{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:08:42Z","timestamp":1780384122103,"version":"3.54.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2008,11,11]],"date-time":"2008-11-11T00:00:00Z","timestamp":1226361600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1007\/s11064-008-9874-7","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T11:20:18Z","timestamp":1226316018000},"page":"1057-1065","source":"Crossref","is-referenced-by-count":12,"title":["Brain Lipid Analysis in Mice with Rett Syndrome"],"prefix":"10.1007","volume":"34","author":[{"given":"Thomas N.","family":"Seyfried","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karie A.","family":"Heinecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Mantis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine A.","family":"Denny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,11,11]]},"reference":[{"key":"9874_CR1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0896-6273(02)00768-7","volume":"35","author":"M Shahbazian","year":"2002","unstructured":"Shahbazian M, Young J, Yuva-Paylor L et al (2002) Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3. Neuron 35:243\u2013254. doi: 10.1016\/S0896-6273(02)00768-7","journal-title":"Neuron"},{"key":"9874_CR2","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/ana.410140412","volume":"14","author":"B Hagberg","year":"1983","unstructured":"Hagberg B, Aicardi J, Dias K et al (1983) A progressive syndrome of autism, dementia, ataxia, and loss of purposeful hand use in girls: Rett\u2019s syndrome: report of 35 cases. Ann Neurol 14:471\u2013479. doi: 10.1002\/ana.410140412","journal-title":"Ann Neurol"},{"key":"9874_CR3","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/S0733-8619(02)00022-1","volume":"20","author":"AK Percy","year":"2002","unstructured":"Percy AK (2002) Rett syndrome. Current status and new vistas. Neurol Clin 20:1125\u20131141. doi: 10.1016\/S0733-8619(02)00022-1","journal-title":"Neurol Clin"},{"key":"9874_CR4","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/13810","volume":"23","author":"RE Amir","year":"1999","unstructured":"Amir RE, Van den Veyver IB, Wan M et al (1999) Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat Genet 23:185\u2013188. doi: 10.1038\/13810","journal-title":"Nat Genet"},{"key":"9874_CR5","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1126\/science.1153252","volume":"320","author":"M Chahrour","year":"2008","unstructured":"Chahrour M, Jung SY, Shaw C et al (2008) MeCP2, a key contributor to neurological disease, activates and represses transcription. Science 320:1224\u20131229. doi: 10.1126\/science.1153252","journal-title":"Science"},{"key":"9874_CR6","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/85899","volume":"27","author":"J Guy","year":"2001","unstructured":"Guy J, Hendrich B, Holmes M et al (2001) A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome. Nat Genet 27:322\u2013326. doi: 10.1038\/85899","journal-title":"Nat Genet"},{"key":"9874_CR7","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1097\/01.mop.0000143693.59408.ce","volume":"16","author":"AK Percy","year":"2004","unstructured":"Percy AK, Lane JB (2004) Rett syndrome: clinical and molecular update. Curr Opin Pediatr 16:670\u2013677. doi: 10.1097\/01.mop.0000143693.59408.ce","journal-title":"Curr Opin Pediatr"},{"key":"9874_CR8","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1093\/hmg\/ddh063","volume":"13","author":"RC Samaco","year":"2004","unstructured":"Samaco RC, Nagarajan RP, Braunschweig D et al (2004) Multiple pathways regulate MeCP2 expression in normal brain development and exhibit defects in autism-spectrum disorders. Hum Mol Genet 13:629\u2013639. doi: 10.1093\/hmg\/ddh063","journal-title":"Hum Mol Genet"},{"key":"9874_CR9","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/0197-0186(91)90068-O","volume":"19","author":"A Lekman","year":"1991","unstructured":"Lekman A, Hagberg B, Svennerholm L (1991) Altered cerebellar ganglioside pattern in Rett syndrome. Neurochem Int 19:505\u2013509. doi: 10.1016\/0197-0186(91)90068-O","journal-title":"Neurochem Int"},{"key":"9874_CR10","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/0887-8994(91)90082-V","volume":"7","author":"AY Lekman","year":"1991","unstructured":"Lekman AY, Hagberg BA, Svennerholm LT (1991) Membrane cerebral lipids in Rett syndrome. Pediatr Neurol 7:186\u2013190. doi: 10.1016\/0887-8994(91)90082-V","journal-title":"Pediatr Neurol"},{"key":"9874_CR11","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S1090-3798(99)90099-5","volume":"3","author":"AY Lekman","year":"1999","unstructured":"Lekman AY, Hagberg BA, Svennerholm LT (1999) Cerebrospinal fluid gangliosides in patients with Rett syndrome and infantile neuronal ceroid lipofuscinosis. Eur J Paediatr Neurol 3:119\u2013123. doi: 10.1016\/S1090-3798(99)90099-5","journal-title":"Eur J Paediatr Neurol"},{"key":"9874_CR12","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/ajmg.1320290216","volume":"29","author":"JM Papadimitriou","year":"1988","unstructured":"Papadimitriou JM, Hockey A, Tan N et al (1988) Rett syndrome: abnormal membrane-bound lamellated inclusions in neurons and oligodendroglia. Am J Med Genet 29:365\u2013368. doi: 10.1002\/ajmg.1320290216","journal-title":"Am J Med Genet"},{"key":"9874_CR13","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/0887-8994(90)90022-S","volume":"6","author":"A Oldfors","year":"1990","unstructured":"Oldfors A, Sourander P, Armstrong DL et al (1990) Rett syndrome: cerebellar pathology. Pediatr Neurol 6:310\u2013314. doi: 10.1016\/0887-8994(90)90022-S","journal-title":"Pediatr Neurol"},{"key":"9874_CR14","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/978-1-4615-7514-6_5","volume-title":"Myelin","author":"WT Norton","year":"1977","unstructured":"Norton WT (1977) Isolation and characterization of myelin. In: Morell P (ed) Myelin. Plenum, New York, pp 161\u2013199"},{"key":"9874_CR15","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1046\/j.1471-4159.2001.00015.x","volume":"76","author":"ED Muse","year":"2001","unstructured":"Muse ED, Jurevics H, Toews AD et al (2001) Parameters related to lipid metabolism as markers of myelination in mouse brain. J Neurochem 76:77\u201386. doi: 10.1046\/j.1471-4159.2001.00015.x","journal-title":"J Neurochem"},{"key":"9874_CR16","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/cne.21673","volume":"508","author":"NP Belichenko","year":"2008","unstructured":"Belichenko NP, Belichenko PV, Li HH et al (2008) Comparative study of brain morphology in Mecp2 mutant mouse models of Rett syndrome. J Comp Neurol 508:184\u2013195. doi: 10.1002\/cne.21673","journal-title":"J Comp Neurol"},{"key":"9874_CR17","doi-asserted-by":"crossref","first-page":"e157","DOI":"10.1371\/journal.pone.0000157","volume":"2","author":"A Viola","year":"2007","unstructured":"Viola A, Saywell V, Villard L et al (2007) Metabolic fingerprints of altered brain growth, osmoregulation and neurotransmission in a Rett syndrome model. PLoS ONE 2:e157. doi: 10.1371\/journal.pone.0000157","journal-title":"PLoS ONE"},{"key":"9874_CR18","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0005-2760(89)90175-6","volume":"1005","author":"L Svennerholm","year":"1989","unstructured":"Svennerholm L, Bostrom K, Fredman P et al (1989) Human brain gangliosides: developmental changes from early fetal stage to advanced age. Biochim Biophys Acta 1005:109\u2013117","journal-title":"Biochim Biophys Acta"},{"key":"9874_CR19","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1111\/j.1471-4159.1984.tb12856.x","volume":"43","author":"TN Seyfried","year":"1984","unstructured":"Seyfried TN, Bernard DJ, Yu RK (1984) Cellular distribution of gangliosides in the developing mouse cerebellum: analysis using the staggerer mutant. J Neurochem 43:1152\u20131162. doi: 10.1111\/j.1471-4159.1984.tb12856.x","journal-title":"J Neurochem"},{"key":"9874_CR20","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/978-1-4684-1200-0_15","volume":"174","author":"TN Seyfried","year":"1984","unstructured":"Seyfried TN, Yu RK (1984) Cellular localization of gangliosides in the mouse cerebellum: analysis using neurological mutants. Adv Exp Med Biol 174:169\u2013181","journal-title":"Adv Exp Med Biol"},{"key":"9874_CR21","first-page":"3","volume":"68","author":"TN Seyfried","year":"1985","unstructured":"Seyfried TN, Yu RK (1985) Ganglioside GD3: structure, cellular distribution, and possible function. Mol Cell Biochem 68:3\u201310","journal-title":"Mol Cell Biochem"},{"key":"9874_CR22","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/j.1471-4159.1983.tb04767.x","volume":"41","author":"TN Seyfried","year":"1983","unstructured":"Seyfried TN, Miyazawa N, Yu RK (1983) Cellular localization of gangliosides in the developing mouse cerebellum: analysis using the weaver mutant. J Neurochem 41:491\u2013505. doi: 10.1111\/j.1471-4159.1983.tb04767.x","journal-title":"J Neurochem"},{"key":"9874_CR23","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/jnr.490260113","volume":"26","author":"TN Seyfried","year":"1990","unstructured":"Seyfried TN, Yu RK (1990) Cerebellar ganglioside abnormalities in pcd mutant mice. J Neurosci Res 26:105\u2013111. doi: 10.1002\/jnr.490260113","journal-title":"J Neurosci Res"},{"key":"9874_CR24","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/j.1471-4159.1982.tb08662.x","volume":"38","author":"TN Seyfried","year":"1982","unstructured":"Seyfried TN, Yu RK, Miyazawa N (1982) Differential cellular enrichment of gangliosides in the mouse cerebellum: analysis using neurological mutants. J Neurochem 38:551\u2013559. doi: 10.1111\/j.1471-4159.1982.tb08662.x","journal-title":"J Neurochem"},{"key":"9874_CR25","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/0014-4886(84)90206-1","volume":"84","author":"TN Seyfried","year":"1984","unstructured":"Seyfried TN, Bernard D, Mayeda F et al (1984) Genetic analysis of cerebellar lipids in mice susceptible to audiogenic seizures. Exp Neurol 84:590\u2013595. doi: 10.1016\/0014-4886(84)90206-1","journal-title":"Exp Neurol"},{"key":"9874_CR26","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1007\/BF00484350","volume":"18","author":"TN Seyfried","year":"1980","unstructured":"Seyfried TN, Yu RK (1980) Heterosis for brain myelin content in mice. Biochem Genet 18:1229\u20131238. doi: 10.1007\/BF00484350","journal-title":"Biochem Genet"},{"key":"9874_CR27","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1471-4159.2008.05383.x","volume":"106","author":"MA Kiebish","year":"2008","unstructured":"Kiebish MA, Han X, Cheng H et al (2008) Lipidomic analysis and electron transport chain activities in C57BL\/6J mouse brain mitochondria. J Neurochem 106:299\u2013312. doi: 10.1111\/j.1471-4159.2008.05383.x","journal-title":"J Neurochem"},{"key":"9874_CR28","first-page":"S90","volume":"88","author":"TN Seyfried","year":"1978","unstructured":"Seyfried TN, Glaser GH, Yu RK (1978) Developmental analysis of regional brain growth and audiogenic seizures in mice. Genetics 88:S90","journal-title":"Genetics"},{"key":"9874_CR29","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1046\/j.1471-4159.2004.02381.x","volume":"89","author":"JL Kasperzyk","year":"2004","unstructured":"Kasperzyk JL, El-Abbadi MM, Hauser EC et al (2004) N-butyldeoxygalactonojirimycin reduces neonatal brain ganglioside content in a mouse model of GM1 gangliosidosis. J Neurochem 89:645\u2013653. doi: 10.1046\/j.1471-4159.2004.02381.x","journal-title":"J Neurochem"},{"key":"9874_CR30","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.neuint.2007.12.001","volume":"52","author":"RC Baek","year":"2008","unstructured":"Baek RC, Kasperzyk JL, Platt FM et al (2008) N-butyldeoxygalactonojirimycin reduces brain ganglioside and GM2 content in neonatal Sandhoff disease mice. Neurochem Int 52:1125\u20131133. doi: 10.1016\/j.neuint.2007.12.001","journal-title":"Neurochem Int"},{"key":"9874_CR31","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/S0022-2275(20)37906-2","volume":"24","author":"LJ Macala","year":"1983","unstructured":"Macala LJ, Yu RK, Ando S (1983) Analysis of brain lipids by high performance thin-layer chromatography and densitometry. J Lipid Res 24:1243\u20131250","journal-title":"J Lipid Res"},{"key":"9874_CR32","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1194\/jlr.M400411-JLR200","volume":"46","author":"JL Kasperzyk","year":"2005","unstructured":"Kasperzyk JL, d\u2019Azzo A, Platt FM et al (2005) Substrate reduction reduces gangliosides in postnatal cerebrum-brainstem and cerebellum in GM1 gangliosidosis mice. J Lipid Res 46:744\u2013751. doi: 10.1194\/jlr.M400411-JLR200","journal-title":"J Lipid Res"},{"key":"9874_CR33","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","volume":"226","author":"J Folch","year":"1957","unstructured":"Folch J, Lees M, Sloane-Stanley GH (1957) A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226:497\u2013509","journal-title":"J Biol Chem"},{"key":"9874_CR34","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/0006-3002(57)90254-8","volume":"24","author":"L Svennerholm","year":"1957","unstructured":"Svennerholm L (1957) Quantitative estimation of sialic acids II. A colorimetric resorcinol-hydrochloric acid method. Biochim Biophys Acta 24:604\u2013611. doi: 10.1016\/0006-3002(57)90254-8","journal-title":"Biochim Biophys Acta"},{"key":"9874_CR35","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1023\/B:BIGI.0000034429.55418.71","volume":"42","author":"EC Hauser","year":"2004","unstructured":"Hauser EC, Kasperzyk JL, d\u2019Azzo A et al (2004) Inheritance of lysosomal acid beta-galactosidase activity and gangliosides in crosses of DBA\/2J and knockout mice. Biochem Genet 42:241\u2013257. doi: 10.1023\/B:BIGI.0000034429.55418.71","journal-title":"Biochem Genet"},{"key":"9874_CR36","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/0003-2697(78)90373-1","volume":"89","author":"S Ando","year":"1978","unstructured":"Ando S, Chang NC, Yu RK (1978) High-performance thin-layer chromatography and densitometric determination of brain ganglioside compositions of several species. Anal Biochem 89:437\u2013450. doi: 10.1016\/0003-2697(78)90373-1","journal-title":"Anal Biochem"},{"key":"9874_CR37","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1471-4159.1978.tb12428.x","volume":"31","author":"TN Seyfried","year":"1978","unstructured":"Seyfried TN, Glaser GH, Yu RK (1978) Cerebral, cerebellar, and brain stem gangliosides in mice susceptible to audiogenic seizures. J Neurochem 31:21\u201327. doi: 10.1111\/j.1471-4159.1978.tb12428.x","journal-title":"J Neurochem"},{"key":"9874_CR38","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/j.1471-4159.1987.tb09995.x","volume":"49","author":"C Sato","year":"1987","unstructured":"Sato C, Yu RK (1987) Myelin galactolipid synthesis in different strains of mice. J Neurochem 49:1069\u20131074. doi: 10.1111\/j.1471-4159.1987.tb09995.x","journal-title":"J Neurochem"},{"key":"9874_CR39","first-page":"69","volume-title":"Basic neurochemistry","author":"P Morell","year":"1999","unstructured":"Morell P, Quarles RH (1999) Myelin formation, structure and biochemistry. In: Siegel GJ et al (eds) Basic neurochemistry. Lippincott-Raven, New York, pp 69\u201393"},{"key":"9874_CR40","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1111\/j.1471-4159.1992.tb09782.x","volume":"58","author":"JV Brigande","year":"1992","unstructured":"Brigande JV, Wieraszko A, Albert MD et al (1992) Biochemical correlates of epilepsy in the E1 mouse: analysis of glial fibrillary acidic protein and gangliosides. J Neurochem 58:752\u2013760. doi: 10.1111\/j.1471-4159.1992.tb09782.x","journal-title":"J Neurochem"},{"key":"9874_CR41","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1042\/bj1740655","volume":"174","author":"HKM Yusuf","year":"1978","unstructured":"Yusuf HKM, Dickerson JWT (1978) Disialoganglioside GD1a of rat brain subcellular particles during development. Biochem J 174:655\u2013657","journal-title":"Biochem J"},{"key":"9874_CR42","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/0006-8993(86)90420-8","volume":"374","author":"SM Levine","year":"1986","unstructured":"Levine SM, Seyfried TN, Yu RK et al (1986) Immunocytochemical localization of GD3 ganglioside to astrocytes in murine cerebellar mutants. Brain Res 374:260\u2013269. doi: 10.1016\/0006-8993(86)90420-8","journal-title":"Brain Res"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-008-9874-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11064-008-9874-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-008-9874-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T06:19:07Z","timestamp":1632118747000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11064-008-9874-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,11]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["9874"],"URL":"https:\/\/doi.org\/10.1007\/s11064-008-9874-7","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,11]]}}}