{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T15:50:04Z","timestamp":1776095404569,"version":"3.50.1"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2011,8,13]],"date-time":"2011-08-13T00:00:00Z","timestamp":1313193600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1007\/s11064-011-0575-2","type":"journal-article","created":{"date-parts":[[2011,8,12]],"date-time":"2011-08-12T14:56:20Z","timestamp":1313160980000},"page":"15-22","source":"Crossref","is-referenced-by-count":12,"title":["Increased Phosphorylation of Tau and Synaptic Protein Loss in the Aged Transgenic Mice Expressing Familiar Alzheimer\u2019s Disease-Linked Presenilin 1 Mutation"],"prefix":"10.1007","volume":"37","author":[{"given":"Xifei","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,8,13]]},"reference":[{"key":"575_CR1","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1097\/00005072-199409000-00003","volume":"53","author":"DJ Selkoe","year":"1994","unstructured":"Selkoe DJ (1994) Alzheimer\u2019s disease: a central role for amyloid. J Neuropathol Exp Neurol 53:438\u2013447","journal-title":"J Neuropathol Exp Neurol"},{"key":"575_CR2","doi-asserted-by":"crossref","first-page":"6084","DOI":"10.1016\/S0021-9258(17)38495-8","volume":"261","author":"I Grundke-Iqbal","year":"1986","unstructured":"Grundke-Iqbal I, Iqbal K, Quinlan M, Tung YC, Zaidi MS, Wisniewski HM (1986) Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. J Biol Chem 261:6084\u20136089","journal-title":"J Biol Chem"},{"key":"575_CR3","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1086\/302553","volume":"65","author":"D Campion","year":"1999","unstructured":"Campion D, Dumanchin C, Hannequin D, Dubois B, Belliard S, Puel M, Thomas-Anterion C, Michon A, Martin C, Charbonnier F, Raux G, Camuzat A, Penet C, Mesnage V, Martinez M, Clerget-Darpoux F, Brice A, Frebourg T (1999) Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum. Am J Hum Genet 65:664\u2013670","journal-title":"Am J Hum Genet"},{"key":"575_CR4","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/hmg\/7.1.43","volume":"7","author":"M Cruts","year":"1998","unstructured":"Cruts M, van Duijn CM, Backhovens H, Van den Broeck M, Wehnert A, Serneels S, Sherrington R, Hutton M, Hardy J, St George-Hyslop PH, Hofman A, Van Broeckhoven C (1998) Estimation of the genetic contribution of presenilin-1 and -2 mutations in a population-based study of presenile Alzheimer disease. Hum Mol Genet 7:43\u201351","journal-title":"Hum Mol Genet"},{"key":"575_CR5","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1093\/hmg\/5.7.985","volume":"5","author":"R Sherrington","year":"1996","unstructured":"Sherrington R, Froelich S, Sorbi S, Campion D, Chi H, Rogaeva EA, Levesque G, Rogaev EI, Lin C, Liang Y, Ikeda M, Mar L, Brice A, Agid Y, Percy ME, Clerget-Darpoux F, Piacentini S, Marcon G, Nacmias B, Amaducci L, Frebourg T, Lannfelt L, Rommens JM, St George-Hyslop PH (1996) Alzheimer\u2019s disease associated with mutations in presenilin 2 is rare and variably penetrant. Hum Mol Genet 5:985\u2013988","journal-title":"Hum Mol Genet"},{"key":"575_CR6","first-page":"273","volume":"51","author":"RE Tanzi","year":"1992","unstructured":"Tanzi RE, Vaula G, Romano DM, Mortilla M, Huang TL, Tupler RG, Wasco W, Hyman BT, Haines JL, Jenkins BJ et al (1992) Assessment of amyloid beta-protein precursor gene mutations in a large set of familial and sporadic Alzheimer disease cases. Am J Hum Genet 51:273\u2013282","journal-title":"Am J Hum Genet"},{"key":"575_CR7","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1001\/archneur.59.11.1759","volume":"59","author":"A Lle\u00f3","year":"2002","unstructured":"Lle\u00f3 A, Blesa R, Queralt R, Ezquerra M, Molinuevo JL, Pe\u00f1a-Casanova J, Rojo A, Oliva R (2002) Frequency of mutations in the presenilin and amyloid precursor protein genes in early-onset Alzheimer disease in Spain. Arch Neurol 59:1759\u20131763","journal-title":"Arch Neurol"},{"key":"575_CR8","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1212\/01.WNL.0000042088.22694.E3","volume":"60","author":"JC Janssen","year":"2003","unstructured":"Janssen JC, Beck JA, Campbell TA, Dickinson A, Fox NC, Harvey RJ, Houlden H, Rossor MN, Collinge J (2003) Early onset familial Alzheimer\u2019s disease: mutation frequency in 31 families. Neurology 60:235\u2013239","journal-title":"Neurology"},{"key":"575_CR9","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1093\/brain\/122.9.1709","volume":"122","author":"T G\u00f3mez-Isla","year":"1999","unstructured":"G\u00f3mez-Isla T, Growdon WB, McNamara MJ, Nochlin D, Bird TD, Arango JC, Lopera F, Kosik KS, Lantos PL, Cairns NJ, Hyman BT (1999) The impact of different presenilin 1 andpresenilin 2 mutations on amyloid deposition, neurofibrillary changes and neuronal loss in the familial Alzheimer\u2019s disease brain: evidence for other phenotype-modifying factors. Brain 122:1709\u20131719","journal-title":"Brain"},{"key":"575_CR10","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0531-5565(00)00111-X","volume":"35","author":"W Xia","year":"2000","unstructured":"Xia W (2000) Role of presenilin in gamma-secretase cleavage of amyloid precursor protein. Exp Gerontol 35:453\u2013460","journal-title":"Exp Gerontol"},{"key":"575_CR11","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/8438","volume":"5","author":"DH Chui","year":"1999","unstructured":"Chui DH, Tanahashi H, Ozawa K, Ikeda S, Checler F, Ueda O, Suzuki H, Araki W, Inoue H, Shirotani K, Takahashi K, Gallyas F, Tabira T (1999) Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation. Nat Med 5:560\u2013564","journal-title":"Nat Med"},{"key":"575_CR12","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s12031-007-9033-7","volume":"34","author":"X Yang","year":"2008","unstructured":"Yang X, Yang Y, Li G, Wang J, Yang ES (2008) Coenzyme Q10 attenuates beta-amyloid pathology in the aged transgenic mice with Alzheimer presenilin 1 mutation. J Mol Neurosci 34:165\u2013171","journal-title":"J Mol Neurosci"},{"key":"575_CR13","doi-asserted-by":"crossref","first-page":"5721","DOI":"10.1242\/jcs.01558","volume":"117","author":"GV Johnson","year":"2004","unstructured":"Johnson GV, Stoothoff WH (2004) Tau phosphorylation in neuronal cell function and dysfunction. J Cell Sci 117:5721\u20135729","journal-title":"J Cell Sci"},{"key":"575_CR14","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1460-9568.2006.05226.x","volume":"25","author":"JZ Wang","year":"2007","unstructured":"Wang JZ, Grundke-Iqbal I, Iqbal K (2007) Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration. Eur J Neurosci 25:59\u201368","journal-title":"Eur J Neurosci"},{"key":"575_CR15","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3233\/JAD-2006-9S335","volume":"9","author":"A Takashima","year":"2006","unstructured":"Takashima A (2006) GSK-3 is essential in the pathogenesis of Alzheimer\u2019s disease. J Alzheimers Dis 9:309\u2013317","journal-title":"J Alzheimers Dis"},{"key":"575_CR16","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1385\/JMN:19:3:337","volume":"19","author":"I Gozes","year":"2002","unstructured":"Gozes I (2002) Tau as a drug target in Alzheimer\u2019s disease. J Mol Neurosci 19:337\u2013338","journal-title":"J Mol Neurosci"},{"key":"575_CR17","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1097\/00005072-199909000-00011","volume":"58","author":"JJ Pei","year":"1999","unstructured":"Pei JJ, Braak E, Braak H, Grundke-Iqbal I, Iqbal K, Winblad B, Cowburn RF (1999) Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes. J Neuropathol Exp Neurol 58:1010\u20131019","journal-title":"J Neuropathol Exp Neurol"},{"key":"575_CR18","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/nrd2111","volume":"6","author":"MP Mazanetz","year":"2007","unstructured":"Mazanetz MP, Fischer PM (2007) Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases. Nat Rev Drug Discov 6:464\u2013479","journal-title":"Nat Rev Drug Discov"},{"key":"575_CR19","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1159\/000074622","volume":"12","author":"LF Lau","year":"2003","unstructured":"Lau LF, Ahlijanian MK (2003) Role of cdk5 in the pathogenesis of Alzheimer\u2019s disease. Neurosignals 12:209\u2013214","journal-title":"Neurosignals"},{"key":"575_CR20","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2174\/1567205043480519","volume":"1","author":"EA Monaco","year":"2004","unstructured":"Monaco EA (2004) Recent evidence regarding a role for Cdk5 dysregulation in Alzheimer\u2019s disease. Curr Alzheimer Res 1:33\u201338","journal-title":"Curr Alzheimer Res"},{"key":"575_CR21","doi-asserted-by":"crossref","first-page":"6758","DOI":"10.1523\/JNEUROSCI.21-17-06758.2001","volume":"21","author":"J Ko","year":"2001","unstructured":"Ko J, Humbert S, Bronson RT, Takahashi S, Kulkarni AB, Li E, Tsai LH (2001) p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment. J Neurosci 21:6758\u20136771","journal-title":"J Neurosci"},{"key":"575_CR22","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.1073\/pnas.040577797","volume":"97","author":"MK Ahlijanian","year":"2000","unstructured":"Ahlijanian MK, Barrezueta NX, Williams RD, Jakowski A, Kowsz KP, McCarthy S, Coskran T, Carlo A, Seymour PA, Burkhardt JE, Nelson RB, McNeish JD (2000) Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5. Proc Natl Acad Sci USA 97:2910\u20132915","journal-title":"Proc Natl Acad Sci USA"},{"key":"575_CR23","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1046\/j.1471-4159.1995.65062804.x","volume":"65","author":"M Goedert","year":"1995","unstructured":"Goedert M, Jakes R, Qi Z, Wang JH, Cohen P (1995) Protein phosphatase 2A is the major enzyme in brain that dephosphorylates tau protein phosphorylated by proline-directed protein kinases or cyclic AMP-dependent protein kinase. J Neurochem 65:2804\u20132807","journal-title":"J Neurochem"},{"key":"575_CR24","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1111\/j.1471-4159.1993.tb03603.x","volume":"61","author":"CX Gong","year":"1993","unstructured":"Gong CX, Singh TJ, Grundke-Iqbal I, Iqbal K (1993) Phosphoprotein phosphatase activities in Alzheimer disease brain. J Neurochem 61:921\u2013927","journal-title":"J Neurochem"},{"key":"575_CR25","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1111\/j.1460-9568.2005.04391.x","volume":"22","author":"F Liu","year":"2005","unstructured":"Liu F, Grundke-Iqbal I, Iqbal K, Gong CX (2005) Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation. Eur J Neurosci 22:1942\u20131950","journal-title":"Eur J Neurosci"},{"key":"575_CR26","doi-asserted-by":"crossref","first-page":"4854","DOI":"10.1074\/jbc.270.9.4854","volume":"270","author":"JZ Wang","year":"1995","unstructured":"Wang JZ, Gong CX, Zaidi T, Grundke-Iqbal I, Iqbal K (1995) Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B. J Biol Chem 270:4854\u20134860","journal-title":"J Biol Chem"},{"key":"575_CR27","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1126\/science.1325671","volume":"257","author":"J Chen","year":"1992","unstructured":"Chen J, Martin BL, Brautigan DL (1992) Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation. Science 257:1261\u20131264","journal-title":"Science"},{"key":"575_CR28","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/BF01273157","volume":"103","author":"K Blennow","year":"1996","unstructured":"Blennow K, Bogdanovic N, Alafuzoff I, Ekman R, Davidsson P (1996) Synaptic pathology in Alzheimer\u2019s disease: relation to severity of dementia, but not to senile plaques, neurofibrillary tangles, or the ApoE4 allele. J Neural Transm 103:603\u2013618","journal-title":"J Neural Transm"},{"key":"575_CR29","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/ana.410270502","volume":"27","author":"ST DeKosky","year":"1990","unstructured":"DeKosky ST, Scheff SW (1990) Synapse loss in frontal cortex biopsies in Alzheimer\u2019s disease: correlation with cognitive severity. Ann Neurol 27:457\u2013464","journal-title":"Ann Neurol"},{"key":"575_CR30","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/j.neurobiolaging.2005.09.012","volume":"27","author":"SW Scheff","year":"2006","unstructured":"Scheff SW, Price DA, Schmitt FA, Mufson EJ (2006) Hippocampal synaptic loss in early Alzheimer\u2019s disease and mild cognitive impairment. Neurobiol Aging 27:1372\u20131384","journal-title":"Neurobiol Aging"},{"key":"575_CR31","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.nbd.2008.02.012","volume":"30","author":"G Leuba","year":"2008","unstructured":"Leuba G, Walzer C, Vernay A, Carnal B, Kraftsik R, Piotton F, Marin P, Bouras C, Savioz A (2008) Postsynaptic density protein PSD-95 expression in Alzheimer\u2019s disease and okadaic acid induced neuritic retraction. Neurobiol Dis 30:408\u2013419","journal-title":"Neurobiol Dis"},{"key":"575_CR32","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.neurobiolaging.2005.04.008","volume":"27","author":"S Love","year":"2006","unstructured":"Love S, Siew LK, Dawbarn D, Wilcock GK, Ben-Shlomo Y, Allen SJ (2006) Premorbid effects of APOE on synaptic proteins in human temporal neocortex. Neurobiol Aging 27:797\u2013803","journal-title":"Neurobiol Aging"},{"key":"575_CR33","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.neurobiolaging.2006.05.005","volume":"28","author":"G Li","year":"2007","unstructured":"Li G, Zou L, Jack CR Jr, Yang Y, Yang ES (2007) Neuroprotective effect of Coenzyme Q10 on ischemic hemisphere in aged mice with mutations in the amyloid precursor protein. Neurobiol Aging 28:877\u2013882","journal-title":"Neurobiol Aging"},{"key":"575_CR34","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/biof.5520320120","volume":"32","author":"G Li","year":"2008","unstructured":"Li G, Jack CR, Yang XF, Yang ES (2008) Diet supplement CoQ10 delays brain atrophy in aged transgenic mice with mutations in the amyloid precursor protein: an in vivo volume MRI study. Biofactors 32:169\u2013178","journal-title":"Biofactors"},{"key":"575_CR35","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.molmed.2005.02.008","volume":"11","author":"HG Lee","year":"2005","unstructured":"Lee HG, Perry G, Moreira PI, Garrett MR, Liu Q, Zhu X, Takeda A, Nunomura A, Smith MA (2005) Tau phosphorylation in Alzheimer\u2019s disease: pathogen or protector? Trends Mol Med 11:164\u2013169","journal-title":"Trends Mol Med"},{"key":"575_CR36","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.2174\/092986708785909111","volume":"15","author":"CX Gong","year":"2008","unstructured":"Gong CX, Iqbal K (2008) Hyperphosphorylation of microtubule-associated protein tau: a promising therapeutic target for Alzheimer disease. Curr Med Chem 15:2321\u20132328","journal-title":"Curr Med Chem"},{"key":"575_CR37","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.neuint.2009.08.005","volume":"55","author":"C Strazielle","year":"2009","unstructured":"Strazielle C, Jazi R, Verdier Y, Qian S, Lalonde R (2009) Regional brain metabolism with cytochrome c oxidase histochemistry in a PS1\/A246E mouse model of autosomal dominant Alzheimer\u2019s disease: correlations with behavior and oxidative stress. Neurochem Int 55:806\u2013814","journal-title":"Neurochem Int"},{"key":"575_CR38","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0014-4886(03)00242-5","volume":"183","author":"XG Huang","year":"2003","unstructured":"Huang XG, Yee BK, Nag S, Chan ST, Tang F (2003) Behavioral and neurochemical characterization of transgenic mice carrying the human presenilin-1 gene with or without the leucine-to-proline mutation at codon 235. Exp Neurol 183:673\u2013681","journal-title":"Exp Neurol"},{"key":"575_CR39","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1038\/sj.emboj.7600251","volume":"23","author":"L Baki","year":"2004","unstructured":"Baki L, Shioi J, Wen P, Shao Z, Schwarzman A, Gama-Sosa M, Neve R, Robakis NK (2004) PS1 activates PI3\u00a0K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations. EMBO J 23:2586\u20132596","journal-title":"EMBO J"},{"key":"575_CR40","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0306-4522(94)00422-2","volume":"64","author":"O Heinonen","year":"1995","unstructured":"Heinonen O, Soininen H, Sorvari H, Kosunen O, Palj\u00e4rvi L, Koivisto E, Riekkinen PJ Sr (1995) Loss of synaptophysin-like immunoreactivity in the hippocampal formation is an early phenomenon in Alzheimer\u2019s disease. Neuroscience 64:375\u2013384","journal-title":"Neuroscience"},{"key":"575_CR41","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1212\/WNL.56.1.127","volume":"56","author":"E Masliah","year":"2001","unstructured":"Masliah E, Mallory M, Alford M, DeTeresa R, Hansen LA, McKeel DW Jr, Morris JC (2001) Altered expression of synaptic proteins occurs early during progression of Alzheimer\u2019s disease. Neurology 56:127\u2013129","journal-title":"Neurology"},{"key":"575_CR42","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/S0197-4580(01)00300-1","volume":"22","author":"SA Frautschy","year":"2001","unstructured":"Frautschy SA, Hu W, Kim P, Miller SA, Chu T, Harris-White ME, Cole GM (2001) Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology. Neurobiol Aging 22:993\u20131005","journal-title":"Neurobiol Aging"},{"key":"575_CR43","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0002-9440(10)62963-X","volume":"167","author":"BP Rutten","year":"2005","unstructured":"Rutten BP, Van der Kolk NM, Schafer S, van Zandvoort MA, Bayer TA, Steinbusch HW, Schmitz C (2005) Age-related loss of synaptophysin immunoreactive presynaptic boutons within the hippocampus of APP751SL, PS1M146L, and APP751SL\/PS1M146L transgenic mice. Am J Pathol 167:161\u2013173","journal-title":"Am J Pathol"},{"key":"575_CR44","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1523\/JNEUROSCI.21-03-00834.2001","volume":"21","author":"G Pigino","year":"2001","unstructured":"Pigino G, Pelsman A, Mori H, Busciglio J (2001) Presenilin-1 mutations reduce cytoskeletal association, deregulate neurite growth, and potentiate neuronal dystrophy and tau phosphorylation. J Neurosci 21:834\u2013842","journal-title":"J Neurosci"},{"key":"575_CR45","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1385\/NMM:2:2:151","volume":"2","author":"D Terwel","year":"2002","unstructured":"Terwel D, Dewachter I, Van Leuven F (2002) Axonal transport, tau protein, and neurodegeneration in Alzheimer\u2019s disease. Neuromolecular Med 2:151\u2013165","journal-title":"Neuromolecular Med"},{"key":"575_CR46","doi-asserted-by":"crossref","first-page":"13666","DOI":"10.1073\/pnas.0706192104","volume":"104","author":"B Cui","year":"2007","unstructured":"Cui B, Wu C, Chen L, Ramirez A, Bearer EL, Li WP, Mobley WC, Chu S (2007) One at a time, live tracking of NGF axonal transport using quantum dots. Proc Natl Acad Sci USA 104:13666\u201313671","journal-title":"Proc Natl Acad Sci USA"},{"key":"575_CR47","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1601-183X.2007.00378.x","volume":"7","author":"K Schindowski","year":"2008","unstructured":"Schindowski K, Belarbi K, Bu\u00e9e L (2008) Neurotrophic factors in Alzheimer\u2019s disease: role of axonal transport. Genes Brain Behav 7:43\u201356","journal-title":"Genes Brain Behav"},{"key":"575_CR48","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/S0002-9440(10)63436-0","volume":"165","author":"KH Gylys","year":"2004","unstructured":"Gylys KH, Fein JA, Yang F, Wiley DJ, Miller CA, Cole GM (2004) Synaptic changes in Alzheimer\u2019s disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence. Am J Pathol 165:1809\u20131817","journal-title":"Am J Pathol"},{"key":"575_CR49","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3233\/JAD-2008-15112","volume":"15","author":"G Leuba","year":"2008","unstructured":"Leuba G, Savioz A, Vernay A, Carnal B, Kraftsik R, Tardif E, Riederer I, Riederer BM (2008) Differential changes in synaptic proteins in the Alzheimer frontal cortex with marked increase in PSD-95 postsynaptic protein. J Alzheimers Dis 15:139\u2013151","journal-title":"J Alzheimers Dis"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-011-0575-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11064-011-0575-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-011-0575-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T08:56:32Z","timestamp":1638262592000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11064-011-0575-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,13]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["575"],"URL":"https:\/\/doi.org\/10.1007\/s11064-011-0575-2","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,13]]}}}