{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T07:14:57Z","timestamp":1793344497843,"version":"4.5.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T00:00:00Z","timestamp":1705881600000},"content-version":"vor","delay-in-days":21,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"German Children\u2019s Cancer Foundation"},{"name":"Universit\u00e4tsklinikum Hamburg-Eppendorf (UKE)"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurooncol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>To provide a treatment-focused review and develop basic treatment guidelines for patients diagnosed with pineal anlage tumor (PAT).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Prospectively collected data of three patients with pineal anlage tumor from Germany was combined with clinical details and treatment information from 17 published cases.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Overall, 20 cases of PAT were identified (3 not previously reported German cases, 17 cases from published reports). Age at diagnosis ranged from 0.3 to 35.0 (median: 3.2\u2009\u00b1\u20097.8) years. All but three cases were diagnosed before the age of three years. For three cases, metastatic disease at initial staging was described. All patients underwent tumor surgery (gross-total resection: 9, subtotal resection\/biopsy: 9, extent of resection unknown: 2). 15\/20 patients were alive at last follow-up. Median follow-up for 10\/15 surviving patients with available follow-up and treatment data was 2.4\u00a0years (0.3\u20136.5). Relapse was reported for 3 patients within 0.8\u00a0years after diagnosis. Five patients died, 3 after relapse and 2 from early postoperative complications. Two-year-progression-free- and -overall survival were 65.2\u2009\u00b1\u200912.7% and 49.2\u2009\u00b1\u200918.2%, respectively. All 4 patients who received intensive chemotherapy including high-dose chemotherapy combined with radiotherapy (2 focal, 2 craniospinal [CSI]) had no recurrence. Focal radiotherapy- and CSI-free survival rates in 13 evaluable patients were 46.2% (6\/13) and 61.5% (8\/13), respectively.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>PAT is an aggressive disease mostly affecting young children. Therefore, adjuvant therapy using intensive chemotherapy and considering radiotherapy appears to comprise an appropriate treatment strategy. Reporting further cases is crucial to evaluate distinct treatment strategies.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11060-023-04547-5","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T18:03:02Z","timestamp":1705946582000},"page":"359-368","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pineal anlage tumor: clinical and diagnostic features, and rationales for treatment"],"prefix":"10.1007","volume":"166","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3216-8452","authenticated-orcid":false,"given":"Denise","family":"Obrecht-Sturm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Pfaff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Mynarek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Bison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Rodeh\u00fcser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Kietz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan M.","family":"Pfister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Sturm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"von Deimling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Sahm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf-Dieter","family":"Kortmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Pietsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gudrun","family":"Fleischhack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Rutkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,22]]},"reference":[{"key":"4547_CR1","first-page":"7","volume":"8","author":"M Schmidbauer","year":"1989","unstructured":"Schmidbauer M, Budka H, Pilz P (1989) Neuroepithelial and ectomesenchymal differentiation in a primitive pineal tumor (\u201cpineal anlage tumor\u201d). Clin Neuropathol 8:7\u201310","journal-title":"Clin Neuropathol"},{"key":"4547_CR2","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","volume":"23","author":"DN Louis","year":"2021","unstructured":"Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, Hawkins C, Ng HK, Pfister SM, Reifenberger G, Soffietti R, von Deimling A, Ellison DW (2021) The 2021 WHO classification of tumors of the central nervous system: a summary. Neuro Oncol 23:1231\u20131251. https:\/\/doi.org\/10.1093\/neuonc\/noab106","journal-title":"Neuro Oncol"},{"key":"4547_CR3","unstructured":"(2021) Classification of Tumours Editorial Board, WHO Classification of Tumours: Central Nervous System Tumours, 5th edn."},{"key":"4547_CR4","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1111\/j.1750-3639.2007.00084.x","volume":"17","author":"GN Fuller","year":"2007","unstructured":"Fuller GN, Scheithauer BW (2007) The 2007 revised World Health Organization (WHO) classification of tumours of the central nervous system: newly codified entities. Brain Pathol 17:304\u2013307. https:\/\/doi.org\/10.1111\/j.1750-3639.2007.00084.x","journal-title":"Brain Pathol"},{"issue":"4","key":"4547_CR5","first-page":"1035","volume":"2","author":"OPA Ajayi","year":"2014","unstructured":"Ajayi OPA, Sadanand V, Deisch J (2014) Pineal anlage tumor: case report and review of literature. JSM Neurosurg Spine 2(4):1035","journal-title":"JSM Neurosurg Spine"},{"key":"4547_CR6","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s00401-007-0243-4","volume":"114","author":"DN Louis","year":"2007","unstructured":"Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW, Kleihues P (2007) The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 114:97\u2013109. https:\/\/doi.org\/10.1007\/s00401-007-0243-4","journal-title":"Acta Neuropathol"},{"key":"4547_CR7","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1111\/j.1750-3639.2000.tb00242.x","volume":"10","author":"A Jouvet","year":"2000","unstructured":"Jouvet A, Saint-Pierre G, Fauchon F, Privat K, Bouffet E, Ruchoux MM, Chauveinc L, Fevre-Montange M (2000) Pineal parenchymal tumors: a correlation of histological features with prognosis in 66 cases. Brain Pathol 10:49\u201360. https:\/\/doi.org\/10.1111\/j.1750-3639.2000.tb00242.x","journal-title":"Brain Pathol"},{"key":"4547_CR8","doi-asserted-by":"publisher","first-page":"52","DOI":"10.14791\/btrt.2015.3.1.52","volume":"3","author":"R Ramdasi","year":"2015","unstructured":"Ramdasi R, Kothari K, Goel N, Mahore A (2015) An unusual variant of anlage tumor of pineal region in an infant. Brain Tumor Res Treat 3:52\u201355. https:\/\/doi.org\/10.14791\/btrt.2015.3.1.52","journal-title":"Brain Tumor Res Treat"},{"issue":"263\u2013264","key":"4547_CR9","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1111\/j.1750-3639.2005.tb00530.x","volume":"15","author":"I Gudinaviciene","year":"2005","unstructured":"Gudinaviciene I, Pranys D, Zheng P, Kros JM (2005) A 10-month-old boy with a large pineal tumor. Brain Pathol 15(263\u2013264):267. https:\/\/doi.org\/10.1111\/j.1750-3639.2005.tb00530.x","journal-title":"Brain Pathol"},{"key":"4547_CR10","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1007\/s00401-015-1519-8","volume":"131","author":"F Sahm","year":"2016","unstructured":"Sahm F, Schrimpf D, Jones DT, Meyer J, Kratz A, Reuss D, Capper D, Koelsche C, Korshunov A, Wiestler B, Buchhalter I, Milde T, Selt F, Sturm D, Kool M, Hummel M, Bewerunge-Hudler M, Mawrin C, Sch\u00fcller U, Jungk C, Wick A, Witt O, Platten M, Herold-Mende C, Unterberg A, Pfister SM, Wick W, von Deimling A (2016) Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets. Acta Neuropathol 131:903\u2013910. https:\/\/doi.org\/10.1007\/s00401-015-1519-8","journal-title":"Acta Neuropathol"},{"key":"4547_CR11","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1093\/neuonc\/nos292","volume":"15","author":"C Friedrich","year":"2013","unstructured":"Friedrich C, von Bueren AO, von Hoff K, Gerber NU, Ottensmeier H, Deinlein F, Benesch M, Kwiecien R, Pietsch T, Warmuth-Metz M, Faldum A, Kuehl J, Kortmann RD, Rutkowski S (2013) Treatment of young children with CNS-primitive neuroectodermal tumors\/pineoblastomas in the prospective multicenter trial HIT 2000 using different chemotherapy regimens and radiotherapy. Neuro Oncol 15:224\u2013234. https:\/\/doi.org\/10.1093\/neuonc\/nos292","journal-title":"Neuro Oncol"},{"key":"4547_CR12","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1093\/neuonc\/now234","volume":"19","author":"M Mynarek","year":"2017","unstructured":"Mynarek M, Pizer B, Dufour C, van Vuurden D, Garami M, Massimino M, Fangusaro J, Davidson T, Gil-da-Costa MJ, Sterba J, Benesch M, Gerber N, Juhnke BO, Kwiecien R, Pietsch T, Kool M, Clifford S, Ellison DW, Giangaspero F, Wesseling P, Gilles F, Gottardo N, Finlay JL, Rutkowski S, von Hoff K (2017) Evaluation of age-dependent treatment strategies for children and young adults with pineoblastoma: analysis of pooled European Society for Paediatric Oncology (SIOP-E) and US Head Start data. Neuro Oncol 19:576\u2013585. https:\/\/doi.org\/10.1093\/neuonc\/now234","journal-title":"Neuro Oncol"},{"key":"4547_CR13","doi-asserted-by":"publisher","first-page":"10017","DOI":"10.1200\/jco.2013.31.15_suppl.10017","volume":"31","author":"S Corbacioglu","year":"2013","unstructured":"Corbacioglu S, Steinbach D, Lode HN, Gruhn B, Fruehwald M, Broeckelmann M, Suttorp M, Escherich G, Cario G, Ehlert K, Meister B, Simon T, Debatin K-M, Kuhlen M, Feddersen I (2013) The RIST design: a molecularly targeted multimodal approach for the treatment of patients with relapsed and refractory neuroblastoma. J Clin Oncol 31:10017\u201310017. https:\/\/doi.org\/10.1200\/jco.2013.31.15_suppl.10017","journal-title":"J Clin Oncol"},{"key":"4547_CR14","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/nature26000","volume":"555","author":"D Capper","year":"2018","unstructured":"Capper D, Jones DTW, Sill M, Hovestadt V, Schrimpf D, Sturm D, Koelsche C, Sahm F, Chavez L, Reuss DE, Kratz A, Wefers AK, Huang K, Pajtler KW, Schweizer L, Stichel D, Olar A, Engel NW, Lindenberg K, Harter PN, Braczynski AK, Plate KH, Dohmen H, Garvalov BK, Coras R, H\u00f6lsken A, Hewer E, Bewerunge-Hudler M, Schick M, Fischer R, Beschorner R, Schittenhelm J, Staszewski O, Wani K, Varlet P, Pages M, Temming P, Lohmann D, Selt F, Witt H, Milde T, Witt O, Aronica E, Giangaspero F, Rushing E, Scheurlen W, Geisenberger C, Rodriguez FJ, Becker A, Preusser M, Haberler C, Bjerkvig R, Cryan J, Farrell M, Deckert M, Hench J, Frank S, Serrano J, Kannan K, Tsirigos A, Br\u00fcck W, Hofer S, Brehmer S, Seiz-Rosenhagen M, H\u00e4nggi D, Hans V, Rozsnoki S, Hansford JR, Kohlhof P, Kristensen BW, Lechner M, Lopes B, Mawrin C, Ketter R, Kulozik A, Khatib Z, Heppner F, Koch A, Jouvet A, Keohane C, M\u00fchleisen H, Mueller W, Pohl U, Prinz M, Benner A, Zapatka M, Gottardo NG, Driever PH, Kramm CM, M\u00fcller HL, Rutkowski S, von Hoff K, Fr\u00fchwald MC, Gnekow A, Fleischhack G, Tippelt S, Calaminus G, Monoranu CM, Perry A, Jones C, Jacques TS, Radlwimmer B, Gessi M, Pietsch T, Schramm J, Schackert G, Westphal M, Reifenberger G, Wesseling P, Weller M, Collins VP, Bl\u00fcmcke I, Bendszus M, Debus J, Huang A, Jabado N, Northcott PA, Paulus W, Gajjar A, Robinson GW, Taylor MD, Jaunmuktane Z, Ryzhova M, Platten M, Unterberg A, Wick W, Karajannis MA, Mittelbronn M, Acker T, Hartmann C, Aldape K, Sch\u00fcller U, Buslei R, Lichter P, Kool M, Herold-Mende C, Ellison DW, Hasselblatt M, Snuderl M, Brandner S, Korshunov A, von Deimling A, Pfister SM (2018) DNA methylation-based classification of central nervous system tumours. Nature 555:469\u2013474. https:\/\/doi.org\/10.1038\/nature26000","journal-title":"Nature"},{"key":"4547_CR15","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/s00401-019-02106-9","volume":"139","author":"APY Liu","year":"2020","unstructured":"Liu APY, Gudenas B, Lin T, Orr BA, Klimo P Jr, Kumar R, Bouffet E, Gururangan S, Crawford JR, Kellie SJ, Chintagumpala M, Fisher MJ, Bowers DC, Hassall T, Indelicato DJ, Onar-Thomas A, Ellison DW, Boop FA, Merchant TE, Robinson GW, Northcott PA, Gajjar A (2020) Risk-adapted therapy and biological heterogeneity in pineoblastoma: integrated clinico-pathological analysis from the prospective, multi-center SJMB03 and SJYC07 trials. Acta Neuropathol 139:259\u2013271. https:\/\/doi.org\/10.1007\/s00401-019-02106-9","journal-title":"Acta Neuropathol"},{"key":"4547_CR16","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.29596","volume":"69","author":"KP Scherpelz","year":"2022","unstructured":"Scherpelz KP, Crotty EE, Paulson VA, Lockwood CM, Leary SES, Ellenbogen RG, Lee A, Ermoian RP, Vitanza NA, Cole BL (2022) Two cases of pineal anlage tumor with molecular analysis. Pediatr Blood Cancer 69:e29596. https:\/\/doi.org\/10.1002\/pbc.29596","journal-title":"Pediatr Blood Cancer"},{"key":"4547_CR17","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-021-05441-z","author":"E Cambruzzi","year":"2022","unstructured":"Cambruzzi E, Medeiros MS, da Silva J, Nascimento GBC, Zandon\u00e1 NB, Kus WP (2022) Pineal anlage tumor: a case report and review of the literature. Child\u2019s Nerv Syst: ChNS: Off J Int Soc Pediatric Neurosurg. https:\/\/doi.org\/10.1007\/s00381-021-05441-z","journal-title":"Child\u2019s Nerv Syst: ChNS: Off J Int Soc Pediatric Neurosurg"},{"key":"4547_CR18","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13040706","author":"O Lopez-Nunez","year":"2021","unstructured":"Lopez-Nunez O, Alaggio R, John I, Ciolfi A, Pedace L, Mastronuzzi A, Gianno F, Giangaspero F, Rossi S, Donofrio V, Cinalli G, Surrey LF, Tartaglia M, Locatelli F, Miele E (2021) Melanotic Neuroectodermal Tumor of Infancy (MNTI) and Pineal Anlage Tumor (PAT) Harbor A medulloblastoma signature by DNA methylation profiling. Cancers (Basel). https:\/\/doi.org\/10.3390\/cancers13040706","journal-title":"Cancers (Basel)"},{"key":"4547_CR19","doi-asserted-by":"publisher","unstructured":"Li JY, Chen L (2020) [Pineal anlage tumor: report of a case]. Zhonghua Bing Li Xue Za Zhi 49: 1190-1192 https:\/\/doi.org\/10.3760\/cma.j.cn112151-20200303-00164","DOI":"10.3760\/cma.j.cn112151-20200303-00164"},{"key":"4547_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2021.106629","volume":"206","author":"DK Uppal","year":"2021","unstructured":"Uppal DK, Madan R, Chatterjee D, Mohindra S, Bhatia V, Goyal S (2021) Pineal anlage tumor: a case report and clinico-pathological review. Clin Neurol Neurosurg 206:106629. https:\/\/doi.org\/10.1016\/j.clineuro.2021.106629","journal-title":"Clin Neurol Neurosurg"},{"key":"4547_CR21","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1111\/neup.12346","volume":"37","author":"T Homma","year":"2017","unstructured":"Homma T, Hemmi A, Ohta T, Kusumi Y, Yoshino A, Hao H (2017) A rare case of a pineoblastoma with a rhabdomyoblastic component. Neuropathology 37:227\u2013232. https:\/\/doi.org\/10.1111\/neup.12346","journal-title":"Neuropathology"},{"issue":"2","key":"4547_CR22","first-page":"S90","volume":"52","author":"A Rodriguez-Velasco","year":"2014","unstructured":"Rodriguez-Velasco A, Ramirez-Reyes AG (2014) [Pineal anlage tumor in a 8-month-old boy. The first case reported in Spanish language]. Revista medica del Instituto Mexicano del Seguro Social 52(2):S90-93","journal-title":"Revista medica del Instituto Mexicano del Seguro Social"},{"key":"4547_CR23","doi-asserted-by":"publisher","first-page":"636","DOI":"10.3171\/2010.2.Peds09294","volume":"5","author":"JE Olaya","year":"2010","unstructured":"Olaya JE, Raghavan R, Totaro L, Zouros A (2010) Pineal anlage tumor in a 5-month-old boy. J Neurosurg Pediatr 5:636\u2013640. https:\/\/doi.org\/10.3171\/2010.2.Peds09294","journal-title":"J Neurosurg Pediatr"},{"key":"4547_CR24","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.jocn.2010.09.016","volume":"18","author":"A Ahuja","year":"2011","unstructured":"Ahuja A, Sharma MC, Suri V, Sarkar C, Sharma BS, Garg A (2011) Pineal anlage tumour - a rare entity with divergent histology. J Clin Neurosci: Off J Neurosurg Soc Australas 18:811\u2013813. https:\/\/doi.org\/10.1016\/j.jocn.2010.09.016","journal-title":"J Clin Neurosci: Off J Neurosurg Soc Australas"},{"key":"4547_CR25","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.5858\/2006-130-1233-ropatw","volume":"130","author":"S Berns","year":"2006","unstructured":"Berns S, Pearl G (2006) Review of pineal anlage tumor with divergent histology. Arch Pathol Lab Med 130:1233\u20131235. https:\/\/doi.org\/10.5858\/2006-130-1233-ropatw","journal-title":"Arch Pathol Lab Med"},{"key":"4547_CR26","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/bf01400641","volume":"117","author":"G McGrogan","year":"1992","unstructured":"McGrogan G, Rivel J, Vital C, Guerin J (1992) A pineal tumour with features of \u201cpineal anlage tumour.\u201d Acta Neurochir (Wien) 117:73\u201377. https:\/\/doi.org\/10.1007\/bf01400641","journal-title":"Acta Neurochir (Wien)"},{"key":"4547_CR27","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/bf02427838","volume":"9","author":"J Raisanen","year":"1990","unstructured":"Raisanen J, Vogel H, Horoupian DS (1990) Primitive pineal tumor with retinoblastomatous and retinal\/ciliary epithelial differentiation: an immunohistochemical study. J Neurooncol 9:165\u2013170. https:\/\/doi.org\/10.1007\/bf02427838","journal-title":"J Neurooncol"}],"container-title":["Journal of Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-023-04547-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11060-023-04547-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-023-04547-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T17:11:37Z","timestamp":1706807497000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11060-023-04547-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["4547"],"URL":"https:\/\/doi.org\/10.1007\/s11060-023-04547-5","relation":{},"ISSN":["0167-594X","1573-7373"],"issn-type":[{"value":"0167-594X","type":"print"},{"value":"1573-7373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"12 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 December 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declare they have no competing financial interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}