{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T08:30:43Z","timestamp":1776673843570,"version":"3.51.2"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K08538"],"award-info":[{"award-number":["23K08538"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurooncol"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1007\/s11060-026-05465-y","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T09:58:32Z","timestamp":1772445512000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Thalamic involvement in glioblastoma is associated with lower risk of seizures: a retrospective cohort study"],"prefix":"10.1007","volume":"177","author":[{"given":"Sho","family":"Fukuda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Tamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9056-2477","authenticated-orcid":false,"given":"Kazuhide","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asumi","family":"Orihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azumi","family":"Kaneoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taketoshi","family":"Maehara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"5465_CR1","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","volume":"23","author":"DN Louis","year":"2021","unstructured":"Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, Hawkins C, Ng HK, Pfister SM, Reifenberger G, Soffietti R, von Deimling A, Ellison DW (2021) The 2021 WHO classification of tumors of the central nervous system: a summary. Neurooncology 23:1231\u20131251. https:\/\/doi.org\/10.1093\/neuonc\/noab106","journal-title":"Neurooncology"},{"key":"5465_CR2","doi-asserted-by":"publisher","unstructured":"Wen PY, Weller M, Lee EQ, Touat M, Khasraw M, Rahman R, Platten M, Lim M, Winkler F, Horbinski C, Verhaak RGW, Huang RY, Ahluwalia MS, Albert NL, Tonn JC, Schiff D, Barnholtz-Sloan JS, Ostrom Q, Aldape KD, Batchelor TT, Bindra RS, Chiocca EA, Cloughesy TF, DeGroot JF, French P, Galanis E, Galldiks N, Gilbert MR, Hegi ME, Lassman AB, Le Rhun E, Mehta MP, Mellinghoff IK, Minniti G, Roth P, Sanson M, Taphoorn MJB, von Deimling A, Weiss T, Wick W, Zadeh G, Reardon DA, Chang SM, Short SC, van den Bent MJ, Preusser M (2025) Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions. Neuro-oncology https:\/\/doi.org\/10.1093\/neuonc\/noaf177","DOI":"10.1093\/neuonc\/noaf177"},{"key":"5465_CR3","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1097\/cco.0000000000000876","volume":"34","author":"PB van der Meer","year":"2022","unstructured":"van der Meer PB, Taphoorn MJB, Koekkoek JAF (2022) Management of epilepsy in brain tumor patients. Curr Opin Oncol 34:685\u2013690. https:\/\/doi.org\/10.1097\/cco.0000000000000876","journal-title":"Curr Opin Oncol"},{"key":"5465_CR4","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.jocn.2014.05.036","volume":"22","author":"T Iuchi","year":"2015","unstructured":"Iuchi T, Hasegawa Y, Kawasaki K, Sakaida T (2015) Epilepsy in patients with gliomas: incidence and control of seizures. J Clin Neurosci 22:87\u201391. https:\/\/doi.org\/10.1016\/j.jocn.2014.05.036","journal-title":"J Clin Neurosci"},{"key":"5465_CR5","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s11060-018-2862-0","volume":"139","author":"DY Chen","year":"2018","unstructured":"Chen DY, Chen CC, Crawford JR, Wang SG (2018) Tumor-related epilepsy: epidemiology, pathogenesis and management. J Neurooncol 139:13\u201321. https:\/\/doi.org\/10.1007\/s11060-018-2862-0","journal-title":"J Neurooncol"},{"key":"5465_CR6","doi-asserted-by":"publisher","first-page":"e0158206","DOI":"10.1371\/journal.pone.0158206","volume":"11","author":"S Liang","year":"2016","unstructured":"Liang S, Zhang J, Zhang S, Fu X (2016) Epilepsy in adults with supratentorial glioblastoma: incidence and influence factors and prophylaxis in 184 patients. PLoS ONE 11:e0158206. https:\/\/doi.org\/10.1371\/journal.pone.0158206","journal-title":"PLoS ONE"},{"key":"5465_CR7","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s11060-024-04787-z","volume":"170","author":"RG Rilinger","year":"2024","unstructured":"Rilinger RG, Guo L, Sharma A, Volovetz J, Thompson NR, Grabowski M, Lobbous M, Dhawan A (2024) Tumor-related epilepsy in high-grade glioma: a large series survival analysis. J Neurooncol 170:153\u2013160. https:\/\/doi.org\/10.1007\/s11060-024-04787-z","journal-title":"J Neurooncol"},{"key":"5465_CR8","doi-asserted-by":"publisher","first-page":"e947","DOI":"10.1016\/j.wneu.2019.01.213","volume":"125","author":"Z Yu","year":"2019","unstructured":"Yu Z, Zhang N, Hameed NUF, Qiu T, Zhuang D, Lu J, Wu J (2019) The analysis of risk factors and survival outcome for Chinese patients with epilepsy with High-Grade glioma. World Neurosurg 125:e947\u2013e957. https:\/\/doi.org\/10.1016\/j.wneu.2019.01.213","journal-title":"World Neurosurg"},{"key":"5465_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.clinph.2022.09.002","volume":"144","author":"B Deutschov\u00e1","year":"2022","unstructured":"Deutschov\u00e1 B, Rektor I (2022) Deep brain stimulation of the anterior nuclei of the thalamus in focal epilepsy. Clin Neurophysiol 144:1\u20137. https:\/\/doi.org\/10.1016\/j.clinph.2022.09.002","journal-title":"Clin Neurophysiol"},{"key":"5465_CR10","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1111\/j.1528-1167.2010.02536.x","volume":"51","author":"R Fisher","year":"2010","unstructured":"Fisher R, Salanova V, Witt T, Worth R, Henry T, Gross R, Oommen K, Osorio I, Nazzaro J, Labar D, Kaplitt M, Sperling M, Sandok E, Neal J, Handforth A, Stern J, DeSalles A, Chung S, Shetter A, Bergen D, Bakay R, Henderson J, French J, Baltuch G, Rosenfeld W, Youkilis A, Marks W, Garcia P, Barbaro N, Fountain N, Bazil C, Goodman R, McKhann G, Babu Krishnamurthy K, Papavassiliou S, Epstein C, Pollard J, Tonder L, Grebin J, Coffey R, Graves N (2010) Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy. Epilepsia 51:899\u2013908. https:\/\/doi.org\/10.1111\/j.1528-1167.2010.02536.x","journal-title":"Epilepsia"},{"key":"5465_CR11","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1212\/wnl.0000000000001334","volume":"84","author":"V Salanova","year":"2015","unstructured":"Salanova V, Witt T, Worth R, Henry TR, Gross RE, Nazzaro JM, Labar D, Sperling MR, Sharan A, Sandok E, Handforth A, Stern JM, Chung S, Henderson JM, French J, Baltuch G, Rosenfeld WE, Garcia P, Barbaro NM, Fountain NB, Elias WJ, Goodman RR, Pollard JR, Tr\u00f6ster AI, Irwin CP, Lambrecht K, Graves N, Fisher R (2015) Long-term efficacy and safety of thalamic stimulation for drug-resistant partial epilepsy. Neurology 84:1017\u20131025. https:\/\/doi.org\/10.1212\/wnl.0000000000001334","journal-title":"Neurology"},{"key":"5465_CR12","doi-asserted-by":"publisher","first-page":"2290","DOI":"10.1111\/epi.17331","volume":"63","author":"JC Yang","year":"2022","unstructured":"Yang JC, Bullinger KL, Dickey AS, Karakis I, Alwaki A, Cabaniss BT, Winkel D, Rodriguez-Ruiz A, Willie JT, Gross RE (2022) Anterior nucleus of the thalamus deep brain stimulation vs Temporal lobe responsive neurostimulation for Temporal lobe epilepsy. Epilepsia 63:2290\u20132300. https:\/\/doi.org\/10.1111\/epi.17331","journal-title":"Epilepsia"},{"key":"5465_CR13","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1111\/epi.17157","volume":"63","author":"A Vetkas","year":"2022","unstructured":"Vetkas A, Fomenko A, Germann J, Sarica C, Iorio-Morin C, Samuel N, Yamamoto K, Milano V, Cheyuo C, Zemmar A, Elias G, Boutet A, Loh A, Santyr B, Gwun D, Tasserie J, Kalia SK, Lozano AM (2022) Deep brain stimulation targets in epilepsy: systematic review and meta-analysis of anterior and centromedian thalamic nuclei and hippocampus. Epilepsia 63:513\u2013524. https:\/\/doi.org\/10.1111\/epi.17157","journal-title":"Epilepsia"},{"key":"5465_CR14","doi-asserted-by":"publisher","first-page":"e197","DOI":"10.1111\/epi.18122","volume":"65","author":"S Park","year":"2024","unstructured":"Park S, Permezel F, Agashe S, Osman G, Simpson HD, Miller KJ, Van Gompel JJ, Starnes K, Lundstrom BN, Worrell GA, Gregg NM (2024) Centromedian thalamic deep brain stimulation for idiopathic generalized epilepsy: connectivity and target optimization. Epilepsia 65:e197\u2013e203. https:\/\/doi.org\/10.1111\/epi.18122","journal-title":"Epilepsia"},{"key":"5465_CR15","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1002\/epi4.12524","volume":"6","author":"D Burdette","year":"2021","unstructured":"Burdette D, Mirro EA, Lawrence M, Patra SE (2021) Brain-responsive corticothalamic stimulation in the pulvinar nucleus for the treatment of regional neocortical epilepsy: A case series. Epilepsia Open 6:611\u2013617. https:\/\/doi.org\/10.1002\/epi4.12524","journal-title":"Epilepsia Open"},{"key":"5465_CR16","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1136\/jnnp-2021-327512","volume":"93","author":"ND Sisterson","year":"2022","unstructured":"Sisterson ND, Kokkinos V, Urban A, Li N, Richardson RM (2022) Responsive neurostimulation of the thalamus improves seizure control in idiopathic generalised epilepsy: initial case series. J Neurol Neurosurg Psychiatry 93:491\u2013498. https:\/\/doi.org\/10.1136\/jnnp-2021-327512","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"5465_CR17","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1093\/neuros\/nyx349","volume":"83","author":"Y Esquenazi","year":"2018","unstructured":"Esquenazi Y, Moussazadeh N, Link TW, Hovinga KE, Reiner AS, DiStefano NM, Brennan C, Gutin P, Tabar V (2018) Thalamic glioblastoma: clinical Presentation, management Strategies, and outcomes. Neurosurgery 83:76\u201385. https:\/\/doi.org\/10.1093\/neuros\/nyx349","journal-title":"Neurosurgery"},{"key":"5465_CR18","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1007\/s12672-023-00632-3","volume":"14","author":"A Kaneoka","year":"2023","unstructured":"Kaneoka A, Fujimoto SH, Tamura K, Inaji M, Maehara T (2023) Nonconvulsive status epilepticus characteristics in glioma patients: a retrospective study. Discov Oncol 14:30. https:\/\/doi.org\/10.1007\/s12672-023-00632-3","journal-title":"Discov Oncol"},{"key":"5465_CR19","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s12957-016-0820-x","volume":"14","author":"P Zhang","year":"2016","unstructured":"Zhang P, Wang X, Ji N, Xie J, Han J, Ren X, Song G, Wu R, Zhang L, Gao Z (2016) Clinical, radiological, and pathological features of 33 adult unilateral thalamic gliomas. World J Surg Oncol 14:78. https:\/\/doi.org\/10.1186\/s12957-016-0820-x","journal-title":"World J Surg Oncol"},{"key":"5465_CR20","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/bmt.2012.244","volume":"48","author":"Y Kanda","year":"2013","unstructured":"Kanda Y (2013) Investigation of the freely available easy-to-use software \u2018EZR\u2019 for medical statistics. Bone Marrow Transpl 48:452\u2013458. https:\/\/doi.org\/10.1038\/bmt.2012.244","journal-title":"Bone Marrow Transpl"},{"key":"5465_CR21","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1038\/nm.2453","volume":"17","author":"SC Buckingham","year":"2011","unstructured":"Buckingham SC, Campbell SL, Haas BR, Montana V, Robel S, Ogunrinu T, Sontheimer H (2011) Glutamate release by primary brain tumors induces epileptic activity. Nat Med 17:1269\u20131274. https:\/\/doi.org\/10.1038\/nm.2453","journal-title":"Nat Med"},{"key":"5465_CR22","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1007\/s12031-025-02335-6","volume":"75","author":"F Golab","year":"2025","unstructured":"Golab F, Hajimirzaei P, Zarbakhsh S, Zolfaghari S, Hayat P, Joghataei MT, Bakhtiarzadeh F, Ahmadirad N (2025) Interplay of neuroinflammation and epilepsy in glioblastoma multiforme: mechanisms and therapeutic implications. J Mol Neurosci 75:68. https:\/\/doi.org\/10.1007\/s12031-025-02335-6","journal-title":"J Mol Neurosci"},{"key":"5465_CR23","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2025.5523","author":"CD Dantio","year":"2025","unstructured":"Dantio CD, Fasoranti DO, Teng C, Li X (2025) Seizures in brain tumors: pathogenesis, risk factors and management (Review). Int J Mol Med 55. https:\/\/doi.org\/10.3892\/ijmm.2025.5523","journal-title":"Int J Mol Med 55"},{"key":"5465_CR24","doi-asserted-by":"publisher","unstructured":"Kong NW, Gibb WR, Tate MC (2016) Neuroplasticity: insights from patients harboring gliomas. Neural Plast 2016(2365063). https:\/\/doi.org\/10.1155\/2016\/2365063","DOI":"10.1155\/2016\/2365063"},{"key":"5465_CR25","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1093\/brain\/awl300","volume":"130","author":"M Desmurget","year":"2007","unstructured":"Desmurget M, Bonnetblanc F, Duffau H (2007) Contrasting acute and slow-growing lesions: a new door to brain plasticity. Brain 130:898\u2013914. https:\/\/doi.org\/10.1093\/brain\/awl300","journal-title":"Brain"},{"key":"5465_CR26","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1093\/neuonc\/noaa044","volume":"22","author":"VM Stoecklein","year":"2020","unstructured":"Stoecklein VM, Stoecklein S, Gali\u00e8 F, Ren J, Schmutzer M, Unterrainer M, Albert NL, Kreth FW, Thon N, Liebig T, Ertl-Wagner B, Tonn JC, Liu H (2020) Resting-state fMRI detects alterations in whole brain connectivity related to tumor biology in glioma patients. Neurooncology 22:1388\u20131398. https:\/\/doi.org\/10.1093\/neuonc\/noaa044","journal-title":"Neurooncology"},{"key":"5465_CR27","doi-asserted-by":"publisher","unstructured":"Pasquini L, Jenabi M, Yildirim O, Silveira P, Peck KK, Holodny AI (2022) Brain functional connectivity in Low- and High-Grade gliomas: differences in network dynamics associated with tumor grade and location. Cancers (Basel) 14. https:\/\/doi.org\/10.3390\/cancers14143327","DOI":"10.3390\/cancers14143327"},{"key":"5465_CR28","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/j.mehy.2012.07.037","volume":"79","author":"O Prakash","year":"2012","unstructured":"Prakash O, Lukiw WJ, Peruzzi F, Reiss K, Musto AE (2012) Gliomas and seizures. Med Hypotheses 79:622\u2013626. https:\/\/doi.org\/10.1016\/j.mehy.2012.07.037","journal-title":"Med Hypotheses"},{"key":"5465_CR29","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.1093\/neuonc\/noab152","volume":"23","author":"T Walbert","year":"2021","unstructured":"Walbert T, Harrison RA, Schiff D, Avila EK, Chen M, Kandula P, Lee JW, Le Rhun E, Stevens GHJ, Vogelbaum MA, Wick W, Weller M, Wen PY, Gerstner ER (2021) SNO and EANO practice guideline update: anticonvulsant prophylaxis in patients with newly diagnosed brain tumors. Neurooncology 23:1835\u20131844. https:\/\/doi.org\/10.1093\/neuonc\/noab152","journal-title":"Neurooncology"}],"container-title":["Journal of Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-026-05465-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11060-026-05465-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-026-05465-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T07:33:15Z","timestamp":1776670395000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11060-026-05465-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["5465"],"URL":"https:\/\/doi.org\/10.1007\/s11060-026-05465-y","relation":{},"ISSN":["0167-594X","1573-7373"],"issn-type":[{"value":"0167-594X","type":"print"},{"value":"1573-7373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"9 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee of Institute of Science Tokyo (approval number: M2000-1307) and performed in accordance with the Declaration of Helsinki. Because of the retrospective study design, the requirement for informed consent was waived according to institutional policy.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"24"}}