{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T14:22:14Z","timestamp":1754144534152,"version":"3.41.2"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:00:00Z","timestamp":1749168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:00:00Z","timestamp":1749168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82060455, 82360566"],"award-info":[{"award-number":["82060455, 82360566"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004775","name":"Natural Science Foundation of Gansu Province","doi-asserted-by":"crossref","award":["22JR5RA966, 22JR5R959"],"award-info":[{"award-number":["22JR5RA966, 22JR5R959"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Natural Science Foundation of Ningxia Hui Autonomous Region","award":["2021AAC03313, 2024AAC03472"],"award-info":[{"award-number":["2021AAC03313, 2024AAC03472"]}]},{"name":"Yinchuan Science and Technology Plan Project","award":["2023SF08"],"award-info":[{"award-number":["2023SF08"]}]},{"name":"Lanzhou Science and Technology Bureau Project","award":["2021-RC-97\/2023-1-48"],"award-info":[{"award-number":["2021-RC-97\/2023-1-48"]}]},{"name":"Cuiying Scientific and Technological Innovation Program of Lanzhou University Second Hospital","award":["CY2022-QN-A12, CY2022-QN-B05, CY2021-MS-A09, CY2021-MS-A19"],"award-info":[{"award-number":["CY2022-QN-A12, CY2022-QN-B05, CY2021-MS-A09, CY2021-MS-A19"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurooncol"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1007\/s11060-025-05095-w","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T05:53:25Z","timestamp":1749189205000},"page":"667-687","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Engineering overexpressing SYNGR1 inhibited the progression of GBM cells by suppressing the intracellular FGF1-mediated LDs accumulation and cytoskeleton remodeling"],"prefix":"10.1007","volume":"174","author":[{"given":"Juncheng","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinlong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufeng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengyu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guopeng","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongming","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoqiang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yawen","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,6]]},"reference":[{"issue":"50","key":"5095_CR1","doi-asserted-by":"publisher","first-page":"e2417420121","DOI":"10.1073\/pnas.2417420121","volume":"121","author":"AL Hsieh","year":"2024","unstructured":"Hsieh AL, Ganesh S, Kula T et al (2024) Widespread neuroanatomical integration and distinct electrophysiological properties of glioma-innervating neurons. Proc Natl Acad Sci U S A 121(50):e2417420121. https:\/\/doi.org\/10.1073\/pnas.2417420121","journal-title":"Proc Natl Acad Sci U S A"},{"key":"5095_CR2","doi-asserted-by":"publisher","first-page":"116799","DOI":"10.1016\/j.ejmech.2024.116799","volume":"278","author":"X Qin","year":"2024","unstructured":"Qin X, Xu W, Hu J et al (2024) Structure-activity relationship study of Pseudellone C as anti-glioma agents by targeting TNF\/TNFR signaling pathway. Eur J Med Chem 278:116799. https:\/\/doi.org\/10.1016\/j.ejmech.2024.116799","journal-title":"Eur J Med Chem"},{"issue":"1","key":"5095_CR3","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s13073-023-01165-8","volume":"15","author":"Y Nam","year":"2023","unstructured":"Nam Y, Koo H, Yang Y et al (2023) Pharmacogenomic profiling reveals molecular features of chemotherapy resistance in IDH wild-type primary glioblastoma. Genome Med 15(1):16. https:\/\/doi.org\/10.1186\/s13073-023-01165-8","journal-title":"Genome Med"},{"issue":"5","key":"5095_CR4","doi-asserted-by":"publisher","first-page":"1594","DOI":"10.3390\/cancers15051594","volume":"15","author":"Z Chen","year":"2023","unstructured":"Chen Z, Bao H, Long J et al (2023) GBE1 promotes glioma progression by enhancing aerobic Glycolysis through Inhibition of FBP1. Cancers (Basel) 15(5):1594. https:\/\/doi.org\/10.3390\/cancers15051594","journal-title":"Cancers (Basel)"},{"issue":"14","key":"5095_CR5","doi-asserted-by":"publisher","first-page":"e2300671","DOI":"10.1002\/adhm.202300671","volume":"12","author":"ZM Khan","year":"2023","unstructured":"Khan ZM, Munson JM, Long TE et al (2023) Development of a synthetic, injectable hydrogel to capture residual glioblastoma and glioblastoma Stem-Like cells with CXCL12-Mediated chemotaxis. Adv Healthc Mater 12(14):e2300671. https:\/\/doi.org\/10.1002\/adhm.202300671","journal-title":"Adv Healthc Mater"},{"issue":"5","key":"5095_CR6","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1080\/01913123.2024.2392728","volume":"48","author":"HH Maraqah","year":"2024","unstructured":"Maraqah HH, Aboubechara JP, Abu-Asab MS et al (2024) Excessive lipid production shapes glioma tumor microenvironment. Ultrastruct Pathol 48(5):367\u2013377. https:\/\/doi.org\/10.1080\/01913123.2024.2392728","journal-title":"Ultrastruct Pathol"},{"key":"5095_CR7","doi-asserted-by":"publisher","first-page":"1085034","DOI":"10.3389\/fonc.2022.1085034","volume":"12","author":"A Bezawork-Geleta","year":"2022","unstructured":"Bezawork-Geleta A, Dimou J, Watt MJ (2022) Lipid droplets and ferroptosis as new players in brain cancer glioblastoma progression and therapeutic resistance. Front Oncol 12:1085034. https:\/\/doi.org\/10.3389\/fonc.2022.1085034","journal-title":"Front Oncol"},{"issue":"3","key":"5095_CR8","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1158\/1541-7786.MCR-20-0560","volume":"19","author":"M Cerezo-Maga\u00f1a","year":"2021","unstructured":"Cerezo-Maga\u00f1a M, Christianson HC, van Kuppevelt TH et al (2021) Hypoxic induction of exosome uptake through Proteoglycan-Dependent endocytosis fuels the lipid droplet phenotype in glioma. Mol Cancer Res 19(3):528\u2013540. https:\/\/doi.org\/10.1158\/1541-7786.MCR-20-0560","journal-title":"Mol Cancer Res"},{"issue":"8","key":"5095_CR9","doi-asserted-by":"publisher","first-page":"5763","DOI":"10.1007\/s12035-019-1489-2","volume":"56","author":"A Islam","year":"2019","unstructured":"Islam A, Kagawa Y, Miyazaki H et al (2019) FABP7 protects astrocytes against ROS toxicity via lipid droplet formation. Mol Neurobiol 56(8):5763\u20135779. https:\/\/doi.org\/10.1007\/s12035-019-1489-2","journal-title":"Mol Neurobiol"},{"issue":"771","key":"5095_CR10","doi-asserted-by":"publisher","first-page":"eadk1168","DOI":"10.1126\/scitranslmed.adk1168","volume":"16","author":"V Governa","year":"2024","unstructured":"Governa V, de Oliveira KG, B\u00e5ng-Rudenstam A et al (2024) Protumoral lipid droplet-loaded macrophages are enriched in human glioblastoma and can be therapeutically targeted. Sci Transl Med 16(771):eadk1168. https:\/\/doi.org\/10.1126\/scitranslmed.adk1168","journal-title":"Sci Transl Med"},{"issue":"7","key":"5095_CR11","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1038\/s41556-023-01162-4","volume":"25","author":"L Han","year":"2023","unstructured":"Han L, Huang D, Wu S et al (2023) Lipid droplet-associated LncRNA LIPTER preserves cardiac lipid metabolism. Nat Cell Biol 25(7):1033\u20131046. https:\/\/doi.org\/10.1038\/s41556-023-01162-4","journal-title":"Nat Cell Biol"},{"issue":"20","key":"5095_CR12","doi-asserted-by":"publisher","first-page":"dev201516","DOI":"10.1242\/dev.201516","volume":"150","author":"MS Giedt","year":"2023","unstructured":"Giedt MS, Thomalla JM, White RP et al (2023) Adipose triglyceride lipase promotes prostaglandin-dependent actin remodeling by regulating substrate release from lipid droplets. Development 150(20):dev201516. https:\/\/doi.org\/10.1242\/dev.201516","journal-title":"Development"},{"issue":"9","key":"5095_CR13","doi-asserted-by":"publisher","first-page":"e2200038","DOI":"10.1002\/bies.202200038","volume":"44","author":"MS Apte","year":"2022","unstructured":"Apte MS, Joshi AS (2022) Membrane shaping proteins, lipids, and cytoskeleton: recipe for nascent lipid droplet formation. BioEssays 44(9):e2200038. https:\/\/doi.org\/10.1002\/bies.202200038","journal-title":"BioEssays"},{"issue":"2","key":"5095_CR14","doi-asserted-by":"publisher","first-page":"e70014","DOI":"10.1002\/jcp.70014","volume":"240","author":"K Grochowalska","year":"2025","unstructured":"Grochowalska K, Szrejder M, Rachubik P et al (2025) Role of metabolic sensor GPR81\/HCAR1 in diabetic podocytes: downregulated lipolysis results in the deterioration of glomerular filtration barrier. J Cell Physiol 240(2):e70014. https:\/\/doi.org\/10.1002\/jcp.70014","journal-title":"J Cell Physiol"},{"key":"5095_CR15","doi-asserted-by":"publisher","first-page":"153791","DOI":"10.1016\/j.tox.2024.153791","volume":"504","author":"NG Khan","year":"2024","unstructured":"Khan NG, Adiga D, Rai PS et al (2024) Integrated in-Silico and in vitro analysis to Decipher the contribution of bisphenol-A in cervical cancer. Toxicology 504:153791. https:\/\/doi.org\/10.1016\/j.tox.2024.153791","journal-title":"Toxicology"},{"issue":"6","key":"5095_CR16","doi-asserted-by":"publisher","first-page":"2767","DOI":"10.3390\/ijms26062767","volume":"26","author":"G Ragazzini","year":"2025","unstructured":"Ragazzini G, Mescola A, Tassinari R et al (2025) A Benzodiazepine-Derived molecule that interferes with the Bio-Mechanical properties of Glioblastoma-Astrocytoma cells altering their proliferation and migration. Int J Mol Sci 26(6):2767. https:\/\/doi.org\/10.3390\/ijms26062767","journal-title":"Int J Mol Sci"},{"issue":"4","key":"5095_CR17","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1038\/s41418-024-01440-0","volume":"32","author":"M Tang","year":"2025","unstructured":"Tang M, Dirks K, Kim SY et al (2025) Inhibition of thioredoxin reductase 1 sensitizes glucose-starved glioblastoma cells to Disulfidptosis. Cell Death Differ 32(4):598\u2013612. https:\/\/doi.org\/10.1038\/s41418-024-01440-0","journal-title":"Cell Death Differ"},{"issue":"12","key":"5095_CR18","doi-asserted-by":"publisher","first-page":"e209096","DOI":"10.1371\/journal.pone.0209096","volume":"13","author":"V Yodsurang","year":"2018","unstructured":"Yodsurang V, Tang Y, Takahashi Y et al (2018) Genome-wide association study (GWAS) of ovarian cancer in Japanese predicted regulatory variants in 22q13.1. PLoS ONE 13(12):e209096. https:\/\/doi.org\/10.1371\/journal.pone.0209096","journal-title":"PLoS ONE"},{"issue":"4","key":"5095_CR19","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.21037\/jgo-21-376","volume":"12","author":"S Tan","year":"2021","unstructured":"Tan S, Gui W, Wang S et al (2021) A methylation-based prognostic model predicts survival in patients with colorectal cancer. J Gastrointest Oncol 12(4):1590\u20131600. https:\/\/doi.org\/10.21037\/jgo-21-376","journal-title":"J Gastrointest Oncol"},{"issue":"37","key":"5095_CR20","doi-asserted-by":"publisher","first-page":"59834","DOI":"10.18632\/oncotarget.10975","volume":"7","author":"L Wang","year":"2016","unstructured":"Wang L, Hu X, Wang P et al (2016) The 3\u2019UTR signature defines a highly metastatic subgroup of triple-negative breast cancer. Oncotarget 7(37):59834\u201359844. https:\/\/doi.org\/10.18632\/oncotarget.10975","journal-title":"Oncotarget"},{"issue":"2","key":"5095_CR21","doi-asserted-by":"publisher","first-page":"152785","DOI":"10.1016\/j.prp.2019.152785","volume":"216","author":"F Zhong","year":"2020","unstructured":"Zhong F, Lu HP, Chen G et al (2020) The clinical significance and potential molecular mechanism of integrin subunit beta 4 in laryngeal squamous cell carcinoma. Pathol Res Pract 216(2):152785. https:\/\/doi.org\/10.1016\/j.prp.2019.152785","journal-title":"Pathol Res Pract"},{"issue":"9","key":"5095_CR22","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.25122\/jml-2022-0067","volume":"15","author":"HT Javanshir","year":"2022","unstructured":"Javanshir HT, Malekraeisi MA, Ebrahimi S et al (2022) Investigation of key signaling pathways and appropriate diagnostic biomarkers selection between non-invasive to invasive stages in pancreatic cancer: a computational observation. J Med Life 15(9):1143\u20131157. https:\/\/doi.org\/10.25122\/jml-2022-0067","journal-title":"J Med Life"},{"issue":"1","key":"5095_CR23","doi-asserted-by":"publisher","first-page":"14574","DOI":"10.1038\/s41598-017-15261-4","volume":"7","author":"K Nakamura","year":"2017","unstructured":"Nakamura K, Komatsu M, Chiwaki F et al (2017) SIM2l attenuates resistance to hypoxia and tumor growth by transcriptional suppression of HIF1A in uterine cervical squamous cell carcinoma. Sci Rep 7(1):14574. https:\/\/doi.org\/10.1038\/s41598-017-15261-4","journal-title":"Sci Rep"},{"key":"5095_CR24","doi-asserted-by":"publisher","first-page":"2091220486","DOI":"10.1177\/15330338211004922","volume":"20","author":"T Zhang","year":"2021","unstructured":"Zhang T, Liu Q, Yu M et al (2021) Expression profiles reveal involvement of VEGF, IGF1, BIRC5, and MMP1 in vulvar carcinogenesis. Technol Cancer Res Treat 20:2091220486. https:\/\/doi.org\/10.1177\/15330338211004922","journal-title":"Technol Cancer Res Treat"},{"issue":"4","key":"5095_CR25","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1016\/j.apsb.2023.01.024","volume":"13","author":"S Bing","year":"2023","unstructured":"Bing S, Xiang S, Xia Z et al (2023) AKT inhibitor Hu7691 induces differentiation of neuroblastoma cells. Acta Pharm Sin B 13(4):1522\u20131536. https:\/\/doi.org\/10.1016\/j.apsb.2023.01.024","journal-title":"Acta Pharm Sin B"},{"issue":"9","key":"5095_CR26","doi-asserted-by":"publisher","first-page":"3174","DOI":"10.1002\/cam4.2969","volume":"9","author":"Y Dai","year":"2020","unstructured":"Dai Y, Lv Q, Qi T et al (2020) Identification of hub methylated-CpG sites and associated genes in oral squamous cell carcinoma. Cancer Med 9(9):3174\u20133187. https:\/\/doi.org\/10.1002\/cam4.2969","journal-title":"Cancer Med"},{"issue":"10","key":"5095_CR27","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.1158\/1535-7163.MCT-11-0055","volume":"10","author":"J Xu","year":"2011","unstructured":"Xu J, Li CX, Lv JY et al (2011) Prioritizing candidate disease MiRNAs by topological features in the MiRNA target-dysregulated network: case study of prostate cancer. Mol Cancer Ther 10(10):1857\u20131866. https:\/\/doi.org\/10.1158\/1535-7163.MCT-11-0055","journal-title":"Mol Cancer Ther"},{"issue":"5","key":"5095_CR28","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.3390\/cancers12051218","volume":"12","author":"M Ettaieb","year":"2020","unstructured":"Ettaieb M, Kerkhofs T, van Engeland M et al (2020) Past, present and future of epigenetics in adrenocortical carcinoma. Cancers (Basel) 12(5):1218. https:\/\/doi.org\/10.3390\/cancers12051218","journal-title":"Cancers (Basel)"},{"issue":"1","key":"5095_CR29","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1186\/s12885-022-09853-1","volume":"22","author":"Y Kawata-Shimamura","year":"2022","unstructured":"Kawata-Shimamura Y, Eguchi H, Kawabata-Iwakawa R et al (2022) Biomarker discovery for practice of precision medicine in hypopharyngeal cancer: a theranostic study on response prediction of the key therapeutic agents. BMC Cancer 22(1):779. https:\/\/doi.org\/10.1186\/s12885-022-09853-1","journal-title":"BMC Cancer"},{"issue":"10","key":"5095_CR30","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1093\/carcin\/bgv111","volume":"36","author":"A Espin-Perez","year":"2015","unstructured":"Espin-Perez A, de Kok TM, Jennen DG et al (2015) Distinct genotype-dependent differences in transcriptome responses in humans exposed to environmental carcinogens. Carcinogenesis 36(10):1154\u20131161. https:\/\/doi.org\/10.1093\/carcin\/bgv111","journal-title":"Carcinogenesis"},{"issue":"7","key":"5095_CR31","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/S1556-0864(15)30373-7","volume":"1","author":"N Choi","year":"2006","unstructured":"Choi N, Son DS, Lee J et al (2006) The signature from messenger RNA expression profiling can predict lymph node metastasis with high accuracy for non-small cell lung cancer. J Thorac Oncol 1(7):622\u2013628. https:\/\/doi.org\/10.1016\/S1556-0864(15)30373-7","journal-title":"J Thorac Oncol"},{"key":"5095_CR32","doi-asserted-by":"publisher","first-page":"1021678","DOI":"10.3389\/fimmu.2023.1021678","volume":"14","author":"J Li","year":"2023","unstructured":"Li J, Zhang S, Chen S et al (2023) Lipid metabolism-related gene signature predicts prognosis and depicts tumor microenvironment immune landscape in gliomas. Front Immunol 14:1021678. https:\/\/doi.org\/10.3389\/fimmu.2023.1021678","journal-title":"Front Immunol"},{"issue":"39","key":"5095_CR33","doi-asserted-by":"publisher","first-page":"3134","DOI":"10.3760\/cma.j.cn112137-20220127-00203","volume":"102","author":"YJ Sheng","year":"2022","unstructured":"Sheng YJ, Jiang QQ, Liu L et al (2022) [Characteristics and regulatory mechanisms of lipid metabolism remodeling after malignant transformation of glioma-associated macrophages]. Zhonghua Yi Xue Za Zhi 102(39):3134\u20133142. https:\/\/doi.org\/10.3760\/cma.j.cn112137-20220127-00203. Chinese","journal-title":"Zhonghua Yi Xue Za Zhi"},{"issue":"11","key":"5095_CR34","doi-asserted-by":"publisher","first-page":"2481","DOI":"10.3390\/biomedicines12112481","volume":"12","author":"K Du","year":"2024","unstructured":"Du K, Grocott L, Anichini G et al (2024) Amino acid deprivation in glioblastoma: the role in survival and the tumour Microenvironment-A narrative review. Biomedicines 12(11):2481. https:\/\/doi.org\/10.3390\/biomedicines12112481","journal-title":"Biomedicines"},{"issue":"31","key":"5095_CR35","doi-asserted-by":"publisher","first-page":"11567","DOI":"10.1021\/acs.analchem.3c00967","volume":"95","author":"N Wang","year":"2023","unstructured":"Wang N, Wang J, Wang P et al (2023) Label-Free Raman spectromicroscopy unravels the relationship between MGMT methylation and intracellular lipid accumulation in glioblastoma. Anal Chem 95(31):11567\u201311571. https:\/\/doi.org\/10.1021\/acs.analchem.3c00967","journal-title":"Anal Chem"},{"issue":"2","key":"5095_CR36","doi-asserted-by":"publisher","first-page":"e9670","DOI":"10.1002\/rcm.9670","volume":"38","author":"S Wen","year":"2024","unstructured":"Wen S, Tu X, Zang Q et al (2024) Liquid chromatography-mass spectrometry-based metabolomics and fluxomics reveals the metabolic alterations in glioma U87MG multicellular tumor spheroids versus two-dimensional cell cultures. Rapid Commun Mass Spectrom 38(2):e9670. https:\/\/doi.org\/10.1002\/rcm.9670","journal-title":"Rapid Commun Mass Spectrom"},{"issue":"2","key":"5095_CR37","doi-asserted-by":"publisher","first-page":"260","DOI":"10.4149\/neo_2023_221126N1140","volume":"70","author":"YZ Miao","year":"2023","unstructured":"Miao YZ, Wang J, Hao SY et al (2023) The Inhibition of Aurora A kinase regulates phospholipid remodeling by upregulating LPCAT1 in glioblastoma. Neoplasma 70(2):260\u2013271. https:\/\/doi.org\/10.4149\/neo_2023_221126N1140","journal-title":"Neoplasma"},{"issue":"1","key":"5095_CR38","doi-asserted-by":"publisher","first-page":"10325","DOI":"10.1038\/s41598-022-13324-9","volume":"12","author":"S Abuhattum","year":"2022","unstructured":"Abuhattum S, Kotzbeck P, Schl\u00fc\u00dfler R et al (2022) Adipose cells and tissues soften with lipid accumulation while in diabetes adipose tissue stiffens. Sci Rep 12(1):10325. https:\/\/doi.org\/10.1038\/s41598-022-13324-9PMID: 35725987; PMCID: PMC9209483","journal-title":"Sci Rep"},{"issue":"2","key":"5095_CR39","doi-asserted-by":"publisher","first-page":"204","DOI":"10.3724\/zdxbyxb-2021-0354","volume":"51","author":"Z Chen","year":"2022","unstructured":"Chen Z, Li W, Chen X et al (2022) Impairment of endometrial decidual reaction in early pregnant mice fed with high fat diet. Zhejiang Da Xue Xue Bao Yi Xue Ban 51(2):204\u2013214. https:\/\/doi.org\/10.3724\/zdxbyxb-2021-0354. English","journal-title":"Zhejiang Da Xue Xue Bao Yi Xue Ban"},{"issue":"9","key":"5095_CR40","doi-asserted-by":"publisher","first-page":"107539","DOI":"10.1016\/j.isci.2023.107539","volume":"26","author":"J Davis","year":"2023","unstructured":"Davis J, Meyer T, Smolnig M et al (2023) A dynamic actin cytoskeleton is required to prevent constitutive VDAC-dependent MAPK signalling and aberrant lipid homeostasis. iScience 26(9):107539. https:\/\/doi.org\/10.1016\/j.isci.2023.107539","journal-title":"iScience"},{"issue":"4","key":"5095_CR41","doi-asserted-by":"publisher","first-page":"159610","DOI":"10.1016\/j.bbalip.2025.159610","volume":"1870","author":"Y Liang","year":"2025","unstructured":"Liang Y, Zhu Z, Lu Y et al (2025) Cytoskeleton regulates lipid droplet fusion and lipid storage by controlling lipid droplet movement. Biochim Biophys Acta Mol Cell Biol Lipids 1870(4):159610. https:\/\/doi.org\/10.1016\/j.bbalip.2025.159610","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"issue":"1","key":"5095_CR42","doi-asserted-by":"publisher","first-page":"317","DOI":"10.3892\/ol.2024.14450","volume":"28","author":"K Zhao","year":"2024","unstructured":"Zhao K, Xu J, Zhao B (2024) Panoramic RNA expression of fibroblast growth factors in human glioblastoma tissues and the impact on the survival of patients. Oncol Lett 28(1):317. https:\/\/doi.org\/10.3892\/ol.2024.14450","journal-title":"Oncol Lett"},{"issue":"11","key":"5095_CR43","doi-asserted-by":"publisher","first-page":"2452","DOI":"10.3390\/ijms18112452","volume":"18","author":"SJ Smith","year":"2017","unstructured":"Smith SJ, Diksin M, Chhaya S et al (2017) The invasive region of glioblastoma defined by 5ALA guided surgery has an altered Cancer stem cell marker profile compared to central tumour. Int J Mol Sci 18(11):2452. https:\/\/doi.org\/10.3390\/ijms18112452","journal-title":"Int J Mol Sci"},{"issue":"5","key":"5095_CR44","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1515\/revneuro-2018-0051","volume":"30","author":"V Georgiou","year":"2019","unstructured":"Georgiou V, Gkretsi V (2019) The role of fibroblast growth factors and their receptors in gliomas: the mutations involved. Rev Neurosci 30(5):543\u2013554. https:\/\/doi.org\/10.1515\/revneuro-2018-0051","journal-title":"Rev Neurosci"},{"issue":"1","key":"5095_CR45","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s40478-024-01755-6","volume":"12","author":"JG Nicholson","year":"2024","unstructured":"Nicholson JG, Cirigliano S, Singhania R et al (2024) Chronic hypoxia remodels the tumor microenvironment to support glioma stem cell growth. Acta Neuropathol Commun 12(1):46. https:\/\/doi.org\/10.1186\/s40478-024-01755-6","journal-title":"Acta Neuropathol Commun"},{"issue":"26","key":"5095_CR46","doi-asserted-by":"publisher","first-page":"21934","DOI":"10.18632\/oncotarget.4290","volume":"6","author":"J Ke","year":"2015","unstructured":"Ke J, Yao YL, Zheng J et al (2015) Knockdown of long non-coding RNA HOTAIR inhibits malignant biological behaviors of human glioma cells via modulation of miR-326. Oncotarget 6(26):21934\u201321949. https:\/\/doi.org\/10.18632\/oncotarget.4290","journal-title":"Oncotarget"},{"key":"5095_CR47","doi-asserted-by":"publisher","first-page":"149271","DOI":"10.1016\/j.gene.2025.149271","volume":"943","author":"J Lu","year":"2025","unstructured":"Lu J, Wang Z, Zhang L (2025) Single-cell transcriptome analysis revealing mechanotransduction via the Hippo\/YAP pathway in promoting fibroblast-to-myofibroblast transition and idiopathic pulmonary fibrosis development. Gene 943:149271. https:\/\/doi.org\/10.1016\/j.gene.2025.149271","journal-title":"Gene"},{"key":"5095_CR48","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.cytogfr.2020.05.004","volume":"57","author":"KD Sluzalska","year":"2021","unstructured":"Sluzalska KD, Slawski J, Sochacka M et al (2021) Intracellular partners of fibroblast growth factors 1 and 2 - implications for functions. Cytokine Growth Factor Rev 57:93\u2013111. https:\/\/doi.org\/10.1016\/j.cytogfr.2020.05.004","journal-title":"Cytokine Growth Factor Rev"},{"issue":"3","key":"5095_CR49","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1002\/jcp.25111","volume":"231","author":"A Poole","year":"2016","unstructured":"Poole A, Kacer D, Cooper E et al (2016) Sustained Inhibition of proliferative response after transient FGF stimulation is mediated by Interleukin 1 signaling. J Cell Physiol 231(3):650\u2013658. https:\/\/doi.org\/10.1002\/jcp.25111","journal-title":"J Cell Physiol"},{"key":"5095_CR50","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1146\/annurev-pharmtox-032322-093904","volume":"63","author":"L Jin","year":"2023","unstructured":"Jin L, Yang R, Geng L et al (2023) Fibroblast growth Factor-Based pharmacotherapies for the treatment of Obesity-Related metabolic complications. Annu Rev Pharmacol Toxicol 63:359\u2013382. https:\/\/doi.org\/10.1146\/annurev-pharmtox-032322-093904","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"6","key":"5095_CR51","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s11892-017-0866-3","volume":"17","author":"M Izaguirre","year":"2017","unstructured":"Izaguirre M, Gil MJ, Monreal I et al (2017) The role and potential therapeutic implications of the fibroblast growth factors in energy balance and type 2 diabetes. Curr Diab Rep 17(6):43. https:\/\/doi.org\/10.1007\/s11892-017-0866-3","journal-title":"Curr Diab Rep"},{"key":"5095_CR52","doi-asserted-by":"publisher","unstructured":"Huang X, Zhuo Y, Jiang D et al (2022) Maternal Low-Protein diet during puberty and adulthood aggravates lipid metabolism of their offspring fed a High-Fat diet in mice. Nutrients 14(19). https:\/\/doi.org\/10.3390\/nu14194057","DOI":"10.3390\/nu14194057"},{"issue":"4","key":"5095_CR53","doi-asserted-by":"publisher","first-page":"e22881","DOI":"10.1096\/fj.202201950R","volume":"37","author":"J Wang","year":"2023","unstructured":"Wang J, Zhang F, Yang W et al (2023) FGF1 ameliorates obesity-associated hepatic steatosis by reversing IGFBP2 hypermethylation. FASEB J 37(4):e22881. https:\/\/doi.org\/10.1096\/fj.202201950R","journal-title":"FASEB J"},{"issue":"6","key":"5095_CR54","doi-asserted-by":"publisher","first-page":"2206","DOI":"10.1002\/hep.31568","volume":"73","author":"Q Lin","year":"2021","unstructured":"Lin Q, Huang Z, Cai G et al (2021) Activating adenosine Monophosphate-Activated protein kinase mediates fibroblast growth factor 1 protection from nonalcoholic fatty liver disease in mice. Hepatology 73(6):2206\u20132222. https:\/\/doi.org\/10.1002\/hep.31568","journal-title":"Hepatology"},{"issue":"1","key":"5095_CR55","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.cmet.2021.12.004","volume":"34","author":"G Sancar","year":"2022","unstructured":"Sancar G, Liu S, Gasser E et al (2022) FGF1 and insulin control lipolysis by convergent pathways. Cell Metab 34(1):171\u2013183. https:\/\/doi.org\/10.1016\/j.cmet.2021.12.004","journal-title":"Cell Metab"},{"issue":"19","key":"5095_CR56","doi-asserted-by":"publisher","first-page":"e70098","DOI":"10.1096\/fj.202400917R","volume":"38","author":"M Zarei","year":"2024","unstructured":"Zarei M, Sadri F, Mohajeri Khorasani A et al (2024) The pan-cancer landscape presented ITGA7 as a prognostic determinant, tumor suppressor, and oncogene in multiple tumor types. FASEB J 38(19):e70098. https:\/\/doi.org\/10.1096\/fj.202400917R","journal-title":"FASEB J"},{"key":"5095_CR57","doi-asserted-by":"publisher","first-page":"107198","DOI":"10.1016\/j.clineuro.2022.107198","volume":"217","author":"C Li","year":"2022","unstructured":"Li C, Liu J, Yang W et al (2022) The relationship among integrin alpha 7, CD133 and Nestin as well as their correlation with clinicopathological features and prognosis in Astrocytoma patients. Clin Neurol Neurosurg 217:107198. https:\/\/doi.org\/10.1016\/j.clineuro.2022.107198","journal-title":"Clin Neurol Neurosurg"},{"issue":"1","key":"5095_CR58","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.stem.2017.04.009","volume":"21","author":"TL Haas","year":"2017","unstructured":"Haas TL, Sciuto MR, Brunetto L et al (2017) Integrin alpha7 is a functional marker and potential therapeutic target in glioblastoma. Cell Stem Cell 21(1):35\u201350. https:\/\/doi.org\/10.1016\/j.stem.2017.04.009","journal-title":"Cell Stem Cell"},{"issue":"7\u20138","key":"5095_CR59","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/j.matbio.2013.07.001","volume":"32","author":"M Ullah","year":"2013","unstructured":"Ullah M, Sittinger M, Ringe J (2013) Extracellular matrix of adipogenically differentiated mesenchymal stem cells reveals a network of collagen filaments, mostly interwoven by hexagonal structural units. Matrix Biol 32(7\u20138):452\u2013465. https:\/\/doi.org\/10.1016\/j.matbio.2013.07.001","journal-title":"Matrix Biol"},{"issue":"7","key":"5095_CR60","doi-asserted-by":"publisher","first-page":"e2101088","DOI":"10.1002\/mnfr.202101088","volume":"66","author":"HJ Chen","year":"2022","unstructured":"Chen HJ, Yan XY, Sun A et al (2022) High-Fat-Diet-Induced extracellular matrix deposition regulates Integrin-FAK signals in adipose tissue to promote obesity. Mol Nutr Food Res 66(7):e2101088. https:\/\/doi.org\/10.1002\/mnfr.202101088","journal-title":"Mol Nutr Food Res"},{"issue":"10","key":"5095_CR61","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1089\/hum.2015.062","volume":"26","author":"KN Heller","year":"2015","unstructured":"Heller KN, Montgomery CL, Shontz KM et al (2015) Human \u03917 integrin gene (ITGA7) delivered by Adeno-Associated virus extends survival of severely affected Dystrophin\/Utrophin-Deficient mice. Hum Gene Ther 26(10):647\u2013656. https:\/\/doi.org\/10.1089\/hum.2015.062","journal-title":"Hum Gene Ther"},{"key":"5095_CR62","doi-asserted-by":"publisher","first-page":"103666","DOI":"10.1016\/j.jri.2022.103666","volume":"153","author":"Y Wang","year":"2022","unstructured":"Wang Y, Yang D, Zhu R et al (2022) YY1\/ITGA3 pathway May affect trophoblastic cells migration and invasion ability. J Reprod Immunol 153:103666. https:\/\/doi.org\/10.1016\/j.jri.2022.103666","journal-title":"J Reprod Immunol"}],"container-title":["Journal of Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-025-05095-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11060-025-05095-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-025-05095-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T16:54:15Z","timestamp":1752598455000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11060-025-05095-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,6]]},"references-count":62,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["5095"],"URL":"https:\/\/doi.org\/10.1007\/s11060-025-05095-w","relation":{},"ISSN":["0167-594X","1573-7373"],"issn-type":[{"type":"print","value":"0167-594X"},{"type":"electronic","value":"1573-7373"}],"subject":[],"published":{"date-parts":[[2025,6,6]]},"assertion":[{"value":"20 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The present study was approved by The Medical Ethics Committee of The Second Hospital of Lanzhou University (2023\u00a0A-163) and People\u2019s Hospital of Ningxia Hui Autonomous Region (2023-NZR-042). All informed consent was obtained from the subject(s) and\/or guardian(s). Animal Studies No: D2023-034.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}