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This study aimed to clarify SE prevalence and their associations with primary versus secondary manifestations, immune status, corticosteroid treatment, and structural MRI features.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>This retrospective, single-center study included histologically confirmed DLBCL cases (WHO ICD-10 C83.3) with intracerebral involvement (March 2011\u2013November 2023). Subjects without cranial MRI or diagnostic susceptibility-based sequences were excluded. T2*WI and SWI were independently reviewed by two neuroradiologists for presence or absence of SE. Identified SE were classified into five types: punctate, linear, confluent, conglomerate, and\/or ring-like. Lesion focality and morphology were assessed on T2WI and contrast-enhanced T1WI. Clinical data included extracranial lymphoma history, immune status, and corticosteroid initiation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Among 128 cases (median age: 70\u00a0years [58\u201375]; 65 men), 119 (93%) had IP-LBCL and 9 (7%) had SCNSL. 110 (85.9%) subjects were immunocompetent. T2*WI was available in 90 (70.3%) datasets and SWI in 38 (29.7%). SE detection was higher on SWI (71.1%) than T2*WI (47.8%; <jats:italic>P<\/jats:italic>\u2009=\u20090.03). No association was found between SE and lymphoma type (<jats:italic>P<\/jats:italic>\u2009=\u20091.00). In IP-LBCL, immunosuppression was significantly associated with SE presence\u00a0(<jats:italic>P<\/jats:italic>\u2009=\u20090.001; OR\u2009=\u200916.1, 95% CI: 2.89\u2013304.79), while age, gender, and corticosteroid use (18.5%) were not. SE showed no significant associations with structural imaging features, including necrosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>SE are common in both IP-LBCL and SCNSL, particularly on SWI, and present with variable patterns unrelated to structural MRI features. In IP-LBCL, immunosuppression, but not pre-existing corticosteroid treatment, is significantly associated with the presence of SE.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s11060-025-05124-8","type":"journal-article","created":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T07:49:23Z","timestamp":1752306563000},"page":"231-241","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Susceptibility- and T2*-weighted MRI features of CNS large B-cell lymphoma in a large single-center cohort: prevalence, patterns, and clinical associations"],"prefix":"10.1007","volume":"175","author":[{"given":"Christophe T.","family":"Arendt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"L\u00f6hlau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"R\u00f6der","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Burger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Hattingen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Weidauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,12]]},"reference":[{"key":"5124_CR1","doi-asserted-by":"crossref","unstructured":"Roschewski M, Phelan JD, Jaffe ES (2024) Primary large B-cell lymphomas of immune\u2013privileged sites. 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