{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T04:02:14Z","timestamp":1787630534124,"version":"build-2736575974"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["H2020206126"],"award-info":[{"award-number":["H2020206126"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurooncol"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Leptomeningeal carcinomatosis (LC) is a rare complication of non-small cell lung cancer (NSCLC) with highly mortality. Cerebrospinal fluid (CSF) as a special kind of tumor microenvironment (TME) better represents alterations than plasma. However, the clinical value of protein profiles of exosome in CSF as liquid biopsy remains unclear.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In this study, CSF samples of NSCLC patients with (LC group) or without (NSCLC group) LC were collected and compared to patients without tumors (normal group). CSF exosomes were isolated by ultracentrifugation and protein profiles were performed by label-free proteomics. Differentially expressed proteins (DEPs) were detected by bioinformatics tools and verified by parallel reaction monitoring (PRM).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 814 proteins were detected. Bioinformatics analysis revealed their shared function in the complement activation, extracellular region, and complement and coagulation cascades. Between LC and NSCLC group, 72 DEPs were found among which FN1 demonstrated the highest betweenness centrality (BC) after protein-protein interaction network analysis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>We investigated the application of label free and PRM based proteomics to detect key proteins related to LC. FN1 may serve as potential indicator to classify LC and NSCLC. Extracellular matrix (ECM) and epithelial-mesenchymal transition (EMT) are important in the process of LC. These data is promising for early prediction and diagnosis of LC.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11060-023-04428-x","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T11:04:26Z","timestamp":1693566266000},"page":"367-376","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Cerebrospinal fluid exosomal protein alterations via proteomic analysis of NSCLC with leptomeningeal carcinomatosis"],"prefix":"10.1007","volume":"164","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6148-8180","authenticated-orcid":false,"given":"Lan","family":"Hou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejiao","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueli","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junying","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6539-6219","authenticated-orcid":false,"given":"Hui","family":"Bu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,1]]},"reference":[{"key":"4428_CR1","doi-asserted-by":"publisher","first-page":"e43","DOI":"10.1016\/S1470-2045(17)30689-7","volume":"19","author":"H Cheng","year":"2018","unstructured":"Cheng H, Perez-Soler R (2018) Leptomeningeal metastases in non-small-cell lung cancer. Lancet Oncol 19:e43\u201355. https:\/\/doi.org\/10.1016\/S1470-2045(17)30689-7","journal-title":"Lancet Oncol"},{"key":"4428_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.lungcan.2022.09.013","volume":"74","author":"Y Wang","year":"2022","unstructured":"Wang Y, Yang X, Li NJ et al (2022) Leptomeningeal metastases in non-small cell lung cancer: diagnosis and treatment. Lung Cancer 74:1\u201313. https:\/\/doi.org\/10.1016\/j.lungcan.2022.09.013","journal-title":"Lung Cancer"},{"key":"4428_CR3","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.ctrv.2016.12.006","volume":"53","author":"J Remon","year":"2017","unstructured":"Remon J, Le Rhun E, Besse B (2017) Leptomeningeal carcinomatosis in non-small cell lung cancer patients: a continuing challenge in the personalized treatment era. Cancer Treat Rev 53:128\u2013137. https:\/\/doi.org\/10.1016\/j.ctrv.2016.12.006","journal-title":"Cancer Treat Rev"},{"key":"4428_CR4","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1016\/j.cell.2017.02.025","volume":"168","author":"A Boire","year":"2017","unstructured":"Boire A, Zou Y, Shieh J et al (2017) Complement component 3 adapts the Cerebrospinal Fluid for Leptomeningeal Metastasis. Cell 168:1101\u20131113e13. https:\/\/doi.org\/10.1016\/j.cell.2017.02.025","journal-title":"Cell"},{"key":"4428_CR5","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1126\/science.aaz2193","volume":"369","author":"Y Chi","year":"2020","unstructured":"Chi Y, Remsik J, Kiseliovas V et al (2020) Cancer cells deploy lipocalin-2 to collect limiting iron in leptomeningeal metastasis. Science 369:276\u2013282. https:\/\/doi.org\/10.1126\/science.aaz2193","journal-title":"Science"},{"key":"4428_CR6","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.3390\/cancers12092401","volume":"12","author":"G Tzanakakis","year":"2020","unstructured":"Tzanakakis G, Giatagana EM, Kuskov A et al (2020) Proteoglycans in the pathogenesis of hormone-dependent cancers: mediators and effectors. Cancers (Basel) 12:2401. https:\/\/doi.org\/10.3390\/cancers12092401","journal-title":"Cancers (Basel)"},{"key":"4428_CR7","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/j.nec.2020.06.011","volume":"31","author":"N Giridharan","year":"2020","unstructured":"Giridharan N, Glitza Oliva IC, O\u2019Brien BJ et al (2020) Targeting the Tumor Microenvironment in Brain Metastasis. Neurosurg Clin N Am 31:641\u2013649. https:\/\/doi.org\/10.1016\/j.nec.2020.06.011","journal-title":"Neurosurg Clin N Am"},{"key":"4428_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12967-019-02189-8","volume":"18","author":"B Cacho-D\u00edaz","year":"2020","unstructured":"Cacho-D\u00edaz B, Garc\u00eda-Botello DR, Wegman-Ostrosky T et al (2020) Tumor microenvironment differences between primary tumor and brain metastases. J Transl Med 18:1. https:\/\/doi.org\/10.1186\/s12967-019-02189-8","journal-title":"J Transl Med"},{"key":"4428_CR9","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1146\/annurev-biochem-013118-111902","volume":"88","author":"DM Pegtel","year":"2019","unstructured":"Pegtel DM, Gould SJ (2019) Exosomes. Annu Rev Biochem 88:487\u2013514. https:\/\/doi.org\/10.1146\/annurev-biochem-013118-111902","journal-title":"Annu Rev Biochem"},{"key":"4428_CR10","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1586\/epr.09.17","volume":"6","author":"RJ Simpson","year":"2009","unstructured":"Simpson RJ, Lim JW, Moritz RL et al (2009) Exosomes: proteomic insights and diagnostic potential. Expert Rev Proteomics 6:267\u2013283. https:\/\/doi.org\/10.1586\/epr.09.17","journal-title":"Expert Rev Proteomics"},{"key":"4428_CR11","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/nature15756","volume":"527","author":"A Hoshino","year":"2015","unstructured":"Hoshino A, Costa-Silva B, Shen TL et al (2015) Tumour exosome integrins determine organotropic metastasis. Nature 527:329\u2013335. https:\/\/doi.org\/10.1038\/nature15756","journal-title":"Nature"},{"key":"4428_CR12","doi-asserted-by":"publisher","first-page":"6716","DOI":"10.1038\/ncomms7716","volume":"6","author":"N Tominaga","year":"2015","unstructured":"Tominaga N, Kosaka N, Ono M et al (2015) Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood-brain barrier. Nat Commun 6:6716. https:\/\/doi.org\/10.1038\/ncomms7716","journal-title":"Nat Commun"},{"key":"4428_CR13","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/S1474-4422(06)70443-4","volume":"5","author":"B Gleissner","year":"2006","unstructured":"Gleissner B, Chamberlain MC (2006) Neoplastic meningitis. Lancet Neurol 5:443\u2013452. https:\/\/doi.org\/10.1016\/S1474-4422(06)70443-4","journal-title":"Lancet Neurol"},{"key":"4428_CR14","first-page":"433","volume":"45","author":"AP Sempere","year":"2007","unstructured":"Sempere AP, Berenguer-Ruiz L, Lezcano-Rodas M et al (2007) Lumbar puncture: its indications, contraindications, complications and technique. Rev Neurol 45:433\u2013436","journal-title":"Rev Neurol"},{"key":"4428_CR15","doi-asserted-by":"publisher","unstructured":"Th\u00e9ry C, Amigorena S, Raposo G et al (2006) Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr Protoc Cell Biol Chapter 3. https:\/\/doi.org\/10.1002\/0471143030.cb0322s30. Unit 3.22","DOI":"10.1002\/0471143030.cb0322s30"},{"key":"4428_CR16","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1093\/jjco\/hyab155","volume":"51","author":"L Hou","year":"2021","unstructured":"Hou L, Han W, Jin J et al (2021) Clinical efficacy and safety of different doses of intrathecal methotrexate in the treatment of leptomeningeal carcinomatosis: a prospective and single-arm study. Jpn J Clin Oncol 51:1715\u20131722. https:\/\/doi.org\/10.1093\/jjco\/hyab155","journal-title":"Jpn J Clin Oncol"},{"key":"4428_CR17","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.jtho.2019.12.113","volume":"15","author":"MJ Ahn","year":"2020","unstructured":"Ahn MJ, Chiu CH, Cheng Y et al (2020) Osimertinib for patients with leptomeningeal metastases associated with EGFR T790M positive advanced NSCLC: the AURA leptomeningeal metastases analysis. J Thorac Oncol 15:637\u2013648. https:\/\/doi.org\/10.1016\/j.jtho.2019.12.113","journal-title":"J Thorac Oncol"},{"key":"4428_CR18","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1200\/JCO.19.00457","volume":"38","author":"JCH Yang","year":"2020","unstructured":"Yang JCH, Kim SW, Kim DW et al (2020) Osimertinib in patients with epidermal growth factor receptor mutation-positive non-small-cell lung cancer and leptomeningeal metastases: the BLOOM study. J Clin Oncol 38:538\u2013547. https:\/\/doi.org\/10.1200\/JCO.19.00457","journal-title":"J Clin Oncol"},{"key":"4428_CR19","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1016\/j.annonc.2020.06.017","volume":"31","author":"S Park","year":"2020","unstructured":"Park S, Lee MH, Seong M et al (2020) A phase II, multicenter, two cohort study of 160\u00a0mg osimertinib in EGFR T790M-positive non-small-cell lung cancer patients with brain metastases or leptomeningeal disease who progressed on prior EGFR TKI therapy. Ann Oncol 31:1397\u20131404. https:\/\/doi.org\/10.1016\/j.annonc.2020.06.017","journal-title":"Ann Oncol"},{"key":"4428_CR20","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/bjc.2017.394","volume":"118","author":"S Nanjo","year":"2018","unstructured":"Nanjo S, Hata A, Okuda C et al (2018) Standard-dose osimertinib for refractory leptomeningeal metastases in T790M-positive EGFR mutant non-small cell lung cancer. Br J Cancer 118:32\u201337. https:\/\/doi.org\/10.1038\/bjc.2017.394","journal-title":"Br J Cancer"},{"key":"4428_CR21","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.annonc.2021.01.074","volume":"32","author":"W Yu","year":"2021","unstructured":"Yu W, Hurley J, Roberts D et al (2021) Exosome-based liquid biopsies in cancer: opportunities and challenges. Ann Oncol 32:466\u2013477. https:\/\/doi.org\/10.1016\/j.annonc.2021.01.074","journal-title":"Ann Oncol"},{"key":"4428_CR22","doi-asserted-by":"crossref","unstructured":"De Leticia R, Mayor CKY, Ng Analysis of cell-free tumor DNA in cerebrospinal fluid to characterize and monitor the genetic alterations of brain tumors. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015;, Philadelphia PA et al (2015) Philadelphia (PA): AACR; Cancer Res 75(15 Suppl):Abstract nr 930","DOI":"10.1158\/1538-7445.AM2015-930"},{"key":"4428_CR23","doi-asserted-by":"publisher","first-page":"e12374","DOI":"10.1016\/j.heliyon.2022.e12374","volume":"8","author":"H Yang","year":"2022","unstructured":"Yang H, Wen L, Zhao C et al (2022) Cerebrospinal fluid-derived circulating tumor DNA is more comprehensive than plasma in NSCLC patients with leptomeningeal metastases regardless of extracranial evolution. Heliyon 8:e12374. https:\/\/doi.org\/10.1016\/j.heliyon.2022.e12374","journal-title":"Heliyon"},{"key":"4428_CR24","doi-asserted-by":"publisher","unstructured":"Li H, Xia M, Zheng S et al (2023) Cerebrospinal fluid exosomal microRNAs as biomarkers for diagnosing or monitoring the progression of non-small cell lung cancer with leptomeningeal metastases. Biotechnol Genet Eng Rev 1\u201322. https:\/\/doi.org\/10.1080\/02648725.2023.2183613","DOI":"10.1080\/02648725.2023.2183613"},{"key":"4428_CR25","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.pneurobio.2019.01.005","volume":"175","author":"M Shi","year":"2019","unstructured":"Shi M, Sheng L, Stewart T et al (2019) New windows into the brain: Central nervous system-derived extracellular vesicles in blood. Prog Neurobiol 175:96\u2013106. https:\/\/doi.org\/10.1016\/j.pneurobio.2019.01.005","journal-title":"Prog Neurobiol"},{"key":"4428_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/bs.acc.2020.06.006","volume":"101","author":"J M\u00fcller Bark","year":"2020","unstructured":"M\u00fcller Bark J, Kulasinghe A, Amen\u00e1bar JM et al (2020) Exosomes in cancer. Adv Clin Chem 101:1\u201340. https:\/\/doi.org\/10.1016\/bs.acc.2020.06.006","journal-title":"Adv Clin Chem"},{"key":"4428_CR27","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.cca.2016.09.001","volume":"462","author":"J Lee","year":"2016","unstructured":"Lee J, McKinney KQ, Pavlopoulos AJ et al (2016) Exosomal proteome analysis of cerebrospinal fluid detects biosignatures of neuromyelitis optica and multiple sclerosis. Clin Chim Acta 462:118\u2013126. https:\/\/doi.org\/10.1016\/j.cca.2016.09.001","journal-title":"Clin Chim Acta"},{"key":"4428_CR28","first-page":"903","volume":"27","author":"V Falsetta","year":"2023","unstructured":"Falsetta V (2023) Proteomic analysis of cerebrospinal fluid exosomes derived from cerebral palsy children. Chin J Tissue Eng Res 27:903\u2013908","journal-title":"Chin J Tissue Eng Res"},{"key":"4428_CR29","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1038\/nature11217","volume":"487","author":"M Yu","year":"2012","unstructured":"Yu M, Ting DT, Stott SL et al (2012) RNA sequencing of pancreatic circulating tumor cells implicates WNT signalling in metastasis. Nature 487:510\u2013513. https:\/\/doi.org\/10.1038\/nature11217","journal-title":"Nature"},{"key":"4428_CR30","doi-asserted-by":"publisher","first-page":"45702","DOI":"10.18632\/oncotarget.10157","volume":"7","author":"C Zhang","year":"2016","unstructured":"Zhang C, Wu M, Zhang L et al (2016) Fibrotic microenvironment promotes the metastatic seeding of tumor cells via activating the fibronectin 1\/secreted phosphoprotein 1-integrin signaling. Oncotarget 7:45702\u201345714. https:\/\/doi.org\/10.18632\/oncotarget.10157","journal-title":"Oncotarget"},{"key":"4428_CR31","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.bbrc.2016.05.081","volume":"476","author":"W Gao","year":"2016","unstructured":"Gao W, Liu Y, Qin R et al (2016) Silence of fibronectin 1 increases cisplatin sensitivity of non-small cell lung cancer cell line. Biochem Biophys Res Commun 476:35\u201341. https:\/\/doi.org\/10.1016\/j.bbrc.2016.05.081","journal-title":"Biochem Biophys Res Commun"},{"key":"4428_CR32","doi-asserted-by":"publisher","first-page":"331","DOI":"10.17305\/bjbms.2020.5066","volume":"21","author":"X Feng","year":"2021","unstructured":"Feng X, Xu ES (2021) Alectinib and lorlatinib function by modulating EMT-related proteins and MMPs in NSCLC metastasis. Bosn J Basic Med Sci 21:331\u2013338. https:\/\/doi.org\/10.17305\/bjbms.2020.5066","journal-title":"Bosn J Basic Med Sci"},{"key":"4428_CR33","doi-asserted-by":"publisher","first-page":"28","DOI":"10.4103\/0973-1482.157337","volume":"12","author":"C Kapoor","year":"2016","unstructured":"Kapoor C, Vaidya S, Wadhwan V et al (2016) Seesaw of matrix metalloproteinases (MMPs). J Cancer Res Ther 12:28\u201335. https:\/\/doi.org\/10.4103\/0973-1482.157337","journal-title":"J Cancer Res Ther"},{"key":"4428_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12195-015-0417-4","volume":"9","author":"K Wang","year":"2016","unstructured":"Wang K, Seo BR, Fischbach C et al (2016) Fibronectin mechanobiology regulates tumorigenesis. Cell Mol Bioeng 9:1\u201311. https:\/\/doi.org\/10.1007\/s12195-015-0417-4","journal-title":"Cell Mol Bioeng"},{"key":"4428_CR35","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1111\/j.1699-0463.1999.tb01533.x","volume":"107","author":"P Henriet","year":"1999","unstructured":"Henriet P, Blavier L, Declerck YA (1999) Tissue inhibitors of metalloproteinases (TIMP) in invasion and proliferation. APMIS 107:111\u2013119. https:\/\/doi.org\/10.1111\/j.1699-0463.1999.tb01533.x","journal-title":"APMIS"},{"key":"4428_CR36","doi-asserted-by":"publisher","first-page":"e00360","DOI":"10.1042\/BSR20160107","volume":"36","author":"S Robert","year":"2016","unstructured":"Robert S, Gicquel T, Victoni T et al (2016) Involvement of matrix metalloproteinases (MMPs) and inflammasome pathway in molecular mechanisms of fibrosis. Biosci Rep 36:e00360. https:\/\/doi.org\/10.1042\/BSR20160107","journal-title":"Biosci Rep"},{"key":"4428_CR37","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1002\/(sici)1097-0215(19970807)72:4<556::aid-ijc2<3.0.co;2-p","volume":"72","author":"B Nawrocki","year":"1997","unstructured":"Nawrocki B, Polette M, Marchand V et al (1997) Expression of matrix metalloproteinases and their inhibitors in human bronchopulmonary carcinomas: quantificative and morphological analyses. Int J Cancer 72:556\u2013564. https:\/\/doi.org\/10.1002\/(sici)1097-0215(19970807)72:4<556::aid-ijc2<3.0.co;2-p","journal-title":"Int J Cancer"},{"key":"4428_CR38","doi-asserted-by":"publisher","first-page":"3221","DOI":"10.1080\/21655979.2021.2020391","volume":"13","author":"P Zeng","year":"2022","unstructured":"Zeng P, Zhang X, Xiang T et al (2022) Secreted phosphoprotein 1 as a potential prognostic and immunotherapy biomarker in multiple human cancers. Bioengineered 13:3221\u20133239. https:\/\/doi.org\/10.1080\/21655979.2021.2020391","journal-title":"Bioengineered"},{"key":"4428_CR39","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1186\/s12935-022-02749-x","volume":"22","author":"X Yi","year":"2022","unstructured":"Yi X, Luo L, Zhu Y et al (2022) SPP1 facilitates cell migration and invasion by targeting COL11A1 in lung adenocarcinoma. Cancer Cell Int 22:324. https:\/\/doi.org\/10.1186\/s12935-022-02749-x","journal-title":"Cancer Cell Int"}],"container-title":["Journal of Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-023-04428-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11060-023-04428-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-023-04428-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T16:10:56Z","timestamp":1695744656000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11060-023-04428-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["4428"],"URL":"https:\/\/doi.org\/10.1007\/s11060-023-04428-x","relation":{},"ISSN":["0167-594X","1573-7373"],"issn-type":[{"value":"0167-594X","type":"print"},{"value":"1573-7373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"18 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 August 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Approval of the research protocol by an Institutional Reviewer Board: Approval was granted by the Ethics Committee of Clinical Research of the Second Hospital of Hebei Medical University (2021-R001).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained in each patient.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}