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Informed consent for treatment was obtained from legal guardians as part of routine clinical care. This is not an interventional study. This is a retrospective review of patients treated according to standard of care in place at the institution. Standard of care was based on the existing literature and a consensus of the members of the multidisciplinary neuro-oncology program. This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Research Ethics Committees of Vice-Chancellor in Research. Affairs-Shahid Beheshti University of Medical Sciences. The need for informed consent and assent was waived given the retrospective nature of the study, the use of fully anonymized patient data and high mortality rate in this cohort. 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