesions are associated with worse neurological function whereas peripheral lesions showed a higher pain intensity. The influence of mutations needs to be further investigated in larger cohorts.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11060-022-04061-0","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T14:04:50Z","timestamp":1656597890000},"page":"271-279","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Management of neurofibromatosis type\u00a02 and schwannomatosis associated peripheral and intraspinal schwannomas: influence of surgery, genetics, and localization"],"prefix":"10.1007","volume":"159","author":[{"given":"Isabel","family":"Gugel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Grimm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos","family":"Tatagiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin U.","family":"Schuhmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Zipfel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,6,30]]},"reference":[{"key":"4061_CR1","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1136\/jmg.35.6.450","volume":"35","author":"DG Evans","year":"1998","unstructured":"Evans DG, Trueman L, Wallace A, Collins S, Strachan T (1998) Genotype\/phenotype correlations in type 2 neurofibromatosis (NF2): evidence for more severe disease associated with truncating mutations. 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Approval was granted by the Ethics Committee of the Medical Faculty and the University Hospital of T\u00fcbingen (No. 026\/2018BO2). Individual consent was waived.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}