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This study aimed to assess the prevalence and profile of PTG among primary brain tumor patients and caregivers, examine associations with demographic, medical, and psychological variables, and inform future neuro-oncology interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective cross-sectional study, 141 participants (96 patients, 45 caregivers) completed validated surveys assessing PTG, depression, anxiety, and death anxiety. Participants were recruited via online neuro-oncology support and advocacy groups. PTG was measured using the Post-Traumatic Growth Inventory (PTGI). PTG profiles were examined using descriptives and associations between PTG and patient\/caregiver characteristics, tumor-related medical variables, and psychological distress were examined using t-tests, ANOVAs, and Pearson correlations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>70% of patients and 48.8% of caregivers reported moderate-to-high PTG. Appreciation of Life was the most frequently endorsed subscale in both groups. Patients with high-grade tumors exhibited significantly higher PTG than those with low-grade tumors; caregivers of patients with left-hemisphere tumors trended toward higher PTG. PTG was positively associated with death anxiety in patients but unrelated to depression or generalized anxiety in either group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite significant distress, many patients and caregivers experience PTG following a brain tumor diagnosis, particularly in appreciating life. These findings highlight the potential for psychosocial and palliative interventions to harness PTG through meaning-making and existential engagement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11060-026-05454-1","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T16:29:35Z","timestamp":1770827375000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Post-traumatic growth in patients and caregivers after a primary brain tumor diagnosis"],"prefix":"10.1007","volume":"176","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7847-5992","authenticated-orcid":false,"given":"Ashlee R.","family":"Loughan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah Ellen","family":"Braun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Autumn","family":"Lanoye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelcie","family":"Willis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Hernand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,11]]},"reference":[{"issue":"1","key":"5454_CR1","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1111\/j.1547-5069.2007.00144.x","volume":"39","author":"SW Fox","year":"2007","unstructured":"Fox SW, Lyon D, Farace E (2007) Symptom clusters in patients with high-grade glioma. 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