{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T20:35:44Z","timestamp":1781210144514,"version":"3.54.1"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100008678","name":"Universit\u00e4t Leipzig","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008678","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurooncol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Peritumoral brain edema (PTBE) is a frequent finding in meningiomas and can significantly affect perioperative outcomes. In addition to well-established clinical, radiological, and histopathological risk factors, molecular markers such as Forkhead Box C1 (FOXC1) may also play a crucial role in the development of PTBE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective, single-center study including 86 patients with histopathologically confirmed meningiomas. Preoperative MRI datasets were analyzed for tumor characteristics using 3D Slicer and ImageJ. FOXC1 expression was assessed immunohistochemically and dichotomized based on receiver operating characteristic (ROC) curve analysis. Univariate analyses were performed to evaluate associations between clinical, radiological, and histopathological variables and the presence of PTBE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PTBE was significantly associated with low FOXC1 expression (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015). Furthermore, WHO grade 2\/3 meningiomas (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012), perioperative seizures (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.024), subtype (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016), tumor laterality (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04), higher MIB-1 index\n                      <jats:italic>(p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and tumor volume (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) were also significantly associated with PTBE. Tumor localization (skull base vs. non-skull-base) and sex showed no significant correlation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Combining molecular and radiological parameters could improve neurosurgical planning and perioperative management. Further studies are needed regarding the assessment of the response to anti-edematous therapies in low and high FOXC1 expressing meningiomas.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11060-026-05441-6","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T12:13:48Z","timestamp":1770120828000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["FOXC1 expression and radiological predictors of peritumoral brain edema in meningiomas"],"prefix":"10.1007","volume":"176","author":[{"given":"Alim Emre","family":"Basaran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Braune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alonso","family":"Barrantes-Freer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolf C.","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Vychopen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdem","family":"G\u00fcresir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Wach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"issue":"6","key":"5441_CR1","doi-asserted-by":"publisher","first-page":"E2","DOI":"10.3171\/2013.8.FOCUS13301","volume":"35","author":"J Hou","year":"2013","unstructured":"Hou J, Kshettry VR, Selman WR, Bambakidis NC (2013) Peritumoral brain edema in intracranial meningiomas: the emergence of vascular endothelial growth factor-directed therapy. Neurosurg Focus 35(6):E2. https:\/\/doi.org\/10.3171\/2013.8.FOCUS13301","journal-title":"Neurosurg Focus"},{"issue":"5","key":"5441_CR2","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.surneu.2008.03.006","volume":"70","author":"A Simis","year":"2008","unstructured":"Simis A, Pires de Aguiar PH, Leite CC, Santana PA, Rosemberg S, Teixeira MJ (2008) Peritumoral brain edema in benign meningiomas: correlation with clinical, radiologic, and surgical factors and possible role on recurrence. Surg Neurol 70(5):471\u2013477 discussion 477. https:\/\/doi.org\/10.1016\/j.surneu.2008.03.006","journal-title":"Surg Neurol"},{"issue":"3","key":"5441_CR3","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1097\/00006123-199803000-00007","volume":"42","author":"MP Sindou","year":"1998","unstructured":"Sindou MP, Alaywan M (1998) Most intracranial meningiomas are not cleavable tumors: anatomic-surgical evidence and angiographic predictibility. Neurosurgery 42(3):476\u2013480. https:\/\/doi.org\/10.1097\/00006123-199803000-00007","journal-title":"Neurosurgery"},{"issue":"3","key":"5441_CR4","doi-asserted-by":"publisher","first-page":"375","DOI":"10.3171\/jns.1999.91.3.0375","volume":"91","author":"RE Mantle","year":"1999","unstructured":"Mantle RE, Lach B, Delgado MR, Baeesa S, B\u00e9langer G (1999) Predicting the probability of meningioma recurrence based on the quantity of peritumoral brain edema on computerized tomography scanning. J Neurosurg 91(3):375\u2013383. https:\/\/doi.org\/10.3171\/jns.1999.91.3.0375","journal-title":"J Neurosurg"},{"issue":"3","key":"5441_CR5","doi-asserted-by":"publisher","first-page":"382","DOI":"10.3171\/jns.2006.104.3.382","volume":"104","author":"M Tanaka","year":"2006","unstructured":"Tanaka M, Imhof HG, Schucknecht B, Kollias S, Yonekawa Y, Valavanis A (2006) Correlation between the efferent venous drainage of the tumor and peritumoral edema in intracranial meningiomas: superselective angiographic analysis of 25 cases. J Neurosurg 104(3):382\u2013388. https:\/\/doi.org\/10.3171\/jns.2006.104.3.382","journal-title":"J Neurosurg"},{"issue":"6","key":"5441_CR6","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1227\/00006123-198306000-00001","volume":"12","author":"JJ Gilbert","year":"1983","unstructured":"Gilbert JJ, Paulseth JE, Coates RK, Malott D (1983) Cerebral edema associated with meningiomas. Neurosurgery 12(6):599\u2013605. https:\/\/doi.org\/10.1227\/00006123-198306000-00001","journal-title":"Neurosurgery"},{"issue":"4","key":"5441_CR7","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1007\/s12094-022-03009-0","volume":"25","author":"B Fiani","year":"2023","unstructured":"Fiani B, Jarrah R, Bhandarkar AR et al (2023) Peritumoral edema in meningiomas: pathophysiology, predictors, and principles for treatment. Clin Transl Oncol 25(4):866\u2013872. https:\/\/doi.org\/10.1007\/s12094-022-03009-0","journal-title":"Clin Transl Oncol"},{"issue":"4","key":"5441_CR8","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1002\/(sici)1097-0142(19990215)85:4<936::aid-cncr23>3.0.co;2-j","volume":"85","author":"H Yoshioka","year":"1999","unstructured":"Yoshioka H, Hama S, Taniguchi E, Sugiyama K, Arita K, Kurisu K (1999) Peritumoral brain edema associated with meningioma: influence of vascular endothelial growth factor expression and vascular blood supply. Cancer 85(4):936\u2013944. https:\/\/doi.org\/10.1002\/(sici)1097-0142(19990215)85:4%3C936::aid-cncr23%3E3.0.co;2-j","journal-title":"Cancer"},{"issue":"6","key":"5441_CR9","doi-asserted-by":"publisher","first-page":"e0252945","DOI":"10.1371\/journal.pone.0252945","volume":"16","author":"C Shin","year":"2021","unstructured":"Shin C, Kim JM, Cheong JH et al (2021) Association between tumor size and peritumoral brain edema in patients with convexity and parasagittal meningiomas. PLoS ONE 16(6):e0252945. https:\/\/doi.org\/10.1371\/journal.pone.0252945","journal-title":"PLoS ONE"},{"issue":"1","key":"5441_CR10","doi-asserted-by":"publisher","first-page":"26","DOI":"10.3340\/jkns.2011.49.1.26","volume":"49","author":"BW Kim","year":"2011","unstructured":"Kim BW, Kim MS, Kim SW, Chang CH, Kim OL (2011) Peritumoral brain edema in meningiomas: correlation of radiologic and pathologic features. J Korean Neurosurg Soc 49(1):26\u201330. https:\/\/doi.org\/10.3340\/jkns.2011.49.1.26","journal-title":"J Korean Neurosurg Soc"},{"key":"5441_CR11","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/978-3-7091-9334-1_97","volume":"60","author":"U Ito","year":"1994","unstructured":"Ito U, Tomita H, Tone O, Masaoka H, Tominaga B (1994) Peritumoral edema in meningioma: a contrast enhanced CT study. Acta Neurochir Suppl (Wien) 60:361\u2013364. https:\/\/doi.org\/10.1007\/978-3-7091-9334-1_97","journal-title":"Acta Neurochir Suppl (Wien)"},{"issue":"1","key":"5441_CR12","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1002\/jmri.27046","volume":"52","author":"MR Sapkota","year":"2020","unstructured":"Sapkota MR, Yang Z, Zhu D et al (2020) Evaluation of epidemiologic Factors, radiographic Features, and pathologic findings for predicting peritumoral brain edema in meningiomas. J Magn Reson Imaging 52(1):174\u2013182. https:\/\/doi.org\/10.1002\/jmri.27046","journal-title":"J Magn Reson Imaging"},{"issue":"2","key":"5441_CR13","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s11060-019-03293-x","volume":"145","author":"A Ressel","year":"2019","unstructured":"Ressel A, Fichte S, Brodhun M, Rosahl SK, Gerlach R (2019) WHO grade of intracranial meningiomas differs with respect to patient\u2019s age, location, tumor size and peritumoral edema. J Neurooncol 145(2):277\u2013286. https:\/\/doi.org\/10.1007\/s11060-019-03293-x","journal-title":"J Neurooncol"},{"issue":"1","key":"5441_CR14","doi-asserted-by":"publisher","first-page":"42","DOI":"10.20471\/acc.2019.58.01.06","volume":"58","author":"H Be\u010duli\u0107","year":"2019","unstructured":"Be\u010duli\u0107 H, Skomorac R, Jusi\u0107 A et al (2019) Correlation of peritumoral brain edema with morphological characteristics and KI67 proliferative index in resected intracranial meningiomas. Acta Clin Croat 58(1):42\u201349. https:\/\/doi.org\/10.20471\/acc.2019.58.01.06","journal-title":"Acta Clin Croat"},{"issue":"1","key":"5441_CR15","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s10014-006-0199-4","volume":"23","author":"T Hashiba","year":"2006","unstructured":"Hashiba T, Hashimoto N, Maruno M et al (2006) Scoring radiologic characteristics to predict proliferative potential in meningiomas. Brain Tumor Pathol 23(1):49\u201354. https:\/\/doi.org\/10.1007\/s10014-006-0199-4","journal-title":"Brain Tumor Pathol"},{"issue":"1","key":"5441_CR16","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.ydbio.2016.09.019","volume":"420","author":"S Mishra","year":"2016","unstructured":"Mishra S, Choe Y, Pleasure SJ, Siegenthaler JA (2016) Cerebrovascular defects in Foxc1 mutants correlate with aberrant WNT and VEGF-A pathways downstream of retinoic acid from the meninges. Dev Biol 420(1):148\u2013165. https:\/\/doi.org\/10.1016\/j.ydbio.2016.09.019","journal-title":"Dev Biol"},{"issue":"7","key":"5441_CR17","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1242\/bio.20135009","volume":"2","author":"JA Siegenthaler","year":"2013","unstructured":"Siegenthaler JA, Choe Y, Patterson KP et al (2013) Foxc1 is required by pericytes during fetal brain angiogenesis. Biol Open 2(7):647\u2013659. https:\/\/doi.org\/10.1242\/bio.20135009","journal-title":"Biol Open"},{"issue":"12","key":"5441_CR18","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1177\/1758834017742576","volume":"9","author":"Z Yang","year":"2017","unstructured":"Yang Z, Jiang S, Cheng Y et al (2017) FOXC1 in cancer development and therapy: Deciphering its emerging and divergent roles. Ther Adv Med Oncol 9(12):797\u2013816. https:\/\/doi.org\/10.1177\/1758834017742576","journal-title":"Ther Adv Med Oncol"},{"issue":"1","key":"5441_CR19","doi-asserted-by":"publisher","first-page":"251","DOI":"10.3892\/mmr.2018.9650","volume":"19","author":"Q Cao","year":"2019","unstructured":"Cao Q, Wang X, Shi Y et al (2019) FOXC1 Silencing inhibits the epithelial-to-mesenchymal transition of glioma cells: involvement of \u03b2-catenin signaling. Mol Med Rep 19(1):251\u2013261. https:\/\/doi.org\/10.3892\/mmr.2018.9650","journal-title":"Mol Med Rep"},{"issue":"6","key":"5441_CR20","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","volume":"131","author":"DN Louis","year":"2016","unstructured":"Louis DN, Perry A, Reifenberger G et al (2016) The 2016 world health organization classification of tumors of the central nervous system: a summary. Acta Neuropathol 131(6):803\u2013820. https:\/\/doi.org\/10.1007\/s00401-016-1545-1","journal-title":"Acta Neuropathol"},{"issue":"8","key":"5441_CR21","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","volume":"23","author":"DN Louis","year":"2021","unstructured":"Louis DN, Perry A, Wesseling P et al (2021) The 2021 WHO classification of tumors of the central nervous system: a summary. Neuro Oncol 23(8):1231\u20131251. https:\/\/doi.org\/10.1093\/neuonc\/noab106","journal-title":"Neuro Oncol"},{"key":"5441_CR22","doi-asserted-by":"publisher","unstructured":"Wach J, Naegeli J, Vychopen M et al (2023) Impact of shape irregularity in medial sphenoid wing meningiomas on postoperative cranial nerve Functioning, Proliferation, and Progression-Free survival. Cancers (Basel) 15(12). https:\/\/doi.org\/10.3390\/cancers15123096","DOI":"10.3390\/cancers15123096"},{"issue":"9","key":"5441_CR23","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1016\/j.mri.2012.05.001","volume":"30","author":"A Fedorov","year":"2012","unstructured":"Fedorov A, Beichel R, Kalpathy-Cramer J et al (2012) 3D slicer as an image computing platform for the quantitative imaging network. Magn Reson Imaging 30(9):1323\u20131341. https:\/\/doi.org\/10.1016\/j.mri.2012.05.001","journal-title":"Magn Reson Imaging"},{"issue":"21","key":"5441_CR24","doi-asserted-by":"publisher","first-page":"e104","DOI":"10.1158\/0008-5472.CAN-17-0339","volume":"77","author":"JJM van Griethuysen","year":"2017","unstructured":"van Griethuysen JJM, Fedorov A, Parmar C et al (2017) Computational radiomics system to Decode the radiographic phenotype. Cancer Res 77(21):e104\u2013e107. https:\/\/doi.org\/10.1158\/0008-5472.CAN-17-0339","journal-title":"Cancer Res"},{"issue":"7","key":"5441_CR25","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nmeth.2089","volume":"9","author":"CA Schneider","year":"2012","unstructured":"Schneider CA, Rasband WS, Eliceiri KW (2012) NIH image to imageJ: 25 years of image analysis. Nat Methods 9(7):671\u2013675. https:\/\/doi.org\/10.1038\/nmeth.2089","journal-title":"Nat Methods"},{"issue":"7","key":"5441_CR26","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","volume":"9","author":"J Schindelin","year":"2012","unstructured":"Schindelin J, Arganda-Carreras I, Frise E et al (2012) Fiji: an open-source platform for biological-image analysis. Nat Methods 9(7):676\u2013682. https:\/\/doi.org\/10.1038\/nmeth.2019","journal-title":"Nat Methods"},{"issue":"1","key":"5441_CR27","doi-asserted-by":"publisher","first-page":"16878","DOI":"10.1038\/s41598-017-17204-5","volume":"7","author":"P Bankhead","year":"2017","unstructured":"Bankhead P, Loughrey MB, Fern\u00e1ndez JA et al (2017) QuPath: open source software for digital pathology image analysis. Sci Rep 7(1):16878. https:\/\/doi.org\/10.1038\/s41598-017-17204-5","journal-title":"Sci Rep"},{"issue":"28","key":"5441_CR28","doi-asserted-by":"publisher","first-page":"3957","DOI":"10.1038\/onc.2017.48","volume":"36","author":"B Han","year":"2017","unstructured":"Han B, Bhowmick N, Qu Y, Chung S, Giuliano AE, Cui X (2017) FOXC1: an emerging marker and therapeutic target for cancer. Oncogene 36(28):3957\u20133963. https:\/\/doi.org\/10.1038\/onc.2017.48","journal-title":"Oncogene"},{"issue":"51","key":"5441_CR29","doi-asserted-by":"publisher","first-page":"84375","DOI":"10.18632\/oncotarget.11224","volume":"7","author":"J Wang","year":"2016","unstructured":"Wang J, Li L, Liu S, Zhao Y, Wang L, Du G (2016) FOXC1 promotes melanoma by activating MST1R\/PI3K\/AKT. Oncotarget 7(51):84375\u201384387. https:\/\/doi.org\/10.18632\/oncotarget.11224","journal-title":"Oncotarget"},{"issue":"5","key":"5441_CR30","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1038\/s41388-020-01568-6","volume":"40","author":"DM Fountain","year":"2021","unstructured":"Fountain DM, Smith MJ, O\u2019Leary C et al (2021) The Spatial phenotype of genotypically distinct meningiomas demonstrate potential implications of the embryology of the meninges. Oncogene 40(5):875\u2013884. https:\/\/doi.org\/10.1038\/s41388-020-01568-6","journal-title":"Oncogene"},{"issue":"11","key":"5441_CR31","doi-asserted-by":"publisher","first-page":"5026","DOI":"10.1167\/iovs.09-3447","volume":"50","author":"JM Skarie","year":"2009","unstructured":"Skarie JM, Link BA (2009) FoxC1 is essential for vascular basement membrane integrity and hyaloid vessel morphogenesis. Invest Ophthalmol Vis Sci 50(11):5026\u20135034. https:\/\/doi.org\/10.1167\/iovs.09-3447","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"11","key":"5441_CR32","doi-asserted-by":"publisher","first-page":"4877","DOI":"10.1172\/JCI75109","volume":"124","author":"CR French","year":"2014","unstructured":"French CR, Seshadri S, Destefano AL et al (2014) Mutation of FOXC1 and PITX2 induces cerebral small-vessel disease. J Clin Invest 124(11):4877\u20134881. https:\/\/doi.org\/10.1172\/JCI75109","journal-title":"J Clin Invest"},{"key":"5441_CR33","doi-asserted-by":"publisher","unstructured":"Wang H, Wang H, Song Y et al (2022) Overexpression of Foxc1 ameliorates sepsis-associated encephalopathy by inhibiting microglial migration and neuroinflammation through the I\u03baB\u03b1\/NF-\u03baB pathway. Mol Med Rep 25(3). https:\/\/doi.org\/10.3892\/mmr.2022.12623","DOI":"10.3892\/mmr.2022.12623"},{"issue":"1","key":"5441_CR34","doi-asserted-by":"publisher","first-page":"vdac084","DOI":"10.1093\/noajnl\/vdac084","volume":"4","author":"MA Wedemeyer","year":"2022","unstructured":"Wedemeyer MA, Muskens I, Strickland BA et al (2022) Epigenetic dysregulation in meningiomas. Neurooncol Adv 4(1):vdac084. https:\/\/doi.org\/10.1093\/noajnl\/vdac084","journal-title":"Neurooncol Adv"},{"issue":"10","key":"5441_CR35","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1093\/neuonc\/noy057","volume":"20","author":"Z Du","year":"2018","unstructured":"Du Z, Brewster R, Merrill PH et al (2018) Meningioma transcription factors link cell lineage with systemic metabolic cues. Neuro Oncol 20(10):1331\u20131343. https:\/\/doi.org\/10.1093\/neuonc\/noy057","journal-title":"Neuro Oncol"},{"issue":"1","key":"5441_CR36","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/s11060-013-1208-1","volume":"115","author":"J Reszec","year":"2013","unstructured":"Reszec J, Hermanowicz A, Rutkowski R, Bernaczyk P, Mariak Z, Chyczewski L (2013) Evaluation of mast cells and hypoxia inducible factor-1 expression in meningiomas of various grades in correlation with peritumoral brain edema. J Neurooncol 115(1):119\u2013125. https:\/\/doi.org\/10.1007\/s11060-013-1208-1","journal-title":"J Neurooncol"},{"issue":"3","key":"5441_CR37","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1590\/S1807-59322005000300004","volume":"60","author":"TA Mattei","year":"2005","unstructured":"Mattei TA, Mattei JA, Ramina R, Aguiar PH, Plese JP, Marino R (2005) Edema and malignancy in meningiomas. Clin (Sao Paulo) 60(3):201\u2013206. https:\/\/doi.org\/10.1590\/S1807-59322005000300004","journal-title":"Clin (Sao Paulo)"},{"issue":"1","key":"5441_CR38","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s11060-025-04964-8","volume":"173","author":"J Laajava","year":"2025","unstructured":"Laajava J, Niemel\u00e4 M, Korja M (2025) Peritumoral edema resolves infrequently in surgically treated patients with intracranial meningioma- a retrospective study of 279 meningioma patients. J Neurooncol 173(1):83\u201394. https:\/\/doi.org\/10.1007\/s11060-025-04964-8","journal-title":"J Neurooncol"},{"key":"5441_CR39","doi-asserted-by":"publisher","first-page":"967420","DOI":"10.3389\/fonc.2022.967420","volume":"12","author":"T Mederer","year":"2022","unstructured":"Mederer T, Schachinger S, Rosengarth K et al (2022) Symptom burden and surgical outcome in non-skull base meningiomas. Front Oncol 12:967420. https:\/\/doi.org\/10.3389\/fonc.2022.967420","journal-title":"Front Oncol"},{"issue":"1","key":"5441_CR40","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s11060-012-0989-y","volume":"111","author":"T Osawa","year":"2013","unstructured":"Osawa T, Tosaka M, Nagaishi M, Yoshimoto Y (2013) Factors affecting peritumoral brain edema in meningioma: special histological subtypes with prominently extensive edema. J Neurooncol 111(1):49\u201357. https:\/\/doi.org\/10.1007\/s11060-012-0989-y","journal-title":"J Neurooncol"},{"key":"5441_CR41","doi-asserted-by":"publisher","first-page":"674898","DOI":"10.3389\/fnins.2021.674898","volume":"15","author":"CH Toh","year":"2021","unstructured":"Toh CH, Siow TY, Castillo M (2021) Peritumoral brain edema in meningiomas May be related to glymphatic dysfunction. Front Neurosci 15:674898. https:\/\/doi.org\/10.3389\/fnins.2021.674898","journal-title":"Front Neurosci"},{"issue":"2","key":"5441_CR42","doi-asserted-by":"publisher","first-page":"94","DOI":"10.14791\/btrt.2016.4.2.94","volume":"4","author":"J Hwang","year":"2016","unstructured":"Hwang J, Kong DS, Seol HJ, Nam DH, Lee JI, Choi JW (2016) Clinical and radiological characteristics of angiomatous meningiomas. Brain Tumor Res Treat 4(2):94. https:\/\/doi.org\/10.14791\/btrt.2016.4.2.94","journal-title":"Brain Tumor Res Treat"},{"key":"5441_CR43","doi-asserted-by":"publisher","first-page":"650939","DOI":"10.1155\/2014\/650939","volume":"2014","author":"A Azizyan","year":"2014","unstructured":"Azizyan A, Eboli P, Drazin D, Mirocha J, Maya MM, Bannykh S (2014) Differentiation of benign angiomatous and microcystic meningiomas with extensive peritumoral edema from high grade meningiomas with aid of diffusion weighted MRI. Biomed Res Int 2014:650939. https:\/\/doi.org\/10.1155\/2014\/650939","journal-title":"Biomed Res Int"},{"issue":"1","key":"5441_CR44","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s10143-025-03416-1","volume":"48","author":"MJ Tanti","year":"2025","unstructured":"Tanti MJ, Nevitt S, Yeo M et al (2025) Oedema as a prognostic factor for seizures in meningioma - a systematic review and meta-analysis. Neurosurg Rev 48(1):249. https:\/\/doi.org\/10.1007\/s10143-025-03416-1","journal-title":"Neurosurg Rev"},{"issue":"1","key":"5441_CR45","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1007\/s00701-024-06057-3","volume":"166","author":"N Teske","year":"2024","unstructured":"Teske N, Teske NC, Greve T et al (2024) Perifocal edema is a risk factor for preoperative seizures in patients with meningioma WHO grade 2 and 3. Acta Neurochir (Wien) 166(1):170. https:\/\/doi.org\/10.1007\/s00701-024-06057-3","journal-title":"Acta Neurochir (Wien)"},{"issue":"6","key":"5441_CR46","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.3171\/2015.4.JNS142742","volume":"124","author":"DJ Englot","year":"2016","unstructured":"Englot DJ, Magill ST, Han SJ, Chang EF, Berger MS, McDermott MW (2016) Seizures in supratentorial meningioma: a systematic review and meta-analysis. J Neurosurg 124(6):1552\u20131561. https:\/\/doi.org\/10.3171\/2015.4.JNS142742","journal-title":"J Neurosurg"},{"issue":"2","key":"5441_CR47","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1093\/neuros\/nyx001","volume":"81","author":"WC Chen","year":"2017","unstructured":"Chen WC, Magill ST, Englot DJ et al (2017) Factors associated with Pre- and postoperative seizures in 1033 patients undergoing supratentorial meningioma resection. Neurosurgery 81(2):297\u2013306. https:\/\/doi.org\/10.1093\/neuros\/nyx001","journal-title":"Neurosurgery"},{"issue":"1","key":"5441_CR48","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1002\/(SICI)1097-0142(19960701)78:1<133::AID-CNCR19>3.0.CO;2-0","volume":"78","author":"M Ide","year":"1996","unstructured":"Ide M, Jimbo M, Yamamoto M, Umebara Y, Hagiwara S, Kubo O (1996) MIB-1 staining index and peritumoral brain edema of meningiomas. Cancer 78(1):133\u2013143. https:\/\/doi.org\/10.1002\/(SICI)1097-0142(19960701)78:1%3C133::AID-CNCR19%3E3.0.CO;2-0","journal-title":"Cancer"},{"issue":"3","key":"5441_CR49","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1227\/01.NEU.0000365366.53337.88","volume":"66","author":"R Cai","year":"2010","unstructured":"Cai R, Barnett GH, Novak E, Chao ST, Suh JH (2010) Principal risk of peritumoral edema after stereotactic radiosurgery for intracranial meningioma is tumor-brain contact interface area. Neurosurgery 66(3):513\u2013522. https:\/\/doi.org\/10.1227\/01.NEU.0000365366.53337.88","journal-title":"Neurosurgery"},{"key":"5441_CR50","doi-asserted-by":"publisher","unstructured":"Kumthekar P, Grimm SA, Aleman RT et al (2022) A multi-institutional phase II trial of bevacizumab for recurrent and refractory meningioma. Neurooncol Adv 4(1). https:\/\/doi.org\/10.1093\/noajnl\/vdac123","DOI":"10.1093\/noajnl\/vdac123"},{"issue":"3","key":"5441_CR51","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1093\/neuonc\/nov183","volume":"18","author":"J Furtner","year":"2016","unstructured":"Furtner J, Sch\u00f6pf V, Seystahl K et al (2016) Kinetics of tumor size and peritumoral brain edema before, during, and after systemic therapy in recurrent WHO grade II or III meningioma. Neuro Oncol 18(3):401\u2013407. https:\/\/doi.org\/10.1093\/neuonc\/nov183","journal-title":"Neuro Oncol"}],"container-title":["Journal of Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-026-05441-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11060-026-05441-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-026-05441-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T10:47:23Z","timestamp":1772102843000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11060-026-05441-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["5441"],"URL":"https:\/\/doi.org\/10.1007\/s11060-026-05441-6","relation":{},"ISSN":["0167-594X","1573-7373"],"issn-type":[{"value":"0167-594X","type":"print"},{"value":"1573-7373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"14 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All methods were carried out in accordance with relevant guidelines and regulations, including the Declaration of Helsinki. The study was approved by the Ethics Committee of the Medical University of Leipzig (approval 321\/25-ek). For this retrospective study involving human participants and the use of existing clinical data, the Ethics Committee waived the requirement to obtain written informed consent. All data were handled in a pseudonymized manner in accordance with applicable data protection regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"194"}}