{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:43:32Z","timestamp":1789785812403,"version":"4.0.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2012,2,10]],"date-time":"2012-02-10T00:00:00Z","timestamp":1328832000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1007\/s11064-012-0717-1","type":"journal-article","created":{"date-parts":[[2012,2,9]],"date-time":"2012-02-09T05:11:05Z","timestamp":1328764265000},"page":"1121-1131","source":"Crossref","is-referenced-by-count":87,"title":["Bacopa monniera (L.) Wettst Ameliorates Behavioral Alterations and Oxidative Markers in Sodium Valproate Induced Autism in Rats"],"prefix":"10.1007","volume":"37","author":[{"given":"T.","family":"Sandhya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Sowjanya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Veeresh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,2,10]]},"reference":[{"key":"717_CR1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s11064-010-0253-9","volume":"36","author":"J Mathew","year":"2011","unstructured":"Mathew J, Gangadharan G, Paulose KP, Kuruvilla CS (2011) Behavioral deficit and decreased GABA receptor functional regulation in the hippocampus of epileptic rats: effect of Bacopa monnieri. Neurochem Res 36:7\u201316","journal-title":"Neurochem Res"},{"key":"717_CR2","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1007\/s11064-007-9513-8","volume":"33","author":"CS Paulose","year":"2008","unstructured":"Paulose CS, Chathu Finla, Reas Khan S, Krishnakumar A (2008) Neuroprotective role of Bacopa monnieri extract in epilepsy and effect of glucose supplementation during hypoxia: glutamate receptor gene expression. Neurochem Res 33:1663\u20131671","journal-title":"Neurochem Res"},{"issue":"2","key":"717_CR3","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0944-7113(98)80001-9","volume":"5","author":"SK Bhattacharya","year":"1998","unstructured":"Bhattacharya SK, Ghoshal S (1998) Axiolytic activity of a standardized extract of Bacopa monniera: an experimental study. Phytomedicine 5(2):77\u201382","journal-title":"Phytomedicine"},{"key":"717_CR4","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1078\/0944-7113-00116","volume":"9","author":"K Sairam","year":"2002","unstructured":"Sairam K, Dorababu M, Goel RK, Bhattacharya SK (2002) Antidepressant activity of standardized extract of Bacopa monniera in experimental models of depression in rats. Phytomedicine 9:207\u2013211","journal-title":"Phytomedicine"},{"key":"717_CR5","doi-asserted-by":"crossref","first-page":"236186","DOI":"10.1093\/ecam\/neq038","volume":"2011","author":"S Manish Kumar","year":"2011","unstructured":"Manish Kumar S, Sudesh P, Krishan Lal K, Akshay A (2011) Bacopa monniera attenuates scopolamine-induced impairment of spatial memory in mice. Evid Based Complement Alternat Med 2011:236186","journal-title":"Evid Based Complement Alternat Med"},{"key":"717_CR6","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.phymed.2003.12.008","volume":"12","author":"A Russo","year":"2005","unstructured":"Russo A, Borrelli F (2005) Bacopa monniera, a reputed nootropic drug: an overview. Phytomedicine 12:305\u2013317","journal-title":"Phytomedicine"},{"key":"717_CR7","first-page":"764","volume":"45","author":"AK Rehni","year":"2007","unstructured":"Rehni AK, Pantlya HS, Shri R, Singh M (2007) Effect of chlorophyll and aqueous extracts of Bacopa monniera and Valeriana wallichii on ischaemia and reperfusion- induced cerebral injury in mice. Indian J Exp Biol 45:764\u2013769","journal-title":"Indian J Exp Biol"},{"key":"717_CR8","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/(SICI)1099-1573(200005)14:3<174::AID-PTR624>3.0.CO;2-O","volume":"14","author":"SK Bhattacharya","year":"2000","unstructured":"Bhattacharya SK, Bhattacharya A, Kumar A, Ghosal S (2000) Antioxidant activity of Bacopa monniera in rat frontal cortex, striatum and hippocampus. Phytother Res 14:174\u2013179","journal-title":"Phytother Res"},{"key":"717_CR9","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.phymed.2010.08.005","volume":"18","author":"GK Shinomol","year":"2011","unstructured":"Shinomol GK, Muralidhara (2011) Bacopa monnieri modulates endogenous cytoplasmic and mitochondrial oxidative markers in prepubertal mice brain. Phytomedicine 18:317\u2013326","journal-title":"Phytomedicine"},{"issue":"3","key":"717_CR10","doi-asserted-by":"crossref","first-page":"338","DOI":"10.4103\/0974-8520.77169","volume":"31","author":"HK Singhal","year":"2010","unstructured":"Singhal HK, Neetu, kumar A, Rai M (2010) Ayurvedic approach for improving reaction time of attention deficit hyperactivity disorder affected children. AYU 31(3):338\u2013342","journal-title":"AYU"},{"issue":"5","key":"717_CR11","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.fitote.2009.11.005","volume":"81","author":"J Mathew","year":"2010","unstructured":"Mathew J, Paul J, Nandhu MS, Paulose CS (2010) Bacopa monniera and bacoside- A for ameliorating epilepsy associated behavioral deficits. Fitoterpia 81(5):315\u2013322","journal-title":"Fitoterpia"},{"key":"717_CR12","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0890-6238(97)80001-U","volume":"11","author":"PM Rodier","year":"1997","unstructured":"Rodier PM, Ingram JL, Tisdale B, Croog VJ (1997) Linking etiologies in humans and animal models: studies of autism. Reprod Toxicol 11:417\u2013422","journal-title":"Reprod Toxicol"},{"key":"717_CR13","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/sj.npp.1300518","volume":"30","author":"T Schneider","year":"2005","unstructured":"Schneider T, Przew\u0142ocki R (2005) Behavioral alterations in rats prenatally exposed to valproic acid: animal model of autism. Neuropsychopharmacology 30:80\u201389","journal-title":"Neuropsychopharmacology"},{"key":"717_CR14","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1007\/s10803-006-0117-y","volume":"36","author":"CG Wagner","year":"2006","unstructured":"Wagner CG, Reuhl KR, Cheh M, McRae P, Halladay AK (2006) A new neurobehavioral model of autism in mice: pre- and postnatal exposure to sodium valproate. J Autism Dev Disord 36:779\u2013793","journal-title":"J Autism Dev Disord"},{"key":"717_CR15","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/sj.npp.1300767","volume":"31","author":"T Schneider","year":"2006","unstructured":"Schneider T, Turczak J, Przew\u0142ocki R (2006) Environmental enrichment reverses behavioral alterations in rats prenatally exposed to valproic acid: issues for a therapeutic approach in autism. Neuropsychopharmacology 31:36\u201346","journal-title":"Neuropsychopharmacology"},{"key":"717_CR16","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/sj.npp.1301453","volume":"33","author":"K Markram","year":"2007","unstructured":"Markram K, Rinaldi T, Mendola DL, Sandi C, Markram H (2007) Abnormal fear conditioning and amygdala processing in an animal model of autism. Neuropsychopharmacology 33:901\u2013912","journal-title":"Neuropsychopharmacology"},{"key":"717_CR17","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.neures.2009.09.001","volume":"66","author":"M Narita","year":"2010","unstructured":"Narita M, Oyabu A, Imura Y, Kamada N, Yokoyama T, Tano K, Uchida A, Narita N (2010) Nonexploratory movement and behavioral alterations in a thalidomide or valproic acid-induced autism model rat. Neurosci Res 66:2\u20136","journal-title":"Neurosci Res"},{"key":"717_CR18","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.psyneuen.2008.02.011","volume":"33","author":"T Schneider","year":"2008","unstructured":"Schneider T, Roman A, Basta-Kaim A, Kubera M, Budziszewska B, Schneider K, Przew\u0142ocki R (2008) Gender-specific behavioral and immunological alterations in an animal model of autism induced by prenatal exposure to valproic acid. Psychoneuroendocrinology 33:728\u2013740","journal-title":"Psychoneuroendocrinology"},{"issue":"1","key":"717_CR19","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3389\/neuro.01.1.1.006.2007","volume":"1","author":"H Markram","year":"2007","unstructured":"Markram H, Rinaldi T, Markram K (2007) The intense world syndrome\u2014an alternative hypothesis for autism. Front Neurosci 1(1):77\u201396","journal-title":"Front Neurosci"},{"key":"717_CR20","first-page":"576","volume":"52","author":"N Narita","year":"2002","unstructured":"Narita N, Kato M, Tazoe M, Miyazaki K, Narita M, Okado N (2002) Increased monoamine concentration in the brain and blood of fetal thalidomide- and valproic acid-exposed rat: putative animal models for autism. Pediatr Res 52:576\u2013579","journal-title":"Pediatr Res"},{"key":"717_CR21","doi-asserted-by":"crossref","first-page":"218","DOI":"10.3844\/ajbbsp.2008.218.225","volume":"4","author":"X Ming","year":"2008","unstructured":"Ming X, Cheh MA, Halladay AK, Wagner GC (2008) Evidence of oxidative stress in autism derived from animal models. Am J Biochem Biotechnol 4:218\u2013225","journal-title":"Am J Biochem Biotechnol"},{"key":"717_CR22","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.brainres.2011.06.063","volume":"1410","author":"D Banjia","year":"2011","unstructured":"Banjia D, Banjia OJF, Abbagonia S, Hayathb MS, Kambama S, Chilukaa VL (2011) Amelioration of behavioral aberrations and oxidative markers by green tea extract in valproate induced autism in animals. Brain Res 1410:141\u2013151","journal-title":"Brain Res"},{"key":"717_CR23","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0028-3908(68)90034-8","volume":"7","author":"RP Maickel","year":"1968","unstructured":"Maickel RP, Cox RH, Saillant J, Miller FP (1968) A method for the determination of serotonin and norepinephrine in discrete areas of rat brain. Int J Neuropharmacol 7:275\u2013281","journal-title":"Int J Neuropharmacol"},{"issue":"5","key":"717_CR24","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/0091-3057(78)90380-5","volume":"8","author":"DM Jacobowitz","year":"1978","unstructured":"Jacobowitz DM, Richardson JS (1978) Method for the rapid determination of norepinephrine, dopamine and serotonin in the same brain region. Pharmacol Biochem Behav 8(5):515\u2013519","journal-title":"Pharmacol Biochem Behav"},{"issue":"1","key":"717_CR25","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","volume":"126","author":"LCDA Green","year":"1982","unstructured":"Green LCDA, Wagner DA (1982) Analysis of nitrate, nitrite and [15\u00a0N] nitrate in biological fluids. Anal Biochem 126(1):131\u2013138","journal-title":"Anal Biochem"},{"issue":"1\u20132","key":"717_CR26","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jchromb.2006.07.054","volume":"851","author":"D Tsikas","year":"2007","unstructured":"Tsikas D (2007) Analysis of nitrite and nitrate in biological fluids by assays based on the Gries reaction: appraisal of the Gries reaction in the l-arginine\/nitric oxide area of research. J Chromatogr B Anal Technol Biomed Life Sci 851(1\u20132):51\u201370","journal-title":"J Chromatogr B Anal Technol Biomed Life Sci"},{"issue":"1","key":"717_CR27","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","volume":"82","author":"GL Ellman","year":"1959","unstructured":"Ellman GL (1959) Tissue sulfhdryl groups. Arch Biochem Biophys 82(1):70\u201377","journal-title":"Arch Biochem Biophys"},{"key":"717_CR28","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/9780470110171.ch14","volume":"1","author":"AC Maehly","year":"1954","unstructured":"Maehly AC, Chance B (1954) The assay of catalase and peroxidase. Methods Biochem Anal 1:357\u2013424","journal-title":"Methods Biochem Anal"},{"key":"717_CR29","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0892-0362(99)00083-5","volume":"22","author":"JL Ingram","year":"2000","unstructured":"Ingram JL, Peckham SM, Tisdale B, Rodier PM (2000) Prenatal exposure of rats to valproic acid reproduces the cerebellar anomalies associated with autism. Neurotoxicol Teratol 22:319\u2013324","journal-title":"Neurotoxicol Teratol"},{"key":"717_CR30","first-page":"531","volume":"53","author":"T Schneider","year":"2001","unstructured":"Schneider T, Labuz D, Przewlocki R (2001) Nociceptive changes in rats prenatal exposure to valproic acid. Pol J Pharmacol 53:531\u2013534","journal-title":"Pol J Pharmacol"},{"key":"717_CR31","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s00213-007-0795-y","volume":"193","author":"R Przewlocki","year":"2007","unstructured":"Przewlocki R, Schneider T, Ziolkowska B, Gieryk A, Tyminska A (2007) Prenatal exposure to valproic acid disturbs the enkephalinergic system functioning, basal hedonic tone, and emotional responses in an animal model of autism. Psychopharmacology (Berl) 193:547\u2013555","journal-title":"Psychopharmacology (Berl)"},{"key":"717_CR32","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1093\/cercor\/bhm117","volume":"18","author":"T Rinaldi","year":"2008","unstructured":"Rinaldi T, Silberberg G, Markram H (2008) Hyperconnectivity of local neocortical microcircuitry induced by prenatal exposure to valproic acid. Cereb Cortex 18:763\u2013770","journal-title":"Cereb Cortex"},{"key":"717_CR33","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.neures.2006.10.018","volume":"57","author":"N Tsujino","year":"2007","unstructured":"Tsujino N, Nakatani Y, Seki Y, Nakasato A, Nakamura M, Sugawara M, Arita H (2007) Abnormality of circadian rhythm accompanied by an increase in frontal cortex serotonin in animal model of autism. Neurosci Res 57:289\u2013295","journal-title":"Neurosci Res"},{"key":"717_CR34","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ijdevneu.2004.05.004","volume":"23","author":"K Miyazaki","year":"2005","unstructured":"Miyazaki K, Narita N, Narita M (2005) Maternal administration of thalidomide or valproic acid causes abnormal serotonergic neurons in the offspring: implication for pathogenesis of autism. Int J Dev Neurosci 23:287\u2013297","journal-title":"Int J Dev Neurosci"},{"key":"717_CR35","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jep.2010.11.045","volume":"134","author":"PD Charles","year":"2011","unstructured":"Charles PD, Ambigapathy G, Geraldine P, Akbarsha MA, Rajan KE (2011) Bacopa monniera leaf extract up-regulates tryptophan hydroxylase (TPH2) and serotonin transporter (SERT) expression: Implications in memory formation. J Ethnopharmacol 134:55\u201361","journal-title":"J Ethnopharmacol"},{"key":"717_CR36","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.jep.2007.01.025","volume":"111","author":"N Sheikh","year":"2007","unstructured":"Sheikh N, Ahmada A, Siripurapu KB, Kuchibhotla VK, Singh S, Palit G (2007) Effect of Bacopa monniera on stress induced changes in plasma corticosterone and brain monoamines in rats. J Ethnopharmacol 111:671\u2013676","journal-title":"J Ethnopharmacol"},{"issue":"3","key":"717_CR37","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.pathophys.2006.05.007","volume":"13","author":"A Chauhan","year":"2006","unstructured":"Chauhan A, Chauhan V (2006) Oxidative stress in autism. Pathophysiology 13(3):171\u2013181","journal-title":"Pathophysiology"},{"issue":"4","key":"717_CR38","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.neuro.2005.12.007","volume":"27","author":"A Jyoti","year":"2006","unstructured":"Jyoti A, Sharma D (2006) Neuroprotective role of Bacopa monniera extract against aluminium induced oxidative stress in the hippocampus of rat brain. Neurotoxicology 27(4):451\u2013457","journal-title":"Neurotoxicology"},{"key":"717_CR39","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.brainres.2008.01.055","volume":"1203","author":"CL Yochum","year":"2008","unstructured":"Yochum CL, Dowling P, Reuhl KR, Wagner GC, Ming X (2008) VPA-induced apoptosis and behavioral deficits in neonatal mice. Brain Res 1203:126\u2013132","journal-title":"Brain Res"},{"key":"717_CR40","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jep.2009.09.056","volume":"127","author":"N Uabundit","year":"2010","unstructured":"Uabundit N, Wattanathorn J, Mucimapura S, Ingkaninan K (2010) Cognitive enhancement and neuroprotective effects of Bacopa monniera in alzheimer\u2019s disease model. J Ethnopharmacol 127:26\u201331","journal-title":"J Ethnopharmacol"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-012-0717-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11064-012-0717-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-012-0717-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T03:21:26Z","timestamp":1742440886000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11064-012-0717-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,10]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["717"],"URL":"https:\/\/doi.org\/10.1007\/s11064-012-0717-1","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,10]]}}}