{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:33:55Z","timestamp":1787063635477,"version":"build-2736575974"},"reference-count":79,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurooncol"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1007\/s11060-023-04327-1","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T09:06:42Z","timestamp":1683536802000},"page":"15-27","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Stereotactic body radiotherapy for spine metastases: a review of 24 Gy in 2 daily fractions"],"prefix":"10.1007","volume":"163","author":[{"given":"Eric K.","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Ruschin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beibei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hany","family":"Soliman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sten","family":"Myrehaug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Detsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanbo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun","family":"Sahgal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Lin","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,8]]},"reference":[{"key":"4327_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3171\/foc.2001.11.6.11","volume":"11","author":"WB Jacobs","year":"2001","unstructured":"Jacobs WB, Perrin RG (2001) Evaluation and treatment of spinal metastases: an overview. Neurosurg Focus FOC 11:1\u201311. https:\/\/doi.org\/10.3171\/foc.2001.11.6.11","journal-title":"Neurosurg Focus FOC"},{"key":"4327_CR2","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1212\/WNL.49.2.452","volume":"49","author":"D Schiff","year":"1997","unstructured":"Schiff D, O\u2019Neill BP, Suman VJ (1997) Spinal epidural metastasis as the initial manifestation of malignancy: clinical features and diagnostic approach. Neurology 49:452\u2013456. https:\/\/doi.org\/10.1212\/WNL.49.2.452","journal-title":"Neurology"},{"key":"4327_CR3","doi-asserted-by":"publisher","first-page":"915","DOI":"10.3389\/fonc.2019.00915","volume":"9","author":"A Conti","year":"2019","unstructured":"Conti A, Acker G, Kluge A et al (2019) Decision making in patients with metastatic spine. The role of minimally invasive treatment modalities. Front Oncol 9:915","journal-title":"Front Oncol"},{"key":"4327_CR4","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1215\/S1152851704000262","volume":"7","author":"P Klimo","year":"2005","unstructured":"Klimo P, Thompson CJ, Kestle JRW, Schmidt MH (2005) A meta-analysis of surgery versus conventional radiotherapy for the treatment of metastatic spinal epidural disease. Neuro Oncol 7:64\u201376. https:\/\/doi.org\/10.1215\/S1152851704000262","journal-title":"Neuro Oncol"},{"key":"4327_CR5","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.prro.2016.08.001","volume":"7","author":"S Lutz","year":"2017","unstructured":"Lutz S, Balboni T, Jones J et al (2017) Palliative radiation therapy for bone metastases: update of an ASTRO evidence-based Guideline. Pract Radiat Oncol 7:4\u201312. https:\/\/doi.org\/10.1016\/j.prro.2016.08.001","journal-title":"Pract Radiat Oncol"},{"key":"4327_CR6","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.clon.2011.11.004","volume":"24","author":"E Chow","year":"2012","unstructured":"Chow E, Zeng L, Salvo N et al (2012) Update on the systematic review of Palliative Radiotherapy trials for bone metastases. Clin Oncol 24:112\u2013124. https:\/\/doi.org\/10.1016\/j.clon.2011.11.004","journal-title":"Clin Oncol"},{"key":"4327_CR7","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.radonc.2018.04.030","volume":"128","author":"T Sprave","year":"2018","unstructured":"Sprave T, Verma V, F\u00f6rster R et al (2018) Randomized phase II trial evaluating pain response in patients with spinal metastases following stereotactic body radiotherapy versus three-dimensional conformal radiotherapy. Radiother Oncol J Eur Soc Ther Radiol Oncol 128:274\u2013282. https:\/\/doi.org\/10.1016\/j.radonc.2018.04.030","journal-title":"Radiother Oncol J Eur Soc Ther Radiol Oncol"},{"key":"4327_CR8","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.radonc.2008.05.018","volume":"89","author":"P Foro Arnalot","year":"2008","unstructured":"Foro Arnalot P, Fontanals AV, Galcer\u00e1n JC et al (2008) Randomized clinical trial with two palliative radiotherapy regimens in painful bone metastases: 30 gy in 10 fractions compared with 8 gy in single fraction. Radiother Oncol J Eur Soc Ther Radiol Oncol 89:150\u2013155. https:\/\/doi.org\/10.1016\/j.radonc.2008.05.018","journal-title":"Radiother Oncol J Eur Soc Ther Radiol Oncol"},{"key":"4327_CR9","doi-asserted-by":"publisher","first-page":"295","DOI":"10.3171\/2017.1.SPINE16684","volume":"27","author":"ZA Husain","year":"2017","unstructured":"Husain ZA, Sahgal A, De Salles A et al (2017) Stereotactic body radiotherapy for de novo spinal metastases: systematic review International Stereotactic Radiosurgery Society practice guidelines. J Neurosurg Spine 27:295\u2013302. https:\/\/doi.org\/10.3171\/2017.1.SPINE16684","journal-title":"J Neurosurg Spine"},{"key":"4327_CR10","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.ijrobp.2009.10.056","volume":"79","author":"M Mizumoto","year":"2011","unstructured":"Mizumoto M, Harada H, Asakura H et al (2011) Radiotherapy for patients with metastases to the spinal column: a review of 603 patients at Shizuoka Cancer Center Hospital. Int J Radiat Oncol Biol Phys 79:208\u2013213. https:\/\/doi.org\/10.1016\/j.ijrobp.2009.10.056","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4327_CR11","doi-asserted-by":"publisher","first-page":"TPS10129","DOI":"10.1200\/JCO.2017.35.15_suppl.TPS10129","volume":"35","author":"A Sahgal","year":"2017","unstructured":"Sahgal A, Myrehaug S, Dennis K et al (2017) A randomized phase II\/III study comparing stereotactic body radiotherapy (SBRT) versus conventional palliative radiotherapy (CRT) for patients with spinal metastases (NCT02512965). J Clin Oncol 35:TPS10129. https:\/\/doi.org\/10.1200\/JCO.2017.35.15_suppl.TPS10129","journal-title":"J Clin Oncol"},{"key":"4327_CR12","doi-asserted-by":"publisher","first-page":"3426","DOI":"10.1200\/JCO.2013.50.1411","volume":"31","author":"A Sahgal","year":"2013","unstructured":"Sahgal A, Atenafu EG, Chao S et al (2013) Vertebral compression fracture after spine stereotactic body radiotherapy: a multi-institutional analysis with a focus on radiation dose and the spinal instability neoplastic score. J Clin Oncol 31:3426\u20133431. https:\/\/doi.org\/10.1200\/JCO.2013.50.1411","journal-title":"J Clin Oncol"},{"key":"4327_CR13","doi-asserted-by":"publisher","first-page":"5075","DOI":"10.1200\/JCO.2008.19.3508","volume":"27","author":"PS Rose","year":"2009","unstructured":"Rose PS, Laufer I, Boland PJ et al (2009) Risk of fracture after single fraction image-guided intensity-modulated radiation therapy to spinal metastases. J Clin Oncol 27:5075\u20135079. https:\/\/doi.org\/10.1200\/JCO.2008.19.3508","journal-title":"J Clin Oncol"},{"key":"4327_CR14","doi-asserted-by":"publisher","first-page":"e119","DOI":"10.1016\/j.clon.2017.02.004","volume":"29","author":"JH Chang","year":"2017","unstructured":"Chang JH, Gandhidasan S, Finnigan R et al (2017) Stereotactic ablative body radiotherapy for the treatment of spinal oligometastases. Clin Oncol (R Coll Radiol) 29:e119\u2013e125. https:\/\/doi.org\/10.1016\/j.clon.2017.02.004","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"4327_CR15","doi-asserted-by":"publisher","first-page":"153303381880647","DOI":"10.1177\/1533033818806472","volume":"17","author":"K Ito","year":"2018","unstructured":"Ito K, Ogawa H, Shimizuguchi T et al (2018) Stereotactic body radiotherapy for spinal metastases: clinical experience in 134 cases from a single Japanese Institution. Technol Cancer Res Treat 17:1533033818806472. https:\/\/doi.org\/10.1177\/1533033818806472","journal-title":"Technol Cancer Res Treat"},{"key":"4327_CR16","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1093\/jjco\/hyaa178","volume":"51","author":"K Ito","year":"2021","unstructured":"Ito K, Ogawa H, Nakajima Y (2021) Efficacy and toxicity of re-irradiation spine stereotactic body radiotherapy with respect to irradiation dose history. Jpn J Clin Oncol 51:264\u2013270. https:\/\/doi.org\/10.1093\/jjco\/hyaa178","journal-title":"Jpn J Clin Oncol"},{"key":"4327_CR17","doi-asserted-by":"publisher","first-page":"E1111","DOI":"10.1093\/neuros\/nyz349","volume":"85","author":"M Alghamdi","year":"2019","unstructured":"Alghamdi M, Sahgal A, Soliman H et al (2019) Postoperative stereotactic body radiotherapy for spinal metastases and the impact of Epidural Disease Grade. Neurosurgery 85:E1111\u2013E1118. https:\/\/doi.org\/10.1093\/neuros\/nyz349","journal-title":"Neurosurgery"},{"key":"4327_CR18","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.1080\/0284186X.2018.1503712","volume":"57","author":"H Ogawa","year":"2018","unstructured":"Ogawa H, Ito K, Shimizuguchi T et al (2018) Re-irradiation for painful bone metastases using stereotactic body radiotherapy. Acta Oncol 57:1700\u20131704. https:\/\/doi.org\/10.1080\/0284186X.2018.1503712","journal-title":"Acta Oncol"},{"key":"4327_CR19","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.ijrobp.2014.10.055","volume":"91","author":"H Kim","year":"2015","unstructured":"Kim H, Rajagopalan MS, Beriwal S et al (2015) Cost-effectiveness analysis of single fraction of stereotactic body radiation therapy compared with single fraction of external beam radiation therapy for palliation of vertebral bone metastases. Int J Radiat Oncol Biol Phys 91:556\u2013563","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4327_CR20","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1093\/neuros\/nyaa583","volume":"88","author":"KL Zeng","year":"2021","unstructured":"Zeng KL, Sahgal A, Tseng C-L et al (2021) Prognostic factors Associated with surviving less than 3 months vs greater than 3 years specific to spine stereotactic body radiotherapy and late adverse events. Neurosurgery 88:971\u2013979. https:\/\/doi.org\/10.1093\/neuros\/nyaa583","journal-title":"Neurosurgery"},{"key":"4327_CR21","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1177\/2192568217694016","volume":"7","author":"CL Tseng","year":"2017","unstructured":"Tseng CL, Eppinga W, Charest-Morin R et al (2017) Spine stereotactic body radiotherapy: indications, outcomes, and points of caution. Glob Spine J 7:179\u2013197. https:\/\/doi.org\/10.1177\/2192568217694016","journal-title":"Glob Spine J"},{"key":"4327_CR22","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1097\/PPO.0000000000000205","volume":"22","author":"S Jabbari","year":"2016","unstructured":"Jabbari S, Gerszten PC, Ruschin M et al (2016) Stereotactic body radiotherapy for spinal metastases: practice guidelines, outcomes, and risks. Cancer J 22:280\u2013289. https:\/\/doi.org\/10.1097\/PPO.0000000000000205","journal-title":"Cancer J"},{"key":"4327_CR23","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1634\/theoncologist.2012-0293","volume":"18","author":"I Laufer","year":"2013","unstructured":"Laufer I, Rubin DG, Lis E et al (2013) The NOMS framework: approach to the treatment of spinal metastatic tumors. Oncologist 18:744\u2013751. https:\/\/doi.org\/10.1634\/theoncologist.2012-0293","journal-title":"Oncologist"},{"key":"4327_CR24","doi-asserted-by":"publisher","first-page":"E1221","DOI":"10.1097\/BRS.0b013e3181e16ae2","volume":"35","author":"CG Fisher","year":"2010","unstructured":"Fisher CG, DiPaola CP, Ryken TC et al (2010) A novel classification system for spinal instability in neoplastic disease: an evidence-based approach and expert consensus from the spine oncology Study Group. Spine (Phila Pa 1976) 35:E1221\u2013E1229. https:\/\/doi.org\/10.1097\/BRS.0b013e3181e16ae2","journal-title":"Spine (Phila Pa 1976)"},{"key":"4327_CR25","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.ijrobp.2019.01.072","volume":"104","author":"Z Wardak","year":"2019","unstructured":"Wardak Z, Bland R, Ahn C et al (2019) A phase 2 clinical trial of SABR followed by Immediate Vertebroplasty for Spine Metastases. Int J Radiat Oncol Biol Phys 104:83\u201389. https:\/\/doi.org\/10.1016\/j.ijrobp.2019.01.072","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4327_CR26","doi-asserted-by":"publisher","first-page":"5766","DOI":"10.1158\/1078-0432.CCR-19-0673","volume":"25","author":"C Fisher","year":"2019","unstructured":"Fisher C, Ali Z, Detsky J et al (2019) Photodynamic therapy for the treatment of vertebral metastases: a phase I clinical trial. Clin cancer Res 25:5766\u20135776. https:\/\/doi.org\/10.1158\/1078-0432.CCR-19-0673","journal-title":"Clin cancer Res"},{"key":"4327_CR27","doi-asserted-by":"publisher","first-page":"324","DOI":"10.3171\/2010.3.SPINE09459","volume":"13","author":"MH Bilsky","year":"2010","unstructured":"Bilsky MH, Laufer I, Fourney DR et al (2010) Reliability analysis of the epidural spinal cord compression scale. J Neurosurg Spine 13:324\u2013328. https:\/\/doi.org\/10.3171\/2010.3.SPINE09459","journal-title":"J Neurosurg Spine"},{"key":"4327_CR28","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1016\/j.ijrobp.2016.03.027","volume":"95","author":"KJ Redmond","year":"2016","unstructured":"Redmond KJ, Lo SS, Fisher C, Sahgal A (2016) Postoperative stereotactic body Radiation Therapy (SBRT) for spine metastases: a critical review to Guide Practice. Int J Radiat Oncol Biol Phys 95:1414\u20131428. https:\/\/doi.org\/10.1016\/j.ijrobp.2016.03.027","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4327_CR29","doi-asserted-by":"publisher","first-page":"100320","DOI":"10.1016\/j.jbo.2020.100320","volume":"25","author":"G Di Perna","year":"2020","unstructured":"Di Perna G, Cofano F, Mantovani C et al (2020) Separation surgery for metastatic epidural spinal cord compression: a qualitative review. J Bone Oncol 25:100320. https:\/\/doi.org\/10.1016\/j.jbo.2020.100320","journal-title":"J Bone Oncol"},{"key":"4327_CR30","doi-asserted-by":"publisher","first-page":"119","DOI":"10.4103\/jcvjs.JCVJS_13_17","volume":"8","author":"MK Turel","year":"2017","unstructured":"Turel MK, Kerolus MG, O\u2019Toole JE (2017) Minimally invasive \u201cseparation surgery\u201d plus adjuvant stereotactic radiotherapy in the management of spinal epidural metastases. J Craniovertebral Junction Spine 8:119\u2013126. https:\/\/doi.org\/10.4103\/jcvjs.JCVJS_13_17","journal-title":"J Craniovertebral Junction Spine"},{"key":"4327_CR31","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.phro.2020.09.005","volume":"16","author":"T Furuya","year":"2020","unstructured":"Furuya T, Lee YK, Archibald-Heeren BR et al (2020) Evaluation of multi-institutional end-to-end testing for post-operative spine stereotactic body radiation therapy. Phys Imaging Radiat Oncol 16:61\u201368. https:\/\/doi.org\/10.1016\/j.phro.2020.09.005","journal-title":"Phys Imaging Radiat Oncol"},{"key":"4327_CR32","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.radonc.2019.11.026","volume":"145","author":"EM Dunne","year":"2020","unstructured":"Dunne EM, Sahgal A, Lo SS et al (2020) International consensus recommendations for target volume delineation specific to sacral metastases and spinal stereotactic body radiation therapy (SBRT). Radiother Oncol 145:21\u201329. https:\/\/doi.org\/10.1016\/j.radonc.2019.11.026","journal-title":"Radiother Oncol"},{"key":"4327_CR33","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.ijrobp.2016.09.014","volume":"97","author":"KJ Redmond","year":"2017","unstructured":"Redmond KJ, Robertson S, Lo SS et al (2017) Consensus Contouring Guidelines for postoperative stereotactic body Radiation Therapy for Metastatic Solid Tumor Malignancies to the spine. Int J Radiat Oncol Biol Phys 97:64\u201374. https:\/\/doi.org\/10.1016\/j.ijrobp.2016.09.014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4327_CR34","doi-asserted-by":"publisher","first-page":"e597","DOI":"10.1016\/j.ijrobp.2012.03.009","volume":"83","author":"BW Cox","year":"2012","unstructured":"Cox BW, Spratt DE, Lovelock M et al (2012) International Spine Radiosurgery Consortium consensus guidelines for target volume definition in spinal stereotactic radiosurgery. Int J Radiat Oncol Biol Phys 83:e597\u2013605. https:\/\/doi.org\/10.1016\/j.ijrobp.2012.03.009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4327_CR35","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.radonc.2022.05.035","volume":"173","author":"X Chen","year":"2022","unstructured":"Chen X, LeCompte MC, Gui C et al (2022) Deviation from consensus contouring guidelines predicts inferior local control after spine stereotactic body radiotherapy. Radiother Oncol 173:215\u2013222. https:\/\/doi.org\/10.1016\/j.radonc.2022.05.035","journal-title":"Radiother Oncol"},{"key":"4327_CR36","doi-asserted-by":"publisher","first-page":"153303382090444","DOI":"10.1177\/1533033820904447","volume":"19","author":"A Pontoriero","year":"2020","unstructured":"Pontoriero A, Iat\u00ec G, Cacciola A et al (2020) Stereotactic body Radiation Therapy with Simultaneous Integrated Boost in patients with spinal metastases. Technol Cancer Res Treat 19:1533033820904447. https:\/\/doi.org\/10.1177\/1533033820904447","journal-title":"Technol Cancer Res Treat"},{"key":"4327_CR37","doi-asserted-by":"publisher","first-page":"101047","DOI":"10.1016\/j.adro.2022.101047","volume":"7","author":"JJ Lucido","year":"2022","unstructured":"Lucido JJ, Mullikin TC, Abraha F et al (2022) Single and multifraction spine stereotactic body radiation therapy and the risk of radiation induced myelopathy. Adv Radiat Oncol 7:101047. https:\/\/doi.org\/10.1016\/j.adro.2022.101047","journal-title":"Adv Radiat Oncol"},{"key":"4327_CR38","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1080\/0284186X.2018.1468089","volume":"57","author":"JM van der Velden","year":"2018","unstructured":"van der Velden JM, Hes J, Sahgal A et al (2018) The use of a simultaneous integrated boost in spinal stereotactic body radiotherapy to reduce the risk of vertebral compression fractures: a treatment planning study. Acta Oncol (Madr) 57:1271\u20131274. https:\/\/doi.org\/10.1080\/0284186X.2018.1468089","journal-title":"Acta Oncol (Madr)"},{"key":"4327_CR39","doi-asserted-by":"publisher","first-page":"652","DOI":"10.3171\/2015.6.SPINE15294","volume":"24","author":"MW Chan","year":"2016","unstructured":"Chan MW, Thibault I, Atenafu EG et al (2016) Patterns of epidural progression following postoperative spine stereotactic body radiotherapy: implications for clinical target volume delineation. J Neurosurg Spine 24:652\u2013659. https:\/\/doi.org\/10.3171\/2015.6.SPINE15294","journal-title":"J Neurosurg Spine"},{"key":"4327_CR40","doi-asserted-by":"publisher","first-page":"e65","DOI":"10.1016\/j.prro.2021.10.004","volume":"12","author":"S Faruqi","year":"2022","unstructured":"Faruqi S, Chen H, Fariselli L et al (2022) Stereotactic radiosurgery for postoperative spine malignancy: a systematic review and International Stereotactic Radiosurgery Society Practice Guidelines. Pract Radiat Oncol 12:e65\u2013e78. https:\/\/doi.org\/10.1016\/j.prro.2021.10.004","journal-title":"Pract Radiat Oncol"},{"key":"4327_CR41","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1016\/j.ijrobp.2011.12.039","volume":"84","author":"W Li","year":"2012","unstructured":"Li W, Sahgal A, Foote M et al (2012) Impact of immobilization on intrafraction motion for spine stereotactic body radiotherapy using cone beam computed tomography. Int J Radiat Oncol Biol Phys 84:520\u2013526. https:\/\/doi.org\/10.1016\/j.ijrobp.2011.12.039","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4327_CR42","doi-asserted-by":"publisher","first-page":"e555","DOI":"10.1016\/j.ijrobp.2011.06.1980","volume":"82","author":"D Hyde","year":"2012","unstructured":"Hyde D, Lochray F, Korol R et al (2012) Spine stereotactic body radiotherapy utilizing cone-beam CT image-guidance with a robotic couch: intrafraction motion analysis accounting for all six degrees of freedom. Int J Radiat Oncol Biol Phys 82:e555\u2013e562. https:\/\/doi.org\/10.1016\/j.ijrobp.2011.06.1980","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4327_CR43","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1177\/1533034616681674","volume":"16","author":"JH Chang","year":"2017","unstructured":"Chang JH, Sangha A, Hyde D et al (2017) Positional accuracy of treating multiple Versus single vertebral metastases with stereotactic body radiotherapy. Technol Cancer Res Treat 16:231\u2013237. https:\/\/doi.org\/10.1177\/1533034616681674","journal-title":"Technol Cancer Res Treat"},{"key":"4327_CR44","doi-asserted-by":"publisher","first-page":"e595","DOI":"10.1016\/S1470-2045(15)00166-7","volume":"16","author":"I Thibault","year":"2015","unstructured":"Thibault I, Chang EL, Sheehan J et al (2015) Response assessment after stereotactic body radiotherapy for spinal metastasis: a report from the SPIne response assessment in Neuro-Oncology (SPINO) group. Lancet Oncol 16:e595\u2013603. https:\/\/doi.org\/10.1016\/S1470-2045(15)00166-7","journal-title":"Lancet Oncol"},{"key":"4327_CR45","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.radonc.2020.05.038","volume":"150","author":"R Mir","year":"2020","unstructured":"Mir R, Kelly SM, Xiao Y et al (2020) Organ at risk delineation for radiation therapy clinical trials: global harmonization group consensus guidelines. Radiother Oncol J Eur Soc Ther Radiol Oncol 150:30\u201339. https:\/\/doi.org\/10.1016\/j.radonc.2020.05.038","journal-title":"Radiother Oncol J Eur Soc Ther Radiol Oncol"},{"key":"4327_CR46","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.ijrobp.2021.08.023","volume":"112","author":"EM Dunne","year":"2022","unstructured":"Dunne EM, Lo SS, Liu MC et al (2022) Thecal Sac Contouring as a surrogate for the Cauda Equina and Intracanal spinal nerve roots for spine stereotactic body Radiation Therapy (SBRT): Contour Variability and Recommendations for Safe Practice. Int J Radiat Oncol Biol Phys 112:114\u2013120. https:\/\/doi.org\/10.1016\/j.ijrobp.2021.08.023","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4327_CR47","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1016\/j.ijrobp.2014.12.037","volume":"91","author":"C-L Tseng","year":"2015","unstructured":"Tseng C-L, Sussman MS, Atenafu EG et al (2015) Magnetic resonance imaging assessment of spinal cord and cauda equina motion in supine patients with spinal metastases planned for spine stereotactic body radiation therapy. Int J Radiat Oncol Biol Phys 91:995\u20131002. https:\/\/doi.org\/10.1016\/j.ijrobp.2014.12.037","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4327_CR48","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1093\/neuros\/nyaa202","volume":"87","author":"MA Oztek","year":"2020","unstructured":"Oztek MA, Mayr NA, Mossa-Basha M et al (2020) The dancing cord: inherent spinal cord motion and its effect on cord dose in spine stereotactic body radiation therapy. Neurosurgery 87:1157\u20131166. https:\/\/doi.org\/10.1093\/neuros\/nyaa202","journal-title":"Neurosurgery"},{"key":"4327_CR49","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.ijrobp.2012.05.007","volume":"85","author":"A Sahgal","year":"2013","unstructured":"Sahgal A, Weinberg V, Ma L et al (2013) Probabilities of radiation myelopathy specific to stereotactic body radiation therapy to guide safe practice. Int J Radiat Oncol Biol Phys 85:341\u2013347. https:\/\/doi.org\/10.1016\/j.ijrobp.2012.05.007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4327_CR50","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.ijrobp.2019.09.038","volume":"110","author":"A Sahgal","year":"2021","unstructured":"Sahgal A, Chang JH, Ma L et al (2021) Spinal cord dose tolerance to stereotactic body Radiation Therapy. Int J Radiat Oncol Biol Phys 110:124\u2013136. https:\/\/doi.org\/10.1016\/j.ijrobp.2019.09.038","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4327_CR51","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.ijrobp.2010.08.021","volume":"82","author":"A Sahgal","year":"2012","unstructured":"Sahgal A, Ma L, Weinberg V et al (2012) Reirradiation human spinal cord tolerance for stereotactic body radiotherapy. Int J Radiat Oncol Biol Phys 82:107\u2013116. https:\/\/doi.org\/10.1016\/j.ijrobp.2010.08.021","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4327_CR52","doi-asserted-by":"publisher","first-page":"646","DOI":"10.3171\/2016.4.SPINE151523","volume":"25","author":"A Hashmi","year":"2016","unstructured":"Hashmi A, Guckenberger M, Kersh R et al (2016) Re-irradiation stereotactic body radiotherapy for spinal metastases: a multi-institutional outcome analysis. J Neurosurg Spine 25:646\u2013653. https:\/\/doi.org\/10.3171\/2016.4.SPINE151523","journal-title":"J Neurosurg Spine"},{"key":"4327_CR53","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.jmir.2013.04.002","volume":"44","author":"A Sangha","year":"2013","unstructured":"Sangha A, Korol R, Sahgal A (2013) Stereotactic body radiotherapy for the treatment of spinal metastases: an overview of the University of Toronto, Sunnybrook Health Sciences Odette Cancer Centre, technique. J Med Imaging Radiat Sci 44:126\u2013133. https:\/\/doi.org\/10.1016\/j.jmir.2013.04.002","journal-title":"J Med Imaging Radiat Sci"},{"key":"4327_CR54","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/S1470-2045(21)00196-0","volume":"22","author":"A Sahgal","year":"2021","unstructured":"Sahgal A, Myrehaug SD, Siva S et al (2021) Stereotactic body radiotherapy versus conventional external beam radiotherapy in patients with painful spinal metastases: an open-label, multicentre, randomised, controlled, phase 2\/3 trial. Lancet Oncol 22:1023\u20131033. https:\/\/doi.org\/10.1016\/S1470-2045(21)00196-0","journal-title":"Lancet Oncol"},{"key":"4327_CR55","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2022.05.043","author":"KL Zeng","year":"2022","unstructured":"Zeng KL, Myrehaug S, Soliman H et al (2022) Mature local control and reirradiation rates comparing spine stereotactic body radiotherapy to Conventional Palliative External Beam Radiotherapy. Int J Radiat Oncol Biol Phys. https:\/\/doi.org\/10.1016\/j.ijrobp.2022.05.043","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4327_CR56","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.ijrobp.2018.06.047","volume":"102","author":"CL Tseng","year":"2018","unstructured":"Tseng CL, Soliman H, Myrehaug S et al (2018) Imaging-based outcomes for 24 gy in 2 daily fractions for patients with de Novo spinal metastases treated with spine stereotactic body Radiation Therapy (SBRT). Int J Radiat Oncol Biol Phys 102:499\u2013507. https:\/\/doi.org\/10.1016\/j.ijrobp.2018.06.047","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4327_CR57","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1093\/neuros\/nyaa109","volume":"87","author":"JS Detsky","year":"2020","unstructured":"Detsky JS, Nguyen TK, Lee Y et al (2020) Mature imaging-based outcomes supporting local control for Complex Reirradiation Salvage spine stereotactic body Radiotherapy. Neurosurgery 87:816\u2013822. https:\/\/doi.org\/10.1093\/neuros\/nyaa109","journal-title":"Neurosurgery"},{"key":"4327_CR58","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.ijrobp.2015.03.029","volume":"93","author":"I Thibault","year":"2015","unstructured":"Thibault I, Campbell M, Tseng C-L et al (2015) Salvage stereotactic body Radiotherapy (SBRT) following In-Field failure of initial SBRT for spinal metastases. Int J Radiat Oncol Biol Phys 93:353\u2013360. https:\/\/doi.org\/10.1016\/j.ijrobp.2015.03.029","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4327_CR59","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1093\/neuonc\/not101","volume":"15","author":"A Al-Omair","year":"2013","unstructured":"Al-Omair A, Masucci L, Masson-Cote L et al (2013) Surgical resection of epidural disease improves local control following postoperative spine stereotactic body radiotherapy. Neuro Oncol 15:1413\u20131419. https:\/\/doi.org\/10.1093\/neuonc\/not101","journal-title":"Neuro Oncol"},{"key":"4327_CR60","doi-asserted-by":"publisher","first-page":"332","DOI":"10.3171\/2018.1.SPINE171155","volume":"29","author":"K Ito","year":"2018","unstructured":"Ito K, Nihei K, Shimizuguchi T et al (2018) Postoperative re-irradiation using stereotactic body radiotherapy for metastatic epidural spinal cord compression. J Neurosurg Spine 29:332\u2013338. https:\/\/doi.org\/10.3171\/2018.1.SPINE171155","journal-title":"J Neurosurg Spine"},{"key":"4327_CR61","first-page":"99","volume":"5","author":"EH Balagamwala","year":"2018","unstructured":"Balagamwala EH, Naik M, Reddy CA et al (2018) Pain flare after stereotactic radiosurgery for spine metastases. J Radiosurg SBRT 5:99\u2013105","journal-title":"J Radiosurg SBRT"},{"key":"4327_CR62","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1016\/j.ijrobp.2014.07.037","volume":"90","author":"HY Pan","year":"2014","unstructured":"Pan HY, Allen PK, Wang XS et al (2014) Incidence and predictive factors of pain flare after spine stereotactic body radiation therapy: secondary analysis of phase 1\/2 trials. Int J Radiat Oncol Biol Phys 90:870\u2013876. https:\/\/doi.org\/10.1016\/j.ijrobp.2014.07.037","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4327_CR63","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1016\/j.ijrobp.2013.03.022","volume":"86","author":"A Chiang","year":"2013","unstructured":"Chiang A, Zeng L, Zhang L et al (2013) Pain flare is a common adverse event in steroid-na\u00efve patients after spine stereotactic body radiation therapy: a prospective clinical trial. Int J Radiat Oncol Biol Phys 86:638\u2013642. https:\/\/doi.org\/10.1016\/j.ijrobp.2013.03.022","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4327_CR64","doi-asserted-by":"publisher","first-page":"2937","DOI":"10.1007\/s00520-015-2659-z","volume":"23","author":"L Khan","year":"2015","unstructured":"Khan L, Chiang A, Zhang L et al (2015) Prophylactic dexamethasone effectively reduces the incidence of pain flare following spine stereotactic body radiotherapy (SBRT): a prospective observational study. Support Care Cancer 23:2937\u20132943. https:\/\/doi.org\/10.1007\/s00520-015-2659-z","journal-title":"Support Care Cancer"},{"key":"4327_CR65","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1093\/neuros\/nyx493","volume":"83","author":"S Faruqi","year":"2018","unstructured":"Faruqi S, Tseng CL, Whyne C et al (2018) Vertebral compression fracture after spine stereotactic body radiation therapy: a review of the pathophysiology and risk factors. Clin Neurosurg 83:314\u2013322. https:\/\/doi.org\/10.1093\/neuros\/nyx493","journal-title":"Clin Neurosurg"},{"key":"4327_CR66","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1016\/j.clon.2020.10.001","volume":"32","author":"MC Tjong","year":"2020","unstructured":"Tjong MC, Moraes FY, Yamada Y et al (2020) Radiation-induced lumbosacral plexopathy after spine stereotactic body radiotherapy 2013; should the lumbosacral plexi be contoured? Clin Oncol 32:884\u2013886. https:\/\/doi.org\/10.1016\/j.clon.2020.10.001","journal-title":"Clin Oncol"},{"key":"4327_CR67","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.clon.2006.03.004","volume":"18","author":"M Dahele","year":"2006","unstructured":"Dahele M, Davey P, Reingold S, Shun Wong C (2006) Radiation-induced lumbo-sacral plexopathy (RILSP): an important enigma. Clin Oncol (R Coll Radiol) 18:427\u2013428","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"4327_CR68","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2022.11.012","author":"MT Milano","year":"2023","unstructured":"Milano MT, Doucette C, Mavroidis P et al (2023) Hypofractionated stereotactic radiation therapy dosimetric tolerances for the inferior aspect of the Brachial Plexus: a systematic review. Int J Radiat Oncol Biol Phys. https:\/\/doi.org\/10.1016\/j.ijrobp.2022.11.012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4327_CR69","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1080\/0284186X.2019.1601255","volume":"58","author":"K Lindberg","year":"2019","unstructured":"Lindberg K, Grozman V, Lindberg S et al (2019) Radiation-induced brachial plexus toxicity after SBRT of apically located lung lesions. Acta Oncol (Madr) 58:1178\u20131186. https:\/\/doi.org\/10.1080\/0284186X.2019.1601255","journal-title":"Acta Oncol (Madr)"},{"key":"4327_CR70","doi-asserted-by":"publisher","first-page":"197","DOI":"10.3171\/2012.8.gks12981","volume":"117 Suppl","author":"PC Gerszten","year":"2012","unstructured":"Gerszten PC, Chen S, Quader M et al (2012) Radiosurgery for benign tumors of the spine using the synergy S with cone-beam computed tomography image guidance. J Neurosurg 117 Suppl:197\u2013202. https:\/\/doi.org\/10.3171\/2012.8.gks12981","journal-title":"J Neurosurg"},{"key":"4327_CR71","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1016\/j.ijrobp.2017.05.053","volume":"99","author":"E Katsoulakis","year":"2017","unstructured":"Katsoulakis E, Jackson A, Cox B et al (2017) A detailed dosimetric analysis of spinal cord tolerance in high-dose spine radiosurgery. Int J Radiat Oncol 99:598\u2013607. https:\/\/doi.org\/10.1016\/j.ijrobp.2017.05.053","journal-title":"Int J Radiat Oncol"},{"key":"4327_CR72","doi-asserted-by":"publisher","first-page":"151","DOI":"10.3171\/SPI-07\/08\/151","volume":"7","author":"EL Chang","year":"2007","unstructured":"Chang EL, Shiu AS, Mendel E et al (2007) Phase I\/II study of stereotactic body radiotherapy for spinal metastasis and its pattern of failure. J Neurosurg Spine 7:151\u2013160. https:\/\/doi.org\/10.3171\/SPI-07\/08\/151","journal-title":"J Neurosurg Spine"},{"key":"4327_CR73","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.jocn.2017.08.007","volume":"46","author":"S McClelland III","year":"2017","unstructured":"McClelland S III, Kim E, Passias PG et al (2017) Spinal stereotactic body radiotherapy in the United States: a decade-long nationwide analysis of patient demographics, practice patterns, and trends over time. J Clin Neurosci 46:109\u2013112. https:\/\/doi.org\/10.1016\/j.jocn.2017.08.007","journal-title":"J Clin Neurosci"},{"key":"4327_CR74","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1016\/j.ijrobp.2013.12.042","volume":"88","author":"MR Folkert","year":"2014","unstructured":"Folkert MR, Bilsky MH, Tom AK et al (2014) Outcomes and toxicity for hypofractionated and single-fraction image-guided stereotactic radiosurgery for sarcomas metastasizing to the spine. Int J Radiat Oncol Biol Phys 88:1085\u20131091. https:\/\/doi.org\/10.1016\/j.ijrobp.2013.12.042","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4327_CR75","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1016\/j.ijrobp.2021.01.004","volume":"110","author":"MJ Zelefsky","year":"2021","unstructured":"Zelefsky MJ, Yamada Y, Greco C et al (2021) Phase 3 multi-center, prospective, randomized trial comparing single-dose 24 gy radiation therapy to a 3-fraction SBRT regimen in the treatment of oligometastatic cancer. Int J Radiat Oncol Biol Phys 110:672\u2013679. https:\/\/doi.org\/10.1016\/j.ijrobp.2021.01.004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4327_CR76","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2022.09.076","author":"KL Zeng","year":"2022","unstructured":"Zeng KL, Abugarib A, Soliman H et al (2022) Dose-escalated two-fraction spine stereotactic body radiotherapy: 28 gy vs. 24 gy in 2 daily fractions. Int J Radiat Oncol Biol Phys. https:\/\/doi.org\/10.1016\/j.ijrobp.2022.09.076","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4327_CR77","doi-asserted-by":"publisher","unstructured":"Zeng KL, Myrehaug S, Soliman H et al (2019) Stereotactic body radiotherapy for spinal metastases at the extreme ends of the spine: imaging-based outcomes for cervical and sacral metastases. Neurosurgery 85:605\u2013612. https:\/\/doi.org\/10.1093\/neuros\/nyy393","DOI":"10.1093\/neuros\/nyy393"},{"key":"4327_CR78","doi-asserted-by":"publisher","unstructured":"Finnigan R, Burmeister B, Barry T et al (2015) Technique and early clinical outcomes for spinal and paraspinal tumours treated with stereotactic body radiotherapy. J Clin Neurosci Off J Neurosurg Soc Australas 22:1258\u20131263. https:\/\/doi.org\/10.1016\/j.jocn.2015.01.030","DOI":"10.1016\/j.jocn.2015.01.030"},{"key":"4327_CR79","doi-asserted-by":"publisher","unstructured":"Thibault I, Al-Omair A, Masucci GL et al (2014) Spine stereotactic body radiotherapy for renal cell cancer spinal metastases: analysis of outcomes and risk of vertebral compression fracture. J Neurosurg Spine 21:711\u2013718. https:\/\/doi.org\/10.3171\/2014.7.SPINE13895","DOI":"10.3171\/2014.7.SPINE13895"}],"container-title":["Journal of Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-023-04327-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11060-023-04327-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-023-04327-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T05:12:46Z","timestamp":1685509966000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11060-023-04327-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":79,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["4327"],"URL":"https:\/\/doi.org\/10.1007\/s11060-023-04327-1","relation":{},"ISSN":["0167-594X","1573-7373"],"issn-type":[{"value":"0167-594X","type":"print"},{"value":"1573-7373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"29 March 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"MR owns intellectual property related to the image-guidance component on the Elekta Gamma Knife system. HS has travel and education grants from Elekta. SM has research support and honoraria from AAA\/Novartis and Ipsen. AS is an advisor\/consultant with Abbvie, Merck, Roche, Varian, Elekta, BrainLAB and VieCure, is a board member of the International Stereotactic Radiosurgery Society, has had past educational seminars with Elekta, Accuray Inc., Varian, BrainLAB, Medtronic Kyphon, received research grants with Elekta and Travel accommodations\/expenses by Elekta, Varian, BrainLAB and belongs to the Elekta MR Linac Research Consortium, Elekta Spine, Oligometastases and Linac Based SRS Consortia. CLT is an advisor\/consultant with Abbvie and Sanofi, has received travel accommodations\/expenses & honoraria for past educational seminars by Elekta and belongs to the Elekta MR-Linac Research Consortium.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This is a review article and no ethical approval is required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}