{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T06:18:46Z","timestamp":1789712326088,"version":"4.0.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2011,7,27]],"date-time":"2011-07-27T00:00:00Z","timestamp":1311724800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1007\/s11064-011-0553-8","type":"journal-article","created":{"date-parts":[[2011,7,26]],"date-time":"2011-07-26T09:30:10Z","timestamp":1311672610000},"page":"2287-2291","source":"Crossref","is-referenced-by-count":39,"title":["Hyperacute Detection of Neurofilament Heavy Chain in Serum Following Stroke: A Transient Sign"],"prefix":"10.1007","volume":"36","author":[{"given":"Johann","family":"Sellner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Dassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin M.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Petzold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,7,27]]},"reference":[{"key":"553_CR1","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S1474-4422(11)70066-7","volume":"10","author":"R Macrez","year":"2011","unstructured":"Macrez R, Ali C, Toutirais O et al (2011) Stroke and the immune system: from pathophysiology to new therapeutic strategies. Lancet Neurol 10:471\u2013480","journal-title":"Lancet Neurol"},{"key":"553_CR2","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/s12975-010-0040-6","volume":"1","author":"R Brunkhorst","year":"2011","unstructured":"Brunkhorst R, Pfeilschifter W, Foerch C (2011) Astroglial proteins as diagnostic markers of acute intracerebral hemorrhage\u2014pathophysiological background and clinical findings. Transl Stroke Res 1:246\u2013251","journal-title":"Transl Stroke Res"},{"key":"553_CR3","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1212\/WNL.0b013e3181b05ef9","volume":"73","author":"C Foerch","year":"2009","unstructured":"Foerch C, Montaner J, Furie KL et al (2009) Invited article: searching for oracles? Blood biomarkers in acute stroke. Neurology 73:393\u2013399","journal-title":"Neurology"},{"key":"553_CR4","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1159\/000172632","volume":"27","author":"F Dvorak","year":"2009","unstructured":"Dvorak F, Haberer I, Sitzer M et al (2009) Characterisation of the diagnostic window of serum glial fibrillary acidic protein for the differentiation of intracerebral haemorrhage and ischaemic stroke. Cerebrovasc Dis 27:37\u201341","journal-title":"Cerebrovasc Dis"},{"key":"553_CR5","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jstrokecerebrovasdis.2008.02.002","volume":"17","author":"A Petzold","year":"2008","unstructured":"Petzold A, Michel P, Stock M et al (2008) Glial and axonal body fluid biomarkers are related to infarct volume, severity, and outcome. J Stroke Cerebrovasc Dis 17:196\u2013203","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"553_CR6","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1001\/archneur.62.7.1130","volume":"62","author":"C Foerch","year":"2005","unstructured":"Foerch C, Singer OC, Neumann-Haefelin T et al (2005) Evaluation of serum S100B as a surrogate marker for long-term outcome and infarct volume in acute middle cerebral artery infarction. Arch Neurol 62:1130\u20131134","journal-title":"Arch Neurol"},{"key":"553_CR7","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jns.2004.08.005","volume":"227","author":"MT Wunderlich","year":"2004","unstructured":"Wunderlich MT, Wallesch CW, Goertler M (2004) Release of neurobiochemical markers of brain damage is related to the neurovascular status on admission and the site of arterial occlusion in acute ischemic stroke. J Neurol Sci 227:49\u201353","journal-title":"J Neurol Sci"},{"key":"553_CR8","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1159\/000199468","volume":"27","author":"P Dassan","year":"2009","unstructured":"Dassan P, Keir G, Brown MM (2009) Criteria for a clinically informative serum biomarker in acute ischaemic stroke: a review of S100B. Cerebrovasc Dis 27:295\u2013302","journal-title":"Cerebrovasc Dis"},{"key":"553_CR9","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jns.2005.03.015","volume":"233","author":"A Petzold","year":"2005","unstructured":"Petzold A (2005) Neurofilament phosphoforms: surrogate markers for axonal injury, degeneration and loss. J Neurol Sci 233:183\u2013198","journal-title":"J Neurol Sci"},{"key":"553_CR10","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jns.2008.12.037","volume":"279","author":"A Petzold","year":"2009","unstructured":"Petzold A, Thompson EJ, Keir G et al (2009) Longitudinal one-year study of levels and stoichiometry of neurofilament heavy and light chain concentrations in CSF in patients with multiple system atrophy. J Neurol Sci 279:76\u201379","journal-title":"J Neurol Sci"},{"key":"553_CR11","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jns.2011.01.025","volume":"304","author":"P Singh","year":"2011","unstructured":"Singh P, Yan J, Hull R et al (2011) Levels of phosphorylated axonal neurofilament subunit H (pNfH) are increased in acute ischemic stroke. J Neurol Sci 304:117\u2013121","journal-title":"J Neurol Sci"},{"key":"553_CR12","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1161\/01.STR.0000143329.81997.8a","volume":"35","author":"WD Heiss","year":"2004","unstructured":"Heiss WD, Sobesky J, Hesselmann V (2004) Identifying thresholds for penumbra and irreversible tissue damage. Stroke 35:2671\u20132674","journal-title":"Stroke"},{"key":"553_CR13","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/jmri.20313","volume":"21","author":"M Lu","year":"2005","unstructured":"Lu M, Mitsias PD, Ewing JR et al (2005) Predicting final infarct size using acute and subacute multiparametric MRI measurements in patients with ischemic stroke. J Magn Reson Imaging 21:495\u2013502","journal-title":"J Magn Reson Imaging"},{"key":"553_CR14","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1161\/CIRCULATIONAHA.110.986497","volume":"123","author":"HA Jensen","year":"2011","unstructured":"Jensen HA, Loukogeorgakis S, Yannopoulos F et al (2011) Remote ischemic preconditioning protects the brain against injury after hypothermic circulatory arrest. Circulation 123:714\u2013721","journal-title":"Circulation"},{"key":"553_CR15","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1007\/s11064-009-9976-x","volume":"34","author":"J Sellner","year":"2009","unstructured":"Sellner J, Petzold A, Sadikovic S et al (2009) The value of the serum neurofilament protein heavy chain as a biomarker for peri-operative brain injury after carotid endarterectomy. Neurochem Res 34:1969\u20131974","journal-title":"Neurochem Res"},{"key":"553_CR16","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jim.2004.01.015","volume":"287","author":"A Petzold","year":"2004","unstructured":"Petzold A, Keir G, Green AJ et al (2004) An ELISA for glial fibrillary acidic protein. J Immunol Methods 287:169\u2013177","journal-title":"J Immunol Methods"},{"key":"553_CR17","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0361-9230(03)00091-1","volume":"61","author":"A Petzold","year":"2003","unstructured":"Petzold A, Keir G, Lim D et al (2003) Cerebrospinal fluid (CSF) and serum S100B: release and wash-out pattern. Brain Res Bull 61:281\u2013285","journal-title":"Brain Res Bull"},{"key":"553_CR18","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.expneurol.2011.01.002","volume":"228","author":"S Lama","year":"2011","unstructured":"Lama S, Qiao M, Kirton A et al (2011) Imaging corticospinal degeneration in neonatal rats with unilateral cerebral infarction. Exp Neurol 228:192\u2013199","journal-title":"Exp Neurol"},{"key":"553_CR19","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1159\/000232556","volume":"31","author":"ZS Vexler","year":"2009","unstructured":"Vexler ZS, Yenari MA (2009) Does inflammation after stroke affect the developing brain differently than adult brain? Dev Neurosci 31:378\u2013393","journal-title":"Dev Neurosci"},{"key":"553_CR20","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1161\/STROKEAHA.106.480111","volume":"38","author":"C Foerch","year":"2007","unstructured":"Foerch C, Wunderlich MT, Dvorak F et al (2007) Elevated serum S100B levels indicate a higher risk of hemorrhagic transformation after thrombolytic therapy in acute stroke. Stroke 38:2491\u20132495","journal-title":"Stroke"},{"key":"553_CR21","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1161\/01.STR.28.10.1956","volume":"28","author":"U Missler","year":"1997","unstructured":"Missler U, Wiesmann M, Friedrich C et al (1997) S-100 protein and neuron-specific enolase concentrations in blood as indicators of infarction volume and prognosis in acute ischemic stroke. Stroke 28:1956\u20131960","journal-title":"Stroke"},{"key":"553_CR22","doi-asserted-by":"crossref","unstructured":"Eikelenboom MJ, Uitdehaag BMJ, Petzold A (2011) Blood and CSF biomarker dynamics in multiple sclerosis: implications for data interpretation. Mult Scler Int Article ID 823176. doi: 10.1155\/2011\/823176","DOI":"10.1155\/2011\/823176"},{"key":"553_CR23","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1002\/ana.22169","volume":"68","author":"A Petzold","year":"2010","unstructured":"Petzold A, Mondria T, Kuhle J et al (2010) Evidence for acute neurotoxicity after chemotherapy. Ann Neurol 68:806\u2013815","journal-title":"Ann Neurol"},{"key":"553_CR24","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1161\/01.STR.31.11.2670","volume":"31","author":"M Herrmann","year":"2000","unstructured":"Herrmann M, Vos P, Wunderlich MT et al (2000) Release of glial tissue-specific proteins after acute stroke: a comparative analysis of serum concentrations of protein S-100B and glial fibrillary acidic protein. Stroke 31:2670\u20132677","journal-title":"Stroke"},{"key":"553_CR25","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1161\/01.STR.0000242290.01174.9e","volume":"37","author":"EC Jauch","year":"2006","unstructured":"Jauch EC, Lindsell C, Broderick J et al (2006) Association of serial biochemical markers with acute ischemic stroke: the national institute of neurological disorders and stroke recombinant tissue plasminogen activator stroke study. Stroke 37:2508\u20132513","journal-title":"Stroke"},{"key":"553_CR26","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1093\/brain\/awq360","volume":"134","author":"A Petzold","year":"2011","unstructured":"Petzold A, Tisdall MM, Girbes AR et al (2011) In vivo monitoring of neuronal loss in traumatic brain injury: a microdialysis study. Brain 134:464\u2013483","journal-title":"Brain"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-011-0553-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11064-011-0553-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-011-0553-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T06:22:33Z","timestamp":1560406953000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11064-011-0553-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,27]]},"references-count":26,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["553"],"URL":"https:\/\/doi.org\/10.1007\/s11064-011-0553-8","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,27]]}}}