{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T14:02:49Z","timestamp":1781013769936,"version":"3.54.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurooncol"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1007\/s11060-026-05618-z","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T16:25:08Z","timestamp":1779726308000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical utility of liquid biopsy in distinguishing true progression from radiation necrosis and pseudoprogression in malignant brain tumor"],"prefix":"10.1007","volume":"178","author":[{"given":"Muhammad","family":"Izhar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke S.","family":"Hori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred C.","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeraj","family":"Kalra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirmeen","family":"Zagzoog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armine","family":"Tayag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louisa","family":"Ustrzynski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara C.","family":"Emrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven D","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,25]]},"reference":[{"issue":"1","key":"5618_CR1","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1002\/cncr.33918","volume":"128","author":"S Gritsch","year":"2022","unstructured":"Gritsch S, Batchelor TT, Gonzalez Castro LN (2022) Diagnostic, therapeutic, and prognostic implications of the 2021 World Health Organization classification of tumors of the central nervous system. Cancer 128(1):47\u201358. https:\/\/doi.org\/10.1002\/cncr.33918","journal-title":"Cancer"},{"issue":"7","key":"5618_CR2","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1158\/0008-5472.CAN-22-3083","volume":"83","author":"M Zhao","year":"2023","unstructured":"Zhao M, Li Y, Lu C, Ding F, Xu M, Ge X et al (2023) PGC1\u03b1 Degradation Suppresses Mitochondrial Biogenesis to Confer Radiation Resistance in Glioma. Cancer Res 83(7):1094\u20131110. https:\/\/doi.org\/10.1158\/0008-5472.CAN-22-3083","journal-title":"Cancer Res"},{"key":"5618_CR3","doi-asserted-by":"publisher","first-page":"100541","DOI":"10.1016\/j.wnsx.2025.100541","volume":"28","author":"M Izhar","year":"2025","unstructured":"Izhar M, Hori YS, Kattaa AH, Lam FC, Kalra N, Zagzoog N et al (2025) Stereotactic radiosurgery for hepatitis C virus-related hepatocellular carcinoma brain metastasis: A retrospective analysis and systematic review. World Neurosurg X 28:100541. https:\/\/doi.org\/10.1016\/j.wnsx.2025.100541","journal-title":"World Neurosurg X"},{"issue":"2","key":"5618_CR4","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1007\/s11060-026-05542-2","volume":"177","author":"M Izhar","year":"2026","unstructured":"Izhar M, Kattaa AH, Hori YS, Lam FC, Kalra N, Zagzoog N et al (2026) Treatment outcomes of stereotactic radiosurgery for sarcoma brain metastases\u2014systematic review. J Neurooncol 177(2):70. https:\/\/doi.org\/10.1007\/s11060-026-05542-2","journal-title":"J Neurooncol"},{"issue":"1","key":"5618_CR5","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s11060-025-05247-y","volume":"176","author":"AH Kattaa","year":"2026","unstructured":"Kattaa AH, Persad AR, Hori YS, Harary PM, Izhar M, Ustrzynski L et al (2026) Peripheral neural crest tumor brain metastases management: a single-institution retrospective study. J Neurooncol 176(1):65. https:\/\/doi.org\/10.1007\/s11060-025-05247-y","journal-title":"J Neurooncol"},{"key":"5618_CR6","doi-asserted-by":"publisher","first-page":"526","DOI":"10.25259\/SNI_806_2025","volume":"16","author":"M Izhar","year":"2025","unstructured":"Izhar M, Kattaa AH, Hori YS, Lam FC, Tayag A, Ustrzynski L et al (2025) Hepatoblastoma brain metastasis treated with stereotactic radiosurgery: Illustrative case and literature search. Surg Neurol Int 16:526. https:\/\/doi.org\/10.25259\/SNI_806_2025","journal-title":"Surg Neurol Int"},{"issue":"3","key":"5618_CR7","doi-asserted-by":"publisher","first-page":"336","DOI":"10.3171\/jns.1977.47.3.0336","volume":"47","author":"AN Martins","year":"1977","unstructured":"Martins AN, Johnston JS, Henry JM, Stoffel TJ, Chiro GD (1977) Delayed radiation necrosis of the brain. J Neurosurg 47(3):336\u2013345. https:\/\/doi.org\/10.3171\/jns.1977.47.3.0336","journal-title":"J Neurosurg"},{"issue":"Supplement1","key":"5618_CR8","doi-asserted-by":"publisher","first-page":"S56","DOI":"10.1093\/neuonc\/noad188","volume":"26","author":"ZS Mayo","year":"2024","unstructured":"Mayo ZS, Billena C, Suh JH, Lo SS, Chao ST (2024) The dilemma of radiation necrosis from diagnosis to treatment in the management of brain metastases. Neuro-Oncol 26(Supplement1):S56\u201365. https:\/\/doi.org\/10.1093\/neuonc\/noad188","journal-title":"Neuro-Oncol"},{"key":"5618_CR9","doi-asserted-by":"publisher","unstructured":"Jablonska PA, Serrano D, Gal\u00e1n N, Barranco J, Leon S, Zelaya V, et al (2026) A new predictive model for radiation necrosis risk based on PTV-enriched blood inflammatory biomarkers in patients with brain metastases treated with stereotactic radiosurgery. Int J Radiat Oncol. S0360301626004888. https:\/\/doi.org\/10.1016\/j.ijrobp.2026.03.005.","DOI":"10.1016\/j.ijrobp.2026.03.005"},{"issue":"3","key":"5618_CR10","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1002\/jmri.26171","volume":"48","author":"SC Van Den Thust","year":"2018","unstructured":"Van Den Thust SC, Smits M (2018) Pseudoprogression of brain tumors. J Magn Reson Imaging 48(3):571\u2013589. https:\/\/doi.org\/10.1002\/jmri.26171","journal-title":"J Magn Reson Imaging"},{"issue":"5","key":"5618_CR11","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/S1470-2045(08)70125-6","volume":"9","author":"D Brandsma","year":"2008","unstructured":"Brandsma D, Stalpers L, Taal W, Van Den Sminia P (2008) Clinical features, mechanisms, and management of pseudoprogression in malignant gliomas. Lancet Oncol 9(5):453\u2013461. https:\/\/doi.org\/10.1016\/S1470-2045(08)70125-6","journal-title":"Lancet Oncol"},{"key":"5618_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/6828396","volume":"2018","author":"A Zikou","year":"2018","unstructured":"Zikou A, Sioka C, Alexiou GA, Fotopoulos A, Voulgaris S, Argyropoulou MI (2018) Radiation Necrosis, Pseudoprogression, Pseudoresponse, and Tumor Recurrence: Imaging Challenges for the Evaluation of Treated Gliomas. Contrast Media Mol Imaging 2018:1\u20136. https:\/\/doi.org\/10.1155\/2018\/6828396","journal-title":"Contrast Media Mol Imaging"},{"issue":"2","key":"5618_CR13","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1002\/cncr.23562","volume":"113","author":"W Taal","year":"2008","unstructured":"Taal W, Brandsma D, De Bruin HG, Bromberg JE, Swaak-Kragten AT, Sillevis Smitt PAE et al (2008) Incidence of early pseudo\u2010progression in a cohort of malignant glioma patients treated with chemoirradiation with temozolomide. Cancer 113(2):405\u2013410. https:\/\/doi.org\/10.1002\/cncr.23562","journal-title":"Cancer"},{"key":"5618_CR14","doi-asserted-by":"publisher","unstructured":"Oberheim Bush NA, Cha S, Chang SM, Clarke JL (2016) Pseudoprogression in Neuro-Oncology. In: Handbook of Neuro-Oncology Neuroimaging [Internet]. Elsevier; [cited 2026 Apr 7]. pp. 681\u201395. Available from: https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/B9780128009451000550https:\/\/doi.org\/10.1016\/B978-0-12-800945-1.00055-0","DOI":"10.1016\/B978-0-12-800945-1.00055-0"},{"key":"5618_CR15","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.radonc.2019.05.020","volume":"140","author":"J K\u0142os","year":"2019","unstructured":"K\u0142os J, Van Laar PJ, Sinnige PF, Enting RH, Van Der Kramer MCA et al (2019) Quantifying effects of radiotherapy-induced microvascular injury; review of established and emerging brain MRI techniques. Radiother Oncol 140:41\u201353. https:\/\/doi.org\/10.1016\/j.radonc.2019.05.020","journal-title":"Radiother Oncol"},{"issue":"5","key":"5618_CR16","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1148\/rg.325125002","volume":"32","author":"R Shah","year":"2012","unstructured":"Shah R, Vattoth S, Jacob R, Manzil FFP, O\u2019Malley JP, Borghei P et al (2012) Radiation Necrosis in the Brain: Imaging Features and Differentiation from Tumor Recurrence. Radiographics 32(5):1343\u20131359. https:\/\/doi.org\/10.1148\/rg.325125002","journal-title":"Radiographics"},{"issue":"4","key":"5618_CR17","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.3171\/2024.6.JNS232187","volume":"142","author":"NS McCall","year":"2025","unstructured":"McCall NS, Lu A, Hopkins BD, Qian D, Hoang KB, Olson JJ et al (2025) Risk of late radiation necrosis more than 5 years after stereotactic radiosurgery. J Neurosurg 142(4):1117\u20131124. https:\/\/doi.org\/10.3171\/2024.6.JNS232187","journal-title":"J Neurosurg"},{"issue":"13","key":"5618_CR18","doi-asserted-by":"publisher","first-page":"7039","DOI":"10.3390\/ijms22137039","volume":"22","author":"W Jelski","year":"2021","unstructured":"Jelski W, Mroczko B (2021) Molecular and Circulating Biomarkers of Brain Tumors. Int J Mol Sci 22(13):7039. https:\/\/doi.org\/10.3390\/ijms22137039","journal-title":"Int J Mol Sci"},{"issue":"1","key":"5618_CR19","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/s41698-023-00448-y","volume":"7","author":"J Yuan","year":"2023","unstructured":"Yuan J, Xu L, Chien CY, Yang Y, Yue Y, Fadera S et al (2023) First-in-human prospective trial of sonobiopsy in high-grade glioma patients using neuronavigation-guided focused ultrasound. Npj Precis Oncol 7(1):92. https:\/\/doi.org\/10.1038\/s41698-023-00448-y","journal-title":"Npj Precis Oncol"},{"key":"5618_CR20","doi-asserted-by":"publisher","first-page":"100170","DOI":"10.1016\/j.jlb.2024.100170","volume":"6","author":"M Izhar","year":"2024","unstructured":"Izhar M, Ahmad Z, Moazzam M, Jader A (2024) Targeted liquid biopsy for brain tumors. J Liq Biopsy 6:100170. https:\/\/doi.org\/10.1016\/j.jlb.2024.100170","journal-title":"J Liq Biopsy"},{"key":"5618_CR21","doi-asserted-by":"publisher","first-page":"100277","DOI":"10.1016\/j.jlb.2024.100277","volume":"6","author":"M Izhar","year":"2024","unstructured":"Izhar M, Thakur A, Park DJ, Chang SD (2024) Ultrasound mediated blood-brain barrier opening increases brain tumor biomarkers: A review of preclinical and clinical trials. J Liq Biopsy 6:100277. https:\/\/doi.org\/10.1016\/j.jlb.2024.100277","journal-title":"J Liq Biopsy"},{"issue":"10","key":"5618_CR22","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1093\/neuonc\/noab057","volume":"23","author":"Y Meng","year":"2021","unstructured":"Meng Y, Pople CB, Suppiah S, Llinas M, Huang Y, Sahgal A et al (2021) MR-guided focused ultrasound liquid biopsy enriches circulating biomarkers in patients with brain tumors. Neuro-Oncol 23(10):1789\u20131797. https:\/\/doi.org\/10.1093\/neuonc\/noab057","journal-title":"Neuro-Oncol"},{"key":"5618_CR23","doi-asserted-by":"publisher","first-page":"105918","DOI":"10.1016\/j.ijsu.2021.105918","volume":"88","author":"C Sohrabi","year":"2021","unstructured":"Sohrabi C, Franchi T, Mathew G, Kerwan A, Nicola M, Griffin M et al (2021) PRISMA 2020 statement: What\u2019s new and the importance of reporting guidelines. Int J Surg 88:105918. https:\/\/doi.org\/10.1016\/j.ijsu.2021.105918","journal-title":"Int J Surg"},{"issue":"1","key":"5618_CR24","doi-asserted-by":"publisher","first-page":"E67","DOI":"10.1093\/neuros\/nyaa334","volume":"88","author":"DC Soler","year":"2021","unstructured":"Soler DC, Kerstetter-Fogle A, Elder T, Raghavan A, Barnholtz-Sloan JS, Cooper KD et al (2021) A Liquid Biopsy to Assess Brain Tumor Recurrence: Presence of Circulating Mo-MDSC and CD14 + VNN2+ Myeloid Cells as Biomarkers That Distinguish Brain Metastasis From Radiation Necrosis Following Stereotactic Radiosurgery. Neurosurgery 88(1):E67\u201372. https:\/\/doi.org\/10.1093\/neuros\/nyaa334","journal-title":"Neurosurgery"},{"key":"5618_CR25","doi-asserted-by":"publisher","unstructured":"Soler DCYA, Cooper KD, Kerstetter Fogle A, Barnholtz Sloan JS, Gittleman H, McCormick TS The ratio of HLA-DR and VNN2(+) expression on CD14(+) myeloid derived suppressor cells can distinguish glioblastoma from radiation necrosis patients. Located at: rayyan. 213404038. https:\/\/doi.org\/10.1007\/s11060-017-2508-7","DOI":"10.1007\/s11060-017-2508-7"},{"issue":"44","key":"5618_CR26","doi-asserted-by":"publisher","first-page":"71330","DOI":"10.18632\/oncotarget.11114","volume":"7","author":"F Gao","year":"2016","unstructured":"Gao F, Cui Y, Jiang H, Sui D, Wang Y, Jiang Z et al (2016) Circulating tumor cell is a common property of brain glioma and promotes the monitoring system. Oncotarget 7(44):71330\u201371340. https:\/\/doi.org\/10.18632\/oncotarget.11114","journal-title":"Oncotarget"},{"issue":"6","key":"5618_CR27","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1007\/s00401-015-1399-y","volume":"129","author":"MG Best","year":"2015","unstructured":"Best MG, Sol N, Zijl S, Reijneveld JC, Wesseling P, Wurdinger T (2015) Liquid biopsies in patients with diffuse glioma. Acta Neuropathol (Berl) 129(6):849\u2013865. https:\/\/doi.org\/10.1007\/s00401-015-1399-y","journal-title":"Acta Neuropathol (Berl)"},{"issue":"29","key":"5618_CR28","doi-asserted-by":"publisher","first-page":"27049","DOI":"10.18632\/oncotarget.4819","volume":"6","author":"F Ge","year":"2015","unstructured":"Ge F, Zhang H, Wang DD, Li L, Lin PP (2015) Enhanced detection and comprehensive in situ phenotypic characterization of circulating and disseminated heteroploid epithelial and glioma tumor cells. Oncotarget 6(29):27049\u201327064. https:\/\/doi.org\/10.18632\/oncotarget.4819","journal-title":"Oncotarget"},{"issue":"20","key":"5618_CR29","doi-asserted-by":"publisher","first-page":"7522","DOI":"10.3390\/ijms21207522","volume":"21","author":"Z Birk\u00f3","year":"2020","unstructured":"Birk\u00f3 Z, Nagy B, Klekner \u00c1, Virga J (2020) Novel Molecular Markers in Glioblastoma\u2014Benefits of Liquid Biopsy. Int J Mol Sci 21(20):7522. https:\/\/doi.org\/10.3390\/ijms21207522","journal-title":"Int J Mol Sci"},{"issue":"1","key":"5618_CR30","doi-asserted-by":"publisher","first-page":"7123","DOI":"10.1038\/s41598-026-37493-z","volume":"16","author":"J Sun","year":"2026","unstructured":"Sun J, Jin C, Chen Y, Hou S (2026) Liquid biopsy of plasma and urinary CfDNA differentiates glioma recurrence from radiation brain necrosis in preclinical models. Sci Rep 16(1):7123. https:\/\/doi.org\/10.1038\/s41598-026-37493-z","journal-title":"Sci Rep"},{"key":"5618_CR31","doi-asserted-by":"publisher","unstructured":"Koch CJLR, Yang XY, Jenkins WT, Wolf RL, Martinez Lage M, Desai A, Williams D, Evans SM microvesicles as a biomarker for tumor progression versus treatment effect in radiation\/temozolomide-treated glioblastoma patients. Located at: rayyan. 213405677. https:\/\/doi.org\/10.1016\/j.tranon.2014.10.004.","DOI":"10.1016\/j.tranon.2014.10.004"},{"issue":"9","key":"5618_CR32","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1093\/neuonc\/noae077","volume":"26","author":"A Lastra Romero","year":"2024","unstructured":"Lastra Romero A, Seitz T, Zisiadis GA, Jeffery H, Osman AM (2024) EDA2R reflects the acute brain response to cranial irradiation in liquid biopsies. Neuro-Oncol 26(9):1617\u20131627. https:\/\/doi.org\/10.1093\/neuonc\/noae077","journal-title":"Neuro-Oncol"},{"key":"5618_CR33","doi-asserted-by":"publisher","unstructured":"Makranz C, Lubotzky A, Zemmour H, Shemer R, Glaser B, Cohen J et al (2023) Short report: Plasma based biomarkers detect radiation induced brain injury in cancer patients treated for brain metastasis: a pilot study. PLoS ONE. 18(11). Located at: rayyan-211277767. https:\/\/doi.org\/10.1371\/journal.pone.0285646","DOI":"10.1371\/journal.pone.0285646"},{"issue":"5","key":"5618_CR34","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.ijrobp.2016.08.039","volume":"96","author":"JA Miller","year":"2016","unstructured":"Miller JA, Bennett EE, Xiao R, Kotecha R, Chao ST, Vogelbaum MA et al (2016) Association Between Radiation Necrosis and Tumor Biology After Stereotactic Radiosurgery for Brain Metastasis. Int J Radiat Oncol 96(5):1060\u20131069. https:\/\/doi.org\/10.1016\/j.ijrobp.2016.08.039","journal-title":"Int J Radiat Oncol"},{"issue":"1","key":"5618_CR35","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/s11060-010-0305-7","volume":"102","author":"HC Kang","year":"2011","unstructured":"Kang HC, Kim CY, Han JH, Choe GY, Kim JH, Kim JH et al (2011) Pseudoprogression in patients with malignant gliomas treated with concurrent temozolomide and radiotherapy: potential role of p53. J Neurooncol 102(1):157\u2013162. https:\/\/doi.org\/10.1007\/s11060-010-0305-7","journal-title":"J Neurooncol"},{"issue":"4","key":"5618_CR36","doi-asserted-by":"publisher","first-page":"923","DOI":"10.3892\/ijo.2011.1260","volume":"40","author":"HB Pouleau","year":"2012","unstructured":"Pouleau HB, Sadeghi N, Bal\u00e9riaux D, M\u00e9lot C, De Witte O, Lefranc F (2012) High levels of cellular proliferation predict pseudoprogression in glioblastoma patients. Int J Oncol 40(4):923\u2013928. https:\/\/doi.org\/10.3892\/ijo.2011.1260","journal-title":"Int J Oncol"},{"issue":"9","key":"5618_CR37","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1038\/nrclinonc.2017.14","volume":"14","author":"G Siravegna","year":"2017","unstructured":"Siravegna G, Marsoni S, Siena S, Bardelli A (2017) Integrating liquid biopsies into the management of cancer. Nat Rev Clin Oncol 14(9):531\u2013548. https:\/\/doi.org\/10.1038\/nrclinonc.2017.14","journal-title":"Nat Rev Clin Oncol"},{"issue":"4","key":"5618_CR38","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1056\/NEJMoa0800668","volume":"359","author":"S Maheswaran","year":"2008","unstructured":"Maheswaran S, Sequist LV, Nagrath S, Ulkus L, Brannigan B, Collura CV et al (2008) Detection of Mutations in EGFR in Circulating Lung-Cancer Cells. N Engl J Med 359(4):366\u2013377. https:\/\/doi.org\/10.1056\/NEJMoa0800668","journal-title":"N Engl J Med"},{"issue":"7732","key":"5618_CR39","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/s41586-018-0703-0","volume":"563","author":"SY Shen","year":"2018","unstructured":"Shen SY, Singhania R, Fehringer G, Chakravarthy A, Roehrl MHA, Chadwick D et al (2018) Sensitive tumour detection and classification using plasma cell-free DNA methylomes. Nature 563(7732):579\u2013583. https:\/\/doi.org\/10.1038\/s41586-018-0703-0","journal-title":"Nature"},{"key":"5618_CR40","doi-asserted-by":"publisher","unstructured":"Noushmehr H, Sabedot T, Malta T, Nelson K, Snyder J, Wells M et al Detection of glioma and prognostic subtypes by non-invasive circulating cell-free DNA methylation markers [Internet]. 2019 [cited 2024 Sep 26]. Available from: https:\/\/doi.org\/10.1101\/601245","DOI":"10.1101\/601245"},{"issue":"13","key":"5618_CR41","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1056\/NEJMoa1213261","volume":"368","author":"SJ Dawson","year":"2013","unstructured":"Dawson SJ, Tsui DWY, Murtaza M, Biggs H, Rueda OM, Chin SF et al (2013) Analysis of Circulating Tumor DNA to Monitor Metastatic Breast Cancer. N Engl J Med 368(13):1199\u20131209. https:\/\/doi.org\/10.1056\/NEJMoa1213261","journal-title":"N Engl J Med"},{"issue":"10","key":"5618_CR42","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.1038\/s41416-023-02423-7","volume":"129","author":"JM Cameron","year":"2023","unstructured":"Cameron JM, Sala A, Antoniou G, Brennan PM, Butler HJ, Conn JJA et al (2023) A spectroscopic liquid biopsy for the earlier detection of multiple cancer types. Br J Cancer 129(10):1658\u20131666. https:\/\/doi.org\/10.1038\/s41416-023-02423-7","journal-title":"Br J Cancer"}],"container-title":["Journal of Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-026-05618-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11060-026-05618-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-026-05618-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T13:40:19Z","timestamp":1781012419000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11060-026-05618-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["5618"],"URL":"https:\/\/doi.org\/10.1007\/s11060-026-05618-z","relation":{},"ISSN":["0167-594X","1573-7373"],"issn-type":[{"value":"0167-594X","type":"print"},{"value":"1573-7373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"19 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted with prior approval from the Stanford University Institutional Review Board (#3910) panel on Medical Human Subjects.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"21"}}