{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T10:59:40Z","timestamp":1774868380417,"version":"3.50.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2007,6,29]],"date-time":"2007-06-29T00:00:00Z","timestamp":1183075200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2007,9,17]]},"DOI":"10.1007\/s11064-007-9410-1","type":"journal-article","created":{"date-parts":[[2007,6,28]],"date-time":"2007-06-28T19:01:16Z","timestamp":1183057276000},"page":"1709-1717","source":"Crossref","is-referenced-by-count":26,"title":["Reduced Brain Antioxidant Capacity in Rat Models of Betacytotoxic-Induced Experimental Sporadic Alzheimer\u2019s Disease and Diabetes Mellitus"],"prefix":"10.1007","volume":"32","author":[{"given":"Ismet","family":"Tahirovic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emin","family":"Sofic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida","family":"Sapcanin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismet","family":"Gavrankapetanovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidija","family":"Bach-Rojecky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melita","family":"Salkovic-Petrisic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zdravko","family":"Lackovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siegfried","family":"Hoyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Riederer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,6,29]]},"reference":[{"key":"9410_CR1","first-page":"51","volume":"31","author":"N Altan","year":"2006","unstructured":"Altan N, Din\u00e7el AS, Koca C (2006) Diabetes mellitus and oxidative stress. Turk J Biochem 31:51\u201356","journal-title":"Turk J Biochem"},{"key":"9410_CR2","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s007020200059","volume":"109","author":"E Sofic","year":"2002","unstructured":"Sofic E, Rustembegovic A, Kroyer G, Cao G (2002) Serum antioxidant capacity in neurological, psychiatric, renal diseases and cardiomyopathy. J Neural Transm 109:711\u2013719","journal-title":"J Neural Transm"},{"key":"9410_CR3","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1093\/humrep\/14.11.2801","volume":"14","author":"RK Sharma","year":"1999","unstructured":"Sharma RK, Pasqualotto FF, Nelson DR, Thomas AJ Jr, Agarwal A (1999) The reactive oxygen species-total antioxidant capacity score is a new measure of oxidative stress to predict male infertility. Hum reprod 14:2801\u20132807","journal-title":"Hum reprod"},{"key":"9410_CR4","first-page":"33","volume":"8","author":"K Danova","year":"2005","unstructured":"Danova K, Dobisova A, Fischer V, Halcak L, Minarova H, Olejarova I, Pechan I (2005) Production of reactive oxygen species and antioxidant defense systems in patients after coronary artery bypass grafting: one-week follow-up study. J Clin Basic Cardiol 8:33\u201336","journal-title":"J Clin Basic Cardiol"},{"key":"9410_CR5","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.1021\/jf0262256","volume":"21","author":"RL Prior","year":"2003","unstructured":"Prior RL, Hoang H, Gu L, Wu X, Bacchiocca M, Howard L, Hampsch-Woodill M, Huang D, Ou B, Jacob R (2003) Assays for hydrophilic and lipophilic antioxidant capacity [oxygen radical absorbance capacity (ORAC-FL)] of plasma and other biological and food samples. J Agric Food Chem 21:3273\u20133279","journal-title":"J Agric Food Chem"},{"key":"9410_CR6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-2999(02)01486-3","volume":"441","author":"GJ Biessels","year":"2002","unstructured":"Biessels GJ, van der Heide LP, Kamal A, Bleys RL, Gispen WH (2002) Ageing and diabetes: implications for brain function. Eur J Pharmacol 441:1\u201314","journal-title":"Eur J Pharmacol"},{"issue":"11","key":"9410_CR7","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/0026-0495(93)90195-T","volume":"42","author":"JS Kumar","year":"1993","unstructured":"Kumar JS, Menon VP (1993) Effect of diabetes on levels of lipid peroxides and glycolipids in rat brain. Metabolism 42(11):1435\u20131439","journal-title":"Metabolism"},{"issue":"21","key":"9410_CR8","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/0024-3205(95)00150-5","volume":"56","author":"T Ohkuwa","year":"1995","unstructured":"Ohkuwa T, Sato Y, Naoi M (1995) Hydroxylradical formation in diabetic rats induced by streptozotocin. Life Sci 56(21):1789\u20131798","journal-title":"Life Sci"},{"key":"9410_CR9","doi-asserted-by":"crossref","first-page":"537","DOI":"10.33549\/physiolres.930111","volume":"50","author":"T Szkudelski","year":"2001","unstructured":"Szkudelski T (2001) The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol Res 50:537\u2013546","journal-title":"Physiol Res"},{"key":"9410_CR10","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/jcbfm.1992.13","volume":"12","author":"A Ding","year":"1992","unstructured":"Ding A, Nitsch R, Hoyer S (1992) Changes in brain monoaminergic neurotransmitter concentrations in rat after intracerebroventricular injections of streptozotocin. J Cereb Blood Flow Metabol 12:103\u2013109","journal-title":"J Cereb Blood Flow Metabol"},{"key":"9410_CR11","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0024-3205(90)90056-W","volume":"46","author":"Z Lackovi\u0107","year":"1990","unstructured":"Lackovi\u0107 Z, \u0160alkovi\u0107 M (1990) Streptozocin and alloxan produce alterations in rat brain monoamines independently of pancreatic beta cells destruction. Life Sci 46:49\u201354","journal-title":"Life Sci"},{"key":"9410_CR12","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/BF01271536","volume":"100","author":"M Salkovic","year":"1995","unstructured":"Salkovic M, Sabolic I, Lackovic Z (1995) Striatal D1 and D2 receptors after intracerebroventricular applications of alloxan and streptozotocin in rat. J Neural Transm 100:127\u2013145","journal-title":"J Neural Transm"},{"key":"9410_CR13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s00702-002-0773-9","volume":"110","author":"M Salkovic-Petrisic","year":"2003","unstructured":"Salkovic-Petrisic M, Lackovic Z (2003) Intracerebroventricular administration of betacytotoxics alters expression of brain monoamine transporter genes. J Neural Transm 110:15\u201329","journal-title":"J Neural Transm"},{"key":"9410_CR14","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1037\/0735-7044.112.5.1199","volume":"112","author":"H Lannert","year":"1998","unstructured":"Lannert H, Hoyer S (1998) Intracerebroventricular administration of streptozotocin causes long-term diminutions in learning and memory abilities and in cerebral energy metabolism in adult rats. Behav Neurosci 112:1199\u20131208","journal-title":"Behav Neurosci"},{"key":"9410_CR15","first-page":"a","volume":"streptozotocin","author":"J Prickaerts","year":"1999","unstructured":"Prickaerts J, Fahring T, Blokland A (1999) Cognitive performance and biochemical markers in septum, hippocampus and striatum of rats after an i.c.v. injection of streptozotocin: a correlation analysis. Behav Brain Res 102:73\u201388","journal-title":"injection of"},{"key":"9410_CR16","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s007020050067","volume":"105","author":"S Hoyer","year":"1998","unstructured":"Hoyer S (1998) Is sporadic Alzheimer disease the brain type of non-insulin dependent diabetes mellitus? A challenging hypothesis. J Neural Transm 105:415\u2013422","journal-title":"J Neural Transm"},{"key":"9410_CR17","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1111\/j.1471-4159.2005.03637.x","volume":"96","author":"M Salkovic-Petrisic","year":"2006","unstructured":"Salkovic-Petrisic M, Tribl F, Schmidt M, Hoyer S, Riederer P (2006) Alzheimer-like changes in protein kinase B and glycogen synthase kinase-3 in rat frontal cortex and hippocampus after damage to the insulin signalling pathway. J Neurochem 96:1005\u20131015","journal-title":"J Neurochem"},{"key":"9410_CR18","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1126\/science.274.5284.99","volume":"274","author":"K Hsiao","year":"1996","unstructured":"Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, Yang F, Cole G (1996) Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 274:99\u2013102","journal-title":"Science"},{"key":"9410_CR19","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0091-3057(01)00611-6","volume":"70","author":"M Sharma","year":"2001","unstructured":"Sharma M, Gupta YK (2001) Effect of chronic treatment of melatoninon learning, memory and oxidative deficiencies induced by intracerebroventricular streptozotocin in rats. Pharmacol Biochem Behav 70:325\u2013331","journal-title":"Pharmacol Biochem Behav"},{"key":"9410_CR20","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1016\/S0024-3205(02)02083-0","volume":"71","author":"M Sharma","year":"2002","unstructured":"Sharma M, Gupta YK (2002) Chronic treatment with trans resveratrol prevents intracerebroventricular streptozotocin induced cognitive impairment and oxidative stress in rats. Life Sci 71:2489\u20132498","journal-title":"Life Sci"},{"key":"9410_CR21","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jchromb.2005.04.023","volume":"827","author":"E Mariani","year":"2005","unstructured":"Mariani E, Polidori MC, Cherubini A, Meccoci P (2005) Oxidative stress in brain aging, neurodegenerative and vascular diseases: an overview. J Chromatogr B Analyt Technol Biomed Life Sci 827:65\u201375","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"9410_CR22","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0891-5849(93)90027-R","volume":"14","author":"G Cao","year":"1993","unstructured":"Cao G, Alessio HM, Cutler RG (1993) Oxygen-radical absorbance capacity assay for antioxidants. Free Radical Biol Med 14:303\u2013311","journal-title":"Free Radical Biol Med"},{"key":"9410_CR23","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1093\/clinchem\/41.12.1738","volume":"41","author":"G Cao","year":"1995","unstructured":"Cao G, Verdon C, Wu AHB, Wang H, Prior RL (1995) Automated oxygen radical absorbance capacity assay using the COBAS FARA II. Clin Chem 41:1738\u20131744","journal-title":"Clin Chem"},{"issue":"11","key":"9410_CR24","doi-asserted-by":"crossref","first-page":"3426","DOI":"10.1021\/jf9602535","volume":"44","author":"G Cao","year":"1996","unstructured":"Cao G, Sofic E, Prior RL (1996) Antioxidant capacity of tea and common vegetables. J Agric Food Chem 44(11):3426\u20133431","journal-title":"J Agric Food Chem"},{"key":"9410_CR25","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S0891-5849(96)00351-6","volume":"22","author":"G Cao","year":"1997","unstructured":"Cao G, Sofic E, Prior R (1997) Antioxidant and prooxidant behavior of flavonoids: structure-activity relationships. Free Radical Biol Med 22:749\u2013760","journal-title":"Free Radical Biol Med"},{"key":"9410_CR26","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1373\/clinchem.2004.031526","volume":"50","author":"CC Wang","year":"2004","unstructured":"Wang CC, Chu CY, Chy KO, Choy KW, Khaw KS, Rogers MS, Pang CP (2004) Trolox equivalent antioxidant capacity assay versus oxygen radical absorbance capacity assay in plasma. Clin Chem 50:952\u2013954","journal-title":"Clin Chem"},{"key":"9410_CR27","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/978-3-211-33328-0_5","volume":"71","author":"E Sofic","year":"2006","unstructured":"Sofic E, Sapcanin A, Tahirovic I, Gavrankapetanovic I, Jellinger K, Reynolds GP, Tatschner T, Riederer P (2006) Antioxidant capacity in postmortem brain tissues of Parkinson\u2019s and Alzheimer\u2019s diseases. J Neural Transm Suppl 71:39\u201343","journal-title":"J Neural Transm Suppl"},{"key":"9410_CR28","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0014-5793(85)81208-4","volume":"187","author":"DDM Wayner","year":"1985","unstructured":"Wayner DDM, Burton GW, Ingold KU, Locke S (1985) Quantitative measurement of the total, peroxyl radical-trapping antioxidant capacity of human plasma by controlled peroxidation. FEBS Lett 187:33\u201337","journal-title":"FEBS Lett"},{"key":"9410_CR29","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0076-6879(90)86106-6","volume":"186","author":"AN Glazer","year":"1990","unstructured":"Glazer AN (1990) Phycoerythrin fluorescence-based assay for reactive oxygen species. Methods Enzymol 186:161\u2013168","journal-title":"Methods Enzymol"},{"key":"9410_CR30","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0891-5849(94)00102-P","volume":"18","author":"A Ghiselli","year":"1994","unstructured":"Ghiselli A, Serafini M, Maiani G, Assini E, Ferro-Luzzi A (1994) A fluorescence-based method for measuring total plasma antioxidant capability. Free Radical Biol Med 18:29\u201336","journal-title":"Free Radical Biol Med"},{"key":"9410_CR31","first-page":"10","volume-title":"Reactive metabolites of oxygen and nitrogen in biology and medicine","author":"MB Grisham","year":"1992","unstructured":"Grisham MB (1992) Reactive metabolites of oxygen and nitrogen in biology and medicine. Landes RG Co., Austin, TX, p 10"},{"key":"9410_CR32","doi-asserted-by":"crossref","first-page":"4619","DOI":"10.1021\/jf010586o","volume":"49","author":"B Ou","year":"2001","unstructured":"Ou B, Hampsch-Woodill M, Prior RL (2001) Development and validation of an improved Oxygen Radical Absorbance Capacity assay using fluorescein as the fluorescent probe. J Agric Food Chem 49:4619\u20134626","journal-title":"J Agric Food Chem"},{"key":"9410_CR33","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0024-3205(67)90157-9","volume":"6","author":"EP Noble","year":"1967","unstructured":"Noble EP, Wurtman RJ, Axelrod J (1967) A simple and rapid method for injecting H3-norepinephrine into the lateral ventricle of the rat brain. Life Sci 6:281\u2013291","journal-title":"Life Sci"},{"key":"9410_CR34","first-page":"409","volume":"111","author":"LO Randall","year":"1957","unstructured":"Randall LO, Selitto JJ (1957) A method for measurements of analgesic activity on inflamed tissue. Arch Int Pharmacodyn Ther 111:409\u2013419","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"9410_CR35","first-page":"201","volume":"46","author":"L Bach-Rojecky","year":"2005","unstructured":"Bach-Rojecky L, Lackovic Z (2005) Antinociceptive effect of botulinum toxin type A in rat model of carrageenan and capsaicin induced pain. Croat Med J 46:201\u2013208","journal-title":"Croat Med J"},{"key":"9410_CR36","first-page":"S457","volume-title":"Matemati\u010dki priru\u010dnik za in\u017eenjere i studente","author":"IN Bronstein","year":"1962","unstructured":"Bronstein IN, Semendjajev KA (1962) Matemati\u010dki priru\u010dnik za in\u017eenjere i studente. \u00abTehni\u010dka knjiga\u00bb, Zagreb, p S457"},{"key":"9410_CR37","unstructured":"Gernot P (1977) Proteine. In: Clinische Chemie, Kurzlehrbuch und Kommentar zum Gegenstandskatalog f\u00fcr den Ersten Abschnitt der \u00c4rztlichen Pr\u00fcfung 1. Auflage, Rathgeber Verlag, M\u00fcnchen, pp 308\u2013367"},{"key":"9410_CR38","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0953-6205(99)00009-6","volume":"10","author":"JP Kuyvenhoven","year":"1999","unstructured":"Kuyvenhoven JP, Meinders AE (1999) Oxidative stress and diabetes mellitus. Pathogenesis of long-term complications. Eur J Intern Med 10:9\u201319","journal-title":"Eur J Intern Med"},{"key":"9410_CR39","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1210\/er.2001-0039","volume":"23","author":"JL Evans","year":"2002","unstructured":"Evans JL, Goldfine ID, Maddux BA, Grodsky GM (2002) Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocrine Rev 23:599\u2013622","journal-title":"Endocrine Rev"},{"key":"9410_CR40","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3181\/00379727-211-43981","volume":"211","author":"G Cao","year":"1996","unstructured":"Cao G, Giovanoni M, Prior R (1996a) Antioxidant capacity in different tissues of young and old rats. Proc Soc Exp Biol Med 211:359\u2013365","journal-title":"Proc Soc Exp Biol Med"},{"key":"9410_CR41","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ejphar.2004.02.041","volume":"490","author":"BS McEwen","year":"2004","unstructured":"McEwen BS, Reagan LP (2004) Glucose transporter expression in the central nervous system: relationship to synaptic function. Eur J Pharmacol 490:13\u201324","journal-title":"Eur J Pharmacol"},{"issue":"3","key":"9410_CR42","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1111\/j.1471-4159.2006.04368.x","volume":"101","author":"E Gr\u00fcnblatt","year":"2007","unstructured":"Gr\u00fcnblatt E, Salkovic-Petrisic M, Osmanovic J, Riederer P, Hoyer S (2007) Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein. J Neurochem 101(3):757\u2013770","journal-title":"J Neurochem"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-007-9410-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11064-007-9410-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-007-9410-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T23:34:52Z","timestamp":1737156892000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11064-007-9410-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6,29]]},"references-count":42,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2007,9,17]]}},"alternative-id":["9410"],"URL":"https:\/\/doi.org\/10.1007\/s11064-007-9410-1","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6,29]]}}}