{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T10:30:22Z","timestamp":1793183422939,"version":"4.5.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurooncol"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Multidisciplinary tumor boards (MTBs) integrate clinical, molecular, and radiological information and facilitate coordination of neuro-oncology care. During the COVID-19 pandemic, our MTB transitioned to a virtual and multi-institutional format. We hypothesized that this expansion would allow expert review of challenging neuro-oncology cases and contribute to the care of patients with limited access to specialized centers.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We retrospectively reviewed records from virtual MTBs held between 04\/2020\u201303\/2021. Data collected included measures of potential clinical impact, including referrals to observational or therapeutic studies, referrals for specialized neuropathology analysis, and whether molecular findings led to a change in diagnosis and\/or guided management suggestions.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>During 25 meetings, 32 presenters discussed 44 cases. Approximately half (<jats:italic>n<\/jats:italic>\u2009=\u200920; 48%) involved a rare central nervous system (CNS) tumor. In 21% (<jats:italic>n<\/jats:italic>\u2009=\u20099) the diagnosis was changed or refined based on molecular profiling obtained at the NIH and in 36% (<jats:italic>n<\/jats:italic>\u2009=\u200915) molecular findings guided management. Clinical trial suggestions were offered to 31% (<jats:italic>n<\/jats:italic>\u2009=\u200913), enrollment in the observational NCI Natural History Study to 21% (<jats:italic>n<\/jats:italic>\u2009=\u20099), neuropathology review and molecular testing at the NIH to 17% (<jats:italic>n<\/jats:italic>\u2009=\u20097), and all received management suggestions.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Virtual multi-institutional MTBs enable remote expert review of CNS tumors. We propose them as a strategy to facilitate expert opinions from specialized centers, especially for rare CNS tumors, helping mitigate geographic barriers to patient care and serving as a pre-screening tool for studies. Advanced molecular testing is key to obtaining a precise diagnosis, discovering potentially actionable targets, and guiding management.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11060-024-04613-6","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T06:02:31Z","timestamp":1709272951000},"page":"349-359","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Virtual multi-institutional tumor board: a strategy for personalized diagnoses and management of rare CNS tumors"],"prefix":"10.1007","volume":"167","author":[{"given":"James L.","family":"Rogers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Wall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvina 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Dr. Cachia is a consultant for RedHill BioPharma Ltd, Guidepoint Global LLC, and Dedham Group and a paid speaker for the Massachusetts Neurological Society. Dr. Drappatz is a stock owner for Gilead, Pfizer, and GSK, receives royalties from Elsevier and Wolters Kluwer and receives research support from Servier and Novocure. Dr. Forsyth\u2019s COI includes NIH\/NCI\u00a0(consultant), Pfizer\u00a0(grant\/research support), DOD\u00a0(grant\/research support), BMS\u00a0(consultant), and Genentech\u00a0(research support). Dr Lukas has served on advisory boards for Merck, AstraZeneca, Bayer, Cardinal Health, and Servier and serves on the speakers\u2019 bureau for Merck and Novocure, receives research support (drug only) from BMS, and has received honoraria for medical editing from Medlink Neurology, Elsevier, EBSCO publishing, and Oxford University Press. Dr. Mandel is on the Medical advisory board for Servier and Bayer. Dr. Snyder received consulting fee from Monteris Medical Corporation and speaker fee from Blue Earth Diagnostics Limited. All other authors report no conflicts of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}