{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:09:21Z","timestamp":1767704961980,"version":"3.48.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurooncol"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s11060-025-05300-w","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T07:38:14Z","timestamp":1760945894000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical utility of repeat brain biopsy in recurrent or refractory primary CNS lymphoma \u2013 a diagnostic dilemma"],"prefix":"10.1007","volume":"176","author":[{"given":"Noor","family":"Malik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William D.","family":"Chow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Gharibi","family":"Loron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo Bin","family":"You","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Kendall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael B.","family":"Keough","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terry C.","family":"Burns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian F.","family":"Parney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,20]]},"reference":[{"issue":"3","key":"5300_CR1","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1093\/neuonc\/noy192","volume":"21","author":"C Grommes","year":"2019","unstructured":"Grommes C, Rubenstein JL, DeAngelis LM, Ferreri AJM, Batchelor TT (2019) Comprehensive approach to diagnosis and treatment of newly diagnosed primary CNS lymphoma. Neuro-Oncol 21(3):296\u2013305. https:\/\/doi.org\/10.1093\/neuonc\/noy192","journal-title":"Neuro-Oncol"},{"issue":"14","key":"5300_CR2","doi-asserted-by":"publisher","first-page":"2318","DOI":"10.1182\/blood-2013-06-453084","volume":"122","author":"JL Rubenstein","year":"2013","unstructured":"Rubenstein JL, Gupta NK, Mannis GN, Lamarre AK, Treseler P (2013) How I treat CNS lymphomas. Blood 122(14):2318\u20132330. https:\/\/doi.org\/10.1182\/blood-2013-06-453084","journal-title":"Blood"},{"issue":"12 Suppl 2","key":"5300_CR3","doi-asserted-by":"publisher","first-page":"iii1","DOI":"10.1093\/neuonc\/noab200","volume":"23","author":"QT Ostrom","year":"2021","unstructured":"Ostrom QT, Cioffi G, Waite K, Kruchko C, Barnholtz-Sloan JS (2021) CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the united States in 2014\u20132018. Neuro-Oncol 23(12 Suppl 2):iii1\u2013iii105. https:\/\/doi.org\/10.1093\/neuonc\/noab200","journal-title":"Neuro-Oncol"},{"issue":"8","key":"5300_CR4","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1038\/bmt.2015.6","volume":"50","author":"A Sureda","year":"2015","unstructured":"Sureda A, Bader P, Cesaro S et al (2015) Indications for allo- and auto-SCT for haematological diseases, solid tumours and immune disorders: current practice in Europe, 2015. Bone Marrow Transpl 50(8):1037\u20131056. https:\/\/doi.org\/10.1038\/bmt.2015.6","journal-title":"Bone Marrow Transpl"},{"issue":"11","key":"5300_CR5","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.3324\/haematol.2011.060434","volume":"97","author":"C Soussain","year":"2012","unstructured":"Soussain C, Choquet S, Fourme E, Delgadillo D, Bouabdallah K, Ghesqui\u00e8res H et al (2012) Intensive chemotherapy with thiotepa, Busulfan and cyclophosphamide and hematopoietic stem cell rescue in relapsed or refractory primary central nervous system lymphoma and intraocular lymphoma: a retrospective study of 79 cases. Haematologica 97(11):1751\u20131756. https:\/\/doi.org\/10.3324\/haematol.2011.060434","journal-title":"Haematologica"},{"issue":"9","key":"5300_CR6","doi-asserted-by":"publisher","first-page":"2100","DOI":"10.3390\/cancers14092100","volume":"14","author":"S Seidel","year":"2022","unstructured":"Seidel S, Nilius-Eliliwi V, Kowalski T et al (2022) High-Dose chemotherapy with autologous hematopoietic stem cell transplantation in relapsed or refractory primary CNS lymphoma: A retrospective monocentric analysis of Long-Term Outcome, prognostic Factors, and toxicity. Cancers 14(9):2100. https:\/\/doi.org\/10.3390\/cancers14092100","journal-title":"Cancers"},{"key":"5300_CR7","doi-asserted-by":"publisher","first-page":"947","DOI":"10.3389\/fonc.2019.00947","volume":"9","author":"SK Akshulakov","year":"2019","unstructured":"Akshulakov SK, Kerimbayev TT, Biryuchkov MY et al (2019) Current trends for improving safety of stereotactic brain biopsies: advanced optical methods for vessel avoidance and tumor detection. Front Oncol 9:947. https:\/\/doi.org\/10.3389\/fonc.2019.00947","journal-title":"Front Oncol"},{"issue":"1","key":"5300_CR8","doi-asserted-by":"publisher","first-page":"26527","DOI":"10.1038\/s41598-024-78187-8","volume":"14","author":"L Hu","year":"2024","unstructured":"Hu L, Tang J, Su X et al (2024) The utilization of cytology for intraoperative diagnosis of primary central nervous system lymphoma. Sci Rep 14(1):26527. https:\/\/doi.org\/10.1038\/s41598-024-78187-8","journal-title":"Sci Rep"},{"key":"5300_CR9","doi-asserted-by":"publisher","first-page":"23","DOI":"10.21037\/aol-21-20","volume":"5","author":"P Ambady","year":"2021","unstructured":"Ambady P, Doolittle ND, Fox CP (2021) Relapsed and refractory primary CNS lymphoma: treatment approaches in routine practice. Ann Lymphoma 5:23. https:\/\/doi.org\/10.21037\/aol-21-20","journal-title":"Ann Lymphoma"},{"issue":"1","key":"5300_CR10","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s10143-019-01234-w","volume":"44","author":"M Riche","year":"2021","unstructured":"Riche M, Amelot A, Peyre M et al (2021) Complications after frame-based stereotactic brain biopsy: a systematic review. Neurosurg Rev 44(1):301\u2013307. https:\/\/doi.org\/10.1007\/s10143-019-01234-w","journal-title":"Neurosurg Rev"},{"key":"5300_CR11","doi-asserted-by":"publisher","unstructured":"Hertler C (2025) Financial burden after brain tumor diagnosis: the cost of disease for patients and caregivers. Neuro-Oncol Pract 12. https:\/\/doi.org\/10.1093\/nop\/npaf010","DOI":"10.1093\/nop\/npaf010"},{"issue":"1","key":"5300_CR12","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1148\/rg.2021200064","volume":"41","author":"M Katsura","year":"2021","unstructured":"Katsura M, Sato J, Akahane M et al (2021) Recognizing radiation-induced changes in the central nervous system: where to look and what to look for. Radiographics 41(1):224\u2013248. https:\/\/doi.org\/10.1148\/rg.2021200064","journal-title":"Radiographics"},{"issue":"3","key":"5300_CR13","doi-asserted-by":"publisher","first-page":"748","DOI":"10.3171\/2022.12.JNS222173","volume":"139","author":"JS Young","year":"2023","unstructured":"Young JS, Al-Adli N, Scotford K, Cha S, Berger MS (2023) Pseudoprogression versus true progression in glioblastoma: what neurosurgeons need to know. J Neurosurg 139(3):748\u2013759. https:\/\/doi.org\/10.3171\/2022.12.JNS222173","journal-title":"J Neurosurg"},{"issue":"17","key":"5300_CR14","doi-asserted-by":"publisher","first-page":"4071","DOI":"10.3390\/cancers14174071","volume":"14","author":"L Rozenblum","year":"2022","unstructured":"Rozenblum L, Houillier C, Soussain C et al (2022) Role of positron emission tomography in primary central nervous system lymphoma. Cancers (Basel) 14(17):4071. https:\/\/doi.org\/10.3390\/cancers14174071","journal-title":"Cancers (Basel)"},{"issue":"3","key":"5300_CR15","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1177\/1971400919830173","volume":"32","author":"G Bathla","year":"2019","unstructured":"Bathla G, Soni N, Endozo R, Ganeshan B (2019) Magnetic resonance texture analysis utility in differentiating intraparenchymal neurosarcoidosis from primary central nervous system lymphoma: a preliminary analysis. Neuroradiol J 32(3):203\u2013209. https:\/\/doi.org\/10.1177\/1971400919830173","journal-title":"Neuroradiol J"},{"issue":"11","key":"5300_CR16","doi-asserted-by":"publisher","first-page":"2665","DOI":"10.3390\/cancers13112665","volume":"13","author":"A Baraniskin","year":"2021","unstructured":"Baraniskin A, Schroers R (2021) Liquid biopsy and other Non-Invasive diagnostic measures in PCNSL. Cancers (Basel) 13(11):2665. https:\/\/doi.org\/10.3390\/cancers13112665","journal-title":"Cancers (Basel)"},{"issue":"3","key":"5300_CR17","doi-asserted-by":"publisher","first-page":"371","DOI":"10.3892\/ijo.2021.5180","volume":"58","author":"Y Liu","year":"2021","unstructured":"Liu Y, Yao Q, Zhang F (2021) Diagnosis, prognosis and treatment of primary central nervous system lymphoma in the elderly population (Review). Int J Oncol 58(3):371\u2013387. https:\/\/doi.org\/10.3892\/ijo.2021.5180","journal-title":"Int J Oncol"},{"issue":"1","key":"5300_CR18","doi-asserted-by":"publisher","first-page":"30","DOI":"10.3171\/2020.12.JNS202517","volume":"136","author":"DA Brown","year":"2021","unstructured":"Brown DA, Goyal A, Richter KR et al (2021) Clinical utility of brain biopsy for presumed CNS relapse of systemic lymphoma. J Neurosurg 136(1):30\u201339. https:\/\/doi.org\/10.3171\/2020.12.JNS202517","journal-title":"J Neurosurg"},{"issue":"4","key":"5300_CR19","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1227\/neu.0000000000002944","volume":"95","author":"K Tosefsky","year":"2024","unstructured":"Tosefsky K, Rebchuk AD, Martin KC et al (2024) Preoperative corticosteroids reduce diagnostic accuracy of stereotactic biopsies in primary central nervous system lymphoma: A systematic review and Meta-Analysis. J Neurosurg 95(4):740\u2013750. https:\/\/doi.org\/10.1227\/neu.0000000000002944","journal-title":"J Neurosurg"},{"issue":"3","key":"5300_CR20","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1053\/j.sult.2023.02.003","volume":"44","author":"R Capasso","year":"2023","unstructured":"Capasso R, Negro A, Russo C et al (2023) Conventional and advanced MRI techniques in the evaluation of primary CNS lymphoma. Semin Ultrasound CT MR 44(3):126\u2013135. https:\/\/doi.org\/10.1053\/j.sult.2023.02.003","journal-title":"Semin Ultrasound CT MR"},{"issue":"7","key":"5300_CR21","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1093\/neuonc\/noab020","volume":"23","author":"RF Barajas","year":"2021","unstructured":"Barajas RF, Politi LS, Anzalone N et al (2021) Consensus recommendations for MRI and PET imaging of primary central nervous system lymphoma: guideline statement from the international primary CNS lymphoma collaborative group (IPCG). Neurooncology 23(7):1056\u20131071. https:\/\/doi.org\/10.1093\/neuonc\/noab020","journal-title":"Neurooncology"},{"issue":"2","key":"5300_CR22","doi-asserted-by":"publisher","first-page":"261","DOI":"10.3171\/jns.2000.92.2.0261","volume":"92","author":"B Bataille","year":"2000","unstructured":"Bataille B, Delwail V, Menet E et al (2000) Primary intracerebral malignant lymphoma: report of 248 cases. J Neurosurg 92(2):261\u2013266. https:\/\/doi.org\/10.3171\/jns.2000.92.2.0261","journal-title":"J Neurosurg"},{"issue":"3","key":"5300_CR23","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.neurol.2022.06.014","volume":"179","author":"L Nguyen-Them","year":"2023","unstructured":"Nguyen-Them L, Alentorn A, Ahle G et al (2023) CSF biomarkers in primary CNS lymphoma. Rev Neurol (Paris) 179(3):141\u2013149. https:\/\/doi.org\/10.1016\/j.neurol.2022.06.014","journal-title":"Rev Neurol (Paris)"},{"issue":"13","key":"5300_CR24","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.1080\/10428194.2024.2389210","volume":"65","author":"E Jamal","year":"2024","unstructured":"Jamal E, Poynton E, Elbogdady M, Shamaa S, Okosun J (2024) Prospects for liquid biopsy approaches in lymphomas. Leuk Lymphoma 65(13):1923\u20131933. https:\/\/doi.org\/10.1080\/10428194.2024.2389210","journal-title":"Leuk Lymphoma"}],"container-title":["Journal of Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-025-05300-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11060-025-05300-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-025-05300-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T12:34:29Z","timestamp":1767702869000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11060-025-05300-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,20]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["5300"],"URL":"https:\/\/doi.org\/10.1007\/s11060-025-05300-w","relation":{},"ISSN":["0167-594X","1573-7373"],"issn-type":[{"type":"print","value":"0167-594X"},{"type":"electronic","value":"1573-7373"}],"subject":[],"published":{"date-parts":[[2025,10,20]]},"assertion":[{"value":"21 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Mayo Clinic Ethics Committee.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"None.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Previous presentations"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"32"}}