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Eligible patients had preoperative, immediate postoperative, and progression MRIs to assess tumor progression patterns. FLAIR imaging was examined for its predictive value in identifying progression sites. Surgical outcomes, progression-free survival (PFS), and overall survival were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 48 patients were identified, of whom 14 (29%) underwent anterior temporal lobectomy and were excluded from further analysis. Among the remaining 34 patients, 21 (62%) exhibited anterior progression. Expert assessment suggested that in 12 of these 21 patients (57%), an anterior temporal lobectomy might have encompassed the region of tumor progression. Superior, inferior, and lateral progression patterns were associated with longer median PFS (~\u200911 months), whereas medial progression correlated with the shortest PFS (5.9 months). FLAIR signal at the temporal tip had moderate sensitivity (71.43%) but low specificity (18.52%) for predicting anterior progression, resulting in a high false-positive rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Temporal lobe glioblastomas often progress anteriorly, suggesting that anterior temporal lobectomy may help reduce progression in select cases. FLAIR imaging had limited predictive value for anterior progression, emphasizing the need for advanced imaging techniques. Future research should identify reliable biomarkers and evaluate the role of anterior temporal lobectomy through well-designed prospective studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11060-025-04991-5","type":"journal-article","created":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T12:59:23Z","timestamp":1741179563000},"page":"353-360","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Spatial invasion patterns of temporal lobe glioblastoma after complete resection of contrast-enhancing tumor"],"prefix":"10.1007","volume":"173","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5368-8764","authenticated-orcid":false,"given":"Jawad","family":"Fares","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhou","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binay","family":"Gurung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaaqib","family":"Nazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Mair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Joannides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Santarius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Matys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,5]]},"reference":[{"key":"4991_CR1","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.jocn.2023.07.016","volume":"115","author":"Y Zheng","year":"2023","unstructured":"Zheng Y, Saffari SE, Low DCY, Lin X, Ker JRX, Ang SYL, Ng WH, Wan KR (2023) Lobectomy versus gross total resection for glioblastoma multiforme: A systematic review and individual-participant data meta-analysis. 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