{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T09:25:15Z","timestamp":1785489915299,"version":"3.56.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T00:00:00Z","timestamp":1667692800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T00:00:00Z","timestamp":1667692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurooncol"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1007\/s11060-022-04183-5","type":"journal-article","created":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T08:02:51Z","timestamp":1667721771000},"page":"643-648","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Long term survivors of stereotactic radiosurgery for brain metastases: do distant brain failures reach a plateau and what factors are associated with a brain metastasis velocity of zero?"],"prefix":"10.1007","volume":"160","author":[{"given":"Claire M.","family":"Lanier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Pearce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Isom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Wen","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher T.","family":"Whitlow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy","family":"Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaclyn J.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian W.","family":"Laxton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen B.","family":"Tatter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina K.","family":"Cramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,6]]},"reference":[{"key":"4183_CR1","doi-asserted-by":"publisher","first-page":"203","DOI":"10.2741\/s458","volume":"8","author":"H-M Devoid","year":"2016","unstructured":"Devoid H-M, McTyre ER, Page BR et al (2016) Recent advances in radiosurgical management of brain metastases. Front Biosci 8:203\u2013214","journal-title":"Front Biosci"},{"key":"4183_CR2","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1002\/cncr.28422","volume":"120","author":"SC Lester","year":"2014","unstructured":"Lester SC, Taksler GB, Kuremsky JG et al (2014) Clinical and economic outcomes of patients with brain metastases based on symptoms: an argument for routine brain screening of those treated with upfront radiosurgery. Cancer 120:433\u2013441","journal-title":"Cancer"},{"key":"4183_CR3","first-page":"402","volume":"6","author":"CM Lanier","year":"2019","unstructured":"Lanier CM, Hughes R, Ahmed T et al (2019) Immunotherapy is associated with improved survival and decreased neurologic death after SRS for brain metastases from lung and melanoma primaries. Neurooncol Pract 6:402\u2013409","journal-title":"Neurooncol Pract"},{"key":"4183_CR4","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.jocn.2014.08.020","volume":"22","author":"F Mu","year":"2015","unstructured":"Mu F, Lucas JT Jr, Watts JM et al (2015) Tumor resection with carmustine wafer placement as salvage therapy after local failure of radiosurgery for brain metastasis. J Clin Neurosci 22:561\u2013565","journal-title":"J Clin Neurosci"},{"key":"4183_CR5","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1001\/jama.2016.9839","volume":"316","author":"PD Brown","year":"2016","unstructured":"Brown PD, Jaeckle K, Ballman KV et al (2016) Effect of radiosurgery alone vs radiosurgery with whole brain radiation therapy on cognitive function in patients with 1 to 3 brain metastases: a randomized clinical trial. JAMA 316:401\u2013409","journal-title":"JAMA"},{"key":"4183_CR6","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/S1470-2045(09)70263-3","volume":"10","author":"EL Chang","year":"2009","unstructured":"Chang EL, Wefel JS, Hess KR et al (2009) Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial. Lancet Oncol 10:1037\u20131044","journal-title":"Lancet Oncol"},{"key":"4183_CR7","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1016\/S1470-2045(17)30441-2","volume":"18","author":"PD Brown","year":"2017","unstructured":"Brown PD, Ballman KV, Cerhan JH et al (2017) Postoperative stereotactic radiosurgery compared with whole brain radiotherapy for resected metastatic brain disease (NCCTG N107C\/CEC\u00b73): a multicentre, randomised, controlled, phase 3 trial. Lancet Oncol 18:1049\u20131060","journal-title":"Lancet Oncol"},{"key":"4183_CR8","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1093\/neuros\/nyy216","volume":"84","author":"MH Soike","year":"2019","unstructured":"Soike MH, Hughes RT, Farris M et al (2019) Does stereotactic radiosurgery have a role in the management of patients presenting with 4 or more brain metastases? Neurosurgery 84:558\u2013566","journal-title":"Neurosurgery"},{"key":"4183_CR9","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1016\/j.ijrobp.2019.03.052","volume":"104","author":"RT Hughes","year":"2019","unstructured":"Hughes RT, Masters AH, McTyre ER et al (2019) Int J Radiat Oncol Biol Phys 104:1091\u20131098","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4183_CR10","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1177\/1724600818803104","volume":"31","author":"A Dohm","year":"2019","unstructured":"Dohm A, Su J, McTyre ER et al (2019) Identification of CD37, cystatin A, and IL-23A gene expression in association with brain metastasis: analysis of a prospective trial. Int J Biol Mark 31:90\u201397","journal-title":"Int J Biol Mark"},{"key":"4183_CR11","first-page":"1283","volume":"16","author":"DN Ayala-Peacock","year":"2014","unstructured":"Ayala-Peacock DN, Peiffer AM, Lucas JT et al (2014) A nomogram for predicting distant brain failure in patients treated with gamma knife stereotactic radiosurgery without whole brain radiotherapy. NeuroOncology 16:1283\u20131288","journal-title":"NeuroOncology"},{"key":"4183_CR12","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1093\/annonc\/mdx740","volume":"29","author":"E McTyre","year":"2018","unstructured":"McTyre E, Ayala-Peacock D, Contessa J et al (2018) Multi-institutional competing risks analysis of distant brain failure and salvage patterns after upfront radiosurgery without whole brain radiotherapy for brain metastasis. Ann Oncol 29:497\u2013503","journal-title":"Ann Oncol"},{"key":"4183_CR13","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s11060-017-2588-4","volume":"135","author":"DN Ayala-Peacock","year":"2017","unstructured":"Ayala-Peacock DN, Attia A, Braunstein SE et al (2017) Prediction of new brain metastases after radiosurgery: validation and analysis of performance of a multi-institutional nomogram. J Neurooncol 135:403\u2013411","journal-title":"J Neurooncol"},{"key":"4183_CR14","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.ijrobp.2016.09.043","volume":"97","author":"D Gorovets","year":"2017","unstructured":"Gorovets D, Ayala-Peacock D, Tybor DJ et al (2017) Int J Radiat Oncol Biol Phys 97:246\u2013253","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4183_CR15","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.ijrobp.2017.01.201","volume":"98","author":"M Farris","year":"2017","unstructured":"Farris M, McTyre ER, Cramer CK et al (2017) Brain metastasis velocity: a novel prognostic metric predictive of overall survival and freedom from whole-brain radiation therapy after distant brain failure following upfront radiosurgery alone. Int J Radiat Oncol Biol Phys 98:131\u2013141","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4183_CR16","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.radonc.2019.08.011","volume":"142","author":"ER McTyre","year":"2020","unstructured":"McTyre ER, Soike MH, Farris M et al (2020) Multi-institutional validation of brain metastasis velocity, a recently defined predictor of outcomes following stereotactic radiosurgery. Radiother Oncol 142:168\u2013174","journal-title":"Radiother Oncol"},{"key":"4183_CR17","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.ijrobp.2018.10.036","volume":"103","author":"M Yamamoto","year":"2019","unstructured":"Yamamoto M, Aiyama H, Koiso T et al (2019) Validity of a recently proposed prognostic grading index, brain metastasis velocity, for patients with brain metastasis undergoing multiple radiosurgical procedures. Int J Radiat Oncol Biol Phys 103:631\u2013637","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4183_CR18","doi-asserted-by":"publisher","first-page":"551","DOI":"10.3389\/fonc.2018.00551","volume":"8","author":"C Fritz","year":"2018","unstructured":"Fritz C, Borsky K, Stark LS et al (2018) Repeated courses of radiosurgery for new brain metastases to defer whole brain radiotherapy: feasibility and outcome with validation of the new prognostic metric brain metastasis velocity. Front Oncol 8:551","journal-title":"Front Oncol"},{"key":"4183_CR19","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1093\/neuros\/nyx376","volume":"83","author":"E Gogineni","year":"2018","unstructured":"Gogineni E, Vargo JA, Glaser SM et al (2018) Long-term survivorship following stereotactic radiosurgery alone for brain metastases: risk of intracranial failure and implications for surveillance and counseling. Neurosurgery 83:203\u2013209","journal-title":"Neurosurgery"},{"key":"4183_CR20","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/S0360-3016(99)00507-6","volume":"47","author":"E Shaw","year":"2000","unstructured":"Shaw E, Scott C, Souhami L et al (2000) Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: final report of RTOG protocol 90\u201305. Int J Radiat Oncol Biol Phys 47:291\u2013298","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4183_CR21","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1007\/s11060-016-2208-8","volume":"129","author":"R Kotecha","year":"2016","unstructured":"Kotecha R, Vogel S, Suh JH et al (2016) A cure is possible: a study of 10-year survivors of brain metastases. J Neurooncol 129:545\u2013555","journal-title":"J Neurooncol"},{"key":"4183_CR22","doi-asserted-by":"publisher","first-page":"18945","DOI":"10.18632\/oncotarget.4153","volume":"6","author":"AG Johnson","year":"2015","unstructured":"Johnson AG, Ruiz J, Hughes R et al (2015) Impact of systemic targeted agents on the clinical outcomes of patients with brain metastases. Oncotarget 6:18945\u201318955","journal-title":"Oncotarget"},{"key":"4183_CR23","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/s11060-019-03368-9","volume":"146","author":"MC LeCompte","year":"2020","unstructured":"LeCompte MC, Hughes RT, Farris M et al (2020) Impact of brain metastasis velocity on neurologic death for brain metastasis patients experiencing distant brain failure after initial stereotactic radiosurgery. J Neurooncol 146:285\u2013292","journal-title":"J Neurooncol"},{"key":"4183_CR24","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.ijrobp.2007.05.084","volume":"70","author":"SM Sawrie","year":"2008","unstructured":"Sawrie SM, Guthrie BL, Spencer SA et al (2008) Predictors of distant brain recurrence for patients with newly diagnosed brain metastases treated with stereotactic radiosurgery alone. Int J Radiat Oncol Biol Phys 70:181\u2013186","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4183_CR25","doi-asserted-by":"publisher","first-page":"107","DOI":"10.3109\/07357908509017493","volume":"3","author":"N Sundaresan","year":"1985","unstructured":"Sundaresan N, Galicich JH (1985) Surgical treatment of single brain metastases from non-small-cell lung cancer. Cancer Invest 3:107\u2013113","journal-title":"Cancer Invest"},{"key":"4183_CR26","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/S1470-2045(14)70061-0","volume":"15","author":"M Yamamoto","year":"2014","unstructured":"Yamamoto M, Serizawa T, Shuto T et al (2014) Stereotactic radiosurgery for patients with multiple brain metastases (JLGK0901): a multi-institutional prospective observational study. Lancet Oncol 15:387\u2013395","journal-title":"Lancet Oncol"},{"key":"4183_CR27","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.rpor.2011.01.002","volume":"16","author":"M Niemiec","year":"2011","unstructured":"Niemiec M, G\u0142ogowski M, Tyc-Szczepaniak D et al (2011) Characteristics of long-term survivors of brain metastases from lung cancer. Rep Pract Oncol Radiother 16:49\u201353","journal-title":"Rep Pract Oncol Radiother"},{"key":"4183_CR28","doi-asserted-by":"publisher","first-page":"101005","DOI":"10.18632\/oncotarget.22291","volume":"8","author":"N Alphonse-Sullivan","year":"2017","unstructured":"Alphonse-Sullivan N, Taksler GB, Lycan T et al (2017) Sociodemographic predictors of patients with brain metastases treated with stereotactic radiosurgery. Oncotarget 8:101005\u2013101011","journal-title":"Oncotarget"}],"container-title":["Journal of Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-022-04183-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11060-022-04183-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-022-04183-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T17:08:14Z","timestamp":1671210494000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11060-022-04183-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,6]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["4183"],"URL":"https:\/\/doi.org\/10.1007\/s11060-022-04183-5","relation":{},"ISSN":["0167-594X","1573-7373"],"issn-type":[{"value":"0167-594X","type":"print"},{"value":"1573-7373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,6]]},"assertion":[{"value":"12 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Financial interests: Adrian W. Laxton, M.D. has received a consulting fee from Monteris Medical. There are no other financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}},{"value":"This is an observational study. The IRB Research Ethics Committee has confirmed that no ethical approval is required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Due to the retrospective and observational nature of this study, the IRB Research Ethics Committee has confirmed no consent to participate is required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Due to the retrospective and observational nature of this study, the IRB Research Ethics Committee has confirmed no consent to publish is required.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}]}}