{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:05:59Z","timestamp":1791187559322,"version":"4.1.0"},"reference-count":147,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2011,1,6]],"date-time":"2011-01-06T00:00:00Z","timestamp":1294272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1007\/s11064-010-0393-y","type":"journal-article","created":{"date-parts":[[2011,1,5]],"date-time":"2011-01-05T05:45:45Z","timestamp":1294206345000},"page":"1186-1197","source":"Crossref","is-referenced-by-count":88,"title":["Role of Inositol 1,4,5-Trishosphate Receptors in Pathogenesis of Huntington\u2019s Disease and Spinocerebellar Ataxias"],"prefix":"10.1007","volume":"36","author":[{"given":"Ilya","family":"Bezprozvanny","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,1,6]]},"reference":[{"key":"393_CR1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/00005072-199805000-00001","volume":"57","author":"JP Vonsattel","year":"1998","unstructured":"Vonsattel JP, DiFiglia M (1998) Huntington disease. J Neuropathol Exp Neurol 57:369\u2013384","journal-title":"J Neuropathol Exp Neurol"},{"key":"393_CR2","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00005072-198511000-00003","volume":"44","author":"JP Vonsattel","year":"1985","unstructured":"Vonsattel JP, Myers RH, Stevens TJ, Ferrante RJ, Bird ED, Richardson EP Jr (1985) Neuropathological classification of Huntington\u2019s disease. J Neuropathol Exp Neurol 44:559\u2013577","journal-title":"J Neuropathol Exp Neurol"},{"key":"393_CR3","doi-asserted-by":"crossref","unstructured":"The Huntington\u2019s Disease Collaborative Research and Group (1993) A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington\u2019s disease chromosomes. Cell 72: 971\u2013983","DOI":"10.1016\/0092-8674(93)90585-E"},{"key":"393_CR4","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1399-0004.2004.00241.x","volume":"65","author":"DR Langbehn","year":"2004","unstructured":"Langbehn DR, Brinkman RR, Falush D, Paulsen JS, Hayden MR (2004) A new model for prediction of the age of onset and penetrance for Huntington\u2019s disease based on CAG length. Clin Genet 65:267\u2013277","journal-title":"Clin Genet"},{"key":"393_CR5","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/0896-6273(93)90127-D","volume":"11","author":"SH Li","year":"1993","unstructured":"Li SH, Schilling G, Young WS III, Li XJ, Margolis RL, Stine OC, Wagster MV, Abbott MH, Franz ML, Ranen NG et al (1993) Huntington\u2019s disease gene (IT15) is widely expressed in human and rat tissues. Neuron 11:985\u2013993","journal-title":"Neuron"},{"key":"393_CR6","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/ng1193-259","volume":"5","author":"TV Strong","year":"1993","unstructured":"Strong TV, Tagle DA, Valdes JM, Elmer LW, Boehm K, Swaroop M, Kaatz KW, Collins FS, Albin RL (1993) Widespread expression of the human and rat Huntington\u2019s disease gene in brain and nonneural tissues. Nat Genet 5:259\u2013265","journal-title":"Nat Genet"},{"key":"393_CR7","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/0896-6273(95)90345-3","volume":"14","author":"AH Sharp","year":"1995","unstructured":"Sharp AH, Loev SJ, Schilling G, Li SH, Li XJ, Bao J, Wagster MV, Kotzuk JA, Steiner JP, Lo A et al (1995) Widespread expression of Huntington\u2019s disease gene (IT15) protein product. Neuron 14:1065\u20131074","journal-title":"Neuron"},{"key":"393_CR8","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/0092-8674(95)90542-1","volume":"81","author":"J Nasir","year":"1995","unstructured":"Nasir J, Floresco SB, O\u2019Kusky JR, Diewert VM, Richman JM, Zeisler J, Borowski A, Marth JD, Phillips AG, Hayden MR (1995) Targeted disruption of the Huntington\u2019s disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes. Cell 81:811\u2013823","journal-title":"Cell"},{"key":"393_CR9","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1126\/science.7618107","volume":"269","author":"MP Duyao","year":"1995","unstructured":"Duyao MP, Auerbach AB, Ryan A, Persichetti F, Barnes GT, McNeil SM, Ge P, Vonsattel JP, Gusella JF, Joyner AL et al (1995) Inactivation of the mouse Huntington\u2019s disease gene homolog Hdh. Science 269:407\u2013410","journal-title":"Science"},{"key":"393_CR10","doi-asserted-by":"crossref","unstructured":"MacDonald ME (2003) Huntingtin: alive and well and working in middle management. Sci STKE 2003: pe48","DOI":"10.1126\/stke.2003.207.pe48"},{"key":"393_CR11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2008.06.005","volume":"32","author":"MY Heng","year":"2008","unstructured":"Heng MY, Detloff PJ, Albin RL (2008) Rodent genetic models of Huntington disease. Neurobiol Dis 32:1\u20139","journal-title":"Neurobiol Dis"},{"key":"393_CR12","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1755-5949.2010.00134.x","volume":"16","author":"VM Andre","year":"2010","unstructured":"Andre VM, Cepeda C, Levine MS (2010) Dopamine and glutamate in Huntington\u2019s disease: a balancing act. CNS Neurosci Ther 16:163\u2013178","journal-title":"CNS Neurosci Ther"},{"key":"393_CR13","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.tins.2010.08.002","volume":"33","author":"AJ Milnerwood","year":"2010","unstructured":"Milnerwood AJ, Raymond LA (2010) Early synaptic pathophysiology in neurodegeneration: insights from Huntington\u2019s disease. Trends Neurosci 33:513\u2013523","journal-title":"Trends Neurosci"},{"key":"393_CR14","doi-asserted-by":"crossref","first-page":"735","DOI":"10.2217\/fnl.10.41","volume":"5","author":"BR Miller","year":"2010","unstructured":"Miller BR, Bezprozvanny I (2010) Corticostriatal circuit dysfunction in Huntington\u2019s disease: intersection of glutamate, dopamine, and calcium. Future Neurol 5:735\u2013756","journal-title":"Future Neurol"},{"key":"393_CR15","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s004150050385","volume":"246","author":"A Filla","year":"1999","unstructured":"Filla A, De Michele G, Santoro L, Calabrese O, Castaldo I, Giuffrida S, Restivo D, Serlenga L, Condorelli DF, Bonuccelli U, Scala R, Coppola G, Caruso G, Cocozza S (1999) Spinocerebellar ataxia type 2 in southern Italy: a clinical and molecular study of 30 families. J Neurol 246:467\u2013471","journal-title":"J Neurol"},{"key":"393_CR16","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S1474-4422(04)00737-9","volume":"3","author":"L Schols","year":"2004","unstructured":"Schols L, Bauer P, Schmidt T, Schulte T, Riess O (2004) Autosomal dominant cerebellar ataxias: clinical features, genetics, and pathogenesis. Lancet Neurol 3:291\u2013304","journal-title":"Lancet Neurol"},{"key":"393_CR17","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s12311-008-0019-y","volume":"7","author":"I Lastres-Becker","year":"2008","unstructured":"Lastres-Becker I, Rub U, Auburger G (2008) Spinocerebellar ataxia 2 (SCA2). Cerebellum 7:115\u2013124","journal-title":"Cerebellum"},{"key":"393_CR18","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1212\/01.wnl.0000311277.71046.a0","volume":"71","author":"K Hara","year":"2008","unstructured":"Hara K, Shiga A, Nozaki H, Mitsui J, Takahashi Y, Ishiguro H, Yomono H, Kurisaki H, Goto J, Ikeuchi T, Tsuji S, Nishizawa M, Onodera O (2008) Total deletion and a missense mutation of ITPR1 in Japanese SCA15 families. Neurology 71:547\u2013551","journal-title":"Neurology"},{"key":"393_CR19","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1136\/jmg.2007.053942","volume":"45","author":"A Iwaki","year":"2008","unstructured":"Iwaki A, Kawano Y, Miura S, Shibata H, Matsuse D, Li W, Furuya H, Ohyagi Y, Taniwaki T, Kira J, Fukumaki Y (2008) Heterozygous deletion of ITPR1, but not SUMF1, in spinocerebellar ataxia type 16. J Med Genet 45:32\u201335","journal-title":"J Med Genet"},{"key":"393_CR20","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1097\/WNO0b013e3181b416de","volume":"29","author":"HL Paulson","year":"2009","unstructured":"Paulson HL (2009) The spinocerebellar ataxias. J Neuroophthalmol 29:227\u2013237","journal-title":"J Neuroophthalmol"},{"key":"393_CR21","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s12311-009-0144-2","volume":"9","author":"A Matilla-Duenas","year":"2010","unstructured":"Matilla-Duenas A, Sanchez I, Corral-Juan M, Davalos A, Alvarez R, Latorre P (2010) Cellular and molecular pathways triggering neurodegeneration in the spinocerebellar ataxias. Cerebellum 9:148\u2013166","journal-title":"Cerebellum"},{"key":"393_CR22","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.gde.2009.02.009","volume":"19","author":"KM Carlson","year":"2009","unstructured":"Carlson KM, Andresen JM, Orr HT (2009) Emerging pathogenic pathways in the spinocerebellar ataxias. Curr Opin Genet Dev 19:247\u2013253","journal-title":"Curr Opin Genet Dev"},{"key":"393_CR23","doi-asserted-by":"crossref","unstructured":"Bezprozvanny I, Klockgether T (2010) Therapeutic prospects for spinocerebellar ataxia type 2 and 3. Drugs Future 34: 991\u2013999","DOI":"10.1358\/dof.2009.034.12.1443434"},{"key":"393_CR24","doi-asserted-by":"crossref","unstructured":"Kasumu A, Bezprozvanny I (2010) Deranged calcium signaling in purkinje cells and pathogenesis in spinocerebellar ataxia 2 (SCA2) and other ataxias. Cerebellum [Epub ahead of print]","DOI":"10.1007\/s12311-010-0182-9"},{"key":"393_CR25","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/mds.10192","volume":"18","author":"W Pirker","year":"2003","unstructured":"Pirker W, Back C, Gerschlager W, Laccone F, Alesch F (2003) Chronic thalamic stimulation in a patient with spinocerebellar ataxia type 2. Mov Disord 18:222\u2013225","journal-title":"Mov Disord"},{"key":"393_CR26","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0896-6273(00)80510-3","volume":"21","author":"MJ Berridge","year":"1998","unstructured":"Berridge MJ (1998) Neuronal calcium signaling. Neuron 21:13\u201326","journal-title":"Neuron"},{"key":"393_CR27","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/0959-4388(94)90089-2","volume":"4","author":"T Furuichi","year":"1994","unstructured":"Furuichi T, Kohda K, Miyawaki A, Mikoshiba K (1994) Intracellular channels. Curr Opinion Neurobiol 4:294\u2013303","journal-title":"Curr Opinion Neurobiol"},{"key":"393_CR28","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/379168a0","volume":"379","author":"M Matsumoto","year":"1996","unstructured":"Matsumoto M, Nakagawa T, Inoue T, Nagata E, Tanaka K, Takano H, Minowa O, Kuno J, Sakakibara S, Yamada M, Yoneshima H, Miyawaki A, Fukuuchi Y, Furuichi T, Okano H, Mikoshiba K, Noda T (1996) Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor. Nature 379:168\u2013171","journal-title":"Nature"},{"key":"393_CR29","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1523\/JNEUROSCI.17-02-00635.1997","volume":"17","author":"VA Street","year":"1997","unstructured":"Street VA, Bosma MM, Demas VP, Regan MR, Lin DD, Robinson LC, Agnew WS, Tempel BL (1997) The type 1 inositol 1, 4, 5-trisphosphate receptor gene is altered in the opisthotonos mouse. J Neurosci 17:635\u2013645","journal-title":"J Neurosci"},{"key":"393_CR30","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.molmed.2009.01.001","volume":"15","author":"I Bezprozvanny","year":"2009","unstructured":"Bezprozvanny I (2009) Calcium signaling and neurodegenerative diseases. Trends Mol Med 15:89\u2013100","journal-title":"Trends Mol Med"},{"key":"393_CR31","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/j.bbrc.2004.08.035","volume":"322","author":"I Bezprozvanny","year":"2004","unstructured":"Bezprozvanny I, Hayden MR (2004) Deranged neuronal calcium signaling and Huntington disease. Biochem Biophys Res Commun 322:1310\u20131317","journal-title":"Biochem Biophys Res Commun"},{"key":"393_CR32","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0896-6273(03)00366-0","volume":"39","author":"TS Tang","year":"2003","unstructured":"Tang TS, Tu H, Chan EY, Maximov A, Wang Z, Wellington CL, Hayden MR, Bezprozvanny I (2003) Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1. Neuron 39:227\u2013239","journal-title":"Neuron"},{"key":"393_CR33","doi-asserted-by":"crossref","unstructured":"Kaltenbach LS, Romero E, Becklin RR, Chettier R, Bell R, Phansalkar A, Strand A, Torcassi C, Savage J, Hurlburt A, Cha GH, Ukani L, Chepanoske CL, Zhen Y, Sahasrabudhe S, Olson J, Kurschner C, Ellerby LM, Peltier JM, Botas J, Hughes RE (2007) Huntingtin interacting proteins are genetic modifiers of neurodegeneration. PLoS Genet 3: e82","DOI":"10.1371\/journal.pgen.0030082"},{"key":"393_CR34","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1073\/pnas.0409402102","volume":"102","author":"TS Tang","year":"2005","unstructured":"Tang TS, Slow E, Lupu V, Stavrovskaya IG, Sugimori M, Llinas R, Kristal BS, Hayden MR, Bezprozvanny I (2005) Disturbed Ca2+\u00a0signaling and apoptosis of medium spiny neurons in Huntington\u2019s disease. Proc Natl Acad Sci USA 102:2602\u20132607","journal-title":"Proc Natl Acad Sci USA"},{"key":"393_CR35","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.nbd.2008.03.010","volume":"31","author":"H Zhang","year":"2008","unstructured":"Zhang H, Li Q, Graham RK, Slow E, Hayden MR, Bezprozvanny I (2008) Full length mutant huntingtin is required for altered Ca2+\u00a0signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington\u2019s disease. Neurobiol Dis 31:80\u201388","journal-title":"Neurobiol Dis"},{"key":"393_CR36","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1523\/JNEUROSCI.4411-08.2009","volume":"29","author":"TS Tang","year":"2009","unstructured":"Tang TS, Guo C, Wang H, Chen X, Bezprozvanny I (2009) Neuroprotective effects of inositol 1,4,5-trisphosphate receptor C-terminal fragment in a Huntington\u2019s disease mouse model. J Neurosci 29:1257\u20131266","journal-title":"J Neurosci"},{"key":"393_CR37","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0169-328X(00)00276-X","volume":"86","author":"L Mao","year":"2001","unstructured":"Mao L, Wang JQ (2001) Upregulation of preprodynorphin and preproenkephalin mRNA expression by selective activation of group I metabotropic glutamate receptors in characterized primary cultures of rat striatal neurons. Brain Res Mol Brain Res 86:125\u2013137","journal-title":"Brain Res Mol Brain Res"},{"key":"393_CR38","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1124\/mol.62.3.473","volume":"62","author":"L Mao","year":"2002","unstructured":"Mao L, Wang JQ (2002) Glutamate cascade to cAMP response element-binding protein phosphorylation in cultured striatal neurons through calcium-coupled group I metabotropic glutamate receptors. Mol Pharmacol 62:473\u2013484","journal-title":"Mol Pharmacol"},{"key":"393_CR39","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S0006-8993(97)01141-4","volume":"780","author":"SJ Tallaksen-Greene","year":"1998","unstructured":"Tallaksen-Greene SJ, Kaatz KW, Romano C, Albin RL (1998) Localization of mGluR1a-like immunoreactivity and mGluR5-like immunoreactivity in identified populations of striatal neurons. Brain Res 780:210\u2013217","journal-title":"Brain Res"},{"key":"393_CR40","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0169-328X(97)00102-2","volume":"48","author":"JA Kerner","year":"1997","unstructured":"Kerner JA, Standaert DG, Penney JB Jr, Young AB, Landwehrmeyer GB (1997) Expression of group one metabotropic glutamate receptor subunit mRNAs in neurochemically identified neurons in the rat neostriatum, neocortex, and hippocampus. Brain Res Mol Brain Res 48:259\u2013269","journal-title":"Brain Res Mol Brain Res"},{"key":"393_CR41","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/cne.903540207","volume":"354","author":"CM Testa","year":"1995","unstructured":"Testa CM, Standaert DG, Landwehrmeyer GB, Penney JB Jr, Young AB (1995) Differential expression of mGluR5 metabotropic glutamate receptor mRNA by rat striatal neurons. J Comp Neurol 354:241\u2013252","journal-title":"J Comp Neurol"},{"key":"393_CR42","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0022-510X(85)90055-3","volume":"71","author":"AJ Cross","year":"1985","unstructured":"Cross AJ, Crow TJ, Johnson JA, Dawson JM, Peters TJ (1985) Loss of endoplasmic reticulum-associated enzymes in affected brain regions in Huntington\u2019s disease and Alzheimer-type dementia. J Neurol Sci 71:137\u2013143","journal-title":"J Neurol Sci"},{"issue":"5","key":"393_CR43","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.neuron.2010.11.010","volume":"68","author":"T Higo","year":"2010","unstructured":"Higo T, Hamada K, Hisatsune C, Nukina N, Hashikawa T, Hattori M, Nakamura T, Mikoshiba K (2010) Mechanism of ER stress-induced brain damage by IP3 receptor. Neuron 68(5):865\u2013878","journal-title":"Neuron"},{"key":"393_CR44","doi-asserted-by":"crossref","first-page":"5297","DOI":"10.1523\/JNEUROSCI.15-07-05297.1995","volume":"15","author":"GB Landwehrmeyer","year":"1995","unstructured":"Landwehrmeyer GB, Standaert DG, Testa CM, Penney JB Jr, Young AB (1995) NMDA receptor subunit mRNA expression by projection neurons and interneurons in rat striatum. J Neurosci 15:5297\u20135307","journal-title":"J Neurosci"},{"key":"393_CR45","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/0896-6273(94)90210-0","volume":"12","author":"H Monyer","year":"1994","unstructured":"Monyer H, Burnashev N, Laurie DJ, Sakmann B, Seeburg PH (1994) Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 12:529\u2013540","journal-title":"Neuron"},{"key":"393_CR46","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1046\/j.1471-4159.1996.66020692.x","volume":"66","author":"C Portera-Cailliau","year":"1996","unstructured":"Portera-Cailliau C, Price DL, Martin LJ (1996) N-methyl-D-aspartate receptor proteins NR2A and NR2B are differentially distributed in the developing rat central nervous system as revealed by subunit-specific antibodies. J Neurochem 66:692\u2013700","journal-title":"J Neurochem"},{"key":"393_CR47","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1046\/j.1471-4159.1999.0721890.x","volume":"72","author":"N Chen","year":"1999","unstructured":"Chen N, Luo T, Wellington C, Metzler M, McCutcheon K, Hayden MR, Raymond LA (1999) Subtype-specific enhancement of NMDA receptor currents by mutant huntingtin. J Neurochem 72:1890\u20131898","journal-title":"J Neurochem"},{"key":"393_CR48","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1006\/mcne.2000.0909","volume":"17","author":"MM Zeron","year":"2001","unstructured":"Zeron MM, Chen N, Moshaver A, Lee AT, Wellington CL, Hayden MR, Raymond LA (2001) Mutant huntingtin enhances excitotoxic cell death. Mol Cell Neurosci 17:41\u201353","journal-title":"Mol Cell Neurosci"},{"key":"393_CR49","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0896-6273(02)00615-3","volume":"33","author":"MM Zeron","year":"2002","unstructured":"Zeron MM, Hansson O, Chen N, Wellington CL, Leavitt BR, Brundin P, Hayden MR, Raymond LA (2002) Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington\u2019s disease. Neuron 33:849\u2013860","journal-title":"Neuron"},{"key":"393_CR50","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1159\/000091921","volume":"28","author":"NJ Ali","year":"2006","unstructured":"Ali NJ, Levine MS (2006) Changes in expression of N-methyl-D-aspartate receptor subunits occur early in the R6\/2 mouse model of Huntington\u2019s disease. Dev Neurosci 28:230\u2013238","journal-title":"Dev Neurosci"},{"key":"393_CR51","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1046\/j.1460-9568.1998.00169.x","volume":"10","author":"JH Li","year":"1998","unstructured":"Li JH, Wang YH, Wolfe BB, Krueger KE, Corsi L, Stocca G, Vicini S (1998) Developmental changes in localization of NMDA receptor subunits in primary cultures of cortical neurons. Eur J Neurosci 10:1704\u20131715","journal-title":"Eur J Neurosci"},{"issue":"Pt 1","key":"393_CR52","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1469-7793.1998.013bu.x","volume":"507","author":"G Stocca","year":"1998","unstructured":"Stocca G, Vicini S (1998) Increased contribution of NR2A subunit to synaptic NMDA receptors in developing rat cortical neurons. J Physiol 507(Pt 1):13\u201324","journal-title":"J Physiol"},{"key":"393_CR53","doi-asserted-by":"crossref","first-page":"4180","DOI":"10.1523\/JNEUROSCI.19-10-04180.1999","volume":"19","author":"KR Tovar","year":"1999","unstructured":"Tovar KR, Westbrook GL (1999) The incorporation of NMDA receptors with a distinct subunit composition at nascent hippocampal synapses in vitro. J Neurosci 19:4180\u20134188","journal-title":"J Neurosci"},{"key":"393_CR54","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1177\/10738584070130060401","volume":"13","author":"S Papadia","year":"2007","unstructured":"Papadia S, Hardingham GE (2007) The dichotomy of NMDA receptor signaling. Neuroscientist 13:572\u2013579","journal-title":"Neuroscientist"},{"key":"393_CR55","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/S0959-4388(03)00073-4","volume":"13","author":"P Vanhoutte","year":"2003","unstructured":"Vanhoutte P, Bading H (2003) Opposing roles of synaptic and extrasynaptic NMDA receptors in neuronal calcium signalling and BDNF gene regulation. Curr Opin Neurobiol 13:366\u2013371","journal-title":"Curr Opin Neurobiol"},{"key":"393_CR56","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.mcn.2009.01.002","volume":"40","author":"E Gouix","year":"2009","unstructured":"Gouix E, Leveille F, Nicole O, Melon C, Had-Aissouni L, Buisson A (2009) Reverse glial glutamate uptake triggers neuronal cell death through extrasynaptic NMDA receptor activation. Mol Cell Neurosci 40:463\u2013473","journal-title":"Mol Cell Neurosci"},{"key":"393_CR57","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nn835","volume":"5","author":"GE Hardingham","year":"2002","unstructured":"Hardingham GE, Fukunaga Y, Bading H (2002) Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. Nat Neurosci 5:405\u2013414","journal-title":"Nat Neurosci"},{"key":"393_CR58","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/nn2071","volume":"11","author":"S Papadia","year":"2008","unstructured":"Papadia S, Soriano FX, Leveille F, Martel MA, Dakin KA, Hansen HH, Kaindl A, Sifringer M, Fowler J, Stefovska V, McKenzie G, Craigon M, Corriveau R, Ghazal P, Horsburgh K, Yankner BA, Wyllie DJ, Ikonomidou C, Hardingham GE (2008) Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses. Nat Neurosci 11:476\u2013487","journal-title":"Nat Neurosci"},{"key":"393_CR59","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neuron.2010.01.008","volume":"65","author":"AJ Milnerwood","year":"2010","unstructured":"Milnerwood AJ, Gladding CM, Pouladi MA, Kaufman AM, Hines RM, Boyd JD, Ko RW, Vasuta OC, Graham RK, Hayden MR, Murphy TH, Raymond LA (2010) Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington\u2019s disease mice. Neuron 65:178\u2013190","journal-title":"Neuron"},{"key":"393_CR60","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1152\/jn.00308.2004","volume":"92","author":"L Li","year":"2004","unstructured":"Li L, Murphy TH, Hayden MR, Raymond LA (2004) Enhanced striatal NR2B-containing N-methyl-D-aspartate receptor-mediated synaptic currents in a mouse model of Huntington disease. J Neurophysiol 92:2738\u20132746","journal-title":"J Neurophysiol"},{"key":"393_CR61","doi-asserted-by":"crossref","first-page":"3200","DOI":"10.1523\/JNEUROSCI.5599-08.2009","volume":"29","author":"MY Heng","year":"2009","unstructured":"Heng MY, Detloff PJ, Wang PL, Tsien JZ, Albin RL (2009) In vivo evidence for NMDA receptor-mediated excitotoxicity in a murine genetic model of Huntington disease. J Neurosci 29:3200\u20133205","journal-title":"J Neurosci"},{"key":"393_CR62","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/978-0-387-32562-0_32","volume-title":"In molecular mechanisms of synaotogenesis","author":"AJ Milnerwood","year":"2006","unstructured":"Milnerwood AJ, Raymond LA (2006) Synaptic abnormalities associated with Huntington\u2019s disease. In: AE-HaA Dityatev (ed) In molecular mechanisms of synaotogenesis. Springer, New York, pp 457\u2013469"},{"key":"393_CR63","doi-asserted-by":"crossref","first-page":"24713","DOI":"10.1074\/jbc.M103501200","volume":"276","author":"Y Sun","year":"2001","unstructured":"Sun Y, Savanenin A, Reddy PH, Liu YF (2001) Polyglutamine-expanded huntingtin promotes sensitization of N-methyl-D- aspartate receptors via post-synaptic density 95. J Biol Chem 276:24713\u201324718","journal-title":"J Biol Chem"},{"key":"393_CR64","doi-asserted-by":"crossref","first-page":"33364","DOI":"10.1074\/jbc.M304240200","volume":"278","author":"C Song","year":"2003","unstructured":"Song C, Zhang Y, Parsons CG, Liu YF (2003) Expression of polyglutamine-expanded huntingtin induces tyrosine phosphorylation of N-methyl-D-aspartate receptors. J Biol Chem 278:33364\u201333369","journal-title":"J Biol Chem"},{"key":"393_CR65","doi-asserted-by":"crossref","first-page":"10928","DOI":"10.1523\/JNEUROSCI.2491-09.2009","volume":"29","author":"J Fan","year":"2009","unstructured":"Fan J, Cowan CM, Zhang LY, Hayden MR, Raymond LA (2009) Interaction of postsynaptic density protein-95 with NMDA receptors influences excitotoxicity in the yeast artificial chromosome mouse model of Huntington\u2019s disease. J Neurosci 29:10928\u201310938","journal-title":"J Neurosci"},{"key":"393_CR66","doi-asserted-by":"crossref","first-page":"3768","DOI":"10.1523\/JNEUROSCI.4356-06.2007","volume":"27","author":"MM Fan","year":"2007","unstructured":"Fan MM, Fernandes HB, Zhang LY, Hayden MR, Raymond LA (2007) Altered NMDA receptor trafficking in a yeast artificial chromosome transgenic mouse model of Huntington\u2019s disease. J Neurosci 27:3768\u20133779","journal-title":"J Neurosci"},{"key":"393_CR67","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/nm.2056","volume":"15","author":"S Okamoto","year":"2009","unstructured":"Okamoto S, Pouladi MA, Talantova M, Yao D, Xia P, Ehrnhoefer DE, Zaidi R, Clemente A, Kaul M, Graham RK, Zhang D, Vincent Chen HS, Tong G, Hayden MR, Lipton SA (2009) Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin. Nat Med 15:1407\u20131413","journal-title":"Nat Med"},{"key":"393_CR68","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.neulet.2006.08.036","volume":"407","author":"J Wu","year":"2006","unstructured":"Wu J, Tang T, Bezprozvanny I (2006) Evaluation of clinically relevant glutamate pathway inhibitors in in vitro model of Huntington\u2019s disease. Neurosci Lett 407:219\u2013223","journal-title":"Neurosci Lett"},{"key":"393_CR69","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.parkreldis.2006.08.005","volume":"13","author":"WG Ondo","year":"2007","unstructured":"Ondo WG, Mejia NI, Hunter CB (2007) A pilot study of the clinical efficacy and safety of memantine for Huntington\u2019s disease. Parkinsonism Relat Disord 13:453\u2013454","journal-title":"Parkinsonism Relat Disord"},{"key":"393_CR70","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/263244a0","volume":"263","author":"JT Coyle","year":"1976","unstructured":"Coyle JT, Schwarcz R (1976) Lesion of striatal neurones with kainic acid provides a model for Huntington\u2019s chorea. Nature 263:244\u2013246","journal-title":"Nature"},{"key":"393_CR71","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/263517a0","volume":"263","author":"EG McGeer","year":"1976","unstructured":"McGeer EG, McGeer PL (1976) Duplication of biochemical changes of Huntington\u2019s chorea by intrastriatal injections of glutamic and kainic acids. Nature 263:517\u2013519","journal-title":"Nature"},{"key":"393_CR72","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/0006-8993(78)90941-1","volume":"139","author":"EG McGeer","year":"1978","unstructured":"McGeer EG, McGeer PL, Singh K (1978) Kainate-induced degeneration of neostriatal neurons: dependency upon corticostriatal tract. Brain Res 139:381\u2013383","journal-title":"Brain Res"},{"key":"393_CR73","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/321168a0","volume":"321","author":"MF Beal","year":"1986","unstructured":"Beal MF, Kowall NW, Ellison DW, Mazurek MF, Swartz KJ, Martin JB (1986) Replication of the neurochemical characteristics of Huntington\u2019s disease by quinolinic acid. Nature 321:168\u2013171","journal-title":"Nature"},{"key":"393_CR74","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0014-4886(90)90014-J","volume":"108","author":"P Hantraye","year":"1990","unstructured":"Hantraye P, Riche D, Maziere M, Isacson O (1990) A primate model of Huntington\u2019s disease: behavioral and anatomical studies of unilateral excitotoxic lesions of the caudate-putamen in the baboon. Exp Neurol 108:91\u2013104","journal-title":"Exp Neurol"},{"key":"393_CR75","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1523\/JNEUROSCI.11-06-01649.1991","volume":"11","author":"MF Beal","year":"1991","unstructured":"Beal MF, Ferrante RJ, Swartz KJ, Kowall NW (1991) Chronic quinolinic acid lesions in rats closely resemble Huntington\u2019s disease. J Neurosci 11:1649\u20131659","journal-title":"J Neurosci"},{"key":"393_CR76","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1093\/hmg\/ddg169","volume":"12","author":"EJ Slow","year":"2003","unstructured":"Slow EJ, van Raamsdonk J, Rogers D, Coleman SH, Graham RK, Deng Y, Oh R, Bissada N, Hossain SM, Yang YZ, Li XJ, Simpson EM, Gutekunst CA, Leavitt BR, Hayden MR (2003) Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease. Hum Mol Genet 12:1555\u20131567","journal-title":"Hum Mol Genet"},{"key":"393_CR77","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0896-6273(00)80764-3","volume":"23","author":"JG Hodgson","year":"1999","unstructured":"Hodgson JG, Agopyan N, Gutekunst CA, Leavitt BR, LePiane F, Singaraja R, Smith DJ, Bissada N, McCutcheon K, Nasir J, Jamot L, Li XJ, Stevens ME, Rosemond E, Roder JC, Phillips AG, Rubin EM, Hersch SM, Hayden MR (1999) A YAC mouse model for Huntington\u2019s disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration. Neuron 23:181\u2013192","journal-title":"Neuron"},{"key":"393_CR78","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1093\/oxfordjournals.jbchem.a021780","volume":"122","author":"T Maruyama","year":"1997","unstructured":"Maruyama T, Kanaji T, Nakade S, Kanno T, Mikoshiba K (1997) 2APB, 2-aminoethoxydiphenyl borate, a membrane-penetrable modulator of Ins(1,4,5)P3-induced Ca2+\u00a0release. J Biochem (Tokyo) 122:498\u2013505","journal-title":"J Biochem (Tokyo)"},{"key":"393_CR79","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/ng1196-269","volume":"14","author":"SM Pulst","year":"1996","unstructured":"Pulst SM, Nechiporuk A, Nechiporuk T, Gispert S, Chen XN, Lopes-Cendes I, Pearlman S, Starkman S, Orozco-Diaz G, Lunkes A, DeJong P, Rouleau GA, Auburger G, Korenberg JR, Figueroa C, Sahba S (1996) Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2. Nat Genet 14:269\u2013276","journal-title":"Nat Genet"},{"key":"393_CR80","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/ng1196-285","volume":"14","author":"G Imbert","year":"1996","unstructured":"Imbert G, Saudou F, Yvert G, Devys D, Trottier Y, Garnier JM, Weber C, Mandel JL, Cancel G, Abbas N, Durr A, Didierjean O, Stevanin G, Agid Y, Brice A (1996) Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG\/glutamine repeats. Nat Genet 14:285\u2013291","journal-title":"Nat Genet"},{"key":"393_CR81","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/ng1196-277","volume":"14","author":"K Sanpei","year":"1996","unstructured":"Sanpei K, Takano H, Igarashi S, Sato T, Oyake M, Sasaki H, Wakisaka A, Tashiro K, Ishida Y, Ikeuchi T, Koide R, Saito M, Sato A, Tanaka T, Hanyu S, Takiyama Y, Nishizawa M, Shimizu N, Nomura Y, Segawa M, Iwabuchi K, Eguchi I, Tanaka H, Takahashi H, Tsuji S (1996) Identification of the spinocerebellar ataxia type 2 gene using a direct identification of repeat expansion and cloning technique, DIRECT. Nat Genet 14:277\u2013284","journal-title":"Nat Genet"},{"key":"393_CR82","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/79162","volume":"26","author":"DP Huynh","year":"2000","unstructured":"Huynh DP, Figueroa K, Hoang N, Pulst SM (2000) Nuclear localization or inclusion body formation of ataxin-2 are not necessary for SCA2 pathogenesis in mouse or human. Nat Genet 26:44\u201350","journal-title":"Nat Genet"},{"key":"393_CR83","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1385\/JMN:15:3:231","volume":"15","author":"TR Kiehl","year":"2000","unstructured":"Kiehl TR, Shibata H, Pulst SM (2000) The ortholog of human ataxin-2 is essential for early embryonic patterning in C. elegans. J Mol Neurosci 15:231\u2013241","journal-title":"J Mol Neurosci"},{"key":"393_CR84","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1093\/genetics\/162.4.1687","volume":"162","author":"TF Satterfield","year":"2002","unstructured":"Satterfield TF, Jackson SM, Pallanck LJ (2002) A drosophila homolog of the polyglutamine disease gene SCA2 is a dosage-sensitive regulator of actin filament formation. Genetics 162:1687\u20131702","journal-title":"Genetics"},{"key":"393_CR85","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.bbrc.2005.10.186","volume":"339","author":"TR Kiehl","year":"2006","unstructured":"Kiehl TR, Nechiporuk A, Figueroa KP, Keating MT, Huynh DP, Pulst SM (2006) Generation and characterization of Sca2 (ataxin-2) knockout mice. Biochem Biophys Res Commun 339:17\u201324","journal-title":"Biochem Biophys Res Commun"},{"key":"393_CR86","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1093\/brain\/awh586","volume":"128","author":"SM Pulst","year":"2005","unstructured":"Pulst SM, Santos N, Wang D, Yang H, Huynh D, Velazquez L, Figueroa KP (2005) Spinocerebellar ataxia type 2: polyQ repeat variation in the CACNA1A calcium channel modifies age of onset. Brain 128:2297\u20132303","journal-title":"Brain"},{"key":"393_CR87","doi-asserted-by":"crossref","first-page":"9148","DOI":"10.1523\/JNEUROSCI.0660-09.2009","volume":"29","author":"J Liu","year":"2009","unstructured":"Liu J, Tang TS, Tu H, Nelson O, Herndon E, Huynh DP, Pulst SM, Bezprozvanny I (2009) Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 2. J Neurosci 29:9148\u20139162","journal-title":"J Neurosci"},{"key":"393_CR88","first-page":"11","volume":"1","author":"T Furuichi","year":"1993","unstructured":"Furuichi T, Simon-Chazottes D, Fujino I, Yamada N, Hasegawa M, Miyawaki A, Yoshikawa S, Guenet JL, Mikoshiba K (1993) Widespread expression of inositol 1, 4, 5-trisphosphate receptor type 1 gene (Insp3r1) in the mouse central nervous system. Recept Channels 1:11\u201324","journal-title":"Recept Channels"},{"key":"393_CR89","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/(SICI)1096-9861(19990405)406:2<207::AID-CNE6>3.0.CO;2-7","volume":"406","author":"AH Sharp","year":"1999","unstructured":"Sharp AH, Nucifora FC Jr, Blondel O, Sheppard CA, Zhang C, Snyder SH, Russell JT, Ryugo DK, Ross CA (1999) Differential cellular expression of isoforms of inositol 1,4,5-triphosphate receptors in neurons and glia in brain. J Comp Neurol 406:207\u2013220","journal-title":"J Comp Neurol"},{"key":"393_CR90","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.expneurol.2008.09.020","volume":"215","author":"S Loo van de","year":"2009","unstructured":"van de Loo S, Eich F, Nonis D, Auburger G, Nowock J (2009) Ataxin-2 associates with rough endoplasmic reticulum. Exp Neurol 215:110\u2013118","journal-title":"Exp Neurol"},{"key":"393_CR91","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/sj.ejhg.5200403","volume":"8","author":"G Stevanin","year":"2000","unstructured":"Stevanin G, Durr A, Brice A (2000) Clinical and molecular advances in autosomal dominant cerebellar ataxias: from genotype to phenotype and physiopathology. Eur J Hum Genet 8:4\u201318","journal-title":"Eur J Hum Genet"},{"key":"393_CR92","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1212\/WNL.28.7.703","volume":"28","author":"P Coutinho","year":"1978","unstructured":"Coutinho P, Andrade C (1978) Autosomal dominant system degeneration in Portuguese families of the Azores Islands. A new genetic disorder involving cerebellar, pyramidal, extrapyramidal and spinal cord motor functions. Neurology 28:703\u2013709","journal-title":"Neurology"},{"key":"393_CR93","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/ana.410410408","volume":"41","author":"HL Paulson","year":"1997","unstructured":"Paulson HL, Das SS, Crino PB, Perez MK, Patel SC, Gotsdiner D, Fischbeck KH, Pittman RN (1997) Machado-Joseph disease gene product is a cytoplasmic protein widely expressed in brain. Ann Neurol 41:453\u2013462","journal-title":"Ann Neurol"},{"key":"393_CR94","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1093\/hmg\/ddg297","volume":"12","author":"H Scheel","year":"2003","unstructured":"Scheel H, Tomiuk S, Hofmann K (2003) Elucidation of ataxin-3 and ataxin-7 function by integrative bioinformatics. Hum Mol Genet 12:2845\u20132852","journal-title":"Hum Mol Genet"},{"key":"393_CR95","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.1111\/j.1432-1033.2004.04245.x","volume":"271","author":"M Albrecht","year":"2004","unstructured":"Albrecht M, Golatta M, Wullner U, Lengauer T (2004) Structural and functional analysis of ataxin-2 and ataxin-3. Eur J Biochem 271:3155\u20133170","journal-title":"Eur J Biochem"},{"key":"393_CR96","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1093\/hmg\/ddg344","volume":"12","author":"B Burnett","year":"2003","unstructured":"Burnett B, Li F, Pittman RN (2003) The polyglutamine neurodegenerative protein ataxin-3 binds polyubiquitylated proteins and has ubiquitin protease activity. Hum Mol Genet 12:3195\u20133205","journal-title":"Hum Mol Genet"},{"key":"393_CR97","doi-asserted-by":"crossref","first-page":"26436","DOI":"10.1074\/jbc.M803692200","volume":"283","author":"BJ Winborn","year":"2008","unstructured":"Winborn BJ, Travis SM, Todi SV, Scaglione KM, Xu P, Williams AJ, Cohen RE, Peng J, Paulson HL (2008) The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits Lys63 linkages in mixed linkage ubiquitin chains. J Biol Chem 283:26436\u201326443","journal-title":"J Biol Chem"},{"key":"393_CR98","doi-asserted-by":"crossref","first-page":"11474","DOI":"10.1523\/JNEUROSCI.2053-06.2006","volume":"26","author":"BO Evert","year":"2006","unstructured":"Evert BO, Araujo J, Vieira-Saecker AM, de Vos RA, Harendza S, Klockgether T, Wullner U (2006) Ataxin-3 represses transcription via chromatin binding, interaction with histone deacetylase 3, and histone deacetylation. J Neurosci 26:11474\u201311486","journal-title":"J Neurosci"},{"key":"393_CR99","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.bbrc.2007.08.062","volume":"362","author":"I Schmitt","year":"2007","unstructured":"Schmitt I, Linden M, Khazneh H, Evert BO, Breuer P, Klockgether T, Wuellner U (2007) Inactivation of the mouse Atxn3 (ataxin-3) gene increases protein ubiquitination. Biochem Biophys Res Commun 362:734\u2013739","journal-title":"Biochem Biophys Res Commun"},{"key":"393_CR100","doi-asserted-by":"crossref","first-page":"18851","DOI":"10.1074\/jbc.M611914200","volume":"282","author":"A Haacke","year":"2007","unstructured":"Haacke A, Hartl FU, Breuer P (2007) Calpain inhibition is sufficient to suppress aggregation of polyglutamine-expanded ataxin-3. J Biol Chem 282:18851\u201318856","journal-title":"J Biol Chem"},{"key":"393_CR101","doi-asserted-by":"crossref","first-page":"12713","DOI":"10.1523\/JNEUROSCI.3909-08.2008","volume":"28","author":"X Chen","year":"2008","unstructured":"Chen X, Tang TS, Tu H, Nelson O, Pook M, Hammer R, Nukina N, Bezprozvanny I (2008) Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3. J Neurosci 28:12713\u201312724","journal-title":"J Neurosci"},{"key":"393_CR102","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.tins.2010.02.005","volume":"33","author":"S Schorge","year":"2010","unstructured":"Schorge S, van de Leemput J, Singleton A, Houlden H, Hardy J (2010) Human ataxias: a genetic dissection of inositol triphosphate receptor (ITPR1)-dependent signaling. Trends Neurosci 33:211\u2013219","journal-title":"Trends Neurosci"},{"key":"393_CR103","doi-asserted-by":"crossref","first-page":"7425","DOI":"10.1074\/jbc.R800041200","volume":"284","author":"HY Zoghbi","year":"2009","unstructured":"Zoghbi HY, Orr HT (2009) Pathogenic mechanisms of a polyglutamine-mediated neurodegenerative disease, spinocerebellar ataxia type 1. J Biol Chem 284:7425\u20137429","journal-title":"J Biol Chem"},{"key":"393_CR104","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0092-8674(00)81781-X","volume":"95","author":"IA Klement","year":"1998","unstructured":"Klement IA, Skinner PJ, Kaytor MD, Yi H, Hersch SM, Clark HB, Zoghbi HY, Orr HT (1998) Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice. Cell 95:41\u201353","journal-title":"Cell"},{"key":"393_CR105","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.cell.2006.09.036","volume":"127","author":"HG Serra","year":"2006","unstructured":"Serra HG, Duvick L, Zu T, Carlson K, Stevens S, Jorgensen N, Lysholm A, Burright E, Zoghbi HY, Clark HB, Andresen JM, Orr HT (2006) RORalpha-mediated Purkinje cell development determines disease severity in adult SCA1 mice. Cell 127:697\u2013708","journal-title":"Cell"},{"key":"393_CR106","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1093\/hmg\/ddm162","volume":"16","author":"R Goold","year":"2007","unstructured":"Goold R, Hubank M, Hunt A, Holton J, Menon RP, Revesz T, Pandolfo M, Matilla-Duenas A (2007) Down-regulation of the dopamine receptor D2 in mice lacking ataxin 1. Hum Mol Genet 16:2122\u20132134","journal-title":"Hum Mol Genet"},{"key":"393_CR107","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/72101","volume":"3","author":"X Lin","year":"2000","unstructured":"Lin X, Antalffy B, Kang D, Orr HT, Zoghbi HY (2000) Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1. Nat Neurosci 3:157\u2013163","journal-title":"Nat Neurosci"},{"key":"393_CR108","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S0022-510X(00)00262-8","volume":"174","author":"PJ Vig","year":"2000","unstructured":"Vig PJ, Subramony SH, Qin Z, McDaniel DO, Fratkin JD (2000) Relationship between ataxin-1 nuclear inclusions and Purkinje cell specific proteins in SCA-1 transgenic mice. J Neurol Sci 174:100\u2013110","journal-title":"J Neurol Sci"},{"key":"393_CR109","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1093\/hmg\/ddh268","volume":"13","author":"HG Serra","year":"2004","unstructured":"Serra HG, Byam CE, Lande JD, Tousey SK, Zoghbi HY, Orr HT (2004) Gene profiling links SCA1 pathophysiology to glutamate signaling in Purkinje cells of transgenic mice. Hum Mol Genet 13:2535\u20132543","journal-title":"Hum Mol Genet"},{"key":"393_CR110","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1152\/jn.2001.85.4.1750","volume":"85","author":"T Inoue","year":"2001","unstructured":"Inoue T, Lin X, Kohlmeier KA, Orr HT, Zoghbi HY, Ross WN (2001) Calcium dynamics and electrophysiological properties of cerebellar Purkinje cells in SCA1 transgenic mice. J Neurophysiol 85:1750\u20131760","journal-title":"J Neurophysiol"},{"key":"393_CR111","doi-asserted-by":"crossref","first-page":"9185","DOI":"10.1523\/JNEUROSCI.21-23-09185.2001","volume":"21","author":"ES Piedras-Renteria","year":"2001","unstructured":"Piedras-Renteria ES, Watase K, Harata N, Zhuchenko O, Zoghbi HY, Lee CC, Tsien RW (2001) Increased expression of alpha 1A Ca2+\u00a0channel currents arising from expanded trinucleotide repeats in spinocerebellar ataxia type 6. J Neurosci 21:9185\u20139193","journal-title":"J Neurosci"},{"key":"393_CR112","doi-asserted-by":"crossref","first-page":"11987","DOI":"10.1073\/pnas.0804350105","volume":"105","author":"K Watase","year":"2008","unstructured":"Watase K, Barrett CF, Miyazaki T, Ishiguro T, Ishikawa K, Hu Y, Unno T, Sun Y, Kasai S, Watanabe M, Gomez CM, Mizusawa H, Tsien RW, Zoghbi HY (2008) Spinocerebellar ataxia type 6 knockin mice develop a progressive neuronal dysfunction with age-dependent accumulation of mutant CaV2.1 channels. Proc Natl Acad Sci USA 105:11987\u201311992","journal-title":"Proc Natl Acad Sci USA"},{"key":"393_CR113","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/ng1728","volume":"38","author":"Y Ikeda","year":"2006","unstructured":"Ikeda Y, Dick KA, Weatherspoon MR, Gincel D, Armbrust KR, Dalton JC, Stevanin G, Durr A, Zuhlke C, Burk K, Clark HB, Brice A, Rothstein JD, Schut LJ, Day JW, Ranum LP (2006) Spectrin mutations cause spinocerebellar ataxia type 5. Nat Genet 38:184\u2013190","journal-title":"Nat Genet"},{"key":"393_CR114","doi-asserted-by":"crossref","first-page":"4262","DOI":"10.1523\/JNEUROSCI.08-11-04262.1988","volume":"8","author":"A Kose","year":"1988","unstructured":"Kose A, Saito N, Ito H, Kikkawa U, Nishizuka Y, Tanaka C (1988) Electron microscopic localization of type I protein kinase C in rat Purkinje cells. J Neurosci 8:4262\u20134268","journal-title":"J Neurosci"},{"key":"393_CR115","doi-asserted-by":"crossref","first-page":"19854","DOI":"10.1074\/jbc.M801492200","volume":"283","author":"N Adachi","year":"2008","unstructured":"Adachi N, Kobayashi T, Takahashi H, Kawasaki T, Shirai Y, Ueyama T, Matsuda T, Seki T, Sakai N, Saito N (2008) Enzymological analysis of mutant protein kinase Cgamma causing spinocerebellar ataxia type 14 and dysfunction in Ca2+\u00a0homeostasis. J Biol Chem 283:19854\u201319863","journal-title":"J Biol Chem"},{"key":"393_CR116","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1054\/ceca.2000.0138","volume":"28","author":"LP Zhu","year":"2000","unstructured":"Zhu LP, Yu XD, Ling S, Brown RA, Kuo TH (2000) Mitochondrial Ca(2+)homeostasis in the regulation of apoptotic and necrotic cell deaths. Cell Calcium 28:107\u2013117","journal-title":"Cell Calcium"},{"key":"393_CR117","doi-asserted-by":"crossref","unstructured":"van de Leemput J, Chandran J, Knight MA, Holtzclaw LA, Scholz S, Cookson MR, Houlden H, Gwinn-Hardy K, Fung HC, Lin X, Hernandez D, Simon-Sanchez J, Wood NW, Giunti P, Rafferty I, Hardy J, Storey E, Gardner RJ, Forrest SM, Fisher EM, Russell JT, Cai H, Singleton AB (2007) Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans. PLoS Genet 3:e108","DOI":"10.1371\/journal.pgen.0030108"},{"key":"393_CR118","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1212\/WNL.57.1.96","volume":"57","author":"Y Miyoshi","year":"2001","unstructured":"Miyoshi Y, Yamada T, Tanimura M, Taniwaki T, Arakawa K, Ohyagi Y, Furuya H, Yamamoto K, Sakai K, Sasazuki T, Kira J (2001) A novel autosomal dominant spinocerebellar ataxia (SCA16) linked to chromosome 8q22.1\u201324.1. Neurology 57:96\u2013100","journal-title":"Neurology"},{"key":"393_CR119","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1212\/01.wnl.0000238510.84932.82","volume":"67","author":"S Miura","year":"2006","unstructured":"Miura S, Shibata H, Furuya H, Ohyagi Y, Osoegawa M, Miyoshi Y, Matsunaga H, Shibata A, Matsumoto N, Iwaki A, Taniwaki T, Kikuchi H, Kira J, Fukumaki Y (2006) The contactin 4 gene locus at 3p26 is a candidate gene of SCA16. Neurology 67:1236\u20131241","journal-title":"Neurology"},{"key":"393_CR120","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.jns.2007.09.004","volume":"266","author":"E Tanaka","year":"2008","unstructured":"Tanaka E, Maruyama H, Morino H, Nakajima E, Kawakami H (2008) The CNTN4 c.4256C\u00a0>\u00a0T mutation is rare in Japanese with inherited spinocerebellar ataxia. J Neurol Sci 266:180\u2013181","journal-title":"J Neurol Sci"},{"key":"393_CR121","doi-asserted-by":"crossref","first-page":"10916","DOI":"10.1523\/JNEUROSCI.3269-06.2006","volume":"26","author":"C Hisatsune","year":"2006","unstructured":"Hisatsune C, Kuroda Y, Akagi T, Torashima T, Hirai H, Hashikawa T, Inoue T, Mikoshiba K (2006) Inositol 1,4,5-trisphosphate receptor type 1 in granule cells, not in Purkinje cells, regulates the dendritic morphology of Purkinje cells through brain-derived neurotrophic factor production. J Neurosci 26:10916\u201310924","journal-title":"J Neurosci"},{"key":"393_CR122","doi-asserted-by":"crossref","first-page":"5366","DOI":"10.1523\/JNEUROSCI.18-14-05366.1998","volume":"18","author":"T Inoue","year":"1998","unstructured":"Inoue T, Kato K, Kohda K, Mikoshiba K (1998) Type 1 inositol 1,4,5-trisphosphate receptor is required for induction of long-term depression in cerebellar Purkinje neurons. J Neurosci 18:5366\u20135373","journal-title":"J Neurosci"},{"key":"393_CR123","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1101\/lm.34100","volume":"7","author":"S Fujii","year":"2000","unstructured":"Fujii S, Matsumoto M, Igarashi K, Kato H, Mikoshiba K (2000) Synaptic plasticity in hippocampal CA1 neurons of mice lacking type 1 inositol-1,4,5-trisphosphate receptors. Learn Mem 7:312\u2013320","journal-title":"Learn Mem"},{"key":"393_CR124","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S0306-4522(02)00803-5","volume":"117","author":"T Nagase","year":"2003","unstructured":"Nagase T, Ito KI, Kato K, Kaneko K, Kohda K, Matsumoto M, Hoshino A, Inoue T, Fujii S, Kato H, Mikoshiba K (2003) Long-term potentiation and long-term depression in hippocampal CA1 neurons of mice lacking the IP(3) type 1 receptor. Neuroscience 117:821\u2013830","journal-title":"Neuroscience"},{"key":"393_CR125","doi-asserted-by":"crossref","first-page":"5820","DOI":"10.1073\/pnas.0501507102","volume":"102","author":"SQ Harper","year":"2005","unstructured":"Harper SQ, Staber PD, He X, Eliason SL, Martins IH, Mao Q, Yang L, Kotin RM, Paulson HL, Davidson BL (2005) RNA interference improves motor and neuropathological abnormalities in a Huntington\u2019s disease mouse model. Proc Natl Acad Sci USA 102:5820\u20135825","journal-title":"Proc Natl Acad Sci USA"},{"key":"393_CR126","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/nm1076","volume":"10","author":"H Xia","year":"2004","unstructured":"Xia H, Mao Q, Eliason SL, Harper SQ, Martins IH, Orr HT, Paulson HL, Yang L, Kotin RM, Davidson BL (2004) RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia. Nat Med 10:816\u2013820","journal-title":"Nat Med"},{"key":"393_CR127","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/nbt.1539","volume":"27","author":"J Hu","year":"2009","unstructured":"Hu J, Matsui M, Gagnon KT, Schwartz JC, Gabillet S, Arar K, Wu J, Bezprozvanny I, Corey DR (2009) Allele-specific silencing of mutant huntingtin and ataxin-3 genes by targeting expanded CAG repeats in mRNAs. Nat Biotechnol 27:478\u2013484","journal-title":"Nat Biotechnol"},{"key":"393_CR128","doi-asserted-by":"crossref","unstructured":"Shao J, Diamond MI (2007) Polyglutamine diseases: emerging concepts in pathogenesis and therapy. Hum Mol Genet 16 (2): R115\u2013R123","DOI":"10.1093\/hmg\/ddm213"},{"key":"393_CR129","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/70532","volume":"23","author":"JM Warrick","year":"1999","unstructured":"Warrick JM, Chan HY, Gray-Board GL, Chai Y, Paulson HL, Bonini NM (1999) Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70. Nat Genet 23:425\u2013428","journal-title":"Nat Genet"},{"key":"393_CR130","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1093\/hmg\/11.9.1137","volume":"11","author":"A Wyttenbach","year":"2002","unstructured":"Wyttenbach A, Sauvageot O, Carmichael J, Diaz-Latoud C, Arrigo AP, Rubinsztein DC (2002) Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin. Hum Mol Genet 11:1137\u20131151","journal-title":"Hum Mol Genet"},{"key":"393_CR131","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1038\/nsmb860","volume":"11","author":"JL Wacker","year":"2004","unstructured":"Wacker JL, Zareie MH, Fong H, Sarikaya M, Muchowski PJ (2004) Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer. Nat Struct Mol Biol 11:1215\u20131222","journal-title":"Nat Struct Mol Biol"},{"issue":"Suppl 4","key":"393_CR132","doi-asserted-by":"crossref","first-page":"16400","DOI":"10.1073\/pnas.182426599","volume":"99","author":"V Heiser","year":"2002","unstructured":"Heiser V, Engemann S, Brocker W, Dunkel I, Boeddrich A, Waelter S, Nordhoff E, Lurz R, Schugardt N, Rautenberg S, Herhaus C, Barnickel G, Bottcher H, Lehrach H, Wanker EE (2002) Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington\u2019s disease by using an automated filter retardation assay. Proc Natl Acad Sci USA 99(Suppl 4):16400\u201316406","journal-title":"Proc Natl Acad Sci USA"},{"key":"393_CR133","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nature01301","volume":"421","author":"I Sanchez","year":"2003","unstructured":"Sanchez I, Mahlke C, Yuan J (2003) Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders. Nature 421:373\u2013379","journal-title":"Nature"},{"key":"393_CR134","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1073\/pnas.0408936102","volume":"102","author":"X Zhang","year":"2005","unstructured":"Zhang X, Smith DL, Meriin AB, Engemann S, Russel DE, Roark M, Washington SL, Maxwell MM, Marsh JL, Thompson LM, Wanker EE, Young AB, Housman DE, Bates GP, Sherman MY, Kazantsev AG (2005) A potent small molecule inhibits polyglutamine aggregation in Huntington\u2019s disease neurons and suppresses neurodegeneration in vivo. Proc Natl Acad Sci USA 102:892\u2013897","journal-title":"Proc Natl Acad Sci USA"},{"key":"393_CR135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2202-6-1","volume":"6","author":"J Wang","year":"2005","unstructured":"Wang J, Gines S, MacDonald ME, Gusella JF (2005) Reversal of a full-length mutant huntingtin neuronal cell phenotype by chemical inhibitors of polyglutamine-mediated aggregation. BMC Neurosci 6:1","journal-title":"BMC Neurosci"},{"key":"393_CR136","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1093\/hmg\/ddl210","volume":"15","author":"DE Ehrnhoefer","year":"2006","unstructured":"Ehrnhoefer DE, Duennwald M, Markovic P, Wacker JL, Engemann S, Roark M, Legleiter J, Marsh JL, Thompson LM, Lindquist S, Muchowski PJ, Wanker EE (2006) Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington\u2019s disease models. Hum Mol Genet 15:2743\u20132751","journal-title":"Hum Mol Genet"},{"key":"393_CR137","doi-asserted-by":"crossref","first-page":"16685","DOI":"10.1073\/pnas.0707842104","volume":"104","author":"V Chopra","year":"2007","unstructured":"Chopra V, Fox JH, Lieberman G, Dorsey K, Matson W, Waldmeier P, Housman DE, Kazantsev A, Young AB, Hersch S (2007) A small-molecule therapeutic lead for Huntington\u2019s disease: preclinical pharmacology and efficacy of C2\u20138 in the R6\/2 transgenic mouse. Proc Natl Acad Sci USA 104:16685\u201316689","journal-title":"Proc Natl Acad Sci USA"},{"key":"393_CR138","doi-asserted-by":"crossref","first-page":"10437","DOI":"10.1074\/jbc.275.14.10437","volume":"275","author":"Y Nagai","year":"2000","unstructured":"Nagai Y, Tucker T, Ren H, Kenan DJ, Henderson BS, Keene JD, Strittmatter WJ, Burke JR (2000) Inhibition of polyglutamine protein aggregation and cell death by novel peptides identified by phage display screening. J Biol Chem 275:10437\u201310442","journal-title":"J Biol Chem"},{"key":"393_CR139","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1093\/hmg\/ddg144","volume":"12","author":"Y Nagai","year":"2003","unstructured":"Nagai Y, Fujikake N, Ohno K, Higashiyama H, Popiel HA, Rahadian J, Yamaguchi M, Strittmatter WJ, Burke JR, Toda T (2003) Prevention of polyglutamine oligomerization and neurodegeneration by the peptide inhibitor QBP1 in Drosophila. Hum Mol Genet 12:1253\u20131259","journal-title":"Hum Mol Genet"},{"key":"393_CR140","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/sj.mt.6300045","volume":"15","author":"HA Popiel","year":"2007","unstructured":"Popiel HA, Nagai Y, Fujikake N, Toda T (2007) Protein transduction domain-mediated delivery of QBP1 suppresses polyglutamine-induced neurodegeneration in vivo. Mol Ther 15:303\u2013309","journal-title":"Mol Ther"},{"key":"393_CR141","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.neulet.2008.06.015","volume":"449","author":"HA Popiel","year":"2009","unstructured":"Popiel HA, Nagai Y, Fujikake N, Toda T (2009) Delivery of the aggregate inhibitor peptide QBP1 into the mouse brain using PTDs and its therapeutic effect on polyglutamine disease mice. Neurosci Lett 449:87\u201392","journal-title":"Neurosci Lett"},{"key":"393_CR142","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.str.2009.08.002","volume":"17","author":"MW Kim","year":"2009","unstructured":"Kim MW, Chelliah Y, Kim SW, Otwinowski Z, Bezprozvanny I (2009) Secondary structure of Huntingtin amino-terminal region. Structure\u00a017:1205\u20131212","journal-title":"Structure"},{"key":"393_CR143","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.brainres.2006.08.035","volume":"1118","author":"ST Lee","year":"2006","unstructured":"Lee ST, Chu K, Park JE, Kang L, Ko SY, Jung KH, Kim M (2006) Memantine reduces striatal cell death with decreasing calpain level in 3-nitropropionic model of Huntington\u2019s disease. Brain Res 1118:199\u2013207","journal-title":"Brain Res"},{"key":"393_CR144","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1002\/ana.21181","volume":"62","author":"GB Landwehrmeyer","year":"2007","unstructured":"Landwehrmeyer GB, Dubois B, de Yebenes JG, Kremer B, Gaus W, Kraus PH, Przuntek H, Dib M, Doble A, Fischer W, Ludolph AC (2007) Riluzole in Huntington\u2019s disease: a 3-year, randomized controlled study. Ann Neurol 62:262\u2013272","journal-title":"Ann Neurol"},{"key":"393_CR145","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1038\/nature05865","volume":"447","author":"CS Chan","year":"2007","unstructured":"Chan CS, Guzman JN, Ilijic E, Mercer JN, Rick C, Tkatch T, Meredith GE, Surmeier DJ (2007) \u2018Rejuvenation\u2019 protects neurons in mouse models of Parkinson\u2019s disease. Nature 447:1081\u20131086","journal-title":"Nature"},{"key":"393_CR146","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1212\/01.wnl.0000303818.38960.44","volume":"70","author":"C Becker","year":"2008","unstructured":"Becker C, Jick SS, Meier CR (2008) Use of antihypertensives and the risk of Parkinson disease. Neurology 70:1438\u20131444","journal-title":"Neurology"},{"key":"393_CR147","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1196\/annals.1427.027","volume":"1147","author":"RK Chaturvedi","year":"2008","unstructured":"Chaturvedi RK, Beal MF (2008) Mitochondrial approaches for neuroprotection. Ann N Y Acad Sci 1147:395\u2013412","journal-title":"Ann N Y Acad Sci"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-010-0393-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11064-010-0393-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-010-0393-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T21:58:23Z","timestamp":1637099903000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11064-010-0393-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,6]]},"references-count":147,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["393"],"URL":"https:\/\/doi.org\/10.1007\/s11064-010-0393-y","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,6]]}}}