{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:52:38Z","timestamp":1791406358625,"version":"4.3.3"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Capital\u2019s Funds for Health Improvement and Research","award":["2026-1Q-1112"],"award-info":[{"award-number":["2026-1Q-1112"]}]},{"name":"the Beijing Neurosurgical Institute","award":["11000025T000003319495-3"],"award-info":[{"award-number":["11000025T000003319495-3"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurooncol"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1007\/s11060-026-05775-1","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T15:07:08Z","timestamp":1788275228000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["\u03b1-Synuclein suppresses glioma progression through the CDH13\u2013JNK\/c-Jun pathway"],"prefix":"10.1007","volume":"179","author":[{"given":"Zhenwei","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoshi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gengxuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7222-8317","authenticated-orcid":false,"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"5775_CR1","doi-asserted-by":"publisher","first-page":"218185","DOI":"10.1016\/j.canlet.2025.218185","volume":"640","author":"T Jiang","year":"2026","unstructured":"Jiang T, Nam DH, Ram Z, Poo WS, Wang J, Boldbaatar D, Mao Y, Ma W, Mao Q, You Y, Jiang C, Yang X, Tergaonkar V, Zhang W, Wang Z, Kang C, Qiu X, Li S, Chen L, Li X, Liu Z, Bai H, Yao Y, Li S, Wu A, Mou Y, Sai K, Li G, Wei X, Liu X, Zhang Z, Dai Y, Lv S, Wang L, Lin Z, Dong J, Xu G, Ma X, Yu R, Kang D, Liu Y, Li G, Zhang S, Qu Y, Wang Y, Zhang C, Chen B, You G, Wang Y, Wang Y, Bao Z, Fan X, Liu X, Zhao Z, Li Y, Wang Z, Li G, Fang S, Liu Y, Shan X, Liu Y, Chai R, Hu H, Chen J, Yan W, Cai J, Wang Y (2026) Updated clinical practice guidelines for the management of adult diffuse gliomas. Cancer Lett 640:218185. https:\/\/doi.org\/10.1016\/j.canlet.2025.218185","journal-title":"Cancer Lett"},{"key":"5775_CR2","doi-asserted-by":"publisher","first-page":"1984","DOI":"10.1016\/s0140-6736(11)61346-9","volume":"379","author":"D Ricard","year":"2012","unstructured":"Ricard D, Idbaih A, Ducray F, Lahutte M, Hoang-Xuan K, Delattre JY (2012) Primary brain tumours in adults. Lancet (London England) 379:1984\u20131996. https:\/\/doi.org\/10.1016\/s0140-6736(11)61346-9","journal-title":"Lancet (London England)"},{"key":"5775_CR3","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s11060-004-2751-6","volume":"70","author":"T Demuth","year":"2004","unstructured":"Demuth T, Berens ME (2004) Molecular mechanisms of glioma cell migration and invasion. J Neurooncol 70:217\u2013228. https:\/\/doi.org\/10.1007\/s11060-004-2751-6","journal-title":"J Neurooncol"},{"key":"5775_CR4","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/s11060-013-1103-9","volume":"113","author":"P Yang","year":"2013","unstructured":"Yang P, Wang Y, Peng X, You G, Zhang W, Yan W, Bao Z, Wang Y, Qiu X, Jiang T (2013) Management and survival rates in patients with glioma in China (2004\u20132010): a retrospective study from a single-institution. J Neurooncol 113:259\u2013266. https:\/\/doi.org\/10.1007\/s11060-013-1103-9","journal-title":"J Neurooncol"},{"key":"5775_CR5","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1001\/jamaneurol.2014.1205","volume":"71","author":"Z Turkalp","year":"2014","unstructured":"Turkalp Z, Karamchandani J, Das S (2014) IDH mutation in glioma: new insights and promises for the future. JAMA Neurol 71:1319\u20131325. https:\/\/doi.org\/10.1001\/jamaneurol.2014.1205","journal-title":"JAMA Neurol"},{"key":"5775_CR6","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1111\/j.1349-7006.2011.02134.x","volume":"103","author":"Q SongTao","year":"2012","unstructured":"SongTao Q, Lei Y, Si G, YanQing D, HuiXia H, XueLin Z, LanXiao W, Fei Y (2012) IDH mutations predict longer survival and response to temozolomide in secondary glioblastoma. Cancer Sci 103:269\u2013273. https:\/\/doi.org\/10.1111\/j.1349-7006.2011.02134.x","journal-title":"Cancer Sci"},{"key":"5775_CR7","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1007\/s10522-014-9523-2","volume":"15","author":"JA Driver","year":"2014","unstructured":"Driver JA (2014) Inverse association between cancer and neurodegenerative disease: review of the epidemiologic and biological evidence. Biogerontology 15:547\u2013557. https:\/\/doi.org\/10.1007\/s10522-014-9523-2","journal-title":"Biogerontology"},{"key":"5775_CR8","doi-asserted-by":"publisher","unstructured":"Gargini R, Segura-Collar B, Herr\u00e1nz B, Garc\u00eda-Escudero V, Romero-Bravo A, N\u00fa\u00f1ez FJ, Garc\u00eda-P\u00e9rez D, Guti\u00e9rrez-Guam\u00e1n J, Ayuso-Sacido A, Seoane J, P\u00e9rez-N\u00fa\u00f1ez A, Sep\u00falveda-S\u00e1nchez JM, Hern\u00e1ndez-La\u00edn A, Castro MG, Garc\u00eda-Escudero R, \u00c1vila J, S\u00e1nchez-G\u00f3mez P (2020) The IDH-TAU-EGFR triad defines the neovascular landscape of diffuse gliomas. Sci Transl Med 12. https:\/\/doi.org\/10.1126\/scitranslmed.aax1501","DOI":"10.1126\/scitranslmed.aax1501"},{"key":"5775_CR9","doi-asserted-by":"publisher","unstructured":"Burr\u00e9 J, Sharma M, S\u00fcdhof TC (2018) Cell biology and pathophysiology of \u03b1-Synuclein. Cold Spring Harbor Perspect Med 8. https:\/\/doi.org\/10.1101\/cshperspect.a024091","DOI":"10.1101\/cshperspect.a024091"},{"key":"5775_CR10","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1038\/s41419-025-07509-z","volume":"16","author":"E Duplan","year":"2025","unstructured":"Duplan E, Bernardin A, Goiran T, Leroudier N, Casimiro M, Pestell R, Tanaka S, Malleval C, Honnorat J, Idbaih A, Martin L, Castel H, Checler F, Alves da Costa C (2025) \u03b1-synuclein expression in glioblastoma restores tumor suppressor function and rescues temozolomide drug resistance. Cell Death Dis 16:188. https:\/\/doi.org\/10.1038\/s41419-025-07509-z","journal-title":"Cell Death Dis"},{"key":"5775_CR11","doi-asserted-by":"publisher","unstructured":"Huang Y, Wen D, Yuan Y, Chen W (2023) Gene set enrichment analysis and genetic experiment reveal changes in cell signaling pathways induced by \u03b1-Synuclein overexpression. Biomedicines 11. https:\/\/doi.org\/10.3390\/biomedicines11020263","DOI":"10.3390\/biomedicines11020263"},{"key":"5775_CR12","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.neulet.2017.01.067","volume":"642","author":"J Duan","year":"2017","unstructured":"Duan J, Ying Z, Su Y, Lin F, Deng Y (2017) \u03b1-Synuclein binds to cytoplasmic vesicles in U251 glioblastoma cells. Neurosci Lett 642:148\u2013152. https:\/\/doi.org\/10.1016\/j.neulet.2017.01.067","journal-title":"Neurosci Lett"},{"key":"5775_CR13","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1002\/jnr.10662","volume":"73","author":"N Stefanova","year":"2003","unstructured":"Stefanova N, Schanda K, Klimaschewski L, Poewe W, Wenning GK, Reindl M (2003) Tumor necrosis factor-alpha-induced cell death in U373 cells overexpressing alpha-synuclein. J Neurosci Res 73:334\u2013340. https:\/\/doi.org\/10.1002\/jnr.10662","journal-title":"J Neurosci Res"},{"key":"5775_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.gpb.2020.10.005","volume":"19","author":"Z Zhao","year":"2021","unstructured":"Zhao Z, Zhang KN, Wang Q, Li G, Zeng F, Zhang Y, Wu F, Chai R, Wang Z, Zhang C, Zhang W, Bao Z, Jiang T (2021) Chinese Glioma Genome Atlas (CGGA): A Comprehensive Resource with Functional Genomic Data from Chinese Glioma Patients. Genom Proteom Bioinform 19:1\u201312. https:\/\/doi.org\/10.1016\/j.gpb.2020.10.005","journal-title":"Genom Proteom Bioinform"},{"key":"5775_CR15","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.canlet.2020.10.050","volume":"499","author":"T Jiang","year":"2021","unstructured":"Jiang T, Nam DH, Ram Z, Poon WS, Wang J, Boldbaatar D, Mao Y, Ma W, Mao Q, You Y, Jiang C, Yang X, Kang C, Qiu X, Li W, Li S, Chen L, Li X, Liu Z, Wang W, Bai H, Yao Y, Li S, Wu A, Sai K, Li G, Yao K, Wei X, Liu X, Zhang Z, Dai Y, Lv S, Wang L, Lin Z, Dong J, Xu G, Ma X, Zhang W, Zhang C, Chen B, You G, Wang Y, Wang Y, Bao Z, Yang P, Fan X, Liu X, Zhao Z, Wang Z, Li Y, Wang Z, Li G, Fang S, Li L, Liu Y, Liu S, Shan X, Liu Y, Chai R, Hu H, Chen J, Yan W, Cai J, Wang H, Chen L, Yang Y, Wang Y, Han L, Wang Q (2021) Clinical practice guidelines for the management of adult diffuse gliomas. Cancer Lett 499:60\u201372. https:\/\/doi.org\/10.1016\/j.canlet.2020.10.050","journal-title":"Cancer Lett"},{"key":"5775_CR16","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.ccr.2009.12.020","volume":"17","author":"RG Verhaak","year":"2010","unstructured":"Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD, Miller CR, Ding L, Golub T, Mesirov JP, Alexe G, Lawrence M, O\u2019Kelly M, Tamayo P, Weir BA, Gabriel S, Winckler W, Gupta S, Jakkula L, Feiler HS, Hodgson JG, James CD, Sarkaria JN, Brennan C, Kahn A, Spellman PT, Wilson RK, Speed TP, Gray JW, Meyerson M, Getz G, Perou CM, Hayes DN (2010) Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 17:98\u2013110. https:\/\/doi.org\/10.1016\/j.ccr.2009.12.020","journal-title":"Cancer Cell"},{"key":"5775_CR17","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.cell.2010.03.015","volume":"141","author":"K Kessenbrock","year":"2010","unstructured":"Kessenbrock K, Plaks V, Werb Z (2010) Matrix metalloproteinases: regulators of the tumor microenvironment. Cell 141:52\u201367. https:\/\/doi.org\/10.1016\/j.cell.2010.03.015","journal-title":"Cell"},{"key":"5775_CR18","doi-asserted-by":"publisher","first-page":"3106","DOI":"10.1016\/j.neuron.2024.06.029","volume":"112","author":"H Scheiblich","year":"2024","unstructured":"Scheiblich H, Eikens F, Wischhof L, Opitz S, J\u00fcngling K, Cser\u00e9p C, Schmidt SV, Lambertz J, Bellande T, P\u00f3sfai B, Geck C, Spitzer J, Odainic A, Castro-Gomez S, Schwartz S, Boussaad I, Kr\u00fcger R, Glaab E, Di Monte DA, Bano D, D\u00e9nes \u00c1, Latz E, Melki R, Pape HC, Heneka MT (2024) Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes. Neuron 112:3106\u20133125e3108. https:\/\/doi.org\/10.1016\/j.neuron.2024.06.029","journal-title":"Neuron"},{"key":"5775_CR19","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1002\/gcc.20787","volume":"49","author":"AV Andreeva","year":"2010","unstructured":"Andreeva AV, Kutuzov MA (2010) Cadherin 13 in cancer. Genes Chromosomes Cancer 49:775\u2013790. https:\/\/doi.org\/10.1002\/gcc.20787","journal-title":"Genes Chromosomes Cancer"},{"key":"5775_CR20","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s12964-021-00728-9","volume":"19","author":"W Zheng","year":"2021","unstructured":"Zheng W, Zhang S, Guo H, Chen X, Huang Z, Jiang S, Li M (2021) Multi-omics analysis of tumor angiogenesis characteristics and potential epigenetic regulation mechanisms in renal clear cell carcinoma. Cell communication signaling: CCS 19:39. https:\/\/doi.org\/10.1186\/s12964-021-00728-9","journal-title":"Cell communication signaling: CCS"},{"key":"5775_CR21","doi-asserted-by":"publisher","first-page":"881","DOI":"10.18632\/oncotarget.22971","volume":"9","author":"Y Li","year":"2018","unstructured":"Li Y, Li C, Ma Q, Zhang Y, Yao Y, Liu S, Zhang X, Hong C, Tan F, Shi L, Yao Y (2018) Genetic variation in CDH13 gene was associated with non-small cell lung cancer (NSCLC): A population-based case-control study. Oncotarget 9:881\u2013891. https:\/\/doi.org\/10.18632\/oncotarget.22971","journal-title":"Oncotarget"},{"key":"5775_CR22","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.12659\/msm.892130","volume":"20","author":"YL Lin","year":"2014","unstructured":"Lin YL, Xie PG, Ma JG (2014) Aberrant methylation of CDH13 is a potential biomarker for predicting the recurrence and progression of non muscle invasive bladder cancer. Med Sci monitor: Int Med J experimental Clin Res 20:1572\u20131577. https:\/\/doi.org\/10.12659\/msm.892130","journal-title":"Med Sci monitor: Int Med J experimental Clin Res"},{"key":"5775_CR23","doi-asserted-by":"publisher","first-page":"e0149185","DOI":"10.1371\/journal.pone.0149185","volume":"11","author":"J Yang","year":"2016","unstructured":"Yang J, Niu H, Huang Y, Yang K (2016) A Systematic Analysis of the Relationship of CDH13 Promoter Methylation and Breast Cancer Risk and Prognosis. PLoS ONE 11:e0149185. https:\/\/doi.org\/10.1371\/journal.pone.0149185","journal-title":"PLoS ONE"},{"key":"5775_CR24","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.7150\/jca.37762","volume":"11","author":"D Xu","year":"2020","unstructured":"Xu D, Yuan H, Meng Z, Yang C, Li Z, Li M, Zhang Z, Gan Y, Tu H (2020) Cadherin 13 Inhibits Pancreatic Cancer Progression and Epithelial-mesenchymal Transition by Wnt\/\u03b2-Catenin Signaling. J Cancer 11:2101\u20132112. https:\/\/doi.org\/10.7150\/jca.37762","journal-title":"J Cancer"},{"key":"5775_CR25","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1126\/science.276.5321.2045","volume":"276","author":"MH Polymeropoulos","year":"1997","unstructured":"Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A, Pike B, Root H, Rubenstein J, Boyer R, Stenroos ES, Chandrasekharappa S, Athanassiadou A, Papapetropoulos T, Johnson WG, Lazzarini AM, Duvoisin RC, Di Iorio G, Golbe LI, Nussbaum RL (1997) Mutation in the alpha-synuclein gene identified in families with Parkinson\u2019s disease. Sci (New York NY) 276:2045\u20132047. https:\/\/doi.org\/10.1126\/science.276.5321.2045","journal-title":"Sci (New York NY)"},{"key":"5775_CR26","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1002\/ana.410440324","volume":"44","author":"PH Tu","year":"1998","unstructured":"Tu PH, Galvin JE, Baba M, Giasson B, Tomita T, Leight S, Nakajo S, Iwatsubo T, Trojanowski JQ, Lee VM (1998) Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein. Ann Neurol 44:415\u2013422. https:\/\/doi.org\/10.1002\/ana.410440324","journal-title":"Ann Neurol"},{"key":"5775_CR27","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/s0304-3940(98)00407-8","volume":"249","author":"K Wakabayashi","year":"1998","unstructured":"Wakabayashi K, Yoshimoto M, Tsuji S, Takahashi H (1998) Alpha-synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy. Neurosci Lett 249:180\u2013182. https:\/\/doi.org\/10.1016\/s0304-3940(98)00407-8","journal-title":"Neurosci Lett"}],"container-title":["Journal of Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-026-05775-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11060-026-05775-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11060-026-05775-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:03:42Z","timestamp":1791403422000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11060-026-05775-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["5775"],"URL":"https:\/\/doi.org\/10.1007\/s11060-026-05775-1","relation":{},"ISSN":["0167-594X","1573-7373"],"issn-type":[{"value":"0167-594X","type":"print"},{"value":"1573-7373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"22 July 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The collection and use of human glioma tissue samples were reviewed and approved by the Institutional Review Board of Beijing Tiantan Hospital (Approval No. KY2014-002-02). All procedures involving human participants were conducted in accordance with the Declaration of Helsinki and its later amendments. All animal experiments were approved by the Beijing Neurosurgical Institute Animal Welfare and Ethics Committee (Approval No. VST20240901-1) and were conducted in accordance with institutional guidelines and applicable national regulations for the care and use of laboratory animals.","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was obtained from all individual participants before tissue collection.","order":2,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that no large language models were used in the preparation of this manuscript.","order":4,"name":"Ethics","label":"LLM\/AI use declaration","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"66"}}