{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:01:08Z","timestamp":1758906068815},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2009,10,23]],"date-time":"2009-10-23T00:00:00Z","timestamp":1256256000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1007\/s11064-009-0078-6","type":"journal-article","created":{"date-parts":[[2009,10,22]],"date-time":"2009-10-22T09:36:42Z","timestamp":1256204202000},"page":"444-451","source":"Crossref","is-referenced-by-count":19,"title":["D-\u03b2-Hydroxybutyrate Prevents MPP+-Induced Neurotoxicity in PC12 Cells"],"prefix":"10.1007","volume":"35","author":[{"given":"Baohua","family":"Cheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinxin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengchun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danfu","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xudong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuewen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,10,23]]},"reference":[{"key":"78_CR1","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S1474-4422(06)70471-9","volume":"5","author":"LM Lau de","year":"2006","unstructured":"de Lau LM, Breteler MM (2006) Epidemiology of Parkinson\u2019s disease. Lancet neurol 5:525\u2013535","journal-title":"Lancet neurol"},{"issue":"Suppl 2","key":"78_CR2","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1038\/sj.cdd.4401724","volume":"12","author":"G Kroemer","year":"2005","unstructured":"Kroemer G, El-Deiry WS, Golstein P, Peter ME, Vaux D, Vandenabeele P et al (2005) Classification of cell death: recommendations of the nomenclature committee on cell death. Cell Death Differ 12(Suppl 2):1463\u20131467","journal-title":"Cell Death Differ"},{"key":"78_CR3","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/nrn1100","volume":"4","author":"M Vila","year":"2003","unstructured":"Vila M, Przedborski S (2003) Targeting programmed cell death in neurodegenerative diseases. Nat Rev 4:365\u2013375","journal-title":"Nat Rev"},{"key":"78_CR4","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/0022-510X(95)00336-Z","volume":"137","author":"H Mochizuki","year":"1996","unstructured":"Mochizuki H, Goto K, Mori H, Mizuno Y (1996) Histochemical detection of apoptosis in Parkinson\u2019s disease. J Neurol Sci 137:120\u2013123","journal-title":"J Neurol Sci"},{"issue":"Suppl 3","key":"78_CR5","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1002\/ana.10483","volume":"53","author":"P Jenner","year":"2003","unstructured":"Jenner P (2003) Oxidative stress in Parkinson\u2019s disease. Ann Neurol 53(Suppl 3):S26\u2013S36 discussion S36\u2013S28","journal-title":"Ann Neurol"},{"key":"78_CR6","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1152\/physrev.00013.2006","volume":"87","author":"G Kroemer","year":"2007","unstructured":"Kroemer G, Galluzzi L, Brenner C (2007) Mitochondrial membrane permeabilization in cell death. Physiol Rev 87:99\u2013163","journal-title":"Physiol Rev"},{"key":"78_CR7","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/jnr.10294","volume":"69","author":"CM Troy","year":"2002","unstructured":"Troy CM, Salvesen GS (2002) Caspases on the brain. J Neurosci Res 69:145\u2013150","journal-title":"J Neurosci Res"},{"key":"78_CR8","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/sj.cdd.4400910","volume":"8","author":"X Roucou","year":"2001","unstructured":"Roucou X, Martinou JC (2001) Conformational change of Bax: a question of life or death. Cell Death Differ 8:875\u2013877","journal-title":"Cell Death Differ"},{"key":"78_CR9","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/BF03159727","volume":"10","author":"RE Heikkila","year":"1989","unstructured":"Heikkila RE, Sieber BA, Manzino L, Sonsalla PK (1989) Some features of the nigrostriatal dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse. Mol chem neuropathol 10:171\u2013183","journal-title":"Mol chem neuropathol"},{"key":"78_CR10","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0896-6273(03)00568-3","volume":"39","author":"W Dauer","year":"2003","unstructured":"Dauer W, Przedborski S (2003) Parkinson\u2019s disease: mechanisms and models. Neuron 39:889\u2013909","journal-title":"Neuron"},{"key":"78_CR11","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/0006-291X(84)91293-2","volume":"120","author":"K Chiba","year":"1984","unstructured":"Chiba K, Trevor A, Castagnoli N Jr (1984) Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase. Biochem Biophys Res Commun 120:574\u2013578","journal-title":"Biochem Biophys Res Commun"},{"key":"78_CR12","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1111\/j.1471-4159.1993.tb13610.x","volume":"61","author":"KF Tipton","year":"1993","unstructured":"Tipton KF, Singer TP (1993) Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds. J Neurochem 61:1191\u20131206","journal-title":"J Neurochem"},{"key":"78_CR13","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/S0028-3908(02)00049-7","volume":"42","author":"H Sawada","year":"2002","unstructured":"Sawada H, Ibi M, Kihara T, Honda K, Nakamizo T, Kanki R et al (2002) Estradiol protects dopaminergic neurons in a MPP+ Parkinson\u2019s disease model. Neuropharmacology 42:1056\u20131064","journal-title":"Neuropharmacology"},{"key":"78_CR14","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1007\/s10571-006-9078-0","volume":"26","author":"M Chalimoniuk","year":"2006","unstructured":"Chalimoniuk M, Snoek GT, Adamczyk A, Malecki A, Strosznajder JB (2006) Phosphatidylinositol transfer protein expression altered by aging and Parkinson disease. Cell Mol Neurobiol 26:1153\u20131166","journal-title":"Cell Mol Neurobiol"},{"key":"78_CR15","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1007\/s10495-006-6715-5","volume":"11","author":"J Chen","year":"2006","unstructured":"Chen J, Tang XQ, Zhi JL, Cui Y, Yu HM, Tang EH et al (2006) Curcumin protects PC12 cells against 1-methyl-4-phenylpyridinium ion-induced apoptosis by bcl-2-mitochondria-ROS-iNOS pathway. Apoptosis 11:943\u2013953","journal-title":"Apoptosis"},{"key":"78_CR16","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S1043-2760(00)00370-2","volume":"12","author":"M Guzman","year":"2001","unstructured":"Guzman M, Blazquez C (2001) Is there an astrocyte-neuron ketone body shuttle? Trends endocrinol metab 12:169\u2013173","journal-title":"Trends endocrinol metab"},{"key":"78_CR17","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1172\/JCI105650","volume":"46","author":"OE Owen","year":"1967","unstructured":"Owen OE, Morgan AP, Kemp HG, Sullivan JM, Herrera MG, Cahill GF Jr (1967) Brain metabolism during fasting. J clin invest 46:1589\u20131595","journal-title":"J clin invest"},{"key":"78_CR18","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/jnr.490050208","volume":"5","author":"M Pollay","year":"1980","unstructured":"Pollay M, Stevens FA (1980) Starvation-induced changes in transport of ketone bodies across the blood\u2013brain barrier. J Neurosci Res 5:163\u2013172","journal-title":"J Neurosci Res"},{"key":"78_CR19","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1161\/01.STR.15.2.319","volume":"15","author":"JR Kirsch","year":"1984","unstructured":"Kirsch JR, D\u2019Alecy LG (1984) Hypoxia induced preferential ketone utilization by rat brain slices. Stroke 15:319\u2013323","journal-title":"Stroke"},{"key":"78_CR20","first-page":"E169","volume":"250","author":"RA Hawkins","year":"1986","unstructured":"Hawkins RA, Mans AM, Davis DW (1986) Regional ketone body utilization by rat brain in starvation and diabetes. Am J Physiol 250:E169\u2013E178","journal-title":"Am J Physiol"},{"key":"78_CR21","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1159\/000111437","volume":"18","author":"A Nehlig","year":"1996","unstructured":"Nehlig A (1996) Respective roles of glucose and ketone bodies as substrates for cerebral energy metabolism in the suckling rat. Dev Neurosci 18:426\u2013433","journal-title":"Dev Neurosci"},{"key":"78_CR22","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.brainresrev.2008.09.002","volume":"59","author":"M Maalouf","year":"2009","unstructured":"Maalouf M, Rho JM, Mattson MP (2009) The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies. Brain Res Rev 59:293\u2013315","journal-title":"Brain Res Rev"},{"key":"78_CR23","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1542\/peds.102.6.1358","volume":"102","author":"JM Freeman","year":"1998","unstructured":"Freeman JM, Vining EP, Pillas DJ, Pyzik PL, Casey JC, Kelly LM (1998) The efficacy of the ketogenic diet-1998: a prospective evaluation of intervention in 150 children. Pediatrics 102:1358\u20131363","journal-title":"Pediatrics"},{"key":"78_CR24","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1172\/JCI1009","volume":"101","author":"Y Izumi","year":"1998","unstructured":"Izumi Y, Ishii K, Katsuki H, Benz AM, Zorumski CF (1998) beta-Hydroxybutyrate fuels synaptic function during development. Histological and physiological evidence in rat hippocampal slices. J Clin Invest 101:1121\u20131132","journal-title":"J Clin Invest"},{"key":"78_CR25","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1007\/s11064-006-9189-5","volume":"31","author":"J Mejia-Toiber","year":"2006","unstructured":"Mejia-Toiber J, Montiel T, Massieu L (2006) D-beta-hydroxybutyrate prevents glutamate-mediated lipoperoxidation and neuronal damage elicited during glycolysis inhibition in vivo. Neurochem Res 31:1399\u20131408","journal-title":"Neurochem Res"},{"key":"78_CR26","doi-asserted-by":"crossref","first-page":"5440","DOI":"10.1073\/pnas.97.10.5440","volume":"97","author":"Y Kashiwaya","year":"2000","unstructured":"Kashiwaya Y, Takeshima T, Mori N, Nakashima K, Clarke K, Veech RL (2000) D-beta-hydroxybutyrate protects neurons in models of Alzheimer\u2019s and Parkinson\u2019s disease. Proc Natl Acad Sci USA 97:5440\u20135444","journal-title":"Proc Natl Acad Sci USA"},{"key":"78_CR27","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1172\/JCI200318797","volume":"112","author":"K Tieu","year":"2003","unstructured":"Tieu K, Perier C, Caspersen C, Teismann P, Wu DC, Yan SD et al (2003) D-beta-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease. J Clin Invest 112:892\u2013901","journal-title":"J Clin Invest"},{"key":"78_CR28","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1111\/j.1528-1157.1992.tb01770.x","volume":"33","author":"SL Kinsman","year":"1992","unstructured":"Kinsman SL, Vining EP, Quaskey SA, Mellits D, Freeman JM (1992) Efficacy of the ketogenic diet for intractable seizure disorders: review of 58 cases. Epilepsia 33:1132\u20131136","journal-title":"Epilepsia"},{"key":"78_CR29","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0920-1211(02)00262-0","volume":"53","author":"HS Noh","year":"2003","unstructured":"Noh HS, Kim YS, Lee HP, Chung KM, Kim DW, Kang SS et al (2003) The protective effect of a ketogenic diet on kainic acid-induced hippocampal cell death in the male ICR mice. Epilepsy Res 53:119\u2013128","journal-title":"Epilepsy Res"},{"key":"78_CR30","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1002\/jnr.21057","volume":"84","author":"HS Noh","year":"2006","unstructured":"Noh HS, Kim YS, Kim YH, Han JY, Park CH, Kang AK et al (2006) Ketogenic diet protects the hippocampus from kainic acid toxicity by inhibiting the dissociation of bad from 14-3-3. J Neurosci Res 84:1829\u20131836","journal-title":"J Neurosci Res"},{"key":"78_CR31","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.neulet.2005.10.073","volume":"395","author":"HS Noh","year":"2006","unstructured":"Noh HS, Kim DW, Kang SS, Kim YH, Cho GJ, Choi WS (2006) Ketogenic diet decreases the level of proenkephalin mRNA induced by kainic acid in the mouse hippocampus. Neurosci Lett 395:87\u201392","journal-title":"Neurosci Lett"},{"key":"78_CR32","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.eplepsyres.2005.05.008","volume":"65","author":"HS Noh","year":"2005","unstructured":"Noh HS, Kang SS, Kim DW, Kim YH, Park CH, Han JY et al (2005) Ketogenic diet increases calbindin-D28\u00a0k in the hippocampi of male ICR mice with kainic acid seizures. Epilepsy Res 65:153\u2013159","journal-title":"Epilepsy Res"},{"key":"78_CR33","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.brainres.2005.01.097","volume":"1042","author":"HS Noh","year":"2005","unstructured":"Noh HS, Kim DW, Kang SS, Cho GJ, Choi WS (2005) Ketogenic diet prevents clusterin accumulation induced by kainic acid in the hippocampus of male ICR mice. Brain Res 1042:114\u2013118","journal-title":"Brain Res"},{"key":"78_CR34","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/jnr.20464","volume":"80","author":"R Masuda","year":"2005","unstructured":"Masuda R, Monahan JW, Kashiwaya Y (2005) D-beta-hydroxybutyrate is neuroprotective against hypoxia in serum-free hippocampal primary cultures. J Neurosci Res 80:501\u2013509","journal-title":"J Neurosci Res"},{"key":"78_CR35","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/BF00999535","volume":"3","author":"KG Go","year":"1988","unstructured":"Go KG, Prenen GH, Korf J (1988) Protective effect of fasting upon cerebral hypoxic-ischemic injury. Metab Brain Dis 3:257\u2013263","journal-title":"Metab Brain Dis"},{"key":"78_CR36","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1254\/jjp.87.143","volume":"87","author":"M Suzuki","year":"2001","unstructured":"Suzuki M, Suzuki M, Sato K, Dohi S, Sato T, Matsuura A et al (2001) Effect of beta-hydroxybutyrate, a cerebral function improving agent, on cerebral hypoxia, anoxia and ischemia in mice and rats. Jpn J Pharmacol 87:143\u2013150","journal-title":"Jpn J Pharmacol"},{"key":"78_CR37","doi-asserted-by":"crossref","first-page":"51783","DOI":"10.1074\/jbc.M407336200","volume":"279","author":"GR Kweon","year":"2004","unstructured":"Kweon GR, Marks JD, Krencik R, Leung EH, Schumacker PT, Hyland K et al (2004) Distinct mechanisms of neurodegeneration induced by chronic complex I inhibition in dopaminergic and non-dopaminergic cells. J Bio Chem 279:51783\u201351792","journal-title":"J Bio Chem"},{"key":"78_CR38","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1002\/jnr.21021","volume":"84","author":"K Imamura","year":"2006","unstructured":"Imamura K, Takeshima T, Kashiwaya Y, Nakaso K, Nakashima K (2006) D-beta-hydroxybutyrate protects dopaminergic SH-SY5Y cells in a rotenone model of Parkinson\u2019s disease. J Neurosci Res 84:1376\u20131384","journal-title":"J Neurosci Res"},{"key":"78_CR39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s007020050001","volume":"107","author":"KA Jellinger","year":"2000","unstructured":"Jellinger KA (2000) Cell death mechanisms in Parkinson\u2019s disease. J Neural Transm 107:1\u201329","journal-title":"J Neural Transm"},{"key":"78_CR40","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0378-4274(02)00428-9","volume":"139","author":"O Eberhardt","year":"2003","unstructured":"Eberhardt O, Schulz JB (2003) Apoptotic mechanisms and antiapoptotic therapy in the MPTP model of Parkinson\u2019s disease. Toxicol Lett 139:135\u2013151","journal-title":"Toxicol Lett"},{"key":"78_CR41","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1263\/jbb.100.511","volume":"100","author":"MK Takata","year":"2005","unstructured":"Takata MK, Yamaguchi F, Nakanose K, Watanabe Y, Hatano N, Tsukamoto I et al (2005) Neuroprotective effect of D-psicose on 6-hydroxydopamine-induced apoptosis in rat pheochromocytoma (PC12) cells. J Biosci Bioeng 100:511\u2013516","journal-title":"J Biosci Bioeng"},{"key":"78_CR42","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/BF03033456","volume":"6","author":"J Segura Aguilar","year":"2004","unstructured":"Segura Aguilar J, Kostrzewa RM (2004) Neurotoxins and neurotoxic species implicated in neurodegeneration. Neurotox Res 6:615\u2013630","journal-title":"Neurotox Res"},{"key":"78_CR43","first-page":"829","volume":"23","author":"XC Chen","year":"2002","unstructured":"Chen XC, Chen Y, Zhu YG, Fang F, Chen LM (2002) Protective effect of ginsenoside Rg1 against MPTP-induced apoptosis in mouse substantia nigra neurons. Acta Pharmacol Sin 23:829\u2013834","journal-title":"Acta Pharmacol Sin"},{"key":"78_CR44","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1007\/s10495-007-0065-9","volume":"12","author":"Y Wu","year":"2007","unstructured":"Wu Y, Shang Y, Sun S, Liang H, Liu R (2007) Erythropoietin prevents PC12 cells from 1-methyl-4-phenylpyridinium ion-induced apoptosis via the Akt\/GSK-3beta\/caspase-3 mediated signaling pathway. Apoptosis 12:1365\u20131375","journal-title":"Apoptosis"},{"key":"78_CR45","doi-asserted-by":"crossref","first-page":"4682","DOI":"10.1167\/iovs.03-0198","volume":"44","author":"S Nakamura","year":"2003","unstructured":"Nakamura S, Shibuya M, Saito Y, Nakashima H, Saito F, Higuchi A et al (2003) Protective effect of D-beta-hydroxybutyrate on corneal epithelia in dry eye conditions through suppression of apoptosis. Invest Ophthalmol Vis Sci 44:4682\u20134688","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"78_CR46","first-page":"76","volume":"39","author":"ZG Hu","year":"2009","unstructured":"Hu ZG, Wang HD, Jin W, Yin HX (2009) Ketogenic diet reduces cytochrome c release and cellular apoptosis following traumatic brain injury in juvenile rats. Ann Clin Lab Sci 39:76\u201383","journal-title":"Ann Clin Lab Sci"},{"key":"78_CR47","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1080\/02699050902788469","volume":"23","author":"ZG Hu","year":"2009","unstructured":"Hu ZG, Wang HD, Qiao L, Yan W, Tan QF, Yin HX (2009) The protective effect of the ketogenic diet on traumatic brain injury-induced cell death in juvenile rats. Brain Inj 23:459\u2013465","journal-title":"Brain Inj"},{"key":"78_CR48","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1006\/excr.2000.4833","volume":"256","author":"M Loeffler","year":"2000","unstructured":"Loeffler M, Kroemer G (2000) The mitochondrion in cell death control: certainties and incognita. Exp Cell Res 256:19\u201326","journal-title":"Exp Cell Res"},{"key":"78_CR49","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/ana.410300409","volume":"30","author":"N Hattori","year":"1991","unstructured":"Hattori N, Tanaka M, Ozawa T, Mizuno Y (1991) Immunohistochemical studies on complexes I, II, III, and IV of mitochondria in Parkinson\u2019s disease. Ann Neurol 30:563\u2013571","journal-title":"Ann Neurol"},{"key":"78_CR50","first-page":"1645","volume":"60","author":"CL Perkins","year":"2000","unstructured":"Perkins CL, Fang G, Kim CN, Bhalla KN (2000) The role of Apaf-1, caspase-9, and bid proteins in etoposide- or paclitaxel-induced mitochondrial events during apoptosis. Cancer Res 60:1645\u20131653","journal-title":"Cancer Res"},{"key":"78_CR51","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S1353-8020(99)00041-3","volume":"5","author":"WG Tatton","year":"1999","unstructured":"Tatton WG, Chalmers-Redman RM, Rideout HJ, Tatton NA (1999) Mitochondrial permeability in neuronal death: possible relevance to the pathogenesis of Parkinson\u2019s disease. Parkinsonism Relat Disord 5:221\u2013229","journal-title":"Parkinsonism Relat Disord"},{"key":"78_CR52","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.tiv.2007.02.004","volume":"21","author":"X Kang","year":"2007","unstructured":"Kang X, Chen J, Xu Z, Li H, Wang B (2007) Protective effects of Ginkgo biloba extract on paraquat-induced apoptosis of PC12 cells. Toxicol In Vitro 21:1003\u20131009","journal-title":"Toxicol In Vitro"},{"key":"78_CR53","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1023\/A:1026119708124","volume":"28","author":"CS Lee","year":"2003","unstructured":"Lee CS, Han ES, Lee WB (2003) Antioxidant effect of phenelzine on MPP+-induced cell viability loss in differentiated PC12 cells. Neurochem Res 28:1833\u20131841","journal-title":"Neurochem Res"},{"key":"78_CR54","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.neures.2005.06.014","volume":"53","author":"J Bo","year":"2005","unstructured":"Bo J, Ming BY, Gang LZ, Lei C, Jia AL (2005) Protection by puerarin against MPP+-induced neurotoxicity in PC12 cells mediated by inhibiting mitochondrial dysfunction and caspase-3-like activation. Neurosci Res 53:183\u2013188","journal-title":"Neurosci Res"},{"key":"78_CR55","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ejphar.2005.10.008","volume":"527","author":"CS Lee","year":"2005","unstructured":"Lee CS, Kim YJ, Ko HH, Han ES (2005) Inhibition of 1-methyl-4-phenylpyridinium-induced mitochondrial dysfunction and cell death in PC12 cells by sulfonylurea glibenclamide. Eur J Pharmacol 527:23\u201330","journal-title":"Eur J Pharmacol"},{"key":"78_CR56","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1126\/science.1087753","volume":"302","author":"TM Dawson","year":"2003","unstructured":"Dawson TM, Dawson VL (2003) Molecular pathways of neurodegeneration in Parkinson\u2019s disease. Science 302:819\u2013822","journal-title":"Science"},{"issue":"Suppl 1","key":"78_CR57","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.parkreldis.2004.10.012","volume":"11","author":"S Przedborski","year":"2005","unstructured":"Przedborski S (2005) Pathogenesis of nigral cell death in Parkinson\u2019s disease. Parkinsonism Relat Disord 11(Suppl 1):S3\u20137","journal-title":"Parkinsonism Relat Disord"},{"key":"78_CR58","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0304-3940(98)00170-0","volume":"245","author":"BK Jin","year":"1998","unstructured":"Jin BK, Shin DY, Jeong MY, Gwag MR, Baik HW, Yoon KS et al (1998) Melatonin protects nigral dopaminergic neurons from 1-methyl-4-phenylpyridinium (MPP+) neurotoxicity in rats. Neurosci Lett 245:61\u201364","journal-title":"Neurosci Lett"},{"key":"78_CR59","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1146\/annurev.pa.36.040196.000503","volume":"36","author":"NA Simonian","year":"1996","unstructured":"Simonian NA, Coyle JT (1996) Oxidative stress in neurodegenerative diseases. Annu Rev Pharmacol Toxicol 36:83\u2013106","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"78_CR60","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.brainres.2006.01.116","volume":"1082","author":"Y Oida","year":"2006","unstructured":"Oida Y, Kitaichi K, Nakayama H, Ito Y, Fujimoto Y, Shimazawa M et al (2006) Rifampicin attenuates the MPTP-induced neurotoxicity in mouse brain. Brain Res 1082:196\u2013204","journal-title":"Brain Res"},{"key":"78_CR61","doi-asserted-by":"crossref","first-page":"4326","DOI":"10.1523\/JNEUROSCI.0019-07.2007","volume":"27","author":"LP Liang","year":"2007","unstructured":"Liang LP, Huang J, Fulton R, Day BJ, Patel M (2007) An orally active catalytic metalloporphyrin protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity in vivo. J Neurosci 27:4326\u20134333","journal-title":"J Neurosci"},{"key":"78_CR62","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/S0006-2952(02)01174-7","volume":"64","author":"S Bharath","year":"2002","unstructured":"Bharath S, Hsu M, Kaur D, Rajagopalan S, Andersen JK (2002) Glutathione, iron and Parkinson\u2019s disease. Biochem Pharmacol 64:1037\u20131048","journal-title":"Biochem Pharmacol"},{"key":"78_CR63","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0197-0186(99)00156-4","volume":"36","author":"J Seyfried","year":"2000","unstructured":"Seyfried J, Soldner F, Kunz WS, Schulz JB, Klockgether T, Kovar KA et al (2000) Effect of 1-methyl-4-phenylpyridinium on glutathione in rat pheochromocytoma PC 12 cells. Neurochem Int 36:489\u2013497","journal-title":"Neurochem Int"},{"key":"78_CR64","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.expneurol.2006.09.004","volume":"203","author":"GD Zeevalk","year":"2007","unstructured":"Zeevalk GD, Manzino L, Sonsalla PK, Bernard LP (2007) Characterization of intracellular elevation of glutathione (GSH) with glutathione monoethyl ester and GSH in brain and neuronal cultures: relevance to Parkinson\u2019s disease. Exp Neurol 203:512\u2013520","journal-title":"Exp Neurol"},{"key":"78_CR65","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1111\/j.1471-4159.2008.05460.x","volume":"106","author":"SG Jarrett","year":"2008","unstructured":"Jarrett SG, Milder JB, Liang LP, Patel M (2008) The ketogenic diet increases mitochondrial glutathione levels. J Neurochem 106:1044\u20131051","journal-title":"J Neurochem"},{"key":"78_CR66","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1212\/01.WNL.0000152046.11390.45","volume":"64","author":"TB Vanitallie","year":"2005","unstructured":"Vanitallie TB, Nonas C, Di Rocco A, Boyar K, Hyams K, Heymsfield SB (2005) Treatment of Parkinson disease with diet-induced hyperketonemia: a feasibility study. Neurology 64:728\u2013730","journal-title":"Neurology"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-009-0078-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11064-009-0078-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-009-0078-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:36:10Z","timestamp":1559349370000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11064-009-0078-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,23]]},"references-count":66,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["78"],"URL":"https:\/\/doi.org\/10.1007\/s11064-009-0078-6","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,23]]}}}