{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T03:10:41Z","timestamp":1780110641123,"version":"3.54.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2007,3,31]],"date-time":"2007-03-31T00:00:00Z","timestamp":1175299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2007,3,31]],"date-time":"2007-03-31T00:00:00Z","timestamp":1175299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2007,7]]},"DOI":"10.1007\/s11064-007-9286-0","type":"journal-article","created":{"date-parts":[[2007,3,30]],"date-time":"2007-03-30T21:29:35Z","timestamp":1175290175000},"page":"1163-1168","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Erythropoietin in Cerebrospinal Fluid: Age-related Reference Values and Relevance in Neurological Disease"],"prefix":"10.1007","volume":"32","author":[{"given":"Karin","family":"Widl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Brettschneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"Schattauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigurd","family":"S\u00fc\u00dfmuth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Huber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert C.","family":"Ludolph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayrettin","family":"Tumani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,3,31]]},"reference":[{"key":"9286_CR1","doi-asserted-by":"publisher","first-page":"10526","DOI":"10.1073\/pnas.97.19.10526","volume":"97","author":"ML Brines","year":"2000","unstructured":"Brines ML, Ghezzi P, Keenan S et al (2000) Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury. Proc Natl Acad Sci USA 97:10526\u201310531","journal-title":"Proc Natl Acad Sci USA"},{"key":"9286_CR2","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1203\/00006450-199801000-00007","volume":"43","author":"SE Juul","year":"1998","unstructured":"Juul SE, Anderson DK, Li Y et al (1998) Erythropoietin and erythropoietin receptor in the developing human central nervous system. Pediatr Res 43:40\u201349","journal-title":"Pediatr Res"},{"key":"9286_CR3","doi-asserted-by":"publisher","first-page":"3233","DOI":"10.1242\/jeb.01049","volume":"207","author":"HH Marti","year":"2004","unstructured":"Marti HH (2004) Erythropoietin and the hypoxic brain. J Exp Biol 207:3233\u20133242","journal-title":"J Exp Biol"},{"key":"9286_CR4","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1042\/cs1030275","volume":"103","author":"M Buemi","year":"2002","unstructured":"Buemi M, Cavallaro E, Floccari F et al (2002) Erythropoietin and the brain: from neurodevelopment to neuroprotection. Clin Sci (Lond) 103:275\u2013282","journal-title":"Clin Sci (Lond)"},{"key":"9286_CR5","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1007\/s00429-003-0365-y","volume":"207","author":"W Knabe","year":"2004","unstructured":"Knabe W, Knerlich F, Washausen S et al (2004) Expression patterns of erythropoietin and its receptor in the developing midbrain. Anat Embryol (Berl) 207:503\u2013512","journal-title":"Anat Embryol (Berl)"},{"key":"9286_CR6","doi-asserted-by":"publisher","first-page":"4635","DOI":"10.1073\/pnas.95.8.4635","volume":"95","author":"M Sakanaka","year":"1998","unstructured":"Sakanaka M, Wen TC, Matsuda S et al (1998) In vivo evidence that erythropoietin protects neurons from ischemic damage. Proc Natl Acad Sci USA 95:4635\u20134640","journal-title":"Proc Natl Acad Sci USA"},{"key":"9286_CR7","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/S0006-8993(02)03239-0","volume":"952","author":"D Agnello","year":"2002","unstructured":"Agnello D, Bigini P, Villa P et al (2002) Erythropoietin exerts an anti-inflammatory effect on the CNS in a model of experimental autoimmune encephalomyelitis. Brain Res 952:128\u2013134","journal-title":"Brain Res"},{"issue":"Suppl 3","key":"9286_CR8","first-page":"S109","volume":"3","author":"M Eid TBrines","year":"2002","unstructured":"Eid TBrines M (2002) Recombinant human erythropoietin for neuroprotection: what is the evidence? Clin. Breast Cancer 3(Suppl 3):S109\u2013115","journal-title":"Breast Cancer"},{"key":"9286_CR9","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1080\/146608200300079536","volume":"1","author":"BR Brooks","year":"2000","unstructured":"Brooks BR, Miller RG, Swash M et al (2000) El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord 1:293\u2013299","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord"},{"key":"9286_CR10","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1080\/14660820310011250","volume":"4","author":"M Strong","year":"2003","unstructured":"Strong M, Rosenfeld J (2003) Amyotrophic lateral sclerosis: a review of current concepts. Amyotroph Lateral Scler Other Motor Neuron Disord 4:136\u2013143","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord"},{"key":"9286_CR11","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","volume":"34","author":"G McKhann","year":"1984","unstructured":"McKhann G, Drachman D, Folstein M et al (1984) Clinical diagnosis of Alzheimer\u2019s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer\u2019s Disease. Neurology 34:939\u2013944","journal-title":"Neurology"},{"key":"9286_CR12","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1212\/WNL.51.6.1546","volume":"51","author":"D Neary","year":"1998","unstructured":"Neary D, Snowden JS, Gustafson L et al (1998) Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology 51:1546\u20131554","journal-title":"Neurology"},{"key":"9286_CR13","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1212\/WNL.43.2.250","volume":"43","author":"GC Roman","year":"1993","unstructured":"Roman GC, Tatemichi TK, Erkinjuntti T et al (1993) Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN international workshop. Neurology 43:250\u2013260","journal-title":"Neurology"},{"key":"9286_CR14","doi-asserted-by":"crossref","unstructured":"Petersen RC, Smith GE, Waring SC et al (1997) Aging, memory, and mild cognitive impairment. Int Psychogeriatr1:(Suppl 9) 65\u201369","DOI":"10.1017\/S1041610297004717"},{"key":"9286_CR15","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.neulet.2003.09.018","volume":"353","author":"SD Sussmuth","year":"2003","unstructured":"Sussmuth SD, Tumani H, Ecker D et al (2003) Amyotrophic lateral sclerosis: disease stage related changes of tau protein and S100 beta in cerebrospinal fluid and creatine kinase in serum. Neurosci Lett 353:57\u201360","journal-title":"Neurosci Lett"},{"key":"9286_CR16","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1007\/BF01466734","volume":"52","author":"K Felgenhauer","year":"1974","unstructured":"Felgenhauer K (1974) Protein size and cerebrospinal fluid composition. Klin Wochenschr 52:1158\u20131164","journal-title":"Klin Wochenschr"},{"key":"9286_CR17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/153537020322800101","volume":"228","author":"JW Fisher","year":"2003","unstructured":"Fisher JW (2003) Erythropoietin: physiology and pharmacology update. Exp Biol Med (Maywood) 228:1\u201314","journal-title":"Exp Biol Med (Maywood)"},{"key":"9286_CR18","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/s00228-005-0896-7","volume":"61","author":"A Xenocostas","year":"2005","unstructured":"Xenocostas A, Cheung WK, Farrell F et al (2005) The pharmacokinetics of erythropoietin in the cerebrospinal fluid after intravenous administration of recombinant human erythropoietin. Eur J Clin Pharmacol 61:189\u2013195","journal-title":"Eur J Clin Pharmacol"},{"key":"9286_CR19","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1097\/00000441-199803000-00010","volume":"315","author":"T Nakamura","year":"1998","unstructured":"Nakamura T, Ebihara I, Shimada N et al (1998) Elevated levels of erythropoietin in cerebrospinal fluid of depressed patients. Am J Med Sci 315:199\u2013201","journal-title":"Am J Med Sci"},{"key":"9286_CR20","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/S0022-3476(97)70205-1","volume":"130","author":"SE Juul","year":"1997","unstructured":"Juul SE, Harcum J, Li Y et al (1997) Erythropoietin is present in the cerebrospinal fluid of neonates. J Pediatr 130:428\u2013430","journal-title":"J Pediatr"},{"key":"9286_CR21","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1093\/clinchem\/38.6.813","volume":"38","author":"BG van Engelen","year":"1992","unstructured":"van Engelen BG, Lamers KJ, Gabreels FJ et al (1992) Age-related changes of neuron-specific enolase, S-100 protein, and myelin basic protein concentrations in cerebrospinal fluid. Clin Chem 38:813\u2013816","journal-title":"Clin Chem"},{"key":"9286_CR22","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1212\/WNL.40.3_Part_1.500","volume":"40","author":"C May","year":"1990","unstructured":"May C, Kaye JA, Atack JR et al (1990) Cerebrospinal fluid production is reduced in healthy aging. Neurology 40:500\u2013503","journal-title":"Neurology"},{"key":"9286_CR23","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/BF01748163","volume":"66","author":"KU Eckardt","year":"1988","unstructured":"Eckardt KU, Kurtz A, Hirth P et al (1988) Evaluation of the stability of human erythropoietin in samples for radioimmunoassay. Klin Wochenschr 66:241\u2013245","journal-title":"Klin Wochenschr"},{"key":"9286_CR24","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/S0006-8993(03)03124-X","volume":"984","author":"JB Springborg","year":"2003","unstructured":"Springborg JB, Sonne B, Frederiksen HJ et al (2003) Erythropoietin in the cerebrospinal fluid of patients with aneurysmal subarachnoid haemorrhage originates from the brain. Brain Res 984:143\u2013148","journal-title":"Brain Res"},{"key":"9286_CR25","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/S0304-3940(01)01556-7","volume":"300","author":"SD Sussmuth","year":"2001","unstructured":"Sussmuth SD, Reiber H, Tumani H (2001) Tau protein in cerebrospinal fluid (CSF): a blood-CSF barrier related evaluation in patients with various neurological diseases. Neurosci Lett 300:95\u201398","journal-title":"Neurosci Lett"},{"key":"9286_CR26","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/BF03402029","volume":"8","author":"H Ehrenreich","year":"2002","unstructured":"Ehrenreich H, Hasselblatt M, Dembowski C et al (2002) Erythropoietin therapy for acute stroke is both safe and beneficial. Mol Med 8:495\u2013505","journal-title":"Mol Med"},{"key":"9286_CR27","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1023\/B:MEBR.0000043969.96895.3c","volume":"19","author":"H Ehrenreich","year":"2004","unstructured":"Ehrenreich H, Aust C, Krampe H et al (2004) Erythropoietin: novel approaches to neuroprotection in human brain disease. Metab Brain Dis 19:195\u2013206","journal-title":"Metab Brain Dis"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-007-9286-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11064-007-9286-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-007-9286-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-007-9286-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T04:03:37Z","timestamp":1652846617000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11064-007-9286-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,31]]},"references-count":27,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["9286"],"URL":"https:\/\/doi.org\/10.1007\/s11064-007-9286-0","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3,31]]},"assertion":[{"value":"6 November 2006","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2007","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2007","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}