{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T16:14:16Z","timestamp":1779293656827,"version":"3.51.4"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2008,8,9]],"date-time":"2008-08-09T00:00:00Z","timestamp":1218240000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1007\/s11064-008-9815-5","type":"journal-article","created":{"date-parts":[[2008,8,8]],"date-time":"2008-08-08T16:22:30Z","timestamp":1218212550000},"page":"518-527","source":"Crossref","is-referenced-by-count":59,"title":["Combination of G-CSF Administration and Human Amniotic Fluid Mesenchymal Stem Cell Transplantation Promotes Peripheral Nerve Regeneration"],"prefix":"10.1007","volume":"34","author":[{"given":"Hung-Chuan","family":"Pan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung-Jung","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu-Chou","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Pen","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mu-Jung","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiaw-Min","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Hong","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeou-Chih","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,8,9]]},"reference":[{"key":"9815_CR1","first-page":"278","volume":"14","author":"SP Frostick","year":"1995","unstructured":"Frostick SP (1995) The physiological and metabolic consequences of muscle denervation. Int Angiol 14:278\u2013287","journal-title":"Int Angiol"},{"key":"9815_CR2","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1097\/00019052-199510000-00005","volume":"8","author":"M Pollock","year":"1995","unstructured":"Pollock M (1995) Nerve regeneration. Curr Opin Neurol 8:354\u2013358. doi: 10.1097\/00019052-199510000-00005","journal-title":"Curr Opin Neurol"},{"key":"9815_CR3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0006-8993(03)02539-3","volume":"974","author":"T Murakami","year":"2003","unstructured":"Murakami T, Fujimoto Y, Yasunaga Y, Ishida O, Tanaka N, Ikuta Y et al (2003) Transplanted neuronal progenitor cells in a peripheral nerve gap promote nerve repair. Brain Res 974:17\u201324. doi: 10.1016\/S0006-8993(03)02539-3","journal-title":"Brain Res"},{"key":"9815_CR4","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.jocn.2005.06.007","volume":"13","author":"HC Pan","year":"2006","unstructured":"Pan HC, Yang DY, Chiu YT, Lai SZ, Wang YC, Chang MH et al (2006) Enhanced regeneration in injured sciatic nerve by human amniotic mesenchymal stem cell. J Clin Neurosci 13:570\u2013575. doi: 10.1016\/j.jocn.2005.06.007","journal-title":"J Clin Neurosci"},{"key":"9815_CR5","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.jocn.2006.08.008","volume":"14","author":"HC Pan","year":"2007","unstructured":"Pan HC, Cheng FC, Chen CJ, Lai SZ, Lee CW, Yang DY et al (2007) Post-injury regeneration in rat sciatic nerve facilitated by neurotrophic factors secreted by amniotic fluid mesenchymal stem cells. J Clin Neurosci 14:1089\u20131098. doi: 10.1016\/j.jocn.2006.08.008","journal-title":"J Clin Neurosci"},{"key":"9815_CR6","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/(SICI)1098-2752(1999)19:8<356::AID-MICR2>3.0.CO;2-N","volume":"19","author":"ZL Shen","year":"1999","unstructured":"Shen ZL, Lassner F, Becker M, Walter GF, Bader A, Berger A (1999) Viability of cultured nerve grafts: an assessment of proliferation of Schwann cells and fibroblasts. Microsurgery 19:356\u2013363. doi :10.1002\/(SICI)1098-2752(1999)19:8<356::AID-MICR2>3.0.CO;2-N","journal-title":"Microsurgery"},{"key":"9815_CR7","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1046\/j.0953-816x.2001.01814.x","volume":"14","author":"M Dezawa","year":"2001","unstructured":"Dezawa M, Takahashi I, Esaki M, Takano M, Sawada H (2001) Sciatic nerve regeneration in rats induced by transplantation of in vitro differentiated bone-marrow stromal cells. Eur J Neurosci 14:1771\u20131776. doi: 10.1046\/j.0953-816x.2001.01814.x","journal-title":"Eur J Neurosci"},{"key":"9815_CR8","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/CCO.0b013e3281a3c0ba","volume":"19","author":"M Lyman GHaS","year":"2007","unstructured":"Lyman GHaS M (2007) Granulocyte colony-stimulating factors: finding the right indication. Curr Opin Oncol 19:299\u2013307. doi: 10.1097\/CCO.0b013e3281a3c0ba","journal-title":"Curr Opin Oncol"},{"key":"9815_CR9","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1097\/nen.0b013e3181257176","volume":"66","author":"Y Nishio","year":"2007","unstructured":"Nishio Y, Koda M, Kamada T, Someya Y, Kadota R, Mannoji C et al (2007) Granulocyte colony-stimulating factor attenuates neuronal death and promotes functional recovery after spinal cord injury in mice. J Neuropathol Exp Neurol 66:724\u2013731. doi: 10.1097\/nen.0b013e3181257176","journal-title":"J Neuropathol Exp Neurol"},{"key":"9815_CR10","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.brainres.2007.02.058","volume":"1149","author":"M Koda","year":"2007","unstructured":"Koda M, Nishio Y, Kamada T, Someya Y, Okawa A, Mori C et al (2007) Granulocyte colony-stimulating factor (G-CSF) mobilizes bone marrow-derived cells into injured spinal cord and promotes functional recovery after compression-induced spinal cord injury in mice. Brain Res 1149:223\u2013231. doi: 10.1016\/j.brainres.2007.02.058","journal-title":"Brain Res"},{"key":"9815_CR11","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.neuroscience.2006.09.014","volume":"143","author":"I Solaroglu","year":"2006","unstructured":"Solaroglu I, Tsubokawa T, Cahill J, Zhang JH (2006) Anti-apoptotic effect of granulocyte-colony stimulating factor after focal cerebral ischemia in the rat. Neuroscience 143:965\u2013974. doi: 10.1016\/j.neuroscience.2006.09.014","journal-title":"Neuroscience"},{"key":"9815_CR12","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1111\/j.1471-4159.2006.03727.x","volume":"97","author":"K Meuer","year":"2006","unstructured":"Meuer K, Pitzer C, Teismann P, Kruger C, Goricke B, Laage R et al (2006) Granulocyte-colony stimulating factor is neuroprotective in a model of Parkinson\u2019s disease. J Neurochem 97:675\u2013686. doi: 10.1111\/j.1471-4159.2006.03727.x","journal-title":"J Neurochem"},{"key":"9815_CR13","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1161\/01.STR.0000057814.70180.17","volume":"34","author":"WR Schabitz","year":"2003","unstructured":"Schabitz WR, Kollmar R, Schwaninger M, Juettler E, Bardutzky J, Scholzke MN et al (2003) Neuroprotective effect of granulocyte colony-stimulating factor after focal cerebral ischemia. Stroke 34:745\u2013751. doi: 10.1161\/01.STR.0000057814.70180.17","journal-title":"Stroke"},{"key":"9815_CR14","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.jocn.2007.03.020","volume":"15","author":"HC Pan","year":"2008","unstructured":"Pan HC, Cheng FC, Lai SZ, Yang DY, Wang YC, Lee MS (2008) Enhanced regeneration in spinal cord injury by concomitant treatment with granulocyte colony-stimulating factor and neuronal stem cell. J Clin Neurosci 15:656\u2013664. doi: 10.1016\/j.jocn.2007.03.020","journal-title":"J Clin Neurosci"},{"key":"9815_CR15","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1097\/00062752-199805000-00013","volume":"5","author":"T Hartung","year":"1998","unstructured":"Hartung T (1998) Anti-inflammatory effects of granulocyte colony-stimulating factor. Curr Opin Hematol 5:221\u2013225. doi: 10.1097\/00062752-199805000-00013","journal-title":"Curr Opin Hematol"},{"key":"9815_CR16","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1111\/j.1582-4934.2007.00101.x","volume":"11","author":"BG Xiao","year":"2007","unstructured":"Xiao BG, Lu CZ, Link H (2007) Cell biology and clinical promise of G-CSF: immunomodulation and neuroprotection. J Cell Mol Med 11:1272\u20131290","journal-title":"J Cell Mol Med"},{"key":"9815_CR17","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1172\/JCI23559","volume":"115","author":"A Schneider","year":"2005","unstructured":"Schneider A, Kruger C, Steigleder T, Weber D, Pitzer C, Laage R et al (2005) The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis. J Clin Invest 115:2083\u20132098. doi: 10.1172\/JCI23559","journal-title":"J Clin Invest"},{"key":"9815_CR18","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1095\/biolreprod.105.046029","volume":"74","author":"MS Tsai","year":"2006","unstructured":"Tsai MS, Hwang SM, Tsai YL, Cheng FC, Lee JL, Chang YJ (2006) Clonal amniotic fluid-derived stem cells express characteristics of both mesenchymal and neural stem cells. Biol Reprod 74:545\u2013551. doi: 10.1095\/biolreprod.105.046029","journal-title":"Biol Reprod"},{"key":"9815_CR19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0165-5728(99)00154-X","volume":"102","author":"HS Taskinen","year":"2000","unstructured":"Taskinen HS, Olsson T, Bucht A, Khademi M, Svelander L, Roytta M (2000) Peripheral nerve injury induces endoneurial expression of IFN-gamma, IL-10 and TNF-alpha mRNA. J Neuroimmunol 102:17\u201325. doi: 10.1016\/S0165-5728(99)00154-X","journal-title":"J Neuroimmunol"},{"key":"9815_CR20","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/pd.1970120808","volume":"12","author":"CA Moertel","year":"1992","unstructured":"Moertel CA, Stupca PJ, Dewald GW (1992) Pseudomosacism, true mosaicism, and maternal cell contamination in amniotic fluid processed with in situ culture and robotic harvesting. Prenat Diagn 12:671\u2013683. doi: 10.1002\/pd.1970120808","journal-title":"Prenat Diagn"},{"key":"9815_CR21","doi-asserted-by":"crossref","first-page":"5741","DOI":"10.1523\/JNEUROSCI.20-15-05741.2000","volume":"20","author":"DE Syroid","year":"2000","unstructured":"Syroid DE, Maycox PJ, Soilu-Hanninen M, Petratos S, Bucci T, Burrola P et al (2000) Induction of postnatal schwann cell death by the low-affinity neurotrophin receptor in vitro and after axotomy. J Neurosci 20:5741\u20135747","journal-title":"J Neurosci"},{"key":"9815_CR22","unstructured":"Aminoff MJ (1999) Electrodiagnosis in clinical neurology, vol 4, 4th edn. Churchill Livingstone, New York, pp 257\u2013263"},{"key":"9815_CR23","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1097\/00000637-198906000-00002","volume":"22","author":"JM Rosen","year":"1989","unstructured":"Rosen JM, Pham HN, Hentz VR (1989) Fascicular tubulization: a comparison of nerve experimental nerve repair technique in the cat. Ann Plast Surg 22:467\u2013478. doi: 10.1097\/00000637-198906000-00002","journal-title":"Ann Plast Surg"},{"key":"9815_CR24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.brainres.2003.10.067","volume":"1001","author":"K Omura","year":"2004","unstructured":"Omura K, Ohbayashi M, Sano M, Omura T, Hasegawa T, Nagano A (2004) The recovery of blood-nerve barrier in crush nerve injury\u2014a quantitative analysis utilizing immunohistochemistry. Brain Res 1001:13\u201321. doi: 10.1016\/j.brainres.2003.10.067","journal-title":"Brain Res"},{"key":"9815_CR25","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.yjmcc.2006.12.008","volume":"42","author":"A Chiavegato","year":"2007","unstructured":"Chiavegato A, Bollini S, Pozzobon M, Callegari A, Gasparotto L, Taiani J et al (2007) Human amniotic fluid-derived stem cells are rejected after transplantation in the myocardium of normal, ischemic, immuno-suppressed or immuno-deficient rat. J Mol Cell Cardiol 42:746\u2013759. doi: 10.1016\/j.yjmcc.2006.12.008","journal-title":"J Mol Cell Cardiol"},{"key":"9815_CR26","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1126\/science.1110542","volume":"311","author":"IR Moore KAaL","year":"2006","unstructured":"Moore KAaL IR (2006) Stem cells and their niches. Science 311:1880\u20131885. doi: 10.1126\/science.1110542","journal-title":"Science"},{"key":"9815_CR27","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1182\/blood.V85.9.2482.bloodjournal8592482","volume":"85","author":"T Hartung","year":"1995","unstructured":"Hartung T, Docke WD, Gantner F, Krieger G, Sauer A, Stevens P et al (1995) Effect of granulocyte colony-stimulating factor treatment on ex vivo blood cytokine response in human volunteers. Blood 85:2482\u20132489","journal-title":"Blood"},{"key":"9815_CR28","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1182\/blood.V95.5.1656.005k29_1656_1662","volume":"95","author":"AC Dong FaL","year":"2000","unstructured":"Dong FaL AC (2000) Activation of Akt kinase by granulocyte colony-stimulating factor (G-CSF): evidence for the role of a tyrosine kinase activity distinct from the Janus kinases. Blood 95:1656\u20131662","journal-title":"Blood"},{"key":"9815_CR29","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1182\/blood.V88.7.2442.bloodjournal8872442","volume":"88","author":"A Chakraborty","year":"1996","unstructured":"Chakraborty A, White SM, Schaefer TS, Ball ED, Dyer KF, Tweardy DJ (1996) Granulocyte colony-stimulating factor activation of Stat3 alpha and Stat3 beta in immature normal and leukemic human myeloid cells. Blood 88:2442\u20132449","journal-title":"Blood"},{"key":"9815_CR30","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/nn720","volume":"4","author":"FL Watson","year":"2001","unstructured":"Watson FL, Heerssen HM, Bhattacharyya A, Klesse L, Lin MZ, Segal RA (2001) Neurotrophins use the Erk5 pathway to mediate a retrograde survival response. Nat Neurosci 4:981\u2013988. doi: 10.1038\/nn720","journal-title":"Nat Neurosci"},{"key":"9815_CR31","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/ana.410310119","volume":"31","author":"A Noronha","year":"1992","unstructured":"Noronha A, Toscas A, Jensen MA (1992) Contrasting effects of alpha, beta, and gamma interferons on nonspecific suppressor function in multiple sclerosis. Ann Neurol 31:103\u2013106. doi: 10.1002\/ana.410310119","journal-title":"Ann Neurol"},{"key":"9815_CR32","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0165-5728(99)00154-X","volume":"102","author":"HS Taskinen","year":"2000","unstructured":"Taskinen HS, Olsson T, Bucht A, Khademi M, Svelander L, Roytta M (2000) Peripheral nerve injury induces endoneurial expression of IFN-gamma, IL-10 and TNF-alpha mRNA. J Neuroimmunol 102:17\u201325. doi: 10.1016\/S0165-5728(99)00154-X","journal-title":"J Neuroimmunol"},{"key":"9815_CR33","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1523\/JNEUROSCI.22-08-03052.2002","volume":"22","author":"S Shamash","year":"2002","unstructured":"Shamash S, Reichert F, Rotshenker S (2002) The cytokine network of Wallerian degeneration: tumor necrosis factor-alpha, interleukin-1alpha, and interleukin-1beta. J Neurosci 22:3052\u20133060","journal-title":"J Neurosci"},{"key":"9815_CR34","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jneuroim.2005.06.013","volume":"167","author":"T Al-Shatti","year":"2005","unstructured":"Al-Shatti T, Barr AE, Safadi FF, Amin M, Barbe MF (2005) Increase in inflammatory cytokines in median nerves in a rat model of repetitive motion injury. J Neuroimmunol 167:13\u201322. doi: 10.1016\/j.jneuroim.2005.06.013","journal-title":"J Neuroimmunol"},{"key":"9815_CR35","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1016\/j.ejca.2005.08.016","volume":"41","author":"DR Hodge","year":"2005","unstructured":"Hodge DR, Hurt EM, Farrar WL (2005) The role of IL-6 and STAT3 in inflammation and cancer. Eur J Cancer 41:2502\u20132512. doi: 10.1016\/j.ejca.2005.08.016","journal-title":"Eur J Cancer"},{"key":"9815_CR36","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.coph.2006.02.008","volume":"6","author":"M Krampera","year":"2006","unstructured":"Krampera M, Pasini A, Pizzolo G, Cosmi L, Romagnani S, Annunziato F (2006) Regenerative and immunomodulatory potential of mesenchymal stem cells. Curr Opin Pharmacol 6:435\u2013441. doi: 10.1016\/j.coph.2006.02.008","journal-title":"Curr Opin Pharmacol"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-008-9815-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11064-008-9815-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-008-9815-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T14:38:01Z","timestamp":1588862281000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11064-008-9815-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8,9]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["9815"],"URL":"https:\/\/doi.org\/10.1007\/s11064-008-9815-5","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8,9]]}}}